Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway

Resibufogenin, a low molecular weight bufanolide steroid compound, is isolated from the secretion of Asiatic toad Bufogargarizansa Cantor. It possessed both pharmacological and toxicological effects that were experimentally shown by in vitro and in vivo studies. However, the molecular mechanism of c...
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Autor*in:	Yue Zhang [verfasserIn] Ren-Fu Quan [verfasserIn] Wei-Shan Cheng [verfasserIn] Zhao-Ming Ye [verfasserIn] Wei-Xu Li [verfasserIn] Di-Sheng Yang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Apoptosis MG-63 cell Osteosarcoma Resibufogenin

Übergeordnetes Werk:	In: Bangladesh Journal of Pharmacology - Bangladesh Pharmacological Society, 2016, 9(2014), 3
Übergeordnetes Werk:	volume:9 ; year:2014 ; number:3

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ002436396

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spelling	(DE-627)DOAJ002436396 (DE-599)DOAJf86618800e4c4dc7891ab284a2606613 DE-627 ger DE-627 rakwb eng RM1-950 Yue Zhang verfasserin aut Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Resibufogenin, a low molecular weight bufanolide steroid compound, is isolated from the secretion of Asiatic toad Bufogargarizansa Cantor. It possessed both pharmacological and toxicological effects that were experimentally shown by in vitro and in vivo studies. However, the molecular mechanism of cell apoptosis induced by resibufogenin remains elusive. Here, we investigated the apoptosis in resibufogenin-treated human osteosarcoma MG-63 cells. The results showed that resibufogenin could inhibit cell proliferation and induce apoptosis in a dose- and time-dependent manner. Additional investigations proved that a disruption of mitochondrial transmembrane potential and an up-regulation of reactive oxygen species (ROS) in resibufogenin-treated cells were occurred. Upon western blot analysis, it was found that the up-regulation of Apaf-1, cleaved PARP, cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2, varied with different concentration of resibufogenin. Overall findings suggested that resibufogenin could be used as an effective anti-tumor agent in therapy of osteosarcoma. Apoptosis MG-63 cell Osteosarcoma Resibufogenin Therapeutics. Pharmacology Ren-Fu Quan verfasserin aut Wei-Shan Cheng verfasserin aut Zhao-Ming Ye verfasserin aut Wei-Xu Li verfasserin aut Di-Sheng Yang verfasserin aut In Bangladesh Journal of Pharmacology Bangladesh Pharmacological Society, 2016 9(2014), 3 (DE-627)55869540X (DE-600)2410466-8 19910088 nnns volume:9 year:2014 number:3 https://doaj.org/article/f86618800e4c4dc7891ab284a2606613 kostenfrei https://www.banglajol.info/index.php/BJP/article/view/19483 kostenfrei https://doaj.org/toc/1991-0088 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 3
allfields_unstemmed	(DE-627)DOAJ002436396 (DE-599)DOAJf86618800e4c4dc7891ab284a2606613 DE-627 ger DE-627 rakwb eng RM1-950 Yue Zhang verfasserin aut Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Resibufogenin, a low molecular weight bufanolide steroid compound, is isolated from the secretion of Asiatic toad Bufogargarizansa Cantor. It possessed both pharmacological and toxicological effects that were experimentally shown by in vitro and in vivo studies. However, the molecular mechanism of cell apoptosis induced by resibufogenin remains elusive. Here, we investigated the apoptosis in resibufogenin-treated human osteosarcoma MG-63 cells. The results showed that resibufogenin could inhibit cell proliferation and induce apoptosis in a dose- and time-dependent manner. Additional investigations proved that a disruption of mitochondrial transmembrane potential and an up-regulation of reactive oxygen species (ROS) in resibufogenin-treated cells were occurred. Upon western blot analysis, it was found that the up-regulation of Apaf-1, cleaved PARP, cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2, varied with different concentration of resibufogenin. Overall findings suggested that resibufogenin could be used as an effective anti-tumor agent in therapy of osteosarcoma. Apoptosis MG-63 cell Osteosarcoma Resibufogenin Therapeutics. Pharmacology Ren-Fu Quan verfasserin aut Wei-Shan Cheng verfasserin aut Zhao-Ming Ye verfasserin aut Wei-Xu Li verfasserin aut Di-Sheng Yang verfasserin aut In Bangladesh Journal of Pharmacology Bangladesh Pharmacological Society, 2016 9(2014), 3 (DE-627)55869540X (DE-600)2410466-8 19910088 nnns volume:9 year:2014 number:3 https://doaj.org/article/f86618800e4c4dc7891ab284a2606613 kostenfrei https://www.banglajol.info/index.php/BJP/article/view/19483 kostenfrei https://doaj.org/toc/1991-0088 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 3
allfieldsGer	(DE-627)DOAJ002436396 (DE-599)DOAJf86618800e4c4dc7891ab284a2606613 DE-627 ger DE-627 rakwb eng RM1-950 Yue Zhang verfasserin aut Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Resibufogenin, a low molecular weight bufanolide steroid compound, is isolated from the secretion of Asiatic toad Bufogargarizansa Cantor. It possessed both pharmacological and toxicological effects that were experimentally shown by in vitro and in vivo studies. However, the molecular mechanism of cell apoptosis induced by resibufogenin remains elusive. Here, we investigated the apoptosis in resibufogenin-treated human osteosarcoma MG-63 cells. The results showed that resibufogenin could inhibit cell proliferation and induce apoptosis in a dose- and time-dependent manner. Additional investigations proved that a disruption of mitochondrial transmembrane potential and an up-regulation of reactive oxygen species (ROS) in resibufogenin-treated cells were occurred. Upon western blot analysis, it was found that the up-regulation of Apaf-1, cleaved PARP, cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2, varied with different concentration of resibufogenin. Overall findings suggested that resibufogenin could be used as an effective anti-tumor agent in therapy of osteosarcoma. Apoptosis MG-63 cell Osteosarcoma Resibufogenin Therapeutics. Pharmacology Ren-Fu Quan verfasserin aut Wei-Shan Cheng verfasserin aut Zhao-Ming Ye verfasserin aut Wei-Xu Li verfasserin aut Di-Sheng Yang verfasserin aut In Bangladesh Journal of Pharmacology Bangladesh Pharmacological Society, 2016 9(2014), 3 (DE-627)55869540X (DE-600)2410466-8 19910088 nnns volume:9 year:2014 number:3 https://doaj.org/article/f86618800e4c4dc7891ab284a2606613 kostenfrei https://www.banglajol.info/index.php/BJP/article/view/19483 kostenfrei https://doaj.org/toc/1991-0088 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 3
allfieldsSound	(DE-627)DOAJ002436396 (DE-599)DOAJf86618800e4c4dc7891ab284a2606613 DE-627 ger DE-627 rakwb eng RM1-950 Yue Zhang verfasserin aut Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Resibufogenin, a low molecular weight bufanolide steroid compound, is isolated from the secretion of Asiatic toad Bufogargarizansa Cantor. It possessed both pharmacological and toxicological effects that were experimentally shown by in vitro and in vivo studies. However, the molecular mechanism of cell apoptosis induced by resibufogenin remains elusive. Here, we investigated the apoptosis in resibufogenin-treated human osteosarcoma MG-63 cells. The results showed that resibufogenin could inhibit cell proliferation and induce apoptosis in a dose- and time-dependent manner. Additional investigations proved that a disruption of mitochondrial transmembrane potential and an up-regulation of reactive oxygen species (ROS) in resibufogenin-treated cells were occurred. Upon western blot analysis, it was found that the up-regulation of Apaf-1, cleaved PARP, cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2, varied with different concentration of resibufogenin. Overall findings suggested that resibufogenin could be used as an effective anti-tumor agent in therapy of osteosarcoma. Apoptosis MG-63 cell Osteosarcoma Resibufogenin Therapeutics. Pharmacology Ren-Fu Quan verfasserin aut Wei-Shan Cheng verfasserin aut Zhao-Ming Ye verfasserin aut Wei-Xu Li verfasserin aut Di-Sheng Yang verfasserin aut In Bangladesh Journal of Pharmacology Bangladesh Pharmacological Society, 2016 9(2014), 3 (DE-627)55869540X (DE-600)2410466-8 19910088 nnns volume:9 year:2014 number:3 https://doaj.org/article/f86618800e4c4dc7891ab284a2606613 kostenfrei https://www.banglajol.info/index.php/BJP/article/view/19483 kostenfrei https://doaj.org/toc/1991-0088 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 3
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authorswithroles_txt_mv	Yue Zhang @@aut@@ Ren-Fu Quan @@aut@@ Wei-Shan Cheng @@aut@@ Zhao-Ming Ye @@aut@@ Wei-Xu Li @@aut@@ Di-Sheng Yang @@aut@@
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callnumber-first	R - Medicine
author	Yue Zhang
spellingShingle	Yue Zhang misc RM1-950 misc Apoptosis misc MG-63 cell misc Osteosarcoma misc Resibufogenin misc Therapeutics. Pharmacology Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway
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topic_title	RM1-950 Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway Apoptosis MG-63 cell Osteosarcoma Resibufogenin
topic	misc RM1-950 misc Apoptosis misc MG-63 cell misc Osteosarcoma misc Resibufogenin misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc Apoptosis misc MG-63 cell misc Osteosarcoma misc Resibufogenin misc Therapeutics. Pharmacology
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title	Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway
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title_full	Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway
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title_sort	resibufogenin inhibits the growth of human osteosarcoma mg-63 cells via mitochondrial pathway
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title_auth	Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway
abstract	Resibufogenin, a low molecular weight bufanolide steroid compound, is isolated from the secretion of Asiatic toad Bufogargarizansa Cantor. It possessed both pharmacological and toxicological effects that were experimentally shown by in vitro and in vivo studies. However, the molecular mechanism of cell apoptosis induced by resibufogenin remains elusive. Here, we investigated the apoptosis in resibufogenin-treated human osteosarcoma MG-63 cells. The results showed that resibufogenin could inhibit cell proliferation and induce apoptosis in a dose- and time-dependent manner. Additional investigations proved that a disruption of mitochondrial transmembrane potential and an up-regulation of reactive oxygen species (ROS) in resibufogenin-treated cells were occurred. Upon western blot analysis, it was found that the up-regulation of Apaf-1, cleaved PARP, cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2, varied with different concentration of resibufogenin. Overall findings suggested that resibufogenin could be used as an effective anti-tumor agent in therapy of osteosarcoma.
abstractGer	Resibufogenin, a low molecular weight bufanolide steroid compound, is isolated from the secretion of Asiatic toad Bufogargarizansa Cantor. It possessed both pharmacological and toxicological effects that were experimentally shown by in vitro and in vivo studies. However, the molecular mechanism of cell apoptosis induced by resibufogenin remains elusive. Here, we investigated the apoptosis in resibufogenin-treated human osteosarcoma MG-63 cells. The results showed that resibufogenin could inhibit cell proliferation and induce apoptosis in a dose- and time-dependent manner. Additional investigations proved that a disruption of mitochondrial transmembrane potential and an up-regulation of reactive oxygen species (ROS) in resibufogenin-treated cells were occurred. Upon western blot analysis, it was found that the up-regulation of Apaf-1, cleaved PARP, cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2, varied with different concentration of resibufogenin. Overall findings suggested that resibufogenin could be used as an effective anti-tumor agent in therapy of osteosarcoma.
abstract_unstemmed	Resibufogenin, a low molecular weight bufanolide steroid compound, is isolated from the secretion of Asiatic toad Bufogargarizansa Cantor. It possessed both pharmacological and toxicological effects that were experimentally shown by in vitro and in vivo studies. However, the molecular mechanism of cell apoptosis induced by resibufogenin remains elusive. Here, we investigated the apoptosis in resibufogenin-treated human osteosarcoma MG-63 cells. The results showed that resibufogenin could inhibit cell proliferation and induce apoptosis in a dose- and time-dependent manner. Additional investigations proved that a disruption of mitochondrial transmembrane potential and an up-regulation of reactive oxygen species (ROS) in resibufogenin-treated cells were occurred. Upon western blot analysis, it was found that the up-regulation of Apaf-1, cleaved PARP, cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2, varied with different concentration of resibufogenin. Overall findings suggested that resibufogenin could be used as an effective anti-tumor agent in therapy of osteosarcoma.
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title_short	Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway
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Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway

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