Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis

Seven styrylquinolines were synthesized in this study. Two of these styrylquinolines are new and were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, and normal cells...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Vanesa Bedoya-Betancur [verfasserIn] Elizabeth Correa [verfasserIn] Juan Pablo Rendón [verfasserIn] Andrés F. Yepes-Pérez [verfasserIn] Wilson Cardona-Galeano [verfasserIn] Tonny W. Naranjo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	styrylquinolines colorectal cancer antiproliferation cell death apoptosis inflammation

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 27(2022), 20, p 7108
Übergeordnetes Werk:	volume:27 ; year:2022 ; number:20, p 7108

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules27207108

Katalog-ID:	DOAJ002219670

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allfields	10.3390/molecules27207108 doi (DE-627)DOAJ002219670 (DE-599)DOAJc43f946720614c639b71516a09482530 DE-627 ger DE-627 rakwb eng QD241-441 Vanesa Bedoya-Betancur verfasserin aut Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Seven styrylquinolines were synthesized in this study. Two of these styrylquinolines are new and were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, and normal cells (HaCaT). According to the results, compounds <b<3a</b< and <b<3d</b< showed antiproliferative activity in SW480 and SW620 cells, but their effect seemed to be caused by different mechanisms of action. Compound <b<3a</b< induced apoptosis independent of ROS production, as evidenced by increased levels of caspase 3, and had an immunomodulatory effect, positively regulating the production of different immunological markers in malignant cell lines. In contrast, compound <b<3d</b< generated a pro-oxidant response and inhibited the growth of cancer cells, probably by another type of cell death other than apoptosis. Molecular docking studies indicated that the most active compound, <b<3a,</b< could efficiently bind to the proapoptotic human caspases-3 protein, a result that could provide valuable information on the biochemical mechanism for the in vitro cytotoxic response of this compound in SW620 colon carcinoma cell lines. The obtained results suggest that these compounds have chemopreventive potential against CRC, but more studies should be carried out to elucidate the molecular mechanisms of action of each of them in depth. styrylquinolines colorectal cancer antiproliferation cell death apoptosis inflammation Organic chemistry Elizabeth Correa verfasserin aut Juan Pablo Rendón verfasserin aut Andrés F. Yepes-Pérez verfasserin aut Wilson Cardona-Galeano verfasserin aut Tonny W. Naranjo verfasserin aut In Molecules MDPI AG, 2003 27(2022), 20, p 7108 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:20, p 7108 https://doi.org/10.3390/molecules27207108 kostenfrei https://doaj.org/article/c43f946720614c639b71516a09482530 kostenfrei https://www.mdpi.com/1420-3049/27/20/7108 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 20, p 7108
spelling	10.3390/molecules27207108 doi (DE-627)DOAJ002219670 (DE-599)DOAJc43f946720614c639b71516a09482530 DE-627 ger DE-627 rakwb eng QD241-441 Vanesa Bedoya-Betancur verfasserin aut Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Seven styrylquinolines were synthesized in this study. Two of these styrylquinolines are new and were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, and normal cells (HaCaT). According to the results, compounds <b<3a</b< and <b<3d</b< showed antiproliferative activity in SW480 and SW620 cells, but their effect seemed to be caused by different mechanisms of action. Compound <b<3a</b< induced apoptosis independent of ROS production, as evidenced by increased levels of caspase 3, and had an immunomodulatory effect, positively regulating the production of different immunological markers in malignant cell lines. In contrast, compound <b<3d</b< generated a pro-oxidant response and inhibited the growth of cancer cells, probably by another type of cell death other than apoptosis. Molecular docking studies indicated that the most active compound, <b<3a,</b< could efficiently bind to the proapoptotic human caspases-3 protein, a result that could provide valuable information on the biochemical mechanism for the in vitro cytotoxic response of this compound in SW620 colon carcinoma cell lines. The obtained results suggest that these compounds have chemopreventive potential against CRC, but more studies should be carried out to elucidate the molecular mechanisms of action of each of them in depth. styrylquinolines colorectal cancer antiproliferation cell death apoptosis inflammation Organic chemistry Elizabeth Correa verfasserin aut Juan Pablo Rendón verfasserin aut Andrés F. Yepes-Pérez verfasserin aut Wilson Cardona-Galeano verfasserin aut Tonny W. Naranjo verfasserin aut In Molecules MDPI AG, 2003 27(2022), 20, p 7108 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:20, p 7108 https://doi.org/10.3390/molecules27207108 kostenfrei https://doaj.org/article/c43f946720614c639b71516a09482530 kostenfrei https://www.mdpi.com/1420-3049/27/20/7108 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 20, p 7108
allfields_unstemmed	10.3390/molecules27207108 doi (DE-627)DOAJ002219670 (DE-599)DOAJc43f946720614c639b71516a09482530 DE-627 ger DE-627 rakwb eng QD241-441 Vanesa Bedoya-Betancur verfasserin aut Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Seven styrylquinolines were synthesized in this study. Two of these styrylquinolines are new and were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, and normal cells (HaCaT). According to the results, compounds <b<3a</b< and <b<3d</b< showed antiproliferative activity in SW480 and SW620 cells, but their effect seemed to be caused by different mechanisms of action. Compound <b<3a</b< induced apoptosis independent of ROS production, as evidenced by increased levels of caspase 3, and had an immunomodulatory effect, positively regulating the production of different immunological markers in malignant cell lines. In contrast, compound <b<3d</b< generated a pro-oxidant response and inhibited the growth of cancer cells, probably by another type of cell death other than apoptosis. Molecular docking studies indicated that the most active compound, <b<3a,</b< could efficiently bind to the proapoptotic human caspases-3 protein, a result that could provide valuable information on the biochemical mechanism for the in vitro cytotoxic response of this compound in SW620 colon carcinoma cell lines. The obtained results suggest that these compounds have chemopreventive potential against CRC, but more studies should be carried out to elucidate the molecular mechanisms of action of each of them in depth. styrylquinolines colorectal cancer antiproliferation cell death apoptosis inflammation Organic chemistry Elizabeth Correa verfasserin aut Juan Pablo Rendón verfasserin aut Andrés F. Yepes-Pérez verfasserin aut Wilson Cardona-Galeano verfasserin aut Tonny W. Naranjo verfasserin aut In Molecules MDPI AG, 2003 27(2022), 20, p 7108 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:20, p 7108 https://doi.org/10.3390/molecules27207108 kostenfrei https://doaj.org/article/c43f946720614c639b71516a09482530 kostenfrei https://www.mdpi.com/1420-3049/27/20/7108 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 20, p 7108
allfieldsGer	10.3390/molecules27207108 doi (DE-627)DOAJ002219670 (DE-599)DOAJc43f946720614c639b71516a09482530 DE-627 ger DE-627 rakwb eng QD241-441 Vanesa Bedoya-Betancur verfasserin aut Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Seven styrylquinolines were synthesized in this study. Two of these styrylquinolines are new and were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, and normal cells (HaCaT). According to the results, compounds <b<3a</b< and <b<3d</b< showed antiproliferative activity in SW480 and SW620 cells, but their effect seemed to be caused by different mechanisms of action. Compound <b<3a</b< induced apoptosis independent of ROS production, as evidenced by increased levels of caspase 3, and had an immunomodulatory effect, positively regulating the production of different immunological markers in malignant cell lines. In contrast, compound <b<3d</b< generated a pro-oxidant response and inhibited the growth of cancer cells, probably by another type of cell death other than apoptosis. Molecular docking studies indicated that the most active compound, <b<3a,</b< could efficiently bind to the proapoptotic human caspases-3 protein, a result that could provide valuable information on the biochemical mechanism for the in vitro cytotoxic response of this compound in SW620 colon carcinoma cell lines. The obtained results suggest that these compounds have chemopreventive potential against CRC, but more studies should be carried out to elucidate the molecular mechanisms of action of each of them in depth. styrylquinolines colorectal cancer antiproliferation cell death apoptosis inflammation Organic chemistry Elizabeth Correa verfasserin aut Juan Pablo Rendón verfasserin aut Andrés F. Yepes-Pérez verfasserin aut Wilson Cardona-Galeano verfasserin aut Tonny W. Naranjo verfasserin aut In Molecules MDPI AG, 2003 27(2022), 20, p 7108 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:20, p 7108 https://doi.org/10.3390/molecules27207108 kostenfrei https://doaj.org/article/c43f946720614c639b71516a09482530 kostenfrei https://www.mdpi.com/1420-3049/27/20/7108 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 20, p 7108
allfieldsSound	10.3390/molecules27207108 doi (DE-627)DOAJ002219670 (DE-599)DOAJc43f946720614c639b71516a09482530 DE-627 ger DE-627 rakwb eng QD241-441 Vanesa Bedoya-Betancur verfasserin aut Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Seven styrylquinolines were synthesized in this study. Two of these styrylquinolines are new and were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, and normal cells (HaCaT). According to the results, compounds <b<3a</b< and <b<3d</b< showed antiproliferative activity in SW480 and SW620 cells, but their effect seemed to be caused by different mechanisms of action. Compound <b<3a</b< induced apoptosis independent of ROS production, as evidenced by increased levels of caspase 3, and had an immunomodulatory effect, positively regulating the production of different immunological markers in malignant cell lines. In contrast, compound <b<3d</b< generated a pro-oxidant response and inhibited the growth of cancer cells, probably by another type of cell death other than apoptosis. Molecular docking studies indicated that the most active compound, <b<3a,</b< could efficiently bind to the proapoptotic human caspases-3 protein, a result that could provide valuable information on the biochemical mechanism for the in vitro cytotoxic response of this compound in SW620 colon carcinoma cell lines. The obtained results suggest that these compounds have chemopreventive potential against CRC, but more studies should be carried out to elucidate the molecular mechanisms of action of each of them in depth. styrylquinolines colorectal cancer antiproliferation cell death apoptosis inflammation Organic chemistry Elizabeth Correa verfasserin aut Juan Pablo Rendón verfasserin aut Andrés F. Yepes-Pérez verfasserin aut Wilson Cardona-Galeano verfasserin aut Tonny W. Naranjo verfasserin aut In Molecules MDPI AG, 2003 27(2022), 20, p 7108 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:20, p 7108 https://doi.org/10.3390/molecules27207108 kostenfrei https://doaj.org/article/c43f946720614c639b71516a09482530 kostenfrei https://www.mdpi.com/1420-3049/27/20/7108 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 20, p 7108
language	English
source	In Molecules 27(2022), 20, p 7108 volume:27 year:2022 number:20, p 7108
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topic_facet	styrylquinolines colorectal cancer antiproliferation cell death apoptosis inflammation Organic chemistry
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authorswithroles_txt_mv	Vanesa Bedoya-Betancur @@aut@@ Elizabeth Correa @@aut@@ Juan Pablo Rendón @@aut@@ Andrés F. Yepes-Pérez @@aut@@ Wilson Cardona-Galeano @@aut@@ Tonny W. Naranjo @@aut@@
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callnumber-first	Q - Science
author	Vanesa Bedoya-Betancur
spellingShingle	Vanesa Bedoya-Betancur misc QD241-441 misc styrylquinolines misc colorectal cancer misc antiproliferation misc cell death misc apoptosis misc inflammation misc Organic chemistry Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis
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topic_title	QD241-441 Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis styrylquinolines colorectal cancer antiproliferation cell death apoptosis inflammation
topic	misc QD241-441 misc styrylquinolines misc colorectal cancer misc antiproliferation misc cell death misc apoptosis misc inflammation misc Organic chemistry
topic_unstemmed	misc QD241-441 misc styrylquinolines misc colorectal cancer misc antiproliferation misc cell death misc apoptosis misc inflammation misc Organic chemistry
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title	Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis
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title_full	Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis
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title_sort	chemopreventive effect on human colon adenocarcinoma cells of styrylquinolines: synthesis, cytotoxicity, proapoptotic effect and molecular docking analysis
callnumber	QD241-441
title_auth	Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis
abstract	Seven styrylquinolines were synthesized in this study. Two of these styrylquinolines are new and were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, and normal cells (HaCaT). According to the results, compounds <b<3a</b< and <b<3d</b< showed antiproliferative activity in SW480 and SW620 cells, but their effect seemed to be caused by different mechanisms of action. Compound <b<3a</b< induced apoptosis independent of ROS production, as evidenced by increased levels of caspase 3, and had an immunomodulatory effect, positively regulating the production of different immunological markers in malignant cell lines. In contrast, compound <b<3d</b< generated a pro-oxidant response and inhibited the growth of cancer cells, probably by another type of cell death other than apoptosis. Molecular docking studies indicated that the most active compound, <b<3a,</b< could efficiently bind to the proapoptotic human caspases-3 protein, a result that could provide valuable information on the biochemical mechanism for the in vitro cytotoxic response of this compound in SW620 colon carcinoma cell lines. The obtained results suggest that these compounds have chemopreventive potential against CRC, but more studies should be carried out to elucidate the molecular mechanisms of action of each of them in depth.
abstractGer	Seven styrylquinolines were synthesized in this study. Two of these styrylquinolines are new and were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, and normal cells (HaCaT). According to the results, compounds <b<3a</b< and <b<3d</b< showed antiproliferative activity in SW480 and SW620 cells, but their effect seemed to be caused by different mechanisms of action. Compound <b<3a</b< induced apoptosis independent of ROS production, as evidenced by increased levels of caspase 3, and had an immunomodulatory effect, positively regulating the production of different immunological markers in malignant cell lines. In contrast, compound <b<3d</b< generated a pro-oxidant response and inhibited the growth of cancer cells, probably by another type of cell death other than apoptosis. Molecular docking studies indicated that the most active compound, <b<3a,</b< could efficiently bind to the proapoptotic human caspases-3 protein, a result that could provide valuable information on the biochemical mechanism for the in vitro cytotoxic response of this compound in SW620 colon carcinoma cell lines. The obtained results suggest that these compounds have chemopreventive potential against CRC, but more studies should be carried out to elucidate the molecular mechanisms of action of each of them in depth.
abstract_unstemmed	Seven styrylquinolines were synthesized in this study. Two of these styrylquinolines are new and were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, and normal cells (HaCaT). According to the results, compounds <b<3a</b< and <b<3d</b< showed antiproliferative activity in SW480 and SW620 cells, but their effect seemed to be caused by different mechanisms of action. Compound <b<3a</b< induced apoptosis independent of ROS production, as evidenced by increased levels of caspase 3, and had an immunomodulatory effect, positively regulating the production of different immunological markers in malignant cell lines. In contrast, compound <b<3d</b< generated a pro-oxidant response and inhibited the growth of cancer cells, probably by another type of cell death other than apoptosis. Molecular docking studies indicated that the most active compound, <b<3a,</b< could efficiently bind to the proapoptotic human caspases-3 protein, a result that could provide valuable information on the biochemical mechanism for the in vitro cytotoxic response of this compound in SW620 colon carcinoma cell lines. The obtained results suggest that these compounds have chemopreventive potential against CRC, but more studies should be carried out to elucidate the molecular mechanisms of action of each of them in depth.
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title_short	Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis
url	https://doi.org/10.3390/molecules27207108 https://doaj.org/article/c43f946720614c639b71516a09482530 https://www.mdpi.com/1420-3049/27/20/7108 https://doaj.org/toc/1420-3049
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author2	Elizabeth Correa Juan Pablo Rendón Andrés F. Yepes-Pérez Wilson Cardona-Galeano Tonny W. Naranjo
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up_date	2024-07-04T00:21:41.025Z
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Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis

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