EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup<+</sup<CD45RО<sup<+</sup</CD8<sup<+</sup<CD45RО<sup<+</sup< T CELLS

Effect of γс-cytokines (IL-2, IL-7 и IL-15) upon maturation and differentiation of cytotoxic and helper CD45RО+ Tcell population was studied in the homeostatic in vitro culture conditions. We have found that IL-2, IL-7 and IL-15 mediate maturation and differentiation of CD8 T cells central memory, r...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	K. A. Yurova [verfasserIn] O. G. Khaziakhmatova [verfasserIn] N. M. Todosenko [verfasserIn] L. S. Litvinova [verfasserIn]

Format:	E-Artikel
Sprache:	Russisch

Erschienen:	2018

Schlagwörter:	immunological memory central memory t cells effector memory t cells terminally differentiated cells γc-cytokines differentiation

Übergeordnetes Werk:	In: Медицинская иммунология - St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists, 2015, 20(2018), 1, Seite 45-52
Übergeordnetes Werk:	volume:20 ; year:2018 ; number:1 ; pages:45-52

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.15789/1563-0625-2018-1-45-52

Katalog-ID:	DOAJ002201046

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topic_facet	immunological memory central memory t cells effector memory t cells terminally differentiated cells γc-cytokines differentiation Immunologic diseases. Allergy
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callnumber-first	R - Medicine
author	K. A. Yurova
spellingShingle	K. A. Yurova misc RC581-607 misc immunological memory misc central memory t cells misc effector memory t cells misc terminally differentiated cells misc γc-cytokines misc differentiation misc Immunologic diseases. Allergy EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup<+</sup<CD45RО<sup<+</sup</CD8<sup<+</sup<CD45RО<sup<+</sup< T CELLS
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topic_title	RC581-607 EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup<+</sup<CD45RО<sup<+</sup</CD8<sup<+</sup<CD45RО<sup<+</sup< T CELLS immunological memory central memory t cells effector memory t cells terminally differentiated cells γc-cytokines differentiation
topic	misc RC581-607 misc immunological memory misc central memory t cells misc effector memory t cells misc terminally differentiated cells misc γc-cytokines misc differentiation misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc immunological memory misc central memory t cells misc effector memory t cells misc terminally differentiated cells misc γc-cytokines misc differentiation misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc immunological memory misc central memory t cells misc effector memory t cells misc terminally differentiated cells misc γc-cytokines misc differentiation misc Immunologic diseases. Allergy
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title	EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup<+</sup<CD45RО<sup<+</sup</CD8<sup<+</sup<CD45RО<sup<+</sup< T CELLS
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title_full	EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup<+</sup<CD45RО<sup<+</sup</CD8<sup<+</sup<CD45RО<sup<+</sup< T CELLS
author_sort	K. A. Yurova
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author_browse	K. A. Yurova O. G. Khaziakhmatova N. M. Todosenko L. S. Litvinova
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title_sort	effects of γс-cytokines (il-2, il-7 and il-15) upon in vitro maturation and differentiation of cd4<sup<+</sup<cd45rо<sup<+</sup</cd8<sup<+</sup<cd45rо<sup<+</sup< t cells
callnumber	RC581-607
title_auth	EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup<+</sup<CD45RО<sup<+</sup</CD8<sup<+</sup<CD45RО<sup<+</sup< T CELLS
abstract	Effect of γс-cytokines (IL-2, IL-7 и IL-15) upon maturation and differentiation of cytotoxic and helper CD45RО+ Tcell population was studied in the homeostatic in vitro culture conditions. We have found that IL-2, IL-7 and IL-15 mediate maturation and differentiation of CD8 T cells central memory, replenishing the population of cells that exhibit effector functions. Action of IL-2 on CD4+ central memory T cells is accociated with generation of effector memory cells by reducing the number of immature effectors (CD62L–CD27+), whereas IL-7 promotes the formation of immature (CD62L–CD27+) effectors. IL-2, IL-7 and IL-15 initiate formation of terminally-differentiated cells in a subpopulation of CD8+CD45RO+ lymphocytes, providing a stable immunological memory to a pathogen reinfestation.
abstractGer	Effect of γс-cytokines (IL-2, IL-7 и IL-15) upon maturation and differentiation of cytotoxic and helper CD45RО+ Tcell population was studied in the homeostatic in vitro culture conditions. We have found that IL-2, IL-7 and IL-15 mediate maturation and differentiation of CD8 T cells central memory, replenishing the population of cells that exhibit effector functions. Action of IL-2 on CD4+ central memory T cells is accociated with generation of effector memory cells by reducing the number of immature effectors (CD62L–CD27+), whereas IL-7 promotes the formation of immature (CD62L–CD27+) effectors. IL-2, IL-7 and IL-15 initiate formation of terminally-differentiated cells in a subpopulation of CD8+CD45RO+ lymphocytes, providing a stable immunological memory to a pathogen reinfestation.
abstract_unstemmed	Effect of γс-cytokines (IL-2, IL-7 и IL-15) upon maturation and differentiation of cytotoxic and helper CD45RО+ Tcell population was studied in the homeostatic in vitro culture conditions. We have found that IL-2, IL-7 and IL-15 mediate maturation and differentiation of CD8 T cells central memory, replenishing the population of cells that exhibit effector functions. Action of IL-2 on CD4+ central memory T cells is accociated with generation of effector memory cells by reducing the number of immature effectors (CD62L–CD27+), whereas IL-7 promotes the formation of immature (CD62L–CD27+) effectors. IL-2, IL-7 and IL-15 initiate formation of terminally-differentiated cells in a subpopulation of CD8+CD45RO+ lymphocytes, providing a stable immunological memory to a pathogen reinfestation.
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title_short	EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup<+</sup<CD45RО<sup<+</sup</CD8<sup<+</sup<CD45RО<sup<+</sup< T CELLS
url	https://doi.org/10.15789/1563-0625-2018-1-45-52 https://doaj.org/article/02c48b2b988145c8b7911886c407c9fc https://www.mimmun.ru/mimmun/article/view/1431 https://doaj.org/toc/1563-0625 https://doaj.org/toc/2313-741X
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author2	O. G. Khaziakhmatova N. M. Todosenko L. S. Litvinova
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up_date	2024-07-04T00:17:01.726Z
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EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup<+</sup<CD45RО<sup<+</sup</CD8<sup<+</sup<CD45RО<sup<+</sup< T CELLS

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