Analytical Considerations of Stable Isotope Labelling in Lipidomics

Over the last two decades, lipids have come to be understood as far more than merely components of cellular membranes and forms of energy storage, and are now also being implicated to play important roles in a variety of diseases, with lipid biomarker research one of the most widespread applications...
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Autor*in:	Alexander Triebl [verfasserIn] Markus R. Wenk [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	lipidomics stable isotope labelling mass spectrometry flux analysis

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 8(2018), 4, p 151
Übergeordnetes Werk:	volume:8 ; year:2018 ; number:4, p 151

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom8040151

Katalog-ID:	DOAJ002385171

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source	In Biomolecules 8(2018), 4, p 151 volume:8 year:2018 number:4, p 151
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callnumber-first	Q - Science
author	Alexander Triebl
spellingShingle	Alexander Triebl misc QR1-502 misc lipidomics misc stable isotope labelling misc mass spectrometry misc flux analysis misc Microbiology Analytical Considerations of Stable Isotope Labelling in Lipidomics
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topic_title	QR1-502 Analytical Considerations of Stable Isotope Labelling in Lipidomics lipidomics stable isotope labelling mass spectrometry flux analysis
topic	misc QR1-502 misc lipidomics misc stable isotope labelling misc mass spectrometry misc flux analysis misc Microbiology
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title	Analytical Considerations of Stable Isotope Labelling in Lipidomics
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title_full	Analytical Considerations of Stable Isotope Labelling in Lipidomics
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title_sort	analytical considerations of stable isotope labelling in lipidomics
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title_auth	Analytical Considerations of Stable Isotope Labelling in Lipidomics
abstract	Over the last two decades, lipids have come to be understood as far more than merely components of cellular membranes and forms of energy storage, and are now also being implicated to play important roles in a variety of diseases, with lipid biomarker research one of the most widespread applications of lipidomic techniques both in research and in clinical settings. Stable isotope labelling has become a staple technique in the analysis of small molecule metabolism and dynamics, as it is the only experimental setup by which biosynthesis, remodelling and degradation of biomolecules can be directly measured. Using state-of-the-art analytical technologies such as chromatography-coupled high resolution tandem mass spectrometry, the stable isotope label can be precisely localized and quantified within the biomolecules. The application of stable isotope labelling to lipidomics is however complicated by the diversity of lipids and the complexity of the necessary data analysis. This article discusses key experimental aspects of stable isotope labelling in the field of mass spectrometry-based lipidomics, summarizes current applications and provides an outlook on future developments and potential.
abstractGer	Over the last two decades, lipids have come to be understood as far more than merely components of cellular membranes and forms of energy storage, and are now also being implicated to play important roles in a variety of diseases, with lipid biomarker research one of the most widespread applications of lipidomic techniques both in research and in clinical settings. Stable isotope labelling has become a staple technique in the analysis of small molecule metabolism and dynamics, as it is the only experimental setup by which biosynthesis, remodelling and degradation of biomolecules can be directly measured. Using state-of-the-art analytical technologies such as chromatography-coupled high resolution tandem mass spectrometry, the stable isotope label can be precisely localized and quantified within the biomolecules. The application of stable isotope labelling to lipidomics is however complicated by the diversity of lipids and the complexity of the necessary data analysis. This article discusses key experimental aspects of stable isotope labelling in the field of mass spectrometry-based lipidomics, summarizes current applications and provides an outlook on future developments and potential.
abstract_unstemmed	Over the last two decades, lipids have come to be understood as far more than merely components of cellular membranes and forms of energy storage, and are now also being implicated to play important roles in a variety of diseases, with lipid biomarker research one of the most widespread applications of lipidomic techniques both in research and in clinical settings. Stable isotope labelling has become a staple technique in the analysis of small molecule metabolism and dynamics, as it is the only experimental setup by which biosynthesis, remodelling and degradation of biomolecules can be directly measured. Using state-of-the-art analytical technologies such as chromatography-coupled high resolution tandem mass spectrometry, the stable isotope label can be precisely localized and quantified within the biomolecules. The application of stable isotope labelling to lipidomics is however complicated by the diversity of lipids and the complexity of the necessary data analysis. This article discusses key experimental aspects of stable isotope labelling in the field of mass spectrometry-based lipidomics, summarizes current applications and provides an outlook on future developments and potential.
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title_short	Analytical Considerations of Stable Isotope Labelling in Lipidomics
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Nicht das Richtige dabei?