Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin
Abstract Determination of the primary tumor in periampullary region carcinomas can be difficult, and the pathological assessment and clinicopathological characteristics remain elusive. In this study, we investigated the current recognition and practices for periampullary region adenocarcinoma with a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ryuji Komine [verfasserIn] Motohiro Kojima [verfasserIn] Genichiro Ishi [verfasserIn] Masashi Kudo [verfasserIn] Motokazu Sugimoto [verfasserIn] Shin Kobayashi [verfasserIn] Shinichiro Takahashi [verfasserIn] Masaru Konishi [verfasserIn] Tatsushi Kobayashi [verfasserIn] Tetsuo Akimoto [verfasserIn] Ayumi Murakami [verfasserIn] Motoko Sasaki [verfasserIn] Mariko Tanaka [verfasserIn] Akiko Matsuzaki [verfasserIn] Nobuyuki Ohike [verfasserIn] Katsunori Uchida [verfasserIn] Tomoko Sugiyama [verfasserIn] Kenichi Hirabayashi [verfasserIn] Takuma Tajiri [verfasserIn] Kazuyuki Ishida [verfasserIn] Keita Kai [verfasserIn] Yuko Omori [verfasserIn] Kenji Notohara [verfasserIn] Hiroshi Yamaguchi [verfasserIn] Yoko Matsuda [verfasserIn] Yoshiki Naito [verfasserIn] Yuki Fukumura [verfasserIn] Yoshihiro Hamada [verfasserIn] Yumi Mihara [verfasserIn] Yohei Masugi [verfasserIn] Naoto Gotohda [verfasserIn] Kenichi Harada [verfasserIn] Noriyoshi Fukushima [verfasserIn] Toru Furukawa [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Cancer Medicine - Wiley, 2012, 10(2021), 11, Seite 3499-3510 |
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| Übergeordnetes Werk: |
volume:10 ; year:2021 ; number:11 ; pages:3499-3510 |
| Links: |
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| DOI / URN: |
10.1002/cam4.3809 |
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| Katalog-ID: |
DOAJ003046877 |
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| 245 | 1 | 0 | |a Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin |
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| 520 | |a Abstract Determination of the primary tumor in periampullary region carcinomas can be difficult, and the pathological assessment and clinicopathological characteristics remain elusive. In this study, we investigated the current recognition and practices for periampullary region adenocarcinoma with an indeterminable origin among expert pathologists through a cognitive survey. Simultaneously, we analyzed a prospective collection of cases with an indeterminable primary tumor diagnosed from 2008 to 2018 to elucidate their clinicopathological features. All cases with pathological indeterminable primary tumors were reported and discussed in a clinicopathological conference to elucidate if it was possible to distinguish the primary tumor clinically and pathologically. From the cognitive survey, over 85% of the pathologists had experienced cases with indeterminable primary tumors; however, 70% of the cases was reported as pancreatic cancer without definitive grounds. Interpretation of the main tumor mass varied, and no standardized method was developed to determine the primary tumor. During a prospective study, 42 of the 392 periampullary carcinoma cases (10.7%) were considered as tumors with a pathological indeterminable origin. After the clinicopathological conferences, 21 (5.4%) remained indeterminable and were considered final indeterminable cases. Histological studies showed that the tumors spread along both the bile duct and main pancreatic duct; this was the most representative finding of the final indeterminable cases. This study is the first to elucidate and recognize the current clinicopathological features of periampullary region adenocarcinomas with an indeterminable origin. Adequate assessment of primary tumors in periampullary region carcinomas will help to optimize epidemiological data of pancreatic and bile duct cancer. | ||
| 650 | 4 | |a ampulla of Vater carcinoma | |
| 650 | 4 | |a distal bile duct carcinoma | |
| 650 | 4 | |a indeterminable tumor primary | |
| 650 | 4 | |a pancreatic ductal adenocarcinoma | |
| 650 | 4 | |a periampullary region | |
| 653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
| 700 | 0 | |a Motohiro Kojima |e verfasserin |4 aut | |
| 700 | 0 | |a Genichiro Ishi |e verfasserin |4 aut | |
| 700 | 0 | |a Masashi Kudo |e verfasserin |4 aut | |
| 700 | 0 | |a Motokazu Sugimoto |e verfasserin |4 aut | |
| 700 | 0 | |a Shin Kobayashi |e verfasserin |4 aut | |
| 700 | 0 | |a Shinichiro Takahashi |e verfasserin |4 aut | |
| 700 | 0 | |a Masaru Konishi |e verfasserin |4 aut | |
| 700 | 0 | |a Tatsushi Kobayashi |e verfasserin |4 aut | |
| 700 | 0 | |a Tetsuo Akimoto |e verfasserin |4 aut | |
| 700 | 0 | |a Ayumi Murakami |e verfasserin |4 aut | |
| 700 | 0 | |a Motoko Sasaki |e verfasserin |4 aut | |
| 700 | 0 | |a Mariko Tanaka |e verfasserin |4 aut | |
| 700 | 0 | |a Akiko Matsuzaki |e verfasserin |4 aut | |
| 700 | 0 | |a Nobuyuki Ohike |e verfasserin |4 aut | |
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| 700 | 0 | |a Tomoko Sugiyama |e verfasserin |4 aut | |
| 700 | 0 | |a Kenichi Hirabayashi |e verfasserin |4 aut | |
| 700 | 0 | |a Takuma Tajiri |e verfasserin |4 aut | |
| 700 | 0 | |a Kazuyuki Ishida |e verfasserin |4 aut | |
| 700 | 0 | |a Keita Kai |e verfasserin |4 aut | |
| 700 | 0 | |a Yuko Omori |e verfasserin |4 aut | |
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| 700 | 0 | |a Noriyoshi Fukushima |e verfasserin |4 aut | |
| 700 | 0 | |a Toru Furukawa |e verfasserin |4 aut | |
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10.1002/cam4.3809 doi (DE-627)DOAJ003046877 (DE-599)DOAJ03e063ad5b764aab93be4f1fa94b1b4f DE-627 ger DE-627 rakwb eng RC254-282 Ryuji Komine verfasserin aut Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Determination of the primary tumor in periampullary region carcinomas can be difficult, and the pathological assessment and clinicopathological characteristics remain elusive. In this study, we investigated the current recognition and practices for periampullary region adenocarcinoma with an indeterminable origin among expert pathologists through a cognitive survey. Simultaneously, we analyzed a prospective collection of cases with an indeterminable primary tumor diagnosed from 2008 to 2018 to elucidate their clinicopathological features. All cases with pathological indeterminable primary tumors were reported and discussed in a clinicopathological conference to elucidate if it was possible to distinguish the primary tumor clinically and pathologically. From the cognitive survey, over 85% of the pathologists had experienced cases with indeterminable primary tumors; however, 70% of the cases was reported as pancreatic cancer without definitive grounds. Interpretation of the main tumor mass varied, and no standardized method was developed to determine the primary tumor. During a prospective study, 42 of the 392 periampullary carcinoma cases (10.7%) were considered as tumors with a pathological indeterminable origin. After the clinicopathological conferences, 21 (5.4%) remained indeterminable and were considered final indeterminable cases. Histological studies showed that the tumors spread along both the bile duct and main pancreatic duct; this was the most representative finding of the final indeterminable cases. This study is the first to elucidate and recognize the current clinicopathological features of periampullary region adenocarcinomas with an indeterminable origin. Adequate assessment of primary tumors in periampullary region carcinomas will help to optimize epidemiological data of pancreatic and bile duct cancer. ampulla of Vater carcinoma distal bile duct carcinoma indeterminable tumor primary pancreatic ductal adenocarcinoma periampullary region Neoplasms. Tumors. Oncology. Including cancer and carcinogens Motohiro Kojima verfasserin aut Genichiro Ishi verfasserin aut Masashi Kudo verfasserin aut Motokazu Sugimoto verfasserin aut Shin Kobayashi verfasserin aut Shinichiro Takahashi verfasserin aut Masaru Konishi verfasserin aut Tatsushi Kobayashi verfasserin aut Tetsuo Akimoto verfasserin aut Ayumi Murakami verfasserin aut Motoko Sasaki verfasserin aut Mariko Tanaka verfasserin aut Akiko Matsuzaki verfasserin aut Nobuyuki Ohike verfasserin aut Katsunori Uchida verfasserin aut Tomoko Sugiyama verfasserin aut Kenichi Hirabayashi verfasserin aut Takuma Tajiri verfasserin aut Kazuyuki Ishida verfasserin aut Keita Kai verfasserin aut Yuko Omori verfasserin aut Kenji Notohara verfasserin aut Hiroshi Yamaguchi verfasserin aut Yoko Matsuda verfasserin aut Yoshiki Naito verfasserin aut Yuki Fukumura verfasserin aut Yoshihiro Hamada verfasserin aut Yumi Mihara verfasserin aut Yohei Masugi verfasserin aut Naoto Gotohda verfasserin aut Kenichi Harada verfasserin aut Noriyoshi Fukushima verfasserin aut Toru Furukawa verfasserin aut In Cancer Medicine Wiley, 2012 10(2021), 11, Seite 3499-3510 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:10 year:2021 number:11 pages:3499-3510 https://doi.org/10.1002/cam4.3809 kostenfrei https://doaj.org/article/03e063ad5b764aab93be4f1fa94b1b4f kostenfrei https://doi.org/10.1002/cam4.3809 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11 3499-3510 |
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10.1002/cam4.3809 doi (DE-627)DOAJ003046877 (DE-599)DOAJ03e063ad5b764aab93be4f1fa94b1b4f DE-627 ger DE-627 rakwb eng RC254-282 Ryuji Komine verfasserin aut Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Determination of the primary tumor in periampullary region carcinomas can be difficult, and the pathological assessment and clinicopathological characteristics remain elusive. In this study, we investigated the current recognition and practices for periampullary region adenocarcinoma with an indeterminable origin among expert pathologists through a cognitive survey. Simultaneously, we analyzed a prospective collection of cases with an indeterminable primary tumor diagnosed from 2008 to 2018 to elucidate their clinicopathological features. All cases with pathological indeterminable primary tumors were reported and discussed in a clinicopathological conference to elucidate if it was possible to distinguish the primary tumor clinically and pathologically. From the cognitive survey, over 85% of the pathologists had experienced cases with indeterminable primary tumors; however, 70% of the cases was reported as pancreatic cancer without definitive grounds. Interpretation of the main tumor mass varied, and no standardized method was developed to determine the primary tumor. During a prospective study, 42 of the 392 periampullary carcinoma cases (10.7%) were considered as tumors with a pathological indeterminable origin. After the clinicopathological conferences, 21 (5.4%) remained indeterminable and were considered final indeterminable cases. Histological studies showed that the tumors spread along both the bile duct and main pancreatic duct; this was the most representative finding of the final indeterminable cases. This study is the first to elucidate and recognize the current clinicopathological features of periampullary region adenocarcinomas with an indeterminable origin. Adequate assessment of primary tumors in periampullary region carcinomas will help to optimize epidemiological data of pancreatic and bile duct cancer. ampulla of Vater carcinoma distal bile duct carcinoma indeterminable tumor primary pancreatic ductal adenocarcinoma periampullary region Neoplasms. Tumors. Oncology. Including cancer and carcinogens Motohiro Kojima verfasserin aut Genichiro Ishi verfasserin aut Masashi Kudo verfasserin aut Motokazu Sugimoto verfasserin aut Shin Kobayashi verfasserin aut Shinichiro Takahashi verfasserin aut Masaru Konishi verfasserin aut Tatsushi Kobayashi verfasserin aut Tetsuo Akimoto verfasserin aut Ayumi Murakami verfasserin aut Motoko Sasaki verfasserin aut Mariko Tanaka verfasserin aut Akiko Matsuzaki verfasserin aut Nobuyuki Ohike verfasserin aut Katsunori Uchida verfasserin aut Tomoko Sugiyama verfasserin aut Kenichi Hirabayashi verfasserin aut Takuma Tajiri verfasserin aut Kazuyuki Ishida verfasserin aut Keita Kai verfasserin aut Yuko Omori verfasserin aut Kenji Notohara verfasserin aut Hiroshi Yamaguchi verfasserin aut Yoko Matsuda verfasserin aut Yoshiki Naito verfasserin aut Yuki Fukumura verfasserin aut Yoshihiro Hamada verfasserin aut Yumi Mihara verfasserin aut Yohei Masugi verfasserin aut Naoto Gotohda verfasserin aut Kenichi Harada verfasserin aut Noriyoshi Fukushima verfasserin aut Toru Furukawa verfasserin aut In Cancer Medicine Wiley, 2012 10(2021), 11, Seite 3499-3510 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:10 year:2021 number:11 pages:3499-3510 https://doi.org/10.1002/cam4.3809 kostenfrei https://doaj.org/article/03e063ad5b764aab93be4f1fa94b1b4f kostenfrei https://doi.org/10.1002/cam4.3809 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11 3499-3510 |
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10.1002/cam4.3809 doi (DE-627)DOAJ003046877 (DE-599)DOAJ03e063ad5b764aab93be4f1fa94b1b4f DE-627 ger DE-627 rakwb eng RC254-282 Ryuji Komine verfasserin aut Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Determination of the primary tumor in periampullary region carcinomas can be difficult, and the pathological assessment and clinicopathological characteristics remain elusive. In this study, we investigated the current recognition and practices for periampullary region adenocarcinoma with an indeterminable origin among expert pathologists through a cognitive survey. Simultaneously, we analyzed a prospective collection of cases with an indeterminable primary tumor diagnosed from 2008 to 2018 to elucidate their clinicopathological features. All cases with pathological indeterminable primary tumors were reported and discussed in a clinicopathological conference to elucidate if it was possible to distinguish the primary tumor clinically and pathologically. From the cognitive survey, over 85% of the pathologists had experienced cases with indeterminable primary tumors; however, 70% of the cases was reported as pancreatic cancer without definitive grounds. Interpretation of the main tumor mass varied, and no standardized method was developed to determine the primary tumor. During a prospective study, 42 of the 392 periampullary carcinoma cases (10.7%) were considered as tumors with a pathological indeterminable origin. After the clinicopathological conferences, 21 (5.4%) remained indeterminable and were considered final indeterminable cases. Histological studies showed that the tumors spread along both the bile duct and main pancreatic duct; this was the most representative finding of the final indeterminable cases. This study is the first to elucidate and recognize the current clinicopathological features of periampullary region adenocarcinomas with an indeterminable origin. Adequate assessment of primary tumors in periampullary region carcinomas will help to optimize epidemiological data of pancreatic and bile duct cancer. ampulla of Vater carcinoma distal bile duct carcinoma indeterminable tumor primary pancreatic ductal adenocarcinoma periampullary region Neoplasms. Tumors. Oncology. Including cancer and carcinogens Motohiro Kojima verfasserin aut Genichiro Ishi verfasserin aut Masashi Kudo verfasserin aut Motokazu Sugimoto verfasserin aut Shin Kobayashi verfasserin aut Shinichiro Takahashi verfasserin aut Masaru Konishi verfasserin aut Tatsushi Kobayashi verfasserin aut Tetsuo Akimoto verfasserin aut Ayumi Murakami verfasserin aut Motoko Sasaki verfasserin aut Mariko Tanaka verfasserin aut Akiko Matsuzaki verfasserin aut Nobuyuki Ohike verfasserin aut Katsunori Uchida verfasserin aut Tomoko Sugiyama verfasserin aut Kenichi Hirabayashi verfasserin aut Takuma Tajiri verfasserin aut Kazuyuki Ishida verfasserin aut Keita Kai verfasserin aut Yuko Omori verfasserin aut Kenji Notohara verfasserin aut Hiroshi Yamaguchi verfasserin aut Yoko Matsuda verfasserin aut Yoshiki Naito verfasserin aut Yuki Fukumura verfasserin aut Yoshihiro Hamada verfasserin aut Yumi Mihara verfasserin aut Yohei Masugi verfasserin aut Naoto Gotohda verfasserin aut Kenichi Harada verfasserin aut Noriyoshi Fukushima verfasserin aut Toru Furukawa verfasserin aut In Cancer Medicine Wiley, 2012 10(2021), 11, Seite 3499-3510 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:10 year:2021 number:11 pages:3499-3510 https://doi.org/10.1002/cam4.3809 kostenfrei https://doaj.org/article/03e063ad5b764aab93be4f1fa94b1b4f kostenfrei https://doi.org/10.1002/cam4.3809 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11 3499-3510 |
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10.1002/cam4.3809 doi (DE-627)DOAJ003046877 (DE-599)DOAJ03e063ad5b764aab93be4f1fa94b1b4f DE-627 ger DE-627 rakwb eng RC254-282 Ryuji Komine verfasserin aut Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Determination of the primary tumor in periampullary region carcinomas can be difficult, and the pathological assessment and clinicopathological characteristics remain elusive. In this study, we investigated the current recognition and practices for periampullary region adenocarcinoma with an indeterminable origin among expert pathologists through a cognitive survey. Simultaneously, we analyzed a prospective collection of cases with an indeterminable primary tumor diagnosed from 2008 to 2018 to elucidate their clinicopathological features. All cases with pathological indeterminable primary tumors were reported and discussed in a clinicopathological conference to elucidate if it was possible to distinguish the primary tumor clinically and pathologically. From the cognitive survey, over 85% of the pathologists had experienced cases with indeterminable primary tumors; however, 70% of the cases was reported as pancreatic cancer without definitive grounds. Interpretation of the main tumor mass varied, and no standardized method was developed to determine the primary tumor. During a prospective study, 42 of the 392 periampullary carcinoma cases (10.7%) were considered as tumors with a pathological indeterminable origin. After the clinicopathological conferences, 21 (5.4%) remained indeterminable and were considered final indeterminable cases. Histological studies showed that the tumors spread along both the bile duct and main pancreatic duct; this was the most representative finding of the final indeterminable cases. This study is the first to elucidate and recognize the current clinicopathological features of periampullary region adenocarcinomas with an indeterminable origin. Adequate assessment of primary tumors in periampullary region carcinomas will help to optimize epidemiological data of pancreatic and bile duct cancer. ampulla of Vater carcinoma distal bile duct carcinoma indeterminable tumor primary pancreatic ductal adenocarcinoma periampullary region Neoplasms. Tumors. Oncology. Including cancer and carcinogens Motohiro Kojima verfasserin aut Genichiro Ishi verfasserin aut Masashi Kudo verfasserin aut Motokazu Sugimoto verfasserin aut Shin Kobayashi verfasserin aut Shinichiro Takahashi verfasserin aut Masaru Konishi verfasserin aut Tatsushi Kobayashi verfasserin aut Tetsuo Akimoto verfasserin aut Ayumi Murakami verfasserin aut Motoko Sasaki verfasserin aut Mariko Tanaka verfasserin aut Akiko Matsuzaki verfasserin aut Nobuyuki Ohike verfasserin aut Katsunori Uchida verfasserin aut Tomoko Sugiyama verfasserin aut Kenichi Hirabayashi verfasserin aut Takuma Tajiri verfasserin aut Kazuyuki Ishida verfasserin aut Keita Kai verfasserin aut Yuko Omori verfasserin aut Kenji Notohara verfasserin aut Hiroshi Yamaguchi verfasserin aut Yoko Matsuda verfasserin aut Yoshiki Naito verfasserin aut Yuki Fukumura verfasserin aut Yoshihiro Hamada verfasserin aut Yumi Mihara verfasserin aut Yohei Masugi verfasserin aut Naoto Gotohda verfasserin aut Kenichi Harada verfasserin aut Noriyoshi Fukushima verfasserin aut Toru Furukawa verfasserin aut In Cancer Medicine Wiley, 2012 10(2021), 11, Seite 3499-3510 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:10 year:2021 number:11 pages:3499-3510 https://doi.org/10.1002/cam4.3809 kostenfrei https://doaj.org/article/03e063ad5b764aab93be4f1fa94b1b4f kostenfrei https://doi.org/10.1002/cam4.3809 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11 3499-3510 |
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10.1002/cam4.3809 doi (DE-627)DOAJ003046877 (DE-599)DOAJ03e063ad5b764aab93be4f1fa94b1b4f DE-627 ger DE-627 rakwb eng RC254-282 Ryuji Komine verfasserin aut Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Determination of the primary tumor in periampullary region carcinomas can be difficult, and the pathological assessment and clinicopathological characteristics remain elusive. In this study, we investigated the current recognition and practices for periampullary region adenocarcinoma with an indeterminable origin among expert pathologists through a cognitive survey. Simultaneously, we analyzed a prospective collection of cases with an indeterminable primary tumor diagnosed from 2008 to 2018 to elucidate their clinicopathological features. All cases with pathological indeterminable primary tumors were reported and discussed in a clinicopathological conference to elucidate if it was possible to distinguish the primary tumor clinically and pathologically. From the cognitive survey, over 85% of the pathologists had experienced cases with indeterminable primary tumors; however, 70% of the cases was reported as pancreatic cancer without definitive grounds. Interpretation of the main tumor mass varied, and no standardized method was developed to determine the primary tumor. During a prospective study, 42 of the 392 periampullary carcinoma cases (10.7%) were considered as tumors with a pathological indeterminable origin. After the clinicopathological conferences, 21 (5.4%) remained indeterminable and were considered final indeterminable cases. Histological studies showed that the tumors spread along both the bile duct and main pancreatic duct; this was the most representative finding of the final indeterminable cases. This study is the first to elucidate and recognize the current clinicopathological features of periampullary region adenocarcinomas with an indeterminable origin. Adequate assessment of primary tumors in periampullary region carcinomas will help to optimize epidemiological data of pancreatic and bile duct cancer. ampulla of Vater carcinoma distal bile duct carcinoma indeterminable tumor primary pancreatic ductal adenocarcinoma periampullary region Neoplasms. Tumors. Oncology. Including cancer and carcinogens Motohiro Kojima verfasserin aut Genichiro Ishi verfasserin aut Masashi Kudo verfasserin aut Motokazu Sugimoto verfasserin aut Shin Kobayashi verfasserin aut Shinichiro Takahashi verfasserin aut Masaru Konishi verfasserin aut Tatsushi Kobayashi verfasserin aut Tetsuo Akimoto verfasserin aut Ayumi Murakami verfasserin aut Motoko Sasaki verfasserin aut Mariko Tanaka verfasserin aut Akiko Matsuzaki verfasserin aut Nobuyuki Ohike verfasserin aut Katsunori Uchida verfasserin aut Tomoko Sugiyama verfasserin aut Kenichi Hirabayashi verfasserin aut Takuma Tajiri verfasserin aut Kazuyuki Ishida verfasserin aut Keita Kai verfasserin aut Yuko Omori verfasserin aut Kenji Notohara verfasserin aut Hiroshi Yamaguchi verfasserin aut Yoko Matsuda verfasserin aut Yoshiki Naito verfasserin aut Yuki Fukumura verfasserin aut Yoshihiro Hamada verfasserin aut Yumi Mihara verfasserin aut Yohei Masugi verfasserin aut Naoto Gotohda verfasserin aut Kenichi Harada verfasserin aut Noriyoshi Fukushima verfasserin aut Toru Furukawa verfasserin aut In Cancer Medicine Wiley, 2012 10(2021), 11, Seite 3499-3510 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:10 year:2021 number:11 pages:3499-3510 https://doi.org/10.1002/cam4.3809 kostenfrei https://doaj.org/article/03e063ad5b764aab93be4f1fa94b1b4f kostenfrei https://doi.org/10.1002/cam4.3809 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11 3499-3510 |
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ampulla of Vater carcinoma distal bile duct carcinoma indeterminable tumor primary pancreatic ductal adenocarcinoma periampullary region Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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Ryuji Komine @@aut@@ Motohiro Kojima @@aut@@ Genichiro Ishi @@aut@@ Masashi Kudo @@aut@@ Motokazu Sugimoto @@aut@@ Shin Kobayashi @@aut@@ Shinichiro Takahashi @@aut@@ Masaru Konishi @@aut@@ Tatsushi Kobayashi @@aut@@ Tetsuo Akimoto @@aut@@ Ayumi Murakami @@aut@@ Motoko Sasaki @@aut@@ Mariko Tanaka @@aut@@ Akiko Matsuzaki @@aut@@ Nobuyuki Ohike @@aut@@ Katsunori Uchida @@aut@@ Tomoko Sugiyama @@aut@@ Kenichi Hirabayashi @@aut@@ Takuma Tajiri @@aut@@ Kazuyuki Ishida @@aut@@ Keita Kai @@aut@@ Yuko Omori @@aut@@ Kenji Notohara @@aut@@ Hiroshi Yamaguchi @@aut@@ Yoko Matsuda @@aut@@ Yoshiki Naito @@aut@@ Yuki Fukumura @@aut@@ Yoshihiro Hamada @@aut@@ Yumi Mihara @@aut@@ Yohei Masugi @@aut@@ Naoto Gotohda @@aut@@ Kenichi Harada @@aut@@ Noriyoshi Fukushima @@aut@@ Toru Furukawa @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ003046877</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230503070842.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/cam4.3809</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ003046877</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ03e063ad5b764aab93be4f1fa94b1b4f</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Ryuji Komine</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Determination of the primary tumor in periampullary region carcinomas can be difficult, and the pathological assessment and clinicopathological characteristics remain elusive. In this study, we investigated the current recognition and practices for periampullary region adenocarcinoma with an indeterminable origin among expert pathologists through a cognitive survey. Simultaneously, we analyzed a prospective collection of cases with an indeterminable primary tumor diagnosed from 2008 to 2018 to elucidate their clinicopathological features. All cases with pathological indeterminable primary tumors were reported and discussed in a clinicopathological conference to elucidate if it was possible to distinguish the primary tumor clinically and pathologically. From the cognitive survey, over 85% of the pathologists had experienced cases with indeterminable primary tumors; however, 70% of the cases was reported as pancreatic cancer without definitive grounds. Interpretation of the main tumor mass varied, and no standardized method was developed to determine the primary tumor. During a prospective study, 42 of the 392 periampullary carcinoma cases (10.7%) were considered as tumors with a pathological indeterminable origin. After the clinicopathological conferences, 21 (5.4%) remained indeterminable and were considered final indeterminable cases. Histological studies showed that the tumors spread along both the bile duct and main pancreatic duct; this was the most representative finding of the final indeterminable cases. This study is the first to elucidate and recognize the current clinicopathological features of periampullary region adenocarcinomas with an indeterminable origin. 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Ryuji Komine |
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Ryuji Komine misc RC254-282 misc ampulla of Vater carcinoma misc distal bile duct carcinoma misc indeterminable tumor primary misc pancreatic ductal adenocarcinoma misc periampullary region misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin |
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RC254-282 Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin ampulla of Vater carcinoma distal bile duct carcinoma indeterminable tumor primary pancreatic ductal adenocarcinoma periampullary region |
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misc RC254-282 misc ampulla of Vater carcinoma misc distal bile duct carcinoma misc indeterminable tumor primary misc pancreatic ductal adenocarcinoma misc periampullary region misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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misc RC254-282 misc ampulla of Vater carcinoma misc distal bile duct carcinoma misc indeterminable tumor primary misc pancreatic ductal adenocarcinoma misc periampullary region misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin |
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Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin |
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Ryuji Komine Motohiro Kojima Genichiro Ishi Masashi Kudo Motokazu Sugimoto Shin Kobayashi Shinichiro Takahashi Masaru Konishi Tatsushi Kobayashi Tetsuo Akimoto Ayumi Murakami Motoko Sasaki Mariko Tanaka Akiko Matsuzaki Nobuyuki Ohike Katsunori Uchida Tomoko Sugiyama Kenichi Hirabayashi Takuma Tajiri Kazuyuki Ishida Keita Kai Yuko Omori Kenji Notohara Hiroshi Yamaguchi Yoko Matsuda Yoshiki Naito Yuki Fukumura Yoshihiro Hamada Yumi Mihara Yohei Masugi Naoto Gotohda Kenichi Harada Noriyoshi Fukushima Toru Furukawa |
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recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin |
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Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin |
| abstract |
Abstract Determination of the primary tumor in periampullary region carcinomas can be difficult, and the pathological assessment and clinicopathological characteristics remain elusive. In this study, we investigated the current recognition and practices for periampullary region adenocarcinoma with an indeterminable origin among expert pathologists through a cognitive survey. Simultaneously, we analyzed a prospective collection of cases with an indeterminable primary tumor diagnosed from 2008 to 2018 to elucidate their clinicopathological features. All cases with pathological indeterminable primary tumors were reported and discussed in a clinicopathological conference to elucidate if it was possible to distinguish the primary tumor clinically and pathologically. From the cognitive survey, over 85% of the pathologists had experienced cases with indeterminable primary tumors; however, 70% of the cases was reported as pancreatic cancer without definitive grounds. Interpretation of the main tumor mass varied, and no standardized method was developed to determine the primary tumor. During a prospective study, 42 of the 392 periampullary carcinoma cases (10.7%) were considered as tumors with a pathological indeterminable origin. After the clinicopathological conferences, 21 (5.4%) remained indeterminable and were considered final indeterminable cases. Histological studies showed that the tumors spread along both the bile duct and main pancreatic duct; this was the most representative finding of the final indeterminable cases. This study is the first to elucidate and recognize the current clinicopathological features of periampullary region adenocarcinomas with an indeterminable origin. Adequate assessment of primary tumors in periampullary region carcinomas will help to optimize epidemiological data of pancreatic and bile duct cancer. |
| abstractGer |
Abstract Determination of the primary tumor in periampullary region carcinomas can be difficult, and the pathological assessment and clinicopathological characteristics remain elusive. In this study, we investigated the current recognition and practices for periampullary region adenocarcinoma with an indeterminable origin among expert pathologists through a cognitive survey. Simultaneously, we analyzed a prospective collection of cases with an indeterminable primary tumor diagnosed from 2008 to 2018 to elucidate their clinicopathological features. All cases with pathological indeterminable primary tumors were reported and discussed in a clinicopathological conference to elucidate if it was possible to distinguish the primary tumor clinically and pathologically. From the cognitive survey, over 85% of the pathologists had experienced cases with indeterminable primary tumors; however, 70% of the cases was reported as pancreatic cancer without definitive grounds. Interpretation of the main tumor mass varied, and no standardized method was developed to determine the primary tumor. During a prospective study, 42 of the 392 periampullary carcinoma cases (10.7%) were considered as tumors with a pathological indeterminable origin. After the clinicopathological conferences, 21 (5.4%) remained indeterminable and were considered final indeterminable cases. Histological studies showed that the tumors spread along both the bile duct and main pancreatic duct; this was the most representative finding of the final indeterminable cases. This study is the first to elucidate and recognize the current clinicopathological features of periampullary region adenocarcinomas with an indeterminable origin. Adequate assessment of primary tumors in periampullary region carcinomas will help to optimize epidemiological data of pancreatic and bile duct cancer. |
| abstract_unstemmed |
Abstract Determination of the primary tumor in periampullary region carcinomas can be difficult, and the pathological assessment and clinicopathological characteristics remain elusive. In this study, we investigated the current recognition and practices for periampullary region adenocarcinoma with an indeterminable origin among expert pathologists through a cognitive survey. Simultaneously, we analyzed a prospective collection of cases with an indeterminable primary tumor diagnosed from 2008 to 2018 to elucidate their clinicopathological features. All cases with pathological indeterminable primary tumors were reported and discussed in a clinicopathological conference to elucidate if it was possible to distinguish the primary tumor clinically and pathologically. From the cognitive survey, over 85% of the pathologists had experienced cases with indeterminable primary tumors; however, 70% of the cases was reported as pancreatic cancer without definitive grounds. Interpretation of the main tumor mass varied, and no standardized method was developed to determine the primary tumor. During a prospective study, 42 of the 392 periampullary carcinoma cases (10.7%) were considered as tumors with a pathological indeterminable origin. After the clinicopathological conferences, 21 (5.4%) remained indeterminable and were considered final indeterminable cases. Histological studies showed that the tumors spread along both the bile duct and main pancreatic duct; this was the most representative finding of the final indeterminable cases. This study is the first to elucidate and recognize the current clinicopathological features of periampullary region adenocarcinomas with an indeterminable origin. Adequate assessment of primary tumors in periampullary region carcinomas will help to optimize epidemiological data of pancreatic and bile duct cancer. |
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| container_issue |
11 |
| title_short |
Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin |
| url |
https://doi.org/10.1002/cam4.3809 https://doaj.org/article/03e063ad5b764aab93be4f1fa94b1b4f https://doaj.org/toc/2045-7634 |
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Motohiro Kojima Genichiro Ishi Masashi Kudo Motokazu Sugimoto Shin Kobayashi Shinichiro Takahashi Masaru Konishi Tatsushi Kobayashi Tetsuo Akimoto Ayumi Murakami Motoko Sasaki Mariko Tanaka Akiko Matsuzaki Nobuyuki Ohike Katsunori Uchida Tomoko Sugiyama Kenichi Hirabayashi Takuma Tajiri Kazuyuki Ishida Keita Kai Yuko Omori Kenji Notohara Hiroshi Yamaguchi Yoko Matsuda Yoshiki Naito Yuki Fukumura Yoshihiro Hamada Yumi Mihara Yohei Masugi Naoto Gotohda Kenichi Harada Noriyoshi Fukushima Toru Furukawa |
| author2Str |
Motohiro Kojima Genichiro Ishi Masashi Kudo Motokazu Sugimoto Shin Kobayashi Shinichiro Takahashi Masaru Konishi Tatsushi Kobayashi Tetsuo Akimoto Ayumi Murakami Motoko Sasaki Mariko Tanaka Akiko Matsuzaki Nobuyuki Ohike Katsunori Uchida Tomoko Sugiyama Kenichi Hirabayashi Takuma Tajiri Kazuyuki Ishida Keita Kai Yuko Omori Kenji Notohara Hiroshi Yamaguchi Yoko Matsuda Yoshiki Naito Yuki Fukumura Yoshihiro Hamada Yumi Mihara Yohei Masugi Naoto Gotohda Kenichi Harada Noriyoshi Fukushima Toru Furukawa |
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2024-07-03T15:38:55.551Z |
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| score |
7.398178 |