Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics

Pulmonary fibrosis (PF) is a chronic and progressively fatal disease, but clinically available therapeutic drugs are limited due to efficacy and side effects. The possible mechanism of pulmonary fibrosis includes the damage of alveolar epithelial cells II (AEC2), and activation of immune cells such...
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Autor*in:	Tao Chen [verfasserIn] Zhaowenbin Zhang [verfasserIn] Dong Weng [verfasserIn] LiQin Lu [verfasserIn] XiaoYa Wang [verfasserIn] Min Xing [verfasserIn] Hui Qiu [verfasserIn] MengMeng Zhao [verfasserIn] Li Shen [verfasserIn] Ying Zhou [verfasserIn] Jiang Chang [verfasserIn] Hui-Ping Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Silicate bioceramics Lung fibrosis Alveolar epithelial cells II Macrophages

Übergeordnetes Werk:	In: Bioactive Materials - KeAi Communications Co., Ltd., 2017, 6(2021), 10, Seite 3194-3206
Übergeordnetes Werk:	volume:6 ; year:2021 ; number:10 ; pages:3194-3206

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.bioactmat.2021.02.013

Katalog-ID:	DOAJ003138461

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520			\|a Pulmonary fibrosis (PF) is a chronic and progressively fatal disease, but clinically available therapeutic drugs are limited due to efficacy and side effects. The possible mechanism of pulmonary fibrosis includes the damage of alveolar epithelial cells II (AEC2), and activation of immune cells such as macrophages. The ions released from bioceramics have shown the activity in stimulating soft tissue derived cells such as fibroblasts, endothelia cells and epithelia cells, and regulating macrophage polarization. Therefore, this study proposes an “ion therapy” approach based on the active ions of bioceramic materials, and investigates the therapeutic effect of bioactive ions derived from calcium silicate (CS) bioceramics on mouse models of pulmonary fibrosis. We demonstrate that silicate ions significantly reduce pulmonary fibrosis by simultaneously regulating the functions of AEC2 and macrophages. This result suggests potential clinical applications of ion therapy for lung fibrosis.
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spelling	10.1016/j.bioactmat.2021.02.013 doi (DE-627)DOAJ003138461 (DE-599)DOAJ0e9f94e7d56d4cfcb43c758e49abe5f4 DE-627 ger DE-627 rakwb eng TA401-492 QH301-705.5 Tao Chen verfasserin aut Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pulmonary fibrosis (PF) is a chronic and progressively fatal disease, but clinically available therapeutic drugs are limited due to efficacy and side effects. The possible mechanism of pulmonary fibrosis includes the damage of alveolar epithelial cells II (AEC2), and activation of immune cells such as macrophages. The ions released from bioceramics have shown the activity in stimulating soft tissue derived cells such as fibroblasts, endothelia cells and epithelia cells, and regulating macrophage polarization. Therefore, this study proposes an “ion therapy” approach based on the active ions of bioceramic materials, and investigates the therapeutic effect of bioactive ions derived from calcium silicate (CS) bioceramics on mouse models of pulmonary fibrosis. We demonstrate that silicate ions significantly reduce pulmonary fibrosis by simultaneously regulating the functions of AEC2 and macrophages. This result suggests potential clinical applications of ion therapy for lung fibrosis. Silicate bioceramics Lung fibrosis Alveolar epithelial cells II Macrophages Materials of engineering and construction. Mechanics of materials Biology (General) Zhaowenbin Zhang verfasserin aut Dong Weng verfasserin aut LiQin Lu verfasserin aut XiaoYa Wang verfasserin aut Min Xing verfasserin aut Hui Qiu verfasserin aut MengMeng Zhao verfasserin aut Li Shen verfasserin aut Ying Zhou verfasserin aut Jiang Chang verfasserin aut Hui-Ping Li verfasserin aut In Bioactive Materials KeAi Communications Co., Ltd., 2017 6(2021), 10, Seite 3194-3206 (DE-627)1663654956 (DE-600)2970496-0 2452199X nnns volume:6 year:2021 number:10 pages:3194-3206 https://doi.org/10.1016/j.bioactmat.2021.02.013 kostenfrei https://doaj.org/article/0e9f94e7d56d4cfcb43c758e49abe5f4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452199X21000748 kostenfrei https://doaj.org/toc/2452-199X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 10 3194-3206
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source	In Bioactive Materials 6(2021), 10, Seite 3194-3206 volume:6 year:2021 number:10 pages:3194-3206
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topic_facet	Silicate bioceramics Lung fibrosis Alveolar epithelial cells II Macrophages Materials of engineering and construction. Mechanics of materials Biology (General)
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authorswithroles_txt_mv	Tao Chen @@aut@@ Zhaowenbin Zhang @@aut@@ Dong Weng @@aut@@ LiQin Lu @@aut@@ XiaoYa Wang @@aut@@ Min Xing @@aut@@ Hui Qiu @@aut@@ MengMeng Zhao @@aut@@ Li Shen @@aut@@ Ying Zhou @@aut@@ Jiang Chang @@aut@@ Hui-Ping Li @@aut@@
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callnumber-first	T - Technology
author	Tao Chen
spellingShingle	Tao Chen misc TA401-492 misc QH301-705.5 misc Silicate bioceramics misc Lung fibrosis misc Alveolar epithelial cells II misc Macrophages misc Materials of engineering and construction. Mechanics of materials misc Biology (General) Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics
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topic_title	TA401-492 QH301-705.5 Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics Silicate bioceramics Lung fibrosis Alveolar epithelial cells II Macrophages
topic	misc TA401-492 misc QH301-705.5 misc Silicate bioceramics misc Lung fibrosis misc Alveolar epithelial cells II misc Macrophages misc Materials of engineering and construction. Mechanics of materials misc Biology (General)
topic_unstemmed	misc TA401-492 misc QH301-705.5 misc Silicate bioceramics misc Lung fibrosis misc Alveolar epithelial cells II misc Macrophages misc Materials of engineering and construction. Mechanics of materials misc Biology (General)
topic_browse	misc TA401-492 misc QH301-705.5 misc Silicate bioceramics misc Lung fibrosis misc Alveolar epithelial cells II misc Macrophages misc Materials of engineering and construction. Mechanics of materials misc Biology (General)
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title	Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics
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title_full	Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics
author_sort	Tao Chen
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title_sort	ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics
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title_auth	Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics
abstract	Pulmonary fibrosis (PF) is a chronic and progressively fatal disease, but clinically available therapeutic drugs are limited due to efficacy and side effects. The possible mechanism of pulmonary fibrosis includes the damage of alveolar epithelial cells II (AEC2), and activation of immune cells such as macrophages. The ions released from bioceramics have shown the activity in stimulating soft tissue derived cells such as fibroblasts, endothelia cells and epithelia cells, and regulating macrophage polarization. Therefore, this study proposes an “ion therapy” approach based on the active ions of bioceramic materials, and investigates the therapeutic effect of bioactive ions derived from calcium silicate (CS) bioceramics on mouse models of pulmonary fibrosis. We demonstrate that silicate ions significantly reduce pulmonary fibrosis by simultaneously regulating the functions of AEC2 and macrophages. This result suggests potential clinical applications of ion therapy for lung fibrosis.
abstractGer	Pulmonary fibrosis (PF) is a chronic and progressively fatal disease, but clinically available therapeutic drugs are limited due to efficacy and side effects. The possible mechanism of pulmonary fibrosis includes the damage of alveolar epithelial cells II (AEC2), and activation of immune cells such as macrophages. The ions released from bioceramics have shown the activity in stimulating soft tissue derived cells such as fibroblasts, endothelia cells and epithelia cells, and regulating macrophage polarization. Therefore, this study proposes an “ion therapy” approach based on the active ions of bioceramic materials, and investigates the therapeutic effect of bioactive ions derived from calcium silicate (CS) bioceramics on mouse models of pulmonary fibrosis. We demonstrate that silicate ions significantly reduce pulmonary fibrosis by simultaneously regulating the functions of AEC2 and macrophages. This result suggests potential clinical applications of ion therapy for lung fibrosis.
abstract_unstemmed	Pulmonary fibrosis (PF) is a chronic and progressively fatal disease, but clinically available therapeutic drugs are limited due to efficacy and side effects. The possible mechanism of pulmonary fibrosis includes the damage of alveolar epithelial cells II (AEC2), and activation of immune cells such as macrophages. The ions released from bioceramics have shown the activity in stimulating soft tissue derived cells such as fibroblasts, endothelia cells and epithelia cells, and regulating macrophage polarization. Therefore, this study proposes an “ion therapy” approach based on the active ions of bioceramic materials, and investigates the therapeutic effect of bioactive ions derived from calcium silicate (CS) bioceramics on mouse models of pulmonary fibrosis. We demonstrate that silicate ions significantly reduce pulmonary fibrosis by simultaneously regulating the functions of AEC2 and macrophages. This result suggests potential clinical applications of ion therapy for lung fibrosis.
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title_short	Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics
url	https://doi.org/10.1016/j.bioactmat.2021.02.013 https://doaj.org/article/0e9f94e7d56d4cfcb43c758e49abe5f4 http://www.sciencedirect.com/science/article/pii/S2452199X21000748 https://doaj.org/toc/2452-199X
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author2	Zhaowenbin Zhang Dong Weng LiQin Lu XiaoYa Wang Min Xing Hui Qiu MengMeng Zhao Li Shen Ying Zhou Jiang Chang Hui-Ping Li
author2Str	Zhaowenbin Zhang Dong Weng LiQin Lu XiaoYa Wang Min Xing Hui Qiu MengMeng Zhao Li Shen Ying Zhou Jiang Chang Hui-Ping Li
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up_date	2024-07-03T16:12:21.797Z
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Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics

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