Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i<

<i<Cirsium setosum</i< (<i<C. setosum</i<) has a potential antihyperglycemic effect, but it is unclear what bioactive components play a key role. According to the <i<α</i<-glucosidase inhibition activity, three new taraxastane-type triterpenoids of 3<i<β<...
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Gespeichert in:

Autor*in:	Xiuting Li [verfasserIn] Xiangjian Zhong [verfasserIn] Xin Wang [verfasserIn] Jinjie Li [verfasserIn] Jiachen Liu [verfasserIn] Kaiqi Wang [verfasserIn] Jianyu Yue [verfasserIn] Ximiao Yang [verfasserIn] Xiaoya Shang [verfasserIn] Sheng Lin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	isolation and purification triterpenoid

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 24(2019), 10, p 1844
Übergeordnetes Werk:	volume:24 ; year:2019 ; number:10, p 1844

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules24101844

Katalog-ID:	DOAJ002199963

Internformat


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520			\|a <i<Cirsium setosum</i< (<i<C. setosum</i<) has a potential antihyperglycemic effect, but it is unclear what bioactive components play a key role. According to the <i<α</i<-glucosidase inhibition activity, three new taraxastane-type triterpenoids of 3<i<β</i<-hydroxy-30-hydroperoxy-20-taraxastene (<b<1</b<), 3<i<β</i<-hydroxy-22<i<α</i<-methoxy-20-taraxastene (<b<2</b<), and 30-nor-3<i<β</i<,22<i<α</i<-dihydroxy-20-taraxastene (<b<3</b<), as well as five known taraxastane triterpenoids of 3<i<β</i<,22-dihydroxy-20-taraxastene (<b<4</b<), 20-taraxastene-3,22-dione (<b<5</b<), 3<i<β</i<-acetoxy-20-taraxasten-22-one (<b<6</b<), 3<i<β</i<-hydroxy-20-taraxasten-22-one (<b<7</b<), and 30-nor-3<i<β</i<-hydroxy-20-taraxastene (<b<8</b<) were obtained from the petroleum ether-soluble portion of the ethanol extract from <i<C. setosum</i<. All chemical structures of the compounds were elucidated by spectroscopic data analysis and compared with literature data. Compounds <b<4</b<–<b<8</b< were identified for the first time from this plant, and compounds <b<1</b<, <b<2</b<, <b<4,</b< and <b<7</b< exhibited more potent <i<α</i<-glucosidase inhibitory activity—with IC<sub<50</sub< values of 18.34 ± 1.27, 26.98 ± 0.89, 17.49 ± 1.42, and 22.67 ± 0.25 μM, respectively—than acarbose did (positive control, IC<sub<50</sub< 42.52 ± 0.32 μM).
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allfields	10.3390/molecules24101844 doi (DE-627)DOAJ002199963 (DE-599)DOAJed91f32f36464f5589ea6c9eb5cb7b91 DE-627 ger DE-627 rakwb eng QD241-441 Xiuting Li verfasserin aut Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i< 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Cirsium setosum</i< (<i<C. setosum</i<) has a potential antihyperglycemic effect, but it is unclear what bioactive components play a key role. According to the <i<α</i<-glucosidase inhibition activity, three new taraxastane-type triterpenoids of 3<i<β</i<-hydroxy-30-hydroperoxy-20-taraxastene (<b<1</b<), 3<i<β</i<-hydroxy-22<i<α</i<-methoxy-20-taraxastene (<b<2</b<), and 30-nor-3<i<β</i<,22<i<α</i<-dihydroxy-20-taraxastene (<b<3</b<), as well as five known taraxastane triterpenoids of 3<i<β</i<,22-dihydroxy-20-taraxastene (<b<4</b<), 20-taraxastene-3,22-dione (<b<5</b<), 3<i<β</i<-acetoxy-20-taraxasten-22-one (<b<6</b<), 3<i<β</i<-hydroxy-20-taraxasten-22-one (<b<7</b<), and 30-nor-3<i<β</i<-hydroxy-20-taraxastene (<b<8</b<) were obtained from the petroleum ether-soluble portion of the ethanol extract from <i<C. setosum</i<. All chemical structures of the compounds were elucidated by spectroscopic data analysis and compared with literature data. Compounds <b<4</b<–<b<8</b< were identified for the first time from this plant, and compounds <b<1</b<, <b<2</b<, <b<4,</b< and <b<7</b< exhibited more potent <i<α</i<-glucosidase inhibitory activity—with IC<sub<50</sub< values of 18.34 ± 1.27, 26.98 ± 0.89, 17.49 ± 1.42, and 22.67 ± 0.25 μM, respectively—than acarbose did (positive control, IC<sub<50</sub< 42.52 ± 0.32 μM). <i<Cirsium setosum</i< <i<α</i<-glucosidase inhibitor isolation and purification triterpenoid Organic chemistry Xiangjian Zhong verfasserin aut Xin Wang verfasserin aut Jinjie Li verfasserin aut Jiachen Liu verfasserin aut Kaiqi Wang verfasserin aut Jianyu Yue verfasserin aut Ximiao Yang verfasserin aut Xiaoya Shang verfasserin aut Sheng Lin verfasserin aut In Molecules MDPI AG, 2003 24(2019), 10, p 1844 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:24 year:2019 number:10, p 1844 https://doi.org/10.3390/molecules24101844 kostenfrei https://doaj.org/article/ed91f32f36464f5589ea6c9eb5cb7b91 kostenfrei https://www.mdpi.com/1420-3049/24/10/1844 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2019 10, p 1844
spelling	10.3390/molecules24101844 doi (DE-627)DOAJ002199963 (DE-599)DOAJed91f32f36464f5589ea6c9eb5cb7b91 DE-627 ger DE-627 rakwb eng QD241-441 Xiuting Li verfasserin aut Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i< 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Cirsium setosum</i< (<i<C. setosum</i<) has a potential antihyperglycemic effect, but it is unclear what bioactive components play a key role. According to the <i<α</i<-glucosidase inhibition activity, three new taraxastane-type triterpenoids of 3<i<β</i<-hydroxy-30-hydroperoxy-20-taraxastene (<b<1</b<), 3<i<β</i<-hydroxy-22<i<α</i<-methoxy-20-taraxastene (<b<2</b<), and 30-nor-3<i<β</i<,22<i<α</i<-dihydroxy-20-taraxastene (<b<3</b<), as well as five known taraxastane triterpenoids of 3<i<β</i<,22-dihydroxy-20-taraxastene (<b<4</b<), 20-taraxastene-3,22-dione (<b<5</b<), 3<i<β</i<-acetoxy-20-taraxasten-22-one (<b<6</b<), 3<i<β</i<-hydroxy-20-taraxasten-22-one (<b<7</b<), and 30-nor-3<i<β</i<-hydroxy-20-taraxastene (<b<8</b<) were obtained from the petroleum ether-soluble portion of the ethanol extract from <i<C. setosum</i<. All chemical structures of the compounds were elucidated by spectroscopic data analysis and compared with literature data. Compounds <b<4</b<–<b<8</b< were identified for the first time from this plant, and compounds <b<1</b<, <b<2</b<, <b<4,</b< and <b<7</b< exhibited more potent <i<α</i<-glucosidase inhibitory activity—with IC<sub<50</sub< values of 18.34 ± 1.27, 26.98 ± 0.89, 17.49 ± 1.42, and 22.67 ± 0.25 μM, respectively—than acarbose did (positive control, IC<sub<50</sub< 42.52 ± 0.32 μM). <i<Cirsium setosum</i< <i<α</i<-glucosidase inhibitor isolation and purification triterpenoid Organic chemistry Xiangjian Zhong verfasserin aut Xin Wang verfasserin aut Jinjie Li verfasserin aut Jiachen Liu verfasserin aut Kaiqi Wang verfasserin aut Jianyu Yue verfasserin aut Ximiao Yang verfasserin aut Xiaoya Shang verfasserin aut Sheng Lin verfasserin aut In Molecules MDPI AG, 2003 24(2019), 10, p 1844 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:24 year:2019 number:10, p 1844 https://doi.org/10.3390/molecules24101844 kostenfrei https://doaj.org/article/ed91f32f36464f5589ea6c9eb5cb7b91 kostenfrei https://www.mdpi.com/1420-3049/24/10/1844 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2019 10, p 1844
allfields_unstemmed	10.3390/molecules24101844 doi (DE-627)DOAJ002199963 (DE-599)DOAJed91f32f36464f5589ea6c9eb5cb7b91 DE-627 ger DE-627 rakwb eng QD241-441 Xiuting Li verfasserin aut Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i< 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Cirsium setosum</i< (<i<C. setosum</i<) has a potential antihyperglycemic effect, but it is unclear what bioactive components play a key role. According to the <i<α</i<-glucosidase inhibition activity, three new taraxastane-type triterpenoids of 3<i<β</i<-hydroxy-30-hydroperoxy-20-taraxastene (<b<1</b<), 3<i<β</i<-hydroxy-22<i<α</i<-methoxy-20-taraxastene (<b<2</b<), and 30-nor-3<i<β</i<,22<i<α</i<-dihydroxy-20-taraxastene (<b<3</b<), as well as five known taraxastane triterpenoids of 3<i<β</i<,22-dihydroxy-20-taraxastene (<b<4</b<), 20-taraxastene-3,22-dione (<b<5</b<), 3<i<β</i<-acetoxy-20-taraxasten-22-one (<b<6</b<), 3<i<β</i<-hydroxy-20-taraxasten-22-one (<b<7</b<), and 30-nor-3<i<β</i<-hydroxy-20-taraxastene (<b<8</b<) were obtained from the petroleum ether-soluble portion of the ethanol extract from <i<C. setosum</i<. All chemical structures of the compounds were elucidated by spectroscopic data analysis and compared with literature data. Compounds <b<4</b<–<b<8</b< were identified for the first time from this plant, and compounds <b<1</b<, <b<2</b<, <b<4,</b< and <b<7</b< exhibited more potent <i<α</i<-glucosidase inhibitory activity—with IC<sub<50</sub< values of 18.34 ± 1.27, 26.98 ± 0.89, 17.49 ± 1.42, and 22.67 ± 0.25 μM, respectively—than acarbose did (positive control, IC<sub<50</sub< 42.52 ± 0.32 μM). <i<Cirsium setosum</i< <i<α</i<-glucosidase inhibitor isolation and purification triterpenoid Organic chemistry Xiangjian Zhong verfasserin aut Xin Wang verfasserin aut Jinjie Li verfasserin aut Jiachen Liu verfasserin aut Kaiqi Wang verfasserin aut Jianyu Yue verfasserin aut Ximiao Yang verfasserin aut Xiaoya Shang verfasserin aut Sheng Lin verfasserin aut In Molecules MDPI AG, 2003 24(2019), 10, p 1844 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:24 year:2019 number:10, p 1844 https://doi.org/10.3390/molecules24101844 kostenfrei https://doaj.org/article/ed91f32f36464f5589ea6c9eb5cb7b91 kostenfrei https://www.mdpi.com/1420-3049/24/10/1844 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2019 10, p 1844
allfieldsGer	10.3390/molecules24101844 doi (DE-627)DOAJ002199963 (DE-599)DOAJed91f32f36464f5589ea6c9eb5cb7b91 DE-627 ger DE-627 rakwb eng QD241-441 Xiuting Li verfasserin aut Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i< 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Cirsium setosum</i< (<i<C. setosum</i<) has a potential antihyperglycemic effect, but it is unclear what bioactive components play a key role. According to the <i<α</i<-glucosidase inhibition activity, three new taraxastane-type triterpenoids of 3<i<β</i<-hydroxy-30-hydroperoxy-20-taraxastene (<b<1</b<), 3<i<β</i<-hydroxy-22<i<α</i<-methoxy-20-taraxastene (<b<2</b<), and 30-nor-3<i<β</i<,22<i<α</i<-dihydroxy-20-taraxastene (<b<3</b<), as well as five known taraxastane triterpenoids of 3<i<β</i<,22-dihydroxy-20-taraxastene (<b<4</b<), 20-taraxastene-3,22-dione (<b<5</b<), 3<i<β</i<-acetoxy-20-taraxasten-22-one (<b<6</b<), 3<i<β</i<-hydroxy-20-taraxasten-22-one (<b<7</b<), and 30-nor-3<i<β</i<-hydroxy-20-taraxastene (<b<8</b<) were obtained from the petroleum ether-soluble portion of the ethanol extract from <i<C. setosum</i<. All chemical structures of the compounds were elucidated by spectroscopic data analysis and compared with literature data. Compounds <b<4</b<–<b<8</b< were identified for the first time from this plant, and compounds <b<1</b<, <b<2</b<, <b<4,</b< and <b<7</b< exhibited more potent <i<α</i<-glucosidase inhibitory activity—with IC<sub<50</sub< values of 18.34 ± 1.27, 26.98 ± 0.89, 17.49 ± 1.42, and 22.67 ± 0.25 μM, respectively—than acarbose did (positive control, IC<sub<50</sub< 42.52 ± 0.32 μM). <i<Cirsium setosum</i< <i<α</i<-glucosidase inhibitor isolation and purification triterpenoid Organic chemistry Xiangjian Zhong verfasserin aut Xin Wang verfasserin aut Jinjie Li verfasserin aut Jiachen Liu verfasserin aut Kaiqi Wang verfasserin aut Jianyu Yue verfasserin aut Ximiao Yang verfasserin aut Xiaoya Shang verfasserin aut Sheng Lin verfasserin aut In Molecules MDPI AG, 2003 24(2019), 10, p 1844 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:24 year:2019 number:10, p 1844 https://doi.org/10.3390/molecules24101844 kostenfrei https://doaj.org/article/ed91f32f36464f5589ea6c9eb5cb7b91 kostenfrei https://www.mdpi.com/1420-3049/24/10/1844 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2019 10, p 1844
allfieldsSound	10.3390/molecules24101844 doi (DE-627)DOAJ002199963 (DE-599)DOAJed91f32f36464f5589ea6c9eb5cb7b91 DE-627 ger DE-627 rakwb eng QD241-441 Xiuting Li verfasserin aut Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i< 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Cirsium setosum</i< (<i<C. setosum</i<) has a potential antihyperglycemic effect, but it is unclear what bioactive components play a key role. According to the <i<α</i<-glucosidase inhibition activity, three new taraxastane-type triterpenoids of 3<i<β</i<-hydroxy-30-hydroperoxy-20-taraxastene (<b<1</b<), 3<i<β</i<-hydroxy-22<i<α</i<-methoxy-20-taraxastene (<b<2</b<), and 30-nor-3<i<β</i<,22<i<α</i<-dihydroxy-20-taraxastene (<b<3</b<), as well as five known taraxastane triterpenoids of 3<i<β</i<,22-dihydroxy-20-taraxastene (<b<4</b<), 20-taraxastene-3,22-dione (<b<5</b<), 3<i<β</i<-acetoxy-20-taraxasten-22-one (<b<6</b<), 3<i<β</i<-hydroxy-20-taraxasten-22-one (<b<7</b<), and 30-nor-3<i<β</i<-hydroxy-20-taraxastene (<b<8</b<) were obtained from the petroleum ether-soluble portion of the ethanol extract from <i<C. setosum</i<. All chemical structures of the compounds were elucidated by spectroscopic data analysis and compared with literature data. Compounds <b<4</b<–<b<8</b< were identified for the first time from this plant, and compounds <b<1</b<, <b<2</b<, <b<4,</b< and <b<7</b< exhibited more potent <i<α</i<-glucosidase inhibitory activity—with IC<sub<50</sub< values of 18.34 ± 1.27, 26.98 ± 0.89, 17.49 ± 1.42, and 22.67 ± 0.25 μM, respectively—than acarbose did (positive control, IC<sub<50</sub< 42.52 ± 0.32 μM). <i<Cirsium setosum</i< <i<α</i<-glucosidase inhibitor isolation and purification triterpenoid Organic chemistry Xiangjian Zhong verfasserin aut Xin Wang verfasserin aut Jinjie Li verfasserin aut Jiachen Liu verfasserin aut Kaiqi Wang verfasserin aut Jianyu Yue verfasserin aut Ximiao Yang verfasserin aut Xiaoya Shang verfasserin aut Sheng Lin verfasserin aut In Molecules MDPI AG, 2003 24(2019), 10, p 1844 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:24 year:2019 number:10, p 1844 https://doi.org/10.3390/molecules24101844 kostenfrei https://doaj.org/article/ed91f32f36464f5589ea6c9eb5cb7b91 kostenfrei https://www.mdpi.com/1420-3049/24/10/1844 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2019 10, p 1844
language	English
source	In Molecules 24(2019), 10, p 1844 volume:24 year:2019 number:10, p 1844
sourceStr	In Molecules 24(2019), 10, p 1844 volume:24 year:2019 number:10, p 1844
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	<i<Cirsium setosum</i< <i<α</i<-glucosidase inhibitor isolation and purification triterpenoid Organic chemistry
isfreeaccess_bool	true
container_title	Molecules
authorswithroles_txt_mv	Xiuting Li @@aut@@ Xiangjian Zhong @@aut@@ Xin Wang @@aut@@ Jinjie Li @@aut@@ Jiachen Liu @@aut@@ Kaiqi Wang @@aut@@ Jianyu Yue @@aut@@ Ximiao Yang @@aut@@ Xiaoya Shang @@aut@@ Sheng Lin @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	311313132
id	DOAJ002199963
language_de	englisch
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callnumber-first	Q - Science
author	Xiuting Li
spellingShingle	Xiuting Li misc QD241-441 misc <i<Cirsium setosum</i< misc <i<α</i<-glucosidase inhibitor misc isolation and purification misc triterpenoid misc Organic chemistry Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i<
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topic_title	QD241-441 Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i< <i<Cirsium setosum</i< <i<α</i<-glucosidase inhibitor isolation and purification triterpenoid
topic	misc QD241-441 misc <i<Cirsium setosum</i< misc <i<α</i<-glucosidase inhibitor misc isolation and purification misc triterpenoid misc Organic chemistry
topic_unstemmed	misc QD241-441 misc <i<Cirsium setosum</i< misc <i<α</i<-glucosidase inhibitor misc isolation and purification misc triterpenoid misc Organic chemistry
topic_browse	misc QD241-441 misc <i<Cirsium setosum</i< misc <i<α</i<-glucosidase inhibitor misc isolation and purification misc triterpenoid misc Organic chemistry
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title	Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i<
ctrlnum	(DE-627)DOAJ002199963 (DE-599)DOAJed91f32f36464f5589ea6c9eb5cb7b91
title_full	Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i<
author_sort	Xiuting Li
journal	Molecules
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author_browse	Xiuting Li Xiangjian Zhong Xin Wang Jinjie Li Jiachen Liu Kaiqi Wang Jianyu Yue Ximiao Yang Xiaoya Shang Sheng Lin
container_volume	24
class	QD241-441
format_se	Elektronische Aufsätze
author-letter	Xiuting Li
doi_str_mv	10.3390/molecules24101844
author2-role	verfasserin
title_sort	bioassay-guided isolation of triterpenoids as <i<α</i<-glucosidase inhibitors from <i<cirsium setosum</i<
callnumber	QD241-441
title_auth	Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i<
abstract	<i<Cirsium setosum</i< (<i<C. setosum</i<) has a potential antihyperglycemic effect, but it is unclear what bioactive components play a key role. According to the <i<α</i<-glucosidase inhibition activity, three new taraxastane-type triterpenoids of 3<i<β</i<-hydroxy-30-hydroperoxy-20-taraxastene (<b<1</b<), 3<i<β</i<-hydroxy-22<i<α</i<-methoxy-20-taraxastene (<b<2</b<), and 30-nor-3<i<β</i<,22<i<α</i<-dihydroxy-20-taraxastene (<b<3</b<), as well as five known taraxastane triterpenoids of 3<i<β</i<,22-dihydroxy-20-taraxastene (<b<4</b<), 20-taraxastene-3,22-dione (<b<5</b<), 3<i<β</i<-acetoxy-20-taraxasten-22-one (<b<6</b<), 3<i<β</i<-hydroxy-20-taraxasten-22-one (<b<7</b<), and 30-nor-3<i<β</i<-hydroxy-20-taraxastene (<b<8</b<) were obtained from the petroleum ether-soluble portion of the ethanol extract from <i<C. setosum</i<. All chemical structures of the compounds were elucidated by spectroscopic data analysis and compared with literature data. Compounds <b<4</b<–<b<8</b< were identified for the first time from this plant, and compounds <b<1</b<, <b<2</b<, <b<4,</b< and <b<7</b< exhibited more potent <i<α</i<-glucosidase inhibitory activity—with IC<sub<50</sub< values of 18.34 ± 1.27, 26.98 ± 0.89, 17.49 ± 1.42, and 22.67 ± 0.25 μM, respectively—than acarbose did (positive control, IC<sub<50</sub< 42.52 ± 0.32 μM).
abstractGer	<i<Cirsium setosum</i< (<i<C. setosum</i<) has a potential antihyperglycemic effect, but it is unclear what bioactive components play a key role. According to the <i<α</i<-glucosidase inhibition activity, three new taraxastane-type triterpenoids of 3<i<β</i<-hydroxy-30-hydroperoxy-20-taraxastene (<b<1</b<), 3<i<β</i<-hydroxy-22<i<α</i<-methoxy-20-taraxastene (<b<2</b<), and 30-nor-3<i<β</i<,22<i<α</i<-dihydroxy-20-taraxastene (<b<3</b<), as well as five known taraxastane triterpenoids of 3<i<β</i<,22-dihydroxy-20-taraxastene (<b<4</b<), 20-taraxastene-3,22-dione (<b<5</b<), 3<i<β</i<-acetoxy-20-taraxasten-22-one (<b<6</b<), 3<i<β</i<-hydroxy-20-taraxasten-22-one (<b<7</b<), and 30-nor-3<i<β</i<-hydroxy-20-taraxastene (<b<8</b<) were obtained from the petroleum ether-soluble portion of the ethanol extract from <i<C. setosum</i<. All chemical structures of the compounds were elucidated by spectroscopic data analysis and compared with literature data. Compounds <b<4</b<–<b<8</b< were identified for the first time from this plant, and compounds <b<1</b<, <b<2</b<, <b<4,</b< and <b<7</b< exhibited more potent <i<α</i<-glucosidase inhibitory activity—with IC<sub<50</sub< values of 18.34 ± 1.27, 26.98 ± 0.89, 17.49 ± 1.42, and 22.67 ± 0.25 μM, respectively—than acarbose did (positive control, IC<sub<50</sub< 42.52 ± 0.32 μM).
abstract_unstemmed	<i<Cirsium setosum</i< (<i<C. setosum</i<) has a potential antihyperglycemic effect, but it is unclear what bioactive components play a key role. According to the <i<α</i<-glucosidase inhibition activity, three new taraxastane-type triterpenoids of 3<i<β</i<-hydroxy-30-hydroperoxy-20-taraxastene (<b<1</b<), 3<i<β</i<-hydroxy-22<i<α</i<-methoxy-20-taraxastene (<b<2</b<), and 30-nor-3<i<β</i<,22<i<α</i<-dihydroxy-20-taraxastene (<b<3</b<), as well as five known taraxastane triterpenoids of 3<i<β</i<,22-dihydroxy-20-taraxastene (<b<4</b<), 20-taraxastene-3,22-dione (<b<5</b<), 3<i<β</i<-acetoxy-20-taraxasten-22-one (<b<6</b<), 3<i<β</i<-hydroxy-20-taraxasten-22-one (<b<7</b<), and 30-nor-3<i<β</i<-hydroxy-20-taraxastene (<b<8</b<) were obtained from the petroleum ether-soluble portion of the ethanol extract from <i<C. setosum</i<. All chemical structures of the compounds were elucidated by spectroscopic data analysis and compared with literature data. Compounds <b<4</b<–<b<8</b< were identified for the first time from this plant, and compounds <b<1</b<, <b<2</b<, <b<4,</b< and <b<7</b< exhibited more potent <i<α</i<-glucosidase inhibitory activity—with IC<sub<50</sub< values of 18.34 ± 1.27, 26.98 ± 0.89, 17.49 ± 1.42, and 22.67 ± 0.25 μM, respectively—than acarbose did (positive control, IC<sub<50</sub< 42.52 ± 0.32 μM).
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container_issue	10, p 1844
title_short	Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i<
url	https://doi.org/10.3390/molecules24101844 https://doaj.org/article/ed91f32f36464f5589ea6c9eb5cb7b91 https://www.mdpi.com/1420-3049/24/10/1844 https://doaj.org/toc/1420-3049
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up_date	2024-07-04T00:16:48.254Z
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Bioassay-Guided Isolation of Triterpenoids as <i<α</i<-Glucosidase Inhibitors from <i<Cirsium setosum</i<

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