Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study

Abstract Background Physical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. Conclusions High PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hyunsuk Kim [verfasserIn] Mun Jung Ko [verfasserIn] Chi-Yeon Lim [verfasserIn] Eunjin Bae [verfasserIn] Young Youl Hyun [verfasserIn] Sungjin Chung [verfasserIn] Soon Hyo Kwon [verfasserIn] Jang-Hee Cho [verfasserIn] Kyung Don Yoo [verfasserIn] Woo Yeong Park [verfasserIn] In O Sun [verfasserIn] Byung Chul Yu [verfasserIn] Gang-Jee Ko [verfasserIn] Jae Won Yang [verfasserIn] Won Min Hwang [verfasserIn] Sang Heon Song [verfasserIn] Sung Joon Shin [verfasserIn] Yu Ah Hong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Physical activity Renal function Mortality Older adults

Übergeordnetes Werk:	In: BMC Geriatrics - BMC, 2003, 22(2022), 1, Seite 10
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; pages:10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12877-022-03693-1

Katalog-ID:	DOAJ002162601

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245	1	0	\|a Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study
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520			\|a Abstract Background Physical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. Conclusions High PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults.
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allfields	10.1186/s12877-022-03693-1 doi (DE-627)DOAJ002162601 (DE-599)DOAJ3a4950ac6ee0462bacc34ce06cd163bd DE-627 ger DE-627 rakwb eng RC952-954.6 Hyunsuk Kim verfasserin aut Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Physical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. Conclusions High PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults. Physical activity Renal function Mortality Older adults Geriatrics Mun Jung Ko verfasserin aut Chi-Yeon Lim verfasserin aut Eunjin Bae verfasserin aut Young Youl Hyun verfasserin aut Sungjin Chung verfasserin aut Soon Hyo Kwon verfasserin aut Jang-Hee Cho verfasserin aut Kyung Don Yoo verfasserin aut Woo Yeong Park verfasserin aut In O Sun verfasserin aut Byung Chul Yu verfasserin aut Gang-Jee Ko verfasserin aut Jae Won Yang verfasserin aut Won Min Hwang verfasserin aut Sang Heon Song verfasserin aut Sung Joon Shin verfasserin aut Yu Ah Hong verfasserin aut In BMC Geriatrics BMC, 2003 22(2022), 1, Seite 10 (DE-627)335488994 (DE-600)2059865-8 14712318 nnns volume:22 year:2022 number:1 pages:10 https://doi.org/10.1186/s12877-022-03693-1 kostenfrei https://doaj.org/article/3a4950ac6ee0462bacc34ce06cd163bd kostenfrei https://doi.org/10.1186/s12877-022-03693-1 kostenfrei https://doaj.org/toc/1471-2318 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 10
spelling	10.1186/s12877-022-03693-1 doi (DE-627)DOAJ002162601 (DE-599)DOAJ3a4950ac6ee0462bacc34ce06cd163bd DE-627 ger DE-627 rakwb eng RC952-954.6 Hyunsuk Kim verfasserin aut Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Physical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. Conclusions High PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults. Physical activity Renal function Mortality Older adults Geriatrics Mun Jung Ko verfasserin aut Chi-Yeon Lim verfasserin aut Eunjin Bae verfasserin aut Young Youl Hyun verfasserin aut Sungjin Chung verfasserin aut Soon Hyo Kwon verfasserin aut Jang-Hee Cho verfasserin aut Kyung Don Yoo verfasserin aut Woo Yeong Park verfasserin aut In O Sun verfasserin aut Byung Chul Yu verfasserin aut Gang-Jee Ko verfasserin aut Jae Won Yang verfasserin aut Won Min Hwang verfasserin aut Sang Heon Song verfasserin aut Sung Joon Shin verfasserin aut Yu Ah Hong verfasserin aut In BMC Geriatrics BMC, 2003 22(2022), 1, Seite 10 (DE-627)335488994 (DE-600)2059865-8 14712318 nnns volume:22 year:2022 number:1 pages:10 https://doi.org/10.1186/s12877-022-03693-1 kostenfrei https://doaj.org/article/3a4950ac6ee0462bacc34ce06cd163bd kostenfrei https://doi.org/10.1186/s12877-022-03693-1 kostenfrei https://doaj.org/toc/1471-2318 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 10
allfields_unstemmed	10.1186/s12877-022-03693-1 doi (DE-627)DOAJ002162601 (DE-599)DOAJ3a4950ac6ee0462bacc34ce06cd163bd DE-627 ger DE-627 rakwb eng RC952-954.6 Hyunsuk Kim verfasserin aut Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Physical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. Conclusions High PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults. Physical activity Renal function Mortality Older adults Geriatrics Mun Jung Ko verfasserin aut Chi-Yeon Lim verfasserin aut Eunjin Bae verfasserin aut Young Youl Hyun verfasserin aut Sungjin Chung verfasserin aut Soon Hyo Kwon verfasserin aut Jang-Hee Cho verfasserin aut Kyung Don Yoo verfasserin aut Woo Yeong Park verfasserin aut In O Sun verfasserin aut Byung Chul Yu verfasserin aut Gang-Jee Ko verfasserin aut Jae Won Yang verfasserin aut Won Min Hwang verfasserin aut Sang Heon Song verfasserin aut Sung Joon Shin verfasserin aut Yu Ah Hong verfasserin aut In BMC Geriatrics BMC, 2003 22(2022), 1, Seite 10 (DE-627)335488994 (DE-600)2059865-8 14712318 nnns volume:22 year:2022 number:1 pages:10 https://doi.org/10.1186/s12877-022-03693-1 kostenfrei https://doaj.org/article/3a4950ac6ee0462bacc34ce06cd163bd kostenfrei https://doi.org/10.1186/s12877-022-03693-1 kostenfrei https://doaj.org/toc/1471-2318 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 10
allfieldsGer	10.1186/s12877-022-03693-1 doi (DE-627)DOAJ002162601 (DE-599)DOAJ3a4950ac6ee0462bacc34ce06cd163bd DE-627 ger DE-627 rakwb eng RC952-954.6 Hyunsuk Kim verfasserin aut Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Physical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. Conclusions High PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults. Physical activity Renal function Mortality Older adults Geriatrics Mun Jung Ko verfasserin aut Chi-Yeon Lim verfasserin aut Eunjin Bae verfasserin aut Young Youl Hyun verfasserin aut Sungjin Chung verfasserin aut Soon Hyo Kwon verfasserin aut Jang-Hee Cho verfasserin aut Kyung Don Yoo verfasserin aut Woo Yeong Park verfasserin aut In O Sun verfasserin aut Byung Chul Yu verfasserin aut Gang-Jee Ko verfasserin aut Jae Won Yang verfasserin aut Won Min Hwang verfasserin aut Sang Heon Song verfasserin aut Sung Joon Shin verfasserin aut Yu Ah Hong verfasserin aut In BMC Geriatrics BMC, 2003 22(2022), 1, Seite 10 (DE-627)335488994 (DE-600)2059865-8 14712318 nnns volume:22 year:2022 number:1 pages:10 https://doi.org/10.1186/s12877-022-03693-1 kostenfrei https://doaj.org/article/3a4950ac6ee0462bacc34ce06cd163bd kostenfrei https://doi.org/10.1186/s12877-022-03693-1 kostenfrei https://doaj.org/toc/1471-2318 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 10
allfieldsSound	10.1186/s12877-022-03693-1 doi (DE-627)DOAJ002162601 (DE-599)DOAJ3a4950ac6ee0462bacc34ce06cd163bd DE-627 ger DE-627 rakwb eng RC952-954.6 Hyunsuk Kim verfasserin aut Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Physical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. Conclusions High PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults. Physical activity Renal function Mortality Older adults Geriatrics Mun Jung Ko verfasserin aut Chi-Yeon Lim verfasserin aut Eunjin Bae verfasserin aut Young Youl Hyun verfasserin aut Sungjin Chung verfasserin aut Soon Hyo Kwon verfasserin aut Jang-Hee Cho verfasserin aut Kyung Don Yoo verfasserin aut Woo Yeong Park verfasserin aut In O Sun verfasserin aut Byung Chul Yu verfasserin aut Gang-Jee Ko verfasserin aut Jae Won Yang verfasserin aut Won Min Hwang verfasserin aut Sang Heon Song verfasserin aut Sung Joon Shin verfasserin aut Yu Ah Hong verfasserin aut In BMC Geriatrics BMC, 2003 22(2022), 1, Seite 10 (DE-627)335488994 (DE-600)2059865-8 14712318 nnns volume:22 year:2022 number:1 pages:10 https://doi.org/10.1186/s12877-022-03693-1 kostenfrei https://doaj.org/article/3a4950ac6ee0462bacc34ce06cd163bd kostenfrei https://doi.org/10.1186/s12877-022-03693-1 kostenfrei https://doaj.org/toc/1471-2318 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 10
language	English
source	In BMC Geriatrics 22(2022), 1, Seite 10 volume:22 year:2022 number:1 pages:10
sourceStr	In BMC Geriatrics 22(2022), 1, Seite 10 volume:22 year:2022 number:1 pages:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Physical activity Renal function Mortality Older adults Geriatrics
isfreeaccess_bool	true
container_title	BMC Geriatrics
authorswithroles_txt_mv	Hyunsuk Kim @@aut@@ Mun Jung Ko @@aut@@ Chi-Yeon Lim @@aut@@ Eunjin Bae @@aut@@ Young Youl Hyun @@aut@@ Sungjin Chung @@aut@@ Soon Hyo Kwon @@aut@@ Jang-Hee Cho @@aut@@ Kyung Don Yoo @@aut@@ Woo Yeong Park @@aut@@ In O Sun @@aut@@ Byung Chul Yu @@aut@@ Gang-Jee Ko @@aut@@ Jae Won Yang @@aut@@ Won Min Hwang @@aut@@ Sang Heon Song @@aut@@ Sung Joon Shin @@aut@@ Yu Ah Hong @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	335488994
id	DOAJ002162601
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ002162601</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230503150853.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12877-022-03693-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ002162601</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ3a4950ac6ee0462bacc34ce06cd163bd</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC952-954.6</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Hyunsuk Kim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Physical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. Conclusions High PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Physical activity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Renal function</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mortality</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Older adults</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Geriatrics</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mun Jung Ko</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chi-Yeon Lim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" 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callnumber-first	R - Medicine
author	Hyunsuk Kim
spellingShingle	Hyunsuk Kim misc RC952-954.6 misc Physical activity misc Renal function misc Mortality misc Older adults misc Geriatrics Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study
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topic_title	RC952-954.6 Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study Physical activity Renal function Mortality Older adults
topic	misc RC952-954.6 misc Physical activity misc Renal function misc Mortality misc Older adults misc Geriatrics
topic_unstemmed	misc RC952-954.6 misc Physical activity misc Renal function misc Mortality misc Older adults misc Geriatrics
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title	Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study
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title_full	Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study
author_sort	Hyunsuk Kim
journal	BMC Geriatrics
journalStr	BMC Geriatrics
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author_browse	Hyunsuk Kim Mun Jung Ko Chi-Yeon Lim Eunjin Bae Young Youl Hyun Sungjin Chung Soon Hyo Kwon Jang-Hee Cho Kyung Don Yoo Woo Yeong Park In O Sun Byung Chul Yu Gang-Jee Ko Jae Won Yang Won Min Hwang Sang Heon Song Sung Joon Shin Yu Ah Hong
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doi_str_mv	10.1186/s12877-022-03693-1
author2-role	verfasserin
title_sort	association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study
callnumber	RC952-954.6
title_auth	Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study
abstract	Abstract Background Physical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. Conclusions High PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults.
abstractGer	Abstract Background Physical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. Conclusions High PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults.
abstract_unstemmed	Abstract Background Physical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. Conclusions High PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults.
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container_issue	1
title_short	Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study
url	https://doi.org/10.1186/s12877-022-03693-1 https://doaj.org/article/3a4950ac6ee0462bacc34ce06cd163bd https://doaj.org/toc/1471-2318
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author2	Mun Jung Ko Chi-Yeon Lim Eunjin Bae Young Youl Hyun Sungjin Chung Soon Hyo Kwon Jang-Hee Cho Kyung Don Yoo Woo Yeong Park In O Sun Byung Chul Yu Gang-Jee Ko Jae Won Yang Won Min Hwang Sang Heon Song Sung Joon Shin Yu Ah Hong
author2Str	Mun Jung Ko Chi-Yeon Lim Eunjin Bae Young Youl Hyun Sungjin Chung Soon Hyo Kwon Jang-Hee Cho Kyung Don Yoo Woo Yeong Park In O Sun Byung Chul Yu Gang-Jee Ko Jae Won Yang Won Min Hwang Sang Heon Song Sung Joon Shin Yu Ah Hong
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However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. 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Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study

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