Time-course of corticospinal excitability and autonomic function interplay during and following monopolar tDCS

While polarity-specific after-effects of monopolar transcranial direct current stimulation (tDCS) on cortico-spinal excitability are well-documented, modulation of vital parameters due to current spread through the brainstem is still a matter of debate, raising potential concerns about its use throu...
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Gespeichert in:

Autor*in:	Emiliano eSantarnecchi [verfasserIn] Matteo eFeurra [verfasserIn] Federico eBarneschi [verfasserIn] Maurizio eAcampa [verfasserIn] Giovanni eBianco [verfasserIn] David eCioncoloni [verfasserIn] Alessandro eRossi [verfasserIn] Simone eRossi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Safety Transcranial Magnetic Stimulation Neuromodulation transcranial direct current stimulation (tDCS) tDCS vital parameters

Übergeordnetes Werk:	In: Frontiers in Psychiatry - Frontiers Media S.A., 2010, 5(2014)
Übergeordnetes Werk:	volume:5 ; year:2014

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fpsyt.2014.00086

Katalog-ID:	DOAJ003061531

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allfieldsSound	10.3389/fpsyt.2014.00086 doi (DE-627)DOAJ003061531 (DE-599)DOAJ686558cebd384279b3d4d3e38cd623b5 DE-627 ger DE-627 rakwb eng RC435-571 Emiliano eSantarnecchi verfasserin aut Time-course of corticospinal excitability and autonomic function interplay during and following monopolar tDCS 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier While polarity-specific after-effects of monopolar transcranial direct current stimulation (tDCS) on cortico-spinal excitability are well-documented, modulation of vital parameters due to current spread through the brainstem is still a matter of debate, raising potential concerns about its use through the general public, as well as for neurorehabilitation purposes. We monitored online and after-effects of monopolar tDCS (primary motor cortex) in ten healthy subjects by adopting a neuronavigated transcranial magnetic stimulation (TMS)/tDCS combined protocol. Motor evoked potentials (MEPs) together with vital parameters (e.g. blood pressure, heart-rate variability and sympathovagal balance) were recorded and monitored before, during and after anodal, cathodal or sham tDCS. Ten MEPs every 2.5-minute time windows were recorded from the right First Dorsal Interosseus (FDI), while 5-minute epochs were used to record vital parameters. The protocol included 15 minutes of pre-tDCS and of online-tDCS, (anodal, cathodal or sham). After effects were recorded for 30 minutes. We showed a polarity-independent stabilization of cortical excitability level, a polarity-specific after-effects for cathodal and anodal stimulation, and an absence of persistent excitability changes during online stimulation. No significant effects on vital parameters emerged both during and after tDCS, while a linear increase in systolic/diastolic blood pressure and heart-rate variability was observed during each tDCS condition, as a possible unspecific response to experimental demands. Taken together, current findings provide new insights on the safety of monopolar tDCS, promoting its application both in research and clinical settings. Safety Transcranial Magnetic Stimulation Neuromodulation transcranial direct current stimulation (tDCS) tDCS vital parameters Psychiatry Matteo eFeurra verfasserin aut Federico eBarneschi verfasserin aut Maurizio eAcampa verfasserin aut Giovanni eBianco verfasserin aut David eCioncoloni verfasserin aut Alessandro eRossi verfasserin aut Simone eRossi verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 5(2014) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:5 year:2014 https://doi.org/10.3389/fpsyt.2014.00086 kostenfrei https://doaj.org/article/686558cebd384279b3d4d3e38cd623b5 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00086/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2014
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callnumber-first	R - Medicine
author	Emiliano eSantarnecchi
spellingShingle	Emiliano eSantarnecchi misc RC435-571 misc Safety misc Transcranial Magnetic Stimulation misc Neuromodulation misc transcranial direct current stimulation (tDCS) misc tDCS misc vital parameters misc Psychiatry Time-course of corticospinal excitability and autonomic function interplay during and following monopolar tDCS
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topic_title	RC435-571 Time-course of corticospinal excitability and autonomic function interplay during and following monopolar tDCS Safety Transcranial Magnetic Stimulation Neuromodulation transcranial direct current stimulation (tDCS) tDCS vital parameters
topic	misc RC435-571 misc Safety misc Transcranial Magnetic Stimulation misc Neuromodulation misc transcranial direct current stimulation (tDCS) misc tDCS misc vital parameters misc Psychiatry
topic_unstemmed	misc RC435-571 misc Safety misc Transcranial Magnetic Stimulation misc Neuromodulation misc transcranial direct current stimulation (tDCS) misc tDCS misc vital parameters misc Psychiatry
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title	Time-course of corticospinal excitability and autonomic function interplay during and following monopolar tDCS
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title_sort	time-course of corticospinal excitability and autonomic function interplay during and following monopolar tdcs
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title_auth	Time-course of corticospinal excitability and autonomic function interplay during and following monopolar tDCS
abstract	While polarity-specific after-effects of monopolar transcranial direct current stimulation (tDCS) on cortico-spinal excitability are well-documented, modulation of vital parameters due to current spread through the brainstem is still a matter of debate, raising potential concerns about its use through the general public, as well as for neurorehabilitation purposes. We monitored online and after-effects of monopolar tDCS (primary motor cortex) in ten healthy subjects by adopting a neuronavigated transcranial magnetic stimulation (TMS)/tDCS combined protocol. Motor evoked potentials (MEPs) together with vital parameters (e.g. blood pressure, heart-rate variability and sympathovagal balance) were recorded and monitored before, during and after anodal, cathodal or sham tDCS. Ten MEPs every 2.5-minute time windows were recorded from the right First Dorsal Interosseus (FDI), while 5-minute epochs were used to record vital parameters. The protocol included 15 minutes of pre-tDCS and of online-tDCS, (anodal, cathodal or sham). After effects were recorded for 30 minutes. We showed a polarity-independent stabilization of cortical excitability level, a polarity-specific after-effects for cathodal and anodal stimulation, and an absence of persistent excitability changes during online stimulation. No significant effects on vital parameters emerged both during and after tDCS, while a linear increase in systolic/diastolic blood pressure and heart-rate variability was observed during each tDCS condition, as a possible unspecific response to experimental demands. Taken together, current findings provide new insights on the safety of monopolar tDCS, promoting its application both in research and clinical settings.
abstractGer	While polarity-specific after-effects of monopolar transcranial direct current stimulation (tDCS) on cortico-spinal excitability are well-documented, modulation of vital parameters due to current spread through the brainstem is still a matter of debate, raising potential concerns about its use through the general public, as well as for neurorehabilitation purposes. We monitored online and after-effects of monopolar tDCS (primary motor cortex) in ten healthy subjects by adopting a neuronavigated transcranial magnetic stimulation (TMS)/tDCS combined protocol. Motor evoked potentials (MEPs) together with vital parameters (e.g. blood pressure, heart-rate variability and sympathovagal balance) were recorded and monitored before, during and after anodal, cathodal or sham tDCS. Ten MEPs every 2.5-minute time windows were recorded from the right First Dorsal Interosseus (FDI), while 5-minute epochs were used to record vital parameters. The protocol included 15 minutes of pre-tDCS and of online-tDCS, (anodal, cathodal or sham). After effects were recorded for 30 minutes. We showed a polarity-independent stabilization of cortical excitability level, a polarity-specific after-effects for cathodal and anodal stimulation, and an absence of persistent excitability changes during online stimulation. No significant effects on vital parameters emerged both during and after tDCS, while a linear increase in systolic/diastolic blood pressure and heart-rate variability was observed during each tDCS condition, as a possible unspecific response to experimental demands. Taken together, current findings provide new insights on the safety of monopolar tDCS, promoting its application both in research and clinical settings.
abstract_unstemmed	While polarity-specific after-effects of monopolar transcranial direct current stimulation (tDCS) on cortico-spinal excitability are well-documented, modulation of vital parameters due to current spread through the brainstem is still a matter of debate, raising potential concerns about its use through the general public, as well as for neurorehabilitation purposes. We monitored online and after-effects of monopolar tDCS (primary motor cortex) in ten healthy subjects by adopting a neuronavigated transcranial magnetic stimulation (TMS)/tDCS combined protocol. Motor evoked potentials (MEPs) together with vital parameters (e.g. blood pressure, heart-rate variability and sympathovagal balance) were recorded and monitored before, during and after anodal, cathodal or sham tDCS. Ten MEPs every 2.5-minute time windows were recorded from the right First Dorsal Interosseus (FDI), while 5-minute epochs were used to record vital parameters. The protocol included 15 minutes of pre-tDCS and of online-tDCS, (anodal, cathodal or sham). After effects were recorded for 30 minutes. We showed a polarity-independent stabilization of cortical excitability level, a polarity-specific after-effects for cathodal and anodal stimulation, and an absence of persistent excitability changes during online stimulation. No significant effects on vital parameters emerged both during and after tDCS, while a linear increase in systolic/diastolic blood pressure and heart-rate variability was observed during each tDCS condition, as a possible unspecific response to experimental demands. Taken together, current findings provide new insights on the safety of monopolar tDCS, promoting its application both in research and clinical settings.
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title_short	Time-course of corticospinal excitability and autonomic function interplay during and following monopolar tDCS
url	https://doi.org/10.3389/fpsyt.2014.00086 https://doaj.org/article/686558cebd384279b3d4d3e38cd623b5 http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00086/full https://doaj.org/toc/1664-0640
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Time-course of corticospinal excitability and autonomic function interplay during and following monopolar tDCS

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