Functional organization of the maternal and paternal human 4D Nucleome

Summary: Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific relationship between gene expression and genome structure through the cell cycle is largely unknown. By integrating haplotype-resolved ge...
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Autor*in:	Stephen Lindsly [verfasserIn] Wenlong Jia [verfasserIn] Haiming Chen [verfasserIn] Sijia Liu [verfasserIn] Scott Ronquist [verfasserIn] Can Chen [verfasserIn] Xingzhao Wen [verfasserIn] Cooper Stansbury [verfasserIn] Gabrielle A. Dotson [verfasserIn] Charles Ryan [verfasserIn] Alnawaz Rehemtulla [verfasserIn] Gilbert S. Omenn [verfasserIn] Max Wicha [verfasserIn] Shuai Cheng Li [verfasserIn] Lindsey Muir [verfasserIn] Indika Rajapakse [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Genomics Bioinformatics Genomic analysis

Übergeordnetes Werk:	In: iScience - Elsevier, 2019, 24(2021), 12, Seite 103452-
Übergeordnetes Werk:	volume:24 ; year:2021 ; number:12 ; pages:103452-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.isci.2021.103452

Katalog-ID:	DOAJ003019918

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allfields	10.1016/j.isci.2021.103452 doi (DE-627)DOAJ003019918 (DE-599)DOAJ1464b2f0f40c401fb323e8020e9122d5 DE-627 ger DE-627 rakwb eng Stephen Lindsly verfasserin aut Functional organization of the maternal and paternal human 4D Nucleome 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific relationship between gene expression and genome structure through the cell cycle is largely unknown. By integrating haplotype-resolved genome-wide chromosome conformation capture, mature and nascent mRNA, and protein binding data from a B lymphoblastoid cell line, we investigate this relationship both globally and locally. We introduce the maternal and paternal 4D Nucleome, enabling detailed analysis of the mechanisms and dynamics of genome structure and gene function for diploid organisms. Our analyses find significant coordination between allelic expression biases and local genome conformation, and notably absent expression bias in universally essential cell cycle and glycolysis genes. We propose a model in which coordinated biallelic expression reflects prioritized preservation of essential gene sets. Genomics Bioinformatics Genomic analysis Science Q Wenlong Jia verfasserin aut Haiming Chen verfasserin aut Sijia Liu verfasserin aut Scott Ronquist verfasserin aut Can Chen verfasserin aut Xingzhao Wen verfasserin aut Cooper Stansbury verfasserin aut Gabrielle A. Dotson verfasserin aut Charles Ryan verfasserin aut Alnawaz Rehemtulla verfasserin aut Gilbert S. Omenn verfasserin aut Max Wicha verfasserin aut Shuai Cheng Li verfasserin aut Lindsey Muir verfasserin aut Indika Rajapakse verfasserin aut In iScience Elsevier, 2019 24(2021), 12, Seite 103452- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:12 pages:103452- https://doi.org/10.1016/j.isci.2021.103452 kostenfrei https://doaj.org/article/1464b2f0f40c401fb323e8020e9122d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221014231 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 12 103452-
spelling	10.1016/j.isci.2021.103452 doi (DE-627)DOAJ003019918 (DE-599)DOAJ1464b2f0f40c401fb323e8020e9122d5 DE-627 ger DE-627 rakwb eng Stephen Lindsly verfasserin aut Functional organization of the maternal and paternal human 4D Nucleome 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific relationship between gene expression and genome structure through the cell cycle is largely unknown. By integrating haplotype-resolved genome-wide chromosome conformation capture, mature and nascent mRNA, and protein binding data from a B lymphoblastoid cell line, we investigate this relationship both globally and locally. We introduce the maternal and paternal 4D Nucleome, enabling detailed analysis of the mechanisms and dynamics of genome structure and gene function for diploid organisms. Our analyses find significant coordination between allelic expression biases and local genome conformation, and notably absent expression bias in universally essential cell cycle and glycolysis genes. We propose a model in which coordinated biallelic expression reflects prioritized preservation of essential gene sets. Genomics Bioinformatics Genomic analysis Science Q Wenlong Jia verfasserin aut Haiming Chen verfasserin aut Sijia Liu verfasserin aut Scott Ronquist verfasserin aut Can Chen verfasserin aut Xingzhao Wen verfasserin aut Cooper Stansbury verfasserin aut Gabrielle A. Dotson verfasserin aut Charles Ryan verfasserin aut Alnawaz Rehemtulla verfasserin aut Gilbert S. Omenn verfasserin aut Max Wicha verfasserin aut Shuai Cheng Li verfasserin aut Lindsey Muir verfasserin aut Indika Rajapakse verfasserin aut In iScience Elsevier, 2019 24(2021), 12, Seite 103452- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:12 pages:103452- https://doi.org/10.1016/j.isci.2021.103452 kostenfrei https://doaj.org/article/1464b2f0f40c401fb323e8020e9122d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221014231 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 12 103452-
allfields_unstemmed	10.1016/j.isci.2021.103452 doi (DE-627)DOAJ003019918 (DE-599)DOAJ1464b2f0f40c401fb323e8020e9122d5 DE-627 ger DE-627 rakwb eng Stephen Lindsly verfasserin aut Functional organization of the maternal and paternal human 4D Nucleome 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific relationship between gene expression and genome structure through the cell cycle is largely unknown. By integrating haplotype-resolved genome-wide chromosome conformation capture, mature and nascent mRNA, and protein binding data from a B lymphoblastoid cell line, we investigate this relationship both globally and locally. We introduce the maternal and paternal 4D Nucleome, enabling detailed analysis of the mechanisms and dynamics of genome structure and gene function for diploid organisms. Our analyses find significant coordination between allelic expression biases and local genome conformation, and notably absent expression bias in universally essential cell cycle and glycolysis genes. We propose a model in which coordinated biallelic expression reflects prioritized preservation of essential gene sets. Genomics Bioinformatics Genomic analysis Science Q Wenlong Jia verfasserin aut Haiming Chen verfasserin aut Sijia Liu verfasserin aut Scott Ronquist verfasserin aut Can Chen verfasserin aut Xingzhao Wen verfasserin aut Cooper Stansbury verfasserin aut Gabrielle A. Dotson verfasserin aut Charles Ryan verfasserin aut Alnawaz Rehemtulla verfasserin aut Gilbert S. Omenn verfasserin aut Max Wicha verfasserin aut Shuai Cheng Li verfasserin aut Lindsey Muir verfasserin aut Indika Rajapakse verfasserin aut In iScience Elsevier, 2019 24(2021), 12, Seite 103452- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:12 pages:103452- https://doi.org/10.1016/j.isci.2021.103452 kostenfrei https://doaj.org/article/1464b2f0f40c401fb323e8020e9122d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221014231 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 12 103452-
allfieldsGer	10.1016/j.isci.2021.103452 doi (DE-627)DOAJ003019918 (DE-599)DOAJ1464b2f0f40c401fb323e8020e9122d5 DE-627 ger DE-627 rakwb eng Stephen Lindsly verfasserin aut Functional organization of the maternal and paternal human 4D Nucleome 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific relationship between gene expression and genome structure through the cell cycle is largely unknown. By integrating haplotype-resolved genome-wide chromosome conformation capture, mature and nascent mRNA, and protein binding data from a B lymphoblastoid cell line, we investigate this relationship both globally and locally. We introduce the maternal and paternal 4D Nucleome, enabling detailed analysis of the mechanisms and dynamics of genome structure and gene function for diploid organisms. Our analyses find significant coordination between allelic expression biases and local genome conformation, and notably absent expression bias in universally essential cell cycle and glycolysis genes. We propose a model in which coordinated biallelic expression reflects prioritized preservation of essential gene sets. Genomics Bioinformatics Genomic analysis Science Q Wenlong Jia verfasserin aut Haiming Chen verfasserin aut Sijia Liu verfasserin aut Scott Ronquist verfasserin aut Can Chen verfasserin aut Xingzhao Wen verfasserin aut Cooper Stansbury verfasserin aut Gabrielle A. Dotson verfasserin aut Charles Ryan verfasserin aut Alnawaz Rehemtulla verfasserin aut Gilbert S. Omenn verfasserin aut Max Wicha verfasserin aut Shuai Cheng Li verfasserin aut Lindsey Muir verfasserin aut Indika Rajapakse verfasserin aut In iScience Elsevier, 2019 24(2021), 12, Seite 103452- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:12 pages:103452- https://doi.org/10.1016/j.isci.2021.103452 kostenfrei https://doaj.org/article/1464b2f0f40c401fb323e8020e9122d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221014231 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 12 103452-
allfieldsSound	10.1016/j.isci.2021.103452 doi (DE-627)DOAJ003019918 (DE-599)DOAJ1464b2f0f40c401fb323e8020e9122d5 DE-627 ger DE-627 rakwb eng Stephen Lindsly verfasserin aut Functional organization of the maternal and paternal human 4D Nucleome 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific relationship between gene expression and genome structure through the cell cycle is largely unknown. By integrating haplotype-resolved genome-wide chromosome conformation capture, mature and nascent mRNA, and protein binding data from a B lymphoblastoid cell line, we investigate this relationship both globally and locally. We introduce the maternal and paternal 4D Nucleome, enabling detailed analysis of the mechanisms and dynamics of genome structure and gene function for diploid organisms. Our analyses find significant coordination between allelic expression biases and local genome conformation, and notably absent expression bias in universally essential cell cycle and glycolysis genes. We propose a model in which coordinated biallelic expression reflects prioritized preservation of essential gene sets. Genomics Bioinformatics Genomic analysis Science Q Wenlong Jia verfasserin aut Haiming Chen verfasserin aut Sijia Liu verfasserin aut Scott Ronquist verfasserin aut Can Chen verfasserin aut Xingzhao Wen verfasserin aut Cooper Stansbury verfasserin aut Gabrielle A. Dotson verfasserin aut Charles Ryan verfasserin aut Alnawaz Rehemtulla verfasserin aut Gilbert S. Omenn verfasserin aut Max Wicha verfasserin aut Shuai Cheng Li verfasserin aut Lindsey Muir verfasserin aut Indika Rajapakse verfasserin aut In iScience Elsevier, 2019 24(2021), 12, Seite 103452- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:12 pages:103452- https://doi.org/10.1016/j.isci.2021.103452 kostenfrei https://doaj.org/article/1464b2f0f40c401fb323e8020e9122d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221014231 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 12 103452-
language	English
source	In iScience 24(2021), 12, Seite 103452- volume:24 year:2021 number:12 pages:103452-
sourceStr	In iScience 24(2021), 12, Seite 103452- volume:24 year:2021 number:12 pages:103452-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Genomics Bioinformatics Genomic analysis Science Q
isfreeaccess_bool	true
container_title	iScience
authorswithroles_txt_mv	Stephen Lindsly @@aut@@ Wenlong Jia @@aut@@ Haiming Chen @@aut@@ Sijia Liu @@aut@@ Scott Ronquist @@aut@@ Can Chen @@aut@@ Xingzhao Wen @@aut@@ Cooper Stansbury @@aut@@ Gabrielle A. Dotson @@aut@@ Charles Ryan @@aut@@ Alnawaz Rehemtulla @@aut@@ Gilbert S. Omenn @@aut@@ Max Wicha @@aut@@ Shuai Cheng Li @@aut@@ Lindsey Muir @@aut@@ Indika Rajapakse @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	1019532106
id	DOAJ003019918
language_de	englisch
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author	Stephen Lindsly
spellingShingle	Stephen Lindsly misc Genomics misc Bioinformatics misc Genomic analysis misc Science misc Q Functional organization of the maternal and paternal human 4D Nucleome
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topic_title	Functional organization of the maternal and paternal human 4D Nucleome Genomics Bioinformatics Genomic analysis
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title	Functional organization of the maternal and paternal human 4D Nucleome
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title_full	Functional organization of the maternal and paternal human 4D Nucleome
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author_browse	Stephen Lindsly Wenlong Jia Haiming Chen Sijia Liu Scott Ronquist Can Chen Xingzhao Wen Cooper Stansbury Gabrielle A. Dotson Charles Ryan Alnawaz Rehemtulla Gilbert S. Omenn Max Wicha Shuai Cheng Li Lindsey Muir Indika Rajapakse
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doi_str_mv	10.1016/j.isci.2021.103452
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title_sort	functional organization of the maternal and paternal human 4d nucleome
title_auth	Functional organization of the maternal and paternal human 4D Nucleome
abstract	Summary: Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific relationship between gene expression and genome structure through the cell cycle is largely unknown. By integrating haplotype-resolved genome-wide chromosome conformation capture, mature and nascent mRNA, and protein binding data from a B lymphoblastoid cell line, we investigate this relationship both globally and locally. We introduce the maternal and paternal 4D Nucleome, enabling detailed analysis of the mechanisms and dynamics of genome structure and gene function for diploid organisms. Our analyses find significant coordination between allelic expression biases and local genome conformation, and notably absent expression bias in universally essential cell cycle and glycolysis genes. We propose a model in which coordinated biallelic expression reflects prioritized preservation of essential gene sets.
abstractGer	Summary: Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific relationship between gene expression and genome structure through the cell cycle is largely unknown. By integrating haplotype-resolved genome-wide chromosome conformation capture, mature and nascent mRNA, and protein binding data from a B lymphoblastoid cell line, we investigate this relationship both globally and locally. We introduce the maternal and paternal 4D Nucleome, enabling detailed analysis of the mechanisms and dynamics of genome structure and gene function for diploid organisms. Our analyses find significant coordination between allelic expression biases and local genome conformation, and notably absent expression bias in universally essential cell cycle and glycolysis genes. We propose a model in which coordinated biallelic expression reflects prioritized preservation of essential gene sets.
abstract_unstemmed	Summary: Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific relationship between gene expression and genome structure through the cell cycle is largely unknown. By integrating haplotype-resolved genome-wide chromosome conformation capture, mature and nascent mRNA, and protein binding data from a B lymphoblastoid cell line, we investigate this relationship both globally and locally. We introduce the maternal and paternal 4D Nucleome, enabling detailed analysis of the mechanisms and dynamics of genome structure and gene function for diploid organisms. Our analyses find significant coordination between allelic expression biases and local genome conformation, and notably absent expression bias in universally essential cell cycle and glycolysis genes. We propose a model in which coordinated biallelic expression reflects prioritized preservation of essential gene sets.
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title_short	Functional organization of the maternal and paternal human 4D Nucleome
url	https://doi.org/10.1016/j.isci.2021.103452 https://doaj.org/article/1464b2f0f40c401fb323e8020e9122d5 http://www.sciencedirect.com/science/article/pii/S2589004221014231 https://doaj.org/toc/2589-0042
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up_date	2024-07-03T15:29:30.107Z
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Functional organization of the maternal and paternal human 4D Nucleome

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Zugang & Verfügbarkeit

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