Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres

ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study...
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Autor*in:	Larissa M. Favarello [verfasserIn] Marcio Nucci [verfasserIn] Flavio Queiroz-Telles [verfasserIn] Thaís Guimarães [verfasserIn] Mauro J. Salles [verfasserIn] Teresa C.T. Sukiennik [verfasserIn] Daniel A. da Matta [verfasserIn] Analy S.A. Melo [verfasserIn] Arnaldo L. Colombo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Candida tropicalis Antifungal resistance Candidaemia MALDI-TOF/MS Emergent fungal pathogen Fluconazole resistance

Übergeordnetes Werk:	In: Journal of Global Antimicrobial Resistance - Elsevier, 2021, 25(2021), Seite 199-201
Übergeordnetes Werk:	volume:25 ; year:2021 ; pages:199-201

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jgar.2021.03.018

Katalog-ID:	DOAJ003032329

Internformat


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245	1	0	\|a Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres
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520			\|a ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. Conclusion: Although we failed to demonstrate statistical differences in the rates of azole resistance documented during the period of analysis, trends towards lower susceptibility to fluconazole and voriconazole were shown.
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700	0		\|a Analy S.A. Melo \|e verfasserin \|4 aut
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allfields	10.1016/j.jgar.2021.03.018 doi (DE-627)DOAJ003032329 (DE-599)DOAJ1276b80f41b544ada916547c0e95ee77 DE-627 ger DE-627 rakwb eng QR1-502 Larissa M. Favarello verfasserin aut Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. Conclusion: Although we failed to demonstrate statistical differences in the rates of azole resistance documented during the period of analysis, trends towards lower susceptibility to fluconazole and voriconazole were shown. Candida tropicalis Antifungal resistance Candidaemia MALDI-TOF/MS Emergent fungal pathogen Fluconazole resistance Microbiology Marcio Nucci verfasserin aut Flavio Queiroz-Telles verfasserin aut Thaís Guimarães verfasserin aut Mauro J. Salles verfasserin aut Teresa C.T. Sukiennik verfasserin aut Daniel A. da Matta verfasserin aut Analy S.A. Melo verfasserin aut Arnaldo L. Colombo verfasserin aut In Journal of Global Antimicrobial Resistance Elsevier, 2021 25(2021), Seite 199-201 (DE-627)741167042 (DE-600)2710046-7 22137173 nnns volume:25 year:2021 pages:199-201 https://doi.org/10.1016/j.jgar.2021.03.018 kostenfrei https://doaj.org/article/1276b80f41b544ada916547c0e95ee77 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213716521000849 kostenfrei https://doaj.org/toc/2213-7165 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 25 2021 199-201
spelling	10.1016/j.jgar.2021.03.018 doi (DE-627)DOAJ003032329 (DE-599)DOAJ1276b80f41b544ada916547c0e95ee77 DE-627 ger DE-627 rakwb eng QR1-502 Larissa M. Favarello verfasserin aut Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. Conclusion: Although we failed to demonstrate statistical differences in the rates of azole resistance documented during the period of analysis, trends towards lower susceptibility to fluconazole and voriconazole were shown. Candida tropicalis Antifungal resistance Candidaemia MALDI-TOF/MS Emergent fungal pathogen Fluconazole resistance Microbiology Marcio Nucci verfasserin aut Flavio Queiroz-Telles verfasserin aut Thaís Guimarães verfasserin aut Mauro J. Salles verfasserin aut Teresa C.T. Sukiennik verfasserin aut Daniel A. da Matta verfasserin aut Analy S.A. Melo verfasserin aut Arnaldo L. Colombo verfasserin aut In Journal of Global Antimicrobial Resistance Elsevier, 2021 25(2021), Seite 199-201 (DE-627)741167042 (DE-600)2710046-7 22137173 nnns volume:25 year:2021 pages:199-201 https://doi.org/10.1016/j.jgar.2021.03.018 kostenfrei https://doaj.org/article/1276b80f41b544ada916547c0e95ee77 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213716521000849 kostenfrei https://doaj.org/toc/2213-7165 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 25 2021 199-201
allfields_unstemmed	10.1016/j.jgar.2021.03.018 doi (DE-627)DOAJ003032329 (DE-599)DOAJ1276b80f41b544ada916547c0e95ee77 DE-627 ger DE-627 rakwb eng QR1-502 Larissa M. Favarello verfasserin aut Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. Conclusion: Although we failed to demonstrate statistical differences in the rates of azole resistance documented during the period of analysis, trends towards lower susceptibility to fluconazole and voriconazole were shown. Candida tropicalis Antifungal resistance Candidaemia MALDI-TOF/MS Emergent fungal pathogen Fluconazole resistance Microbiology Marcio Nucci verfasserin aut Flavio Queiroz-Telles verfasserin aut Thaís Guimarães verfasserin aut Mauro J. Salles verfasserin aut Teresa C.T. Sukiennik verfasserin aut Daniel A. da Matta verfasserin aut Analy S.A. Melo verfasserin aut Arnaldo L. Colombo verfasserin aut In Journal of Global Antimicrobial Resistance Elsevier, 2021 25(2021), Seite 199-201 (DE-627)741167042 (DE-600)2710046-7 22137173 nnns volume:25 year:2021 pages:199-201 https://doi.org/10.1016/j.jgar.2021.03.018 kostenfrei https://doaj.org/article/1276b80f41b544ada916547c0e95ee77 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213716521000849 kostenfrei https://doaj.org/toc/2213-7165 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 25 2021 199-201
allfieldsGer	10.1016/j.jgar.2021.03.018 doi (DE-627)DOAJ003032329 (DE-599)DOAJ1276b80f41b544ada916547c0e95ee77 DE-627 ger DE-627 rakwb eng QR1-502 Larissa M. Favarello verfasserin aut Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. Conclusion: Although we failed to demonstrate statistical differences in the rates of azole resistance documented during the period of analysis, trends towards lower susceptibility to fluconazole and voriconazole were shown. Candida tropicalis Antifungal resistance Candidaemia MALDI-TOF/MS Emergent fungal pathogen Fluconazole resistance Microbiology Marcio Nucci verfasserin aut Flavio Queiroz-Telles verfasserin aut Thaís Guimarães verfasserin aut Mauro J. Salles verfasserin aut Teresa C.T. Sukiennik verfasserin aut Daniel A. da Matta verfasserin aut Analy S.A. Melo verfasserin aut Arnaldo L. Colombo verfasserin aut In Journal of Global Antimicrobial Resistance Elsevier, 2021 25(2021), Seite 199-201 (DE-627)741167042 (DE-600)2710046-7 22137173 nnns volume:25 year:2021 pages:199-201 https://doi.org/10.1016/j.jgar.2021.03.018 kostenfrei https://doaj.org/article/1276b80f41b544ada916547c0e95ee77 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213716521000849 kostenfrei https://doaj.org/toc/2213-7165 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 25 2021 199-201
allfieldsSound	10.1016/j.jgar.2021.03.018 doi (DE-627)DOAJ003032329 (DE-599)DOAJ1276b80f41b544ada916547c0e95ee77 DE-627 ger DE-627 rakwb eng QR1-502 Larissa M. Favarello verfasserin aut Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. Conclusion: Although we failed to demonstrate statistical differences in the rates of azole resistance documented during the period of analysis, trends towards lower susceptibility to fluconazole and voriconazole were shown. Candida tropicalis Antifungal resistance Candidaemia MALDI-TOF/MS Emergent fungal pathogen Fluconazole resistance Microbiology Marcio Nucci verfasserin aut Flavio Queiroz-Telles verfasserin aut Thaís Guimarães verfasserin aut Mauro J. Salles verfasserin aut Teresa C.T. Sukiennik verfasserin aut Daniel A. da Matta verfasserin aut Analy S.A. Melo verfasserin aut Arnaldo L. Colombo verfasserin aut In Journal of Global Antimicrobial Resistance Elsevier, 2021 25(2021), Seite 199-201 (DE-627)741167042 (DE-600)2710046-7 22137173 nnns volume:25 year:2021 pages:199-201 https://doi.org/10.1016/j.jgar.2021.03.018 kostenfrei https://doaj.org/article/1276b80f41b544ada916547c0e95ee77 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213716521000849 kostenfrei https://doaj.org/toc/2213-7165 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 25 2021 199-201
language	English
source	In Journal of Global Antimicrobial Resistance 25(2021), Seite 199-201 volume:25 year:2021 pages:199-201
sourceStr	In Journal of Global Antimicrobial Resistance 25(2021), Seite 199-201 volume:25 year:2021 pages:199-201
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institution	findex.gbv.de
topic_facet	Candida tropicalis Antifungal resistance Candidaemia MALDI-TOF/MS Emergent fungal pathogen Fluconazole resistance Microbiology
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container_title	Journal of Global Antimicrobial Resistance
authorswithroles_txt_mv	Larissa M. Favarello @@aut@@ Marcio Nucci @@aut@@ Flavio Queiroz-Telles @@aut@@ Thaís Guimarães @@aut@@ Mauro J. Salles @@aut@@ Teresa C.T. Sukiennik @@aut@@ Daniel A. da Matta @@aut@@ Analy S.A. Melo @@aut@@ Arnaldo L. Colombo @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
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Favarello</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. 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callnumber-first	Q - Science
author	Larissa M. Favarello
spellingShingle	Larissa M. Favarello misc QR1-502 misc Candida tropicalis misc Antifungal resistance misc Candidaemia misc MALDI-TOF/MS misc Emergent fungal pathogen misc Fluconazole resistance misc Microbiology Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres
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topic_title	QR1-502 Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres Candida tropicalis Antifungal resistance Candidaemia MALDI-TOF/MS Emergent fungal pathogen Fluconazole resistance
topic	misc QR1-502 misc Candida tropicalis misc Antifungal resistance misc Candidaemia misc MALDI-TOF/MS misc Emergent fungal pathogen misc Fluconazole resistance misc Microbiology
topic_unstemmed	misc QR1-502 misc Candida tropicalis misc Antifungal resistance misc Candidaemia misc MALDI-TOF/MS misc Emergent fungal pathogen misc Fluconazole resistance misc Microbiology
topic_browse	misc QR1-502 misc Candida tropicalis misc Antifungal resistance misc Candidaemia misc MALDI-TOF/MS misc Emergent fungal pathogen misc Fluconazole resistance misc Microbiology
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title	Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres
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title_full	Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres
author_sort	Larissa M. Favarello
journal	Journal of Global Antimicrobial Resistance
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author_browse	Larissa M. Favarello Marcio Nucci Flavio Queiroz-Telles Thaís Guimarães Mauro J. Salles Teresa C.T. Sukiennik Daniel A. da Matta Analy S.A. Melo Arnaldo L. Colombo
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doi_str_mv	10.1016/j.jgar.2021.03.018
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title_sort	trends towards lower azole susceptibility among 200 candida tropicalis bloodstream isolates from brazilian medical centres
callnumber	QR1-502
title_auth	Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres
abstract	ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. Conclusion: Although we failed to demonstrate statistical differences in the rates of azole resistance documented during the period of analysis, trends towards lower susceptibility to fluconazole and voriconazole were shown.
abstractGer	ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. Conclusion: Although we failed to demonstrate statistical differences in the rates of azole resistance documented during the period of analysis, trends towards lower susceptibility to fluconazole and voriconazole were shown.
abstract_unstemmed	ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. Conclusion: Although we failed to demonstrate statistical differences in the rates of azole resistance documented during the period of analysis, trends towards lower susceptibility to fluconazole and voriconazole were shown.
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title_short	Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres
url	https://doi.org/10.1016/j.jgar.2021.03.018 https://doaj.org/article/1276b80f41b544ada916547c0e95ee77 http://www.sciencedirect.com/science/article/pii/S2213716521000849 https://doaj.org/toc/2213-7165
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author2	Marcio Nucci Flavio Queiroz-Telles Thaís Guimarães Mauro J. Salles Teresa C.T. Sukiennik Daniel A. da Matta Analy S.A. Melo Arnaldo L. Colombo
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up_date	2024-07-03T15:33:50.583Z
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Favarello</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. 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Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres

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