Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting

Abstract Background Healthy individuals and patients with cancer who are carriers of germline pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that require appropriate counseling and specific expertise. Main body On December 5th–7th, 2019, patient advocates and physicia...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Barbara Buonomo [verfasserIn] Claudia Massarotti [verfasserIn] Miriam Dellino [verfasserIn] Paola Anserini [verfasserIn] Alberta Ferrari [verfasserIn] Maria Campanella [verfasserIn] Mirosa Magnotti [verfasserIn] Cristofaro De Stefano [verfasserIn] Fedro Alessandro Peccatori [verfasserIn] Matteo Lambertini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Fertility BRCA Preimplantation genetic testing Oocyte cryopreservation Ovarian reserve Cancer

Übergeordnetes Werk:	In: BMC Medicine - BMC, 2003, 19(2021), 1, Seite 11
Übergeordnetes Werk:	volume:19 ; year:2021 ; number:1 ; pages:11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12916-021-02081-7

Katalog-ID:	DOAJ002133679

Internformat


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520			\|a Abstract Background Healthy individuals and patients with cancer who are carriers of germline pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that require appropriate counseling and specific expertise. Main body On December 5th–7th, 2019, patient advocates and physicians with expertise in the field of reproductive medicine, fertility preservation, and oncology were invited to “San Giuseppe Moscati” Hospital in Avellino (Italy) for a workshop on reproductive management of women with germline pathogenic variants in the BRCA1/2 genes. From the discussion regarding the current evidence and future prospective in the field, eight main research questions were formulated and eight recommendations were developed regarding fertility, fertility preservation, preimplantation genetic testing, and pregnancy in healthy carriers and patients with cancer. Conclusion Several misconceptions about the topic persist among health care providers and patients often resulting in a discontinuous and suboptimal management. With the aim to offer patient-tailored counseling about reproductive issues, both awareness of current evidences and research should be promoted.
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allfields	10.1186/s12916-021-02081-7 doi (DE-627)DOAJ002133679 (DE-599)DOAJ69d9561fdcee419ba0b13d8faf77eaba DE-627 ger DE-627 rakwb eng Barbara Buonomo verfasserin aut Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Healthy individuals and patients with cancer who are carriers of germline pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that require appropriate counseling and specific expertise. Main body On December 5th–7th, 2019, patient advocates and physicians with expertise in the field of reproductive medicine, fertility preservation, and oncology were invited to “San Giuseppe Moscati” Hospital in Avellino (Italy) for a workshop on reproductive management of women with germline pathogenic variants in the BRCA1/2 genes. From the discussion regarding the current evidence and future prospective in the field, eight main research questions were formulated and eight recommendations were developed regarding fertility, fertility preservation, preimplantation genetic testing, and pregnancy in healthy carriers and patients with cancer. Conclusion Several misconceptions about the topic persist among health care providers and patients often resulting in a discontinuous and suboptimal management. With the aim to offer patient-tailored counseling about reproductive issues, both awareness of current evidences and research should be promoted. Fertility BRCA Preimplantation genetic testing Oocyte cryopreservation Ovarian reserve Cancer Medicine R Claudia Massarotti verfasserin aut Miriam Dellino verfasserin aut Paola Anserini verfasserin aut Alberta Ferrari verfasserin aut Maria Campanella verfasserin aut Mirosa Magnotti verfasserin aut Cristofaro De Stefano verfasserin aut Fedro Alessandro Peccatori verfasserin aut Matteo Lambertini verfasserin aut In BMC Medicine BMC, 2003 19(2021), 1, Seite 11 (DE-627)377271225 (DE-600)2131669-7 17417015 nnns volume:19 year:2021 number:1 pages:11 https://doi.org/10.1186/s12916-021-02081-7 kostenfrei https://doaj.org/article/69d9561fdcee419ba0b13d8faf77eaba kostenfrei https://doi.org/10.1186/s12916-021-02081-7 kostenfrei https://doaj.org/toc/1741-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 11
spelling	10.1186/s12916-021-02081-7 doi (DE-627)DOAJ002133679 (DE-599)DOAJ69d9561fdcee419ba0b13d8faf77eaba DE-627 ger DE-627 rakwb eng Barbara Buonomo verfasserin aut Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Healthy individuals and patients with cancer who are carriers of germline pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that require appropriate counseling and specific expertise. Main body On December 5th–7th, 2019, patient advocates and physicians with expertise in the field of reproductive medicine, fertility preservation, and oncology were invited to “San Giuseppe Moscati” Hospital in Avellino (Italy) for a workshop on reproductive management of women with germline pathogenic variants in the BRCA1/2 genes. From the discussion regarding the current evidence and future prospective in the field, eight main research questions were formulated and eight recommendations were developed regarding fertility, fertility preservation, preimplantation genetic testing, and pregnancy in healthy carriers and patients with cancer. Conclusion Several misconceptions about the topic persist among health care providers and patients often resulting in a discontinuous and suboptimal management. With the aim to offer patient-tailored counseling about reproductive issues, both awareness of current evidences and research should be promoted. Fertility BRCA Preimplantation genetic testing Oocyte cryopreservation Ovarian reserve Cancer Medicine R Claudia Massarotti verfasserin aut Miriam Dellino verfasserin aut Paola Anserini verfasserin aut Alberta Ferrari verfasserin aut Maria Campanella verfasserin aut Mirosa Magnotti verfasserin aut Cristofaro De Stefano verfasserin aut Fedro Alessandro Peccatori verfasserin aut Matteo Lambertini verfasserin aut In BMC Medicine BMC, 2003 19(2021), 1, Seite 11 (DE-627)377271225 (DE-600)2131669-7 17417015 nnns volume:19 year:2021 number:1 pages:11 https://doi.org/10.1186/s12916-021-02081-7 kostenfrei https://doaj.org/article/69d9561fdcee419ba0b13d8faf77eaba kostenfrei https://doi.org/10.1186/s12916-021-02081-7 kostenfrei https://doaj.org/toc/1741-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 11
allfields_unstemmed	10.1186/s12916-021-02081-7 doi (DE-627)DOAJ002133679 (DE-599)DOAJ69d9561fdcee419ba0b13d8faf77eaba DE-627 ger DE-627 rakwb eng Barbara Buonomo verfasserin aut Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Healthy individuals and patients with cancer who are carriers of germline pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that require appropriate counseling and specific expertise. Main body On December 5th–7th, 2019, patient advocates and physicians with expertise in the field of reproductive medicine, fertility preservation, and oncology were invited to “San Giuseppe Moscati” Hospital in Avellino (Italy) for a workshop on reproductive management of women with germline pathogenic variants in the BRCA1/2 genes. From the discussion regarding the current evidence and future prospective in the field, eight main research questions were formulated and eight recommendations were developed regarding fertility, fertility preservation, preimplantation genetic testing, and pregnancy in healthy carriers and patients with cancer. Conclusion Several misconceptions about the topic persist among health care providers and patients often resulting in a discontinuous and suboptimal management. With the aim to offer patient-tailored counseling about reproductive issues, both awareness of current evidences and research should be promoted. Fertility BRCA Preimplantation genetic testing Oocyte cryopreservation Ovarian reserve Cancer Medicine R Claudia Massarotti verfasserin aut Miriam Dellino verfasserin aut Paola Anserini verfasserin aut Alberta Ferrari verfasserin aut Maria Campanella verfasserin aut Mirosa Magnotti verfasserin aut Cristofaro De Stefano verfasserin aut Fedro Alessandro Peccatori verfasserin aut Matteo Lambertini verfasserin aut In BMC Medicine BMC, 2003 19(2021), 1, Seite 11 (DE-627)377271225 (DE-600)2131669-7 17417015 nnns volume:19 year:2021 number:1 pages:11 https://doi.org/10.1186/s12916-021-02081-7 kostenfrei https://doaj.org/article/69d9561fdcee419ba0b13d8faf77eaba kostenfrei https://doi.org/10.1186/s12916-021-02081-7 kostenfrei https://doaj.org/toc/1741-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 11
allfieldsGer	10.1186/s12916-021-02081-7 doi (DE-627)DOAJ002133679 (DE-599)DOAJ69d9561fdcee419ba0b13d8faf77eaba DE-627 ger DE-627 rakwb eng Barbara Buonomo verfasserin aut Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Healthy individuals and patients with cancer who are carriers of germline pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that require appropriate counseling and specific expertise. Main body On December 5th–7th, 2019, patient advocates and physicians with expertise in the field of reproductive medicine, fertility preservation, and oncology were invited to “San Giuseppe Moscati” Hospital in Avellino (Italy) for a workshop on reproductive management of women with germline pathogenic variants in the BRCA1/2 genes. From the discussion regarding the current evidence and future prospective in the field, eight main research questions were formulated and eight recommendations were developed regarding fertility, fertility preservation, preimplantation genetic testing, and pregnancy in healthy carriers and patients with cancer. Conclusion Several misconceptions about the topic persist among health care providers and patients often resulting in a discontinuous and suboptimal management. With the aim to offer patient-tailored counseling about reproductive issues, both awareness of current evidences and research should be promoted. Fertility BRCA Preimplantation genetic testing Oocyte cryopreservation Ovarian reserve Cancer Medicine R Claudia Massarotti verfasserin aut Miriam Dellino verfasserin aut Paola Anserini verfasserin aut Alberta Ferrari verfasserin aut Maria Campanella verfasserin aut Mirosa Magnotti verfasserin aut Cristofaro De Stefano verfasserin aut Fedro Alessandro Peccatori verfasserin aut Matteo Lambertini verfasserin aut In BMC Medicine BMC, 2003 19(2021), 1, Seite 11 (DE-627)377271225 (DE-600)2131669-7 17417015 nnns volume:19 year:2021 number:1 pages:11 https://doi.org/10.1186/s12916-021-02081-7 kostenfrei https://doaj.org/article/69d9561fdcee419ba0b13d8faf77eaba kostenfrei https://doi.org/10.1186/s12916-021-02081-7 kostenfrei https://doaj.org/toc/1741-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 11
allfieldsSound	10.1186/s12916-021-02081-7 doi (DE-627)DOAJ002133679 (DE-599)DOAJ69d9561fdcee419ba0b13d8faf77eaba DE-627 ger DE-627 rakwb eng Barbara Buonomo verfasserin aut Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Healthy individuals and patients with cancer who are carriers of germline pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that require appropriate counseling and specific expertise. Main body On December 5th–7th, 2019, patient advocates and physicians with expertise in the field of reproductive medicine, fertility preservation, and oncology were invited to “San Giuseppe Moscati” Hospital in Avellino (Italy) for a workshop on reproductive management of women with germline pathogenic variants in the BRCA1/2 genes. From the discussion regarding the current evidence and future prospective in the field, eight main research questions were formulated and eight recommendations were developed regarding fertility, fertility preservation, preimplantation genetic testing, and pregnancy in healthy carriers and patients with cancer. Conclusion Several misconceptions about the topic persist among health care providers and patients often resulting in a discontinuous and suboptimal management. With the aim to offer patient-tailored counseling about reproductive issues, both awareness of current evidences and research should be promoted. Fertility BRCA Preimplantation genetic testing Oocyte cryopreservation Ovarian reserve Cancer Medicine R Claudia Massarotti verfasserin aut Miriam Dellino verfasserin aut Paola Anserini verfasserin aut Alberta Ferrari verfasserin aut Maria Campanella verfasserin aut Mirosa Magnotti verfasserin aut Cristofaro De Stefano verfasserin aut Fedro Alessandro Peccatori verfasserin aut Matteo Lambertini verfasserin aut In BMC Medicine BMC, 2003 19(2021), 1, Seite 11 (DE-627)377271225 (DE-600)2131669-7 17417015 nnns volume:19 year:2021 number:1 pages:11 https://doi.org/10.1186/s12916-021-02081-7 kostenfrei https://doaj.org/article/69d9561fdcee419ba0b13d8faf77eaba kostenfrei https://doi.org/10.1186/s12916-021-02081-7 kostenfrei https://doaj.org/toc/1741-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 11
language	English
source	In BMC Medicine 19(2021), 1, Seite 11 volume:19 year:2021 number:1 pages:11
sourceStr	In BMC Medicine 19(2021), 1, Seite 11 volume:19 year:2021 number:1 pages:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Fertility BRCA Preimplantation genetic testing Oocyte cryopreservation Ovarian reserve Cancer Medicine R
isfreeaccess_bool	true
container_title	BMC Medicine
authorswithroles_txt_mv	Barbara Buonomo @@aut@@ Claudia Massarotti @@aut@@ Miriam Dellino @@aut@@ Paola Anserini @@aut@@ Alberta Ferrari @@aut@@ Maria Campanella @@aut@@ Mirosa Magnotti @@aut@@ Cristofaro De Stefano @@aut@@ Fedro Alessandro Peccatori @@aut@@ Matteo Lambertini @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	377271225
id	DOAJ002133679
language_de	englisch
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author	Barbara Buonomo
spellingShingle	Barbara Buonomo misc Fertility misc BRCA misc Preimplantation genetic testing misc Oocyte cryopreservation misc Ovarian reserve misc Cancer misc Medicine misc R Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting
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topic_title	Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting Fertility BRCA Preimplantation genetic testing Oocyte cryopreservation Ovarian reserve Cancer
topic	misc Fertility misc BRCA misc Preimplantation genetic testing misc Oocyte cryopreservation misc Ovarian reserve misc Cancer misc Medicine misc R
topic_unstemmed	misc Fertility misc BRCA misc Preimplantation genetic testing misc Oocyte cryopreservation misc Ovarian reserve misc Cancer misc Medicine misc R
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title	Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting
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title_full	Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting
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author_browse	Barbara Buonomo Claudia Massarotti Miriam Dellino Paola Anserini Alberta Ferrari Maria Campanella Mirosa Magnotti Cristofaro De Stefano Fedro Alessandro Peccatori Matteo Lambertini
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title_sort	reproductive issues in carriers of germline pathogenic variants in the brca1/2 genes: an expert meeting
title_auth	Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting
abstract	Abstract Background Healthy individuals and patients with cancer who are carriers of germline pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that require appropriate counseling and specific expertise. Main body On December 5th–7th, 2019, patient advocates and physicians with expertise in the field of reproductive medicine, fertility preservation, and oncology were invited to “San Giuseppe Moscati” Hospital in Avellino (Italy) for a workshop on reproductive management of women with germline pathogenic variants in the BRCA1/2 genes. From the discussion regarding the current evidence and future prospective in the field, eight main research questions were formulated and eight recommendations were developed regarding fertility, fertility preservation, preimplantation genetic testing, and pregnancy in healthy carriers and patients with cancer. Conclusion Several misconceptions about the topic persist among health care providers and patients often resulting in a discontinuous and suboptimal management. With the aim to offer patient-tailored counseling about reproductive issues, both awareness of current evidences and research should be promoted.
abstractGer	Abstract Background Healthy individuals and patients with cancer who are carriers of germline pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that require appropriate counseling and specific expertise. Main body On December 5th–7th, 2019, patient advocates and physicians with expertise in the field of reproductive medicine, fertility preservation, and oncology were invited to “San Giuseppe Moscati” Hospital in Avellino (Italy) for a workshop on reproductive management of women with germline pathogenic variants in the BRCA1/2 genes. From the discussion regarding the current evidence and future prospective in the field, eight main research questions were formulated and eight recommendations were developed regarding fertility, fertility preservation, preimplantation genetic testing, and pregnancy in healthy carriers and patients with cancer. Conclusion Several misconceptions about the topic persist among health care providers and patients often resulting in a discontinuous and suboptimal management. With the aim to offer patient-tailored counseling about reproductive issues, both awareness of current evidences and research should be promoted.
abstract_unstemmed	Abstract Background Healthy individuals and patients with cancer who are carriers of germline pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that require appropriate counseling and specific expertise. Main body On December 5th–7th, 2019, patient advocates and physicians with expertise in the field of reproductive medicine, fertility preservation, and oncology were invited to “San Giuseppe Moscati” Hospital in Avellino (Italy) for a workshop on reproductive management of women with germline pathogenic variants in the BRCA1/2 genes. From the discussion regarding the current evidence and future prospective in the field, eight main research questions were formulated and eight recommendations were developed regarding fertility, fertility preservation, preimplantation genetic testing, and pregnancy in healthy carriers and patients with cancer. Conclusion Several misconceptions about the topic persist among health care providers and patients often resulting in a discontinuous and suboptimal management. With the aim to offer patient-tailored counseling about reproductive issues, both awareness of current evidences and research should be promoted.
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title_short	Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting
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