Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital

Introduction: <i<Clostridioides (Clostridium) difficile</i< can be isolated from stool in 3% of healthy adults and in at least 10% of asymptomatic hospitalized patients. <i<C. difficile</i<, the most common cause of hospital-acquired infectious diarrhea in the developed world, has re-emerged in recent years with increasing incidence and severity. In an effort to reduce the spread of the pathogen, published recommendations suggest isolation and contact precautions for patients suffering from <i<C. difficile</i< infection (CDI). However, asymptomatic colonized patients are not targeted by infection control policies, and active surveillance for colonization is not routinely performed. Moreover, given the current changes in the epidemiology of CDI, particularly the emergence of new virulent strains either in the hospital or community settings, there is a need for identification of factors associated with colonization by <i<C. difficile</i< and CDI. Methods and analysis: We are carrying out a prospective, observational, cohort study in Edouard Herriot Hospital, Hospices Civils de Lyon, a 900-bed university hospital in Lyon, France. All consecutive adult patients admitted on selected units are eligible to participate in the study. Stool samples or rectal swabs for <i<C. difficile</i< testing are obtained on admission, every 3–5 days during hospitalization, at the onset of diarrhea (if applicable), and at discharge. Descriptive and logistic regression analyses will be completed to mainly estimate the proportion of asymptomatic colonization at admission, and to evaluate differences between factors associated with colonization and those related to CDI. Ethics: The study is conducted in accordance with the ethical principles of the Declaration of Helsinki, French law, and the Good Clinical Practice guidelines. The study protocol design was approved by the participating units, the ethics committee and the hospital institutional review board (Comité de protection des personnes et Comission Nationale de l’Informatique et des Libertés; N°: 00009118). Dissemination: The results of this study will be disseminated by presenting the findings locally at each participating ward, as well as national and international scientific meetings. Findings will be shared with interested national societies crafting guidelines in CDI. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Nagham Khanafer [verfasserIn] Philippe Vanhems [verfasserIn] Sabrina Bennia [verfasserIn] Géraldine Martin-Gaujard [verfasserIn] Laurent Juillard [verfasserIn] Thomas Rimmelé [verfasserIn] Laurent Argaud [verfasserIn] Olivier Martin [verfasserIn] Laetitia Huriaux [verfasserIn] Guillaume Marcotte [verfasserIn] Romain Hernu [verfasserIn] Bernard Floccard [verfasserIn] Pierre Cassier [verfasserIn] Study Group [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	asymptomatic colonization follow-up hospital risk factors

Übergeordnetes Werk:	In: International Journal of Environmental Research and Public Health - MDPI AG, 2005, 18(2021), 7528, p 7528
Übergeordnetes Werk:	volume:18 ; year:2021 ; number:7528, p 7528

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijerph18147528

Katalog-ID:	DOAJ002444151

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allfields	10.3390/ijerph18147528 doi (DE-627)DOAJ002444151 (DE-599)DOAJ4d069e699bc64cde803f18abfc24dfde DE-627 ger DE-627 rakwb eng Nagham Khanafer verfasserin aut Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: <i<Clostridioides (Clostridium) difficile</i< can be isolated from stool in 3% of healthy adults and in at least 10% of asymptomatic hospitalized patients. <i<C. difficile</i<, the most common cause of hospital-acquired infectious diarrhea in the developed world, has re-emerged in recent years with increasing incidence and severity. In an effort to reduce the spread of the pathogen, published recommendations suggest isolation and contact precautions for patients suffering from <i<C. difficile</i< infection (CDI). However, asymptomatic colonized patients are not targeted by infection control policies, and active surveillance for colonization is not routinely performed. Moreover, given the current changes in the epidemiology of CDI, particularly the emergence of new virulent strains either in the hospital or community settings, there is a need for identification of factors associated with colonization by <i<C. difficile</i< and CDI. Methods and analysis: We are carrying out a prospective, observational, cohort study in Edouard Herriot Hospital, Hospices Civils de Lyon, a 900-bed university hospital in Lyon, France. All consecutive adult patients admitted on selected units are eligible to participate in the study. Stool samples or rectal swabs for <i<C. difficile</i< testing are obtained on admission, every 3–5 days during hospitalization, at the onset of diarrhea (if applicable), and at discharge. Descriptive and logistic regression analyses will be completed to mainly estimate the proportion of asymptomatic colonization at admission, and to evaluate differences between factors associated with colonization and those related to CDI. Ethics: The study is conducted in accordance with the ethical principles of the Declaration of Helsinki, French law, and the Good Clinical Practice guidelines. The study protocol design was approved by the participating units, the ethics committee and the hospital institutional review board (Comité de protection des personnes et Comission Nationale de l’Informatique et des Libertés; N°: 00009118). Dissemination: The results of this study will be disseminated by presenting the findings locally at each participating ward, as well as national and international scientific meetings. Findings will be shared with interested national societies crafting guidelines in CDI. asymptomatic colonization <i<Clostridioides difficile</i< follow-up hospital risk factors Medicine R Philippe Vanhems verfasserin aut Sabrina Bennia verfasserin aut Géraldine Martin-Gaujard verfasserin aut Laurent Juillard verfasserin aut Thomas Rimmelé verfasserin aut Laurent Argaud verfasserin aut Olivier Martin verfasserin aut Laetitia Huriaux verfasserin aut Guillaume Marcotte verfasserin aut Romain Hernu verfasserin aut Bernard Floccard verfasserin aut Pierre Cassier verfasserin aut Study Group verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 7528, p 7528 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:7528, p 7528 https://doi.org/10.3390/ijerph18147528 kostenfrei https://doaj.org/article/4d069e699bc64cde803f18abfc24dfde kostenfrei https://www.mdpi.com/1660-4601/18/14/7528 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 7528, p 7528
spelling	10.3390/ijerph18147528 doi (DE-627)DOAJ002444151 (DE-599)DOAJ4d069e699bc64cde803f18abfc24dfde DE-627 ger DE-627 rakwb eng Nagham Khanafer verfasserin aut Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: <i<Clostridioides (Clostridium) difficile</i< can be isolated from stool in 3% of healthy adults and in at least 10% of asymptomatic hospitalized patients. <i<C. difficile</i<, the most common cause of hospital-acquired infectious diarrhea in the developed world, has re-emerged in recent years with increasing incidence and severity. In an effort to reduce the spread of the pathogen, published recommendations suggest isolation and contact precautions for patients suffering from <i<C. difficile</i< infection (CDI). However, asymptomatic colonized patients are not targeted by infection control policies, and active surveillance for colonization is not routinely performed. Moreover, given the current changes in the epidemiology of CDI, particularly the emergence of new virulent strains either in the hospital or community settings, there is a need for identification of factors associated with colonization by <i<C. difficile</i< and CDI. Methods and analysis: We are carrying out a prospective, observational, cohort study in Edouard Herriot Hospital, Hospices Civils de Lyon, a 900-bed university hospital in Lyon, France. All consecutive adult patients admitted on selected units are eligible to participate in the study. Stool samples or rectal swabs for <i<C. difficile</i< testing are obtained on admission, every 3–5 days during hospitalization, at the onset of diarrhea (if applicable), and at discharge. Descriptive and logistic regression analyses will be completed to mainly estimate the proportion of asymptomatic colonization at admission, and to evaluate differences between factors associated with colonization and those related to CDI. Ethics: The study is conducted in accordance with the ethical principles of the Declaration of Helsinki, French law, and the Good Clinical Practice guidelines. The study protocol design was approved by the participating units, the ethics committee and the hospital institutional review board (Comité de protection des personnes et Comission Nationale de l’Informatique et des Libertés; N°: 00009118). Dissemination: The results of this study will be disseminated by presenting the findings locally at each participating ward, as well as national and international scientific meetings. Findings will be shared with interested national societies crafting guidelines in CDI. asymptomatic colonization <i<Clostridioides difficile</i< follow-up hospital risk factors Medicine R Philippe Vanhems verfasserin aut Sabrina Bennia verfasserin aut Géraldine Martin-Gaujard verfasserin aut Laurent Juillard verfasserin aut Thomas Rimmelé verfasserin aut Laurent Argaud verfasserin aut Olivier Martin verfasserin aut Laetitia Huriaux verfasserin aut Guillaume Marcotte verfasserin aut Romain Hernu verfasserin aut Bernard Floccard verfasserin aut Pierre Cassier verfasserin aut Study Group verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 7528, p 7528 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:7528, p 7528 https://doi.org/10.3390/ijerph18147528 kostenfrei https://doaj.org/article/4d069e699bc64cde803f18abfc24dfde kostenfrei https://www.mdpi.com/1660-4601/18/14/7528 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 7528, p 7528
allfields_unstemmed	10.3390/ijerph18147528 doi (DE-627)DOAJ002444151 (DE-599)DOAJ4d069e699bc64cde803f18abfc24dfde DE-627 ger DE-627 rakwb eng Nagham Khanafer verfasserin aut Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: <i<Clostridioides (Clostridium) difficile</i< can be isolated from stool in 3% of healthy adults and in at least 10% of asymptomatic hospitalized patients. <i<C. difficile</i<, the most common cause of hospital-acquired infectious diarrhea in the developed world, has re-emerged in recent years with increasing incidence and severity. In an effort to reduce the spread of the pathogen, published recommendations suggest isolation and contact precautions for patients suffering from <i<C. difficile</i< infection (CDI). However, asymptomatic colonized patients are not targeted by infection control policies, and active surveillance for colonization is not routinely performed. Moreover, given the current changes in the epidemiology of CDI, particularly the emergence of new virulent strains either in the hospital or community settings, there is a need for identification of factors associated with colonization by <i<C. difficile</i< and CDI. Methods and analysis: We are carrying out a prospective, observational, cohort study in Edouard Herriot Hospital, Hospices Civils de Lyon, a 900-bed university hospital in Lyon, France. All consecutive adult patients admitted on selected units are eligible to participate in the study. Stool samples or rectal swabs for <i<C. difficile</i< testing are obtained on admission, every 3–5 days during hospitalization, at the onset of diarrhea (if applicable), and at discharge. Descriptive and logistic regression analyses will be completed to mainly estimate the proportion of asymptomatic colonization at admission, and to evaluate differences between factors associated with colonization and those related to CDI. Ethics: The study is conducted in accordance with the ethical principles of the Declaration of Helsinki, French law, and the Good Clinical Practice guidelines. The study protocol design was approved by the participating units, the ethics committee and the hospital institutional review board (Comité de protection des personnes et Comission Nationale de l’Informatique et des Libertés; N°: 00009118). Dissemination: The results of this study will be disseminated by presenting the findings locally at each participating ward, as well as national and international scientific meetings. Findings will be shared with interested national societies crafting guidelines in CDI. asymptomatic colonization <i<Clostridioides difficile</i< follow-up hospital risk factors Medicine R Philippe Vanhems verfasserin aut Sabrina Bennia verfasserin aut Géraldine Martin-Gaujard verfasserin aut Laurent Juillard verfasserin aut Thomas Rimmelé verfasserin aut Laurent Argaud verfasserin aut Olivier Martin verfasserin aut Laetitia Huriaux verfasserin aut Guillaume Marcotte verfasserin aut Romain Hernu verfasserin aut Bernard Floccard verfasserin aut Pierre Cassier verfasserin aut Study Group verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 7528, p 7528 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:7528, p 7528 https://doi.org/10.3390/ijerph18147528 kostenfrei https://doaj.org/article/4d069e699bc64cde803f18abfc24dfde kostenfrei https://www.mdpi.com/1660-4601/18/14/7528 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 7528, p 7528
allfieldsGer	10.3390/ijerph18147528 doi (DE-627)DOAJ002444151 (DE-599)DOAJ4d069e699bc64cde803f18abfc24dfde DE-627 ger DE-627 rakwb eng Nagham Khanafer verfasserin aut Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: <i<Clostridioides (Clostridium) difficile</i< can be isolated from stool in 3% of healthy adults and in at least 10% of asymptomatic hospitalized patients. <i<C. difficile</i<, the most common cause of hospital-acquired infectious diarrhea in the developed world, has re-emerged in recent years with increasing incidence and severity. In an effort to reduce the spread of the pathogen, published recommendations suggest isolation and contact precautions for patients suffering from <i<C. difficile</i< infection (CDI). However, asymptomatic colonized patients are not targeted by infection control policies, and active surveillance for colonization is not routinely performed. Moreover, given the current changes in the epidemiology of CDI, particularly the emergence of new virulent strains either in the hospital or community settings, there is a need for identification of factors associated with colonization by <i<C. difficile</i< and CDI. Methods and analysis: We are carrying out a prospective, observational, cohort study in Edouard Herriot Hospital, Hospices Civils de Lyon, a 900-bed university hospital in Lyon, France. All consecutive adult patients admitted on selected units are eligible to participate in the study. Stool samples or rectal swabs for <i<C. difficile</i< testing are obtained on admission, every 3–5 days during hospitalization, at the onset of diarrhea (if applicable), and at discharge. Descriptive and logistic regression analyses will be completed to mainly estimate the proportion of asymptomatic colonization at admission, and to evaluate differences between factors associated with colonization and those related to CDI. Ethics: The study is conducted in accordance with the ethical principles of the Declaration of Helsinki, French law, and the Good Clinical Practice guidelines. The study protocol design was approved by the participating units, the ethics committee and the hospital institutional review board (Comité de protection des personnes et Comission Nationale de l’Informatique et des Libertés; N°: 00009118). Dissemination: The results of this study will be disseminated by presenting the findings locally at each participating ward, as well as national and international scientific meetings. Findings will be shared with interested national societies crafting guidelines in CDI. asymptomatic colonization <i<Clostridioides difficile</i< follow-up hospital risk factors Medicine R Philippe Vanhems verfasserin aut Sabrina Bennia verfasserin aut Géraldine Martin-Gaujard verfasserin aut Laurent Juillard verfasserin aut Thomas Rimmelé verfasserin aut Laurent Argaud verfasserin aut Olivier Martin verfasserin aut Laetitia Huriaux verfasserin aut Guillaume Marcotte verfasserin aut Romain Hernu verfasserin aut Bernard Floccard verfasserin aut Pierre Cassier verfasserin aut Study Group verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 7528, p 7528 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:7528, p 7528 https://doi.org/10.3390/ijerph18147528 kostenfrei https://doaj.org/article/4d069e699bc64cde803f18abfc24dfde kostenfrei https://www.mdpi.com/1660-4601/18/14/7528 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 7528, p 7528
allfieldsSound	10.3390/ijerph18147528 doi (DE-627)DOAJ002444151 (DE-599)DOAJ4d069e699bc64cde803f18abfc24dfde DE-627 ger DE-627 rakwb eng Nagham Khanafer verfasserin aut Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: <i<Clostridioides (Clostridium) difficile</i< can be isolated from stool in 3% of healthy adults and in at least 10% of asymptomatic hospitalized patients. <i<C. difficile</i<, the most common cause of hospital-acquired infectious diarrhea in the developed world, has re-emerged in recent years with increasing incidence and severity. In an effort to reduce the spread of the pathogen, published recommendations suggest isolation and contact precautions for patients suffering from <i<C. difficile</i< infection (CDI). However, asymptomatic colonized patients are not targeted by infection control policies, and active surveillance for colonization is not routinely performed. Moreover, given the current changes in the epidemiology of CDI, particularly the emergence of new virulent strains either in the hospital or community settings, there is a need for identification of factors associated with colonization by <i<C. difficile</i< and CDI. Methods and analysis: We are carrying out a prospective, observational, cohort study in Edouard Herriot Hospital, Hospices Civils de Lyon, a 900-bed university hospital in Lyon, France. All consecutive adult patients admitted on selected units are eligible to participate in the study. Stool samples or rectal swabs for <i<C. difficile</i< testing are obtained on admission, every 3–5 days during hospitalization, at the onset of diarrhea (if applicable), and at discharge. Descriptive and logistic regression analyses will be completed to mainly estimate the proportion of asymptomatic colonization at admission, and to evaluate differences between factors associated with colonization and those related to CDI. Ethics: The study is conducted in accordance with the ethical principles of the Declaration of Helsinki, French law, and the Good Clinical Practice guidelines. The study protocol design was approved by the participating units, the ethics committee and the hospital institutional review board (Comité de protection des personnes et Comission Nationale de l’Informatique et des Libertés; N°: 00009118). Dissemination: The results of this study will be disseminated by presenting the findings locally at each participating ward, as well as national and international scientific meetings. Findings will be shared with interested national societies crafting guidelines in CDI. asymptomatic colonization <i<Clostridioides difficile</i< follow-up hospital risk factors Medicine R Philippe Vanhems verfasserin aut Sabrina Bennia verfasserin aut Géraldine Martin-Gaujard verfasserin aut Laurent Juillard verfasserin aut Thomas Rimmelé verfasserin aut Laurent Argaud verfasserin aut Olivier Martin verfasserin aut Laetitia Huriaux verfasserin aut Guillaume Marcotte verfasserin aut Romain Hernu verfasserin aut Bernard Floccard verfasserin aut Pierre Cassier verfasserin aut Study Group verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 7528, p 7528 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:7528, p 7528 https://doi.org/10.3390/ijerph18147528 kostenfrei https://doaj.org/article/4d069e699bc64cde803f18abfc24dfde kostenfrei https://www.mdpi.com/1660-4601/18/14/7528 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 7528, p 7528
language	English
source	In International Journal of Environmental Research and Public Health 18(2021), 7528, p 7528 volume:18 year:2021 number:7528, p 7528
sourceStr	In International Journal of Environmental Research and Public Health 18(2021), 7528, p 7528 volume:18 year:2021 number:7528, p 7528
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	asymptomatic colonization <i<Clostridioides difficile</i< follow-up hospital risk factors Medicine R
isfreeaccess_bool	true
container_title	International Journal of Environmental Research and Public Health
authorswithroles_txt_mv	Nagham Khanafer @@aut@@ Philippe Vanhems @@aut@@ Sabrina Bennia @@aut@@ Géraldine Martin-Gaujard @@aut@@ Laurent Juillard @@aut@@ Thomas Rimmelé @@aut@@ Laurent Argaud @@aut@@ Olivier Martin @@aut@@ Laetitia Huriaux @@aut@@ Guillaume Marcotte @@aut@@ Romain Hernu @@aut@@ Bernard Floccard @@aut@@ Pierre Cassier @@aut@@ Study Group @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
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author	Nagham Khanafer
spellingShingle	Nagham Khanafer misc asymptomatic colonization misc <i<Clostridioides difficile</i< misc follow-up misc hospital misc risk factors misc Medicine misc R Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital
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topic_title	Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital asymptomatic colonization <i<Clostridioides difficile</i< follow-up hospital risk factors
topic	misc asymptomatic colonization misc <i<Clostridioides difficile</i< misc follow-up misc hospital misc risk factors misc Medicine misc R
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title	Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital
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title_full	Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital
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author_browse	Nagham Khanafer Philippe Vanhems Sabrina Bennia Géraldine Martin-Gaujard Laurent Juillard Thomas Rimmelé Laurent Argaud Olivier Martin Laetitia Huriaux Guillaume Marcotte Romain Hernu Bernard Floccard Pierre Cassier Study Group
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title_sort	factors associated with clostridioides (clostridium) difficile infection and colonization: ongoing prospective cohort study in a french university hospital
title_auth	Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital
abstract	Introduction: <i<Clostridioides (Clostridium) difficile</i< can be isolated from stool in 3% of healthy adults and in at least 10% of asymptomatic hospitalized patients. <i<C. difficile</i<, the most common cause of hospital-acquired infectious diarrhea in the developed world, has re-emerged in recent years with increasing incidence and severity. In an effort to reduce the spread of the pathogen, published recommendations suggest isolation and contact precautions for patients suffering from <i<C. difficile</i< infection (CDI). However, asymptomatic colonized patients are not targeted by infection control policies, and active surveillance for colonization is not routinely performed. Moreover, given the current changes in the epidemiology of CDI, particularly the emergence of new virulent strains either in the hospital or community settings, there is a need for identification of factors associated with colonization by <i<C. difficile</i< and CDI. Methods and analysis: We are carrying out a prospective, observational, cohort study in Edouard Herriot Hospital, Hospices Civils de Lyon, a 900-bed university hospital in Lyon, France. All consecutive adult patients admitted on selected units are eligible to participate in the study. Stool samples or rectal swabs for <i<C. difficile</i< testing are obtained on admission, every 3–5 days during hospitalization, at the onset of diarrhea (if applicable), and at discharge. Descriptive and logistic regression analyses will be completed to mainly estimate the proportion of asymptomatic colonization at admission, and to evaluate differences between factors associated with colonization and those related to CDI. Ethics: The study is conducted in accordance with the ethical principles of the Declaration of Helsinki, French law, and the Good Clinical Practice guidelines. The study protocol design was approved by the participating units, the ethics committee and the hospital institutional review board (Comité de protection des personnes et Comission Nationale de l’Informatique et des Libertés; N°: 00009118). Dissemination: The results of this study will be disseminated by presenting the findings locally at each participating ward, as well as national and international scientific meetings. Findings will be shared with interested national societies crafting guidelines in CDI.
abstractGer	Introduction: <i<Clostridioides (Clostridium) difficile</i< can be isolated from stool in 3% of healthy adults and in at least 10% of asymptomatic hospitalized patients. <i<C. difficile</i<, the most common cause of hospital-acquired infectious diarrhea in the developed world, has re-emerged in recent years with increasing incidence and severity. In an effort to reduce the spread of the pathogen, published recommendations suggest isolation and contact precautions for patients suffering from <i<C. difficile</i< infection (CDI). However, asymptomatic colonized patients are not targeted by infection control policies, and active surveillance for colonization is not routinely performed. Moreover, given the current changes in the epidemiology of CDI, particularly the emergence of new virulent strains either in the hospital or community settings, there is a need for identification of factors associated with colonization by <i<C. difficile</i< and CDI. Methods and analysis: We are carrying out a prospective, observational, cohort study in Edouard Herriot Hospital, Hospices Civils de Lyon, a 900-bed university hospital in Lyon, France. All consecutive adult patients admitted on selected units are eligible to participate in the study. Stool samples or rectal swabs for <i<C. difficile</i< testing are obtained on admission, every 3–5 days during hospitalization, at the onset of diarrhea (if applicable), and at discharge. Descriptive and logistic regression analyses will be completed to mainly estimate the proportion of asymptomatic colonization at admission, and to evaluate differences between factors associated with colonization and those related to CDI. Ethics: The study is conducted in accordance with the ethical principles of the Declaration of Helsinki, French law, and the Good Clinical Practice guidelines. The study protocol design was approved by the participating units, the ethics committee and the hospital institutional review board (Comité de protection des personnes et Comission Nationale de l’Informatique et des Libertés; N°: 00009118). Dissemination: The results of this study will be disseminated by presenting the findings locally at each participating ward, as well as national and international scientific meetings. Findings will be shared with interested national societies crafting guidelines in CDI.
abstract_unstemmed	Introduction: <i<Clostridioides (Clostridium) difficile</i< can be isolated from stool in 3% of healthy adults and in at least 10% of asymptomatic hospitalized patients. <i<C. difficile</i<, the most common cause of hospital-acquired infectious diarrhea in the developed world, has re-emerged in recent years with increasing incidence and severity. In an effort to reduce the spread of the pathogen, published recommendations suggest isolation and contact precautions for patients suffering from <i<C. difficile</i< infection (CDI). However, asymptomatic colonized patients are not targeted by infection control policies, and active surveillance for colonization is not routinely performed. Moreover, given the current changes in the epidemiology of CDI, particularly the emergence of new virulent strains either in the hospital or community settings, there is a need for identification of factors associated with colonization by <i<C. difficile</i< and CDI. Methods and analysis: We are carrying out a prospective, observational, cohort study in Edouard Herriot Hospital, Hospices Civils de Lyon, a 900-bed university hospital in Lyon, France. All consecutive adult patients admitted on selected units are eligible to participate in the study. Stool samples or rectal swabs for <i<C. difficile</i< testing are obtained on admission, every 3–5 days during hospitalization, at the onset of diarrhea (if applicable), and at discharge. Descriptive and logistic regression analyses will be completed to mainly estimate the proportion of asymptomatic colonization at admission, and to evaluate differences between factors associated with colonization and those related to CDI. Ethics: The study is conducted in accordance with the ethical principles of the Declaration of Helsinki, French law, and the Good Clinical Practice guidelines. The study protocol design was approved by the participating units, the ethics committee and the hospital institutional review board (Comité de protection des personnes et Comission Nationale de l’Informatique et des Libertés; N°: 00009118). Dissemination: The results of this study will be disseminated by presenting the findings locally at each participating ward, as well as national and international scientific meetings. Findings will be shared with interested national societies crafting guidelines in CDI.
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title_short	Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital
url	https://doi.org/10.3390/ijerph18147528 https://doaj.org/article/4d069e699bc64cde803f18abfc24dfde https://www.mdpi.com/1660-4601/18/14/7528 https://doaj.org/toc/1661-7827 https://doaj.org/toc/1660-4601
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Factors Associated with Clostridioides (Clostridium) Difficile Infection and Colonization: Ongoing Prospective Cohort Study in a French University Hospital

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