Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection

Lawsonia (L.) intracellularis is a widespread, economically important bacterium causing the porcine proliferative enteropathy (PPE). In this study, we evaluated intestinal microbiota of naturally exposed L. intracellularis-positive pigs under standardized conditions. To obtain three independent repe...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Julia Hankel [verfasserIn] Saara Sander [verfasserIn] Uthayakumar Muthukumarasamy [verfasserIn] Till Strowig [verfasserIn] Josef Kamphues [verfasserIn] Klaus Jung [verfasserIn] Christian Visscher [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	intestinal pathogen porcine proliferative enteropathy oral vaccination 16S rRNA gene microbiome Prevotella

Übergeordnetes Werk:	In: Frontiers in Veterinary Science - Frontiers Media S.A., 2015, 9(2022)
Übergeordnetes Werk:	volume:9 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fvets.2022.1004506

Katalog-ID:	DOAJ003269256

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520			\|a Lawsonia (L.) intracellularis is a widespread, economically important bacterium causing the porcine proliferative enteropathy (PPE). In this study, we evaluated intestinal microbiota of naturally exposed L. intracellularis-positive pigs under standardized conditions. To obtain three independent repetitions, 27 L. intracellularis-infected pigs (19.0 ± 1.50 kg body weight) from one farm were divided into three groups at an age of 7 to 8 weeks (nine pigs/group). Pigs were either vaccinated against L. intracellularis via oral drenching on their 21st day of life (attenuated live vaccine) or non-vaccinated and selected according to clinical findings (pigs without deviating fecal consistency or with moderate to soft fecal consistency). Comparison of the clinically inconspicuous piglets that differed regarding their vaccination status showed fewer significant differences in fecal microbiota composition. The vaccination led to an overall enrichment of bacterial species belonging to the order Clostridiales, while species of the genus Collinsella and Prevotella were decreased. Several bacterial species belonging to the order Bacteroidales, mainly of the family Prevotellacecae, often closely matching Prevotella copri differed significantly between non-vaccinated clinically inconspicuous and conspicuous piglets. Whether those bacterial species play a role in mitigating the severity of an L. intracellularis infection remains to be defined.
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allfieldsSound	10.3389/fvets.2022.1004506 doi (DE-627)DOAJ003269256 (DE-599)DOAJ986d494f2ce0448db9d33c2925d577c9 DE-627 ger DE-627 rakwb eng SF600-1100 Julia Hankel verfasserin aut Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lawsonia (L.) intracellularis is a widespread, economically important bacterium causing the porcine proliferative enteropathy (PPE). In this study, we evaluated intestinal microbiota of naturally exposed L. intracellularis-positive pigs under standardized conditions. To obtain three independent repetitions, 27 L. intracellularis-infected pigs (19.0 ± 1.50 kg body weight) from one farm were divided into three groups at an age of 7 to 8 weeks (nine pigs/group). Pigs were either vaccinated against L. intracellularis via oral drenching on their 21st day of life (attenuated live vaccine) or non-vaccinated and selected according to clinical findings (pigs without deviating fecal consistency or with moderate to soft fecal consistency). Comparison of the clinically inconspicuous piglets that differed regarding their vaccination status showed fewer significant differences in fecal microbiota composition. The vaccination led to an overall enrichment of bacterial species belonging to the order Clostridiales, while species of the genus Collinsella and Prevotella were decreased. Several bacterial species belonging to the order Bacteroidales, mainly of the family Prevotellacecae, often closely matching Prevotella copri differed significantly between non-vaccinated clinically inconspicuous and conspicuous piglets. Whether those bacterial species play a role in mitigating the severity of an L. intracellularis infection remains to be defined. intestinal pathogen porcine proliferative enteropathy oral vaccination 16S rRNA gene microbiome Prevotella Veterinary medicine Saara Sander verfasserin aut Uthayakumar Muthukumarasamy verfasserin aut Uthayakumar Muthukumarasamy verfasserin aut Till Strowig verfasserin aut Till Strowig verfasserin aut Josef Kamphues verfasserin aut Klaus Jung verfasserin aut Christian Visscher verfasserin aut In Frontiers in Veterinary Science Frontiers Media S.A., 2015 9(2022) (DE-627)835029417 (DE-600)2834243-4 22971769 nnns volume:9 year:2022 https://doi.org/10.3389/fvets.2022.1004506 kostenfrei https://doaj.org/article/986d494f2ce0448db9d33c2925d577c9 kostenfrei https://www.frontiersin.org/articles/10.3389/fvets.2022.1004506/full kostenfrei https://doaj.org/toc/2297-1769 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
language	English
source	In Frontiers in Veterinary Science 9(2022) volume:9 year:2022
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topic_facet	intestinal pathogen porcine proliferative enteropathy oral vaccination 16S rRNA gene microbiome Prevotella Veterinary medicine
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container_title	Frontiers in Veterinary Science
authorswithroles_txt_mv	Julia Hankel @@aut@@ Saara Sander @@aut@@ Uthayakumar Muthukumarasamy @@aut@@ Till Strowig @@aut@@ Josef Kamphues @@aut@@ Klaus Jung @@aut@@ Christian Visscher @@aut@@
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callnumber-first	S - Agriculture
author	Julia Hankel
spellingShingle	Julia Hankel misc SF600-1100 misc intestinal pathogen misc porcine proliferative enteropathy misc oral vaccination misc 16S rRNA gene misc microbiome misc Prevotella misc Veterinary medicine Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection
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topic_title	SF600-1100 Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection intestinal pathogen porcine proliferative enteropathy oral vaccination 16S rRNA gene microbiome Prevotella
topic	misc SF600-1100 misc intestinal pathogen misc porcine proliferative enteropathy misc oral vaccination misc 16S rRNA gene misc microbiome misc Prevotella misc Veterinary medicine
topic_unstemmed	misc SF600-1100 misc intestinal pathogen misc porcine proliferative enteropathy misc oral vaccination misc 16S rRNA gene misc microbiome misc Prevotella misc Veterinary medicine
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title	Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection
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title_full	Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection
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author_browse	Julia Hankel Saara Sander Uthayakumar Muthukumarasamy Till Strowig Josef Kamphues Klaus Jung Christian Visscher
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title_sort	microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural lawsonia intracellularis infection
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title_auth	Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection
abstract	Lawsonia (L.) intracellularis is a widespread, economically important bacterium causing the porcine proliferative enteropathy (PPE). In this study, we evaluated intestinal microbiota of naturally exposed L. intracellularis-positive pigs under standardized conditions. To obtain three independent repetitions, 27 L. intracellularis-infected pigs (19.0 ± 1.50 kg body weight) from one farm were divided into three groups at an age of 7 to 8 weeks (nine pigs/group). Pigs were either vaccinated against L. intracellularis via oral drenching on their 21st day of life (attenuated live vaccine) or non-vaccinated and selected according to clinical findings (pigs without deviating fecal consistency or with moderate to soft fecal consistency). Comparison of the clinically inconspicuous piglets that differed regarding their vaccination status showed fewer significant differences in fecal microbiota composition. The vaccination led to an overall enrichment of bacterial species belonging to the order Clostridiales, while species of the genus Collinsella and Prevotella were decreased. Several bacterial species belonging to the order Bacteroidales, mainly of the family Prevotellacecae, often closely matching Prevotella copri differed significantly between non-vaccinated clinically inconspicuous and conspicuous piglets. Whether those bacterial species play a role in mitigating the severity of an L. intracellularis infection remains to be defined.
abstractGer	Lawsonia (L.) intracellularis is a widespread, economically important bacterium causing the porcine proliferative enteropathy (PPE). In this study, we evaluated intestinal microbiota of naturally exposed L. intracellularis-positive pigs under standardized conditions. To obtain three independent repetitions, 27 L. intracellularis-infected pigs (19.0 ± 1.50 kg body weight) from one farm were divided into three groups at an age of 7 to 8 weeks (nine pigs/group). Pigs were either vaccinated against L. intracellularis via oral drenching on their 21st day of life (attenuated live vaccine) or non-vaccinated and selected according to clinical findings (pigs without deviating fecal consistency or with moderate to soft fecal consistency). Comparison of the clinically inconspicuous piglets that differed regarding their vaccination status showed fewer significant differences in fecal microbiota composition. The vaccination led to an overall enrichment of bacterial species belonging to the order Clostridiales, while species of the genus Collinsella and Prevotella were decreased. Several bacterial species belonging to the order Bacteroidales, mainly of the family Prevotellacecae, often closely matching Prevotella copri differed significantly between non-vaccinated clinically inconspicuous and conspicuous piglets. Whether those bacterial species play a role in mitigating the severity of an L. intracellularis infection remains to be defined.
abstract_unstemmed	Lawsonia (L.) intracellularis is a widespread, economically important bacterium causing the porcine proliferative enteropathy (PPE). In this study, we evaluated intestinal microbiota of naturally exposed L. intracellularis-positive pigs under standardized conditions. To obtain three independent repetitions, 27 L. intracellularis-infected pigs (19.0 ± 1.50 kg body weight) from one farm were divided into three groups at an age of 7 to 8 weeks (nine pigs/group). Pigs were either vaccinated against L. intracellularis via oral drenching on their 21st day of life (attenuated live vaccine) or non-vaccinated and selected according to clinical findings (pigs without deviating fecal consistency or with moderate to soft fecal consistency). Comparison of the clinically inconspicuous piglets that differed regarding their vaccination status showed fewer significant differences in fecal microbiota composition. The vaccination led to an overall enrichment of bacterial species belonging to the order Clostridiales, while species of the genus Collinsella and Prevotella were decreased. Several bacterial species belonging to the order Bacteroidales, mainly of the family Prevotellacecae, often closely matching Prevotella copri differed significantly between non-vaccinated clinically inconspicuous and conspicuous piglets. Whether those bacterial species play a role in mitigating the severity of an L. intracellularis infection remains to be defined.
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title_short	Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection
url	https://doi.org/10.3389/fvets.2022.1004506 https://doaj.org/article/986d494f2ce0448db9d33c2925d577c9 https://www.frontiersin.org/articles/10.3389/fvets.2022.1004506/full https://doaj.org/toc/2297-1769
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author2	Saara Sander Uthayakumar Muthukumarasamy Till Strowig Josef Kamphues Klaus Jung Christian Visscher
author2Str	Saara Sander Uthayakumar Muthukumarasamy Till Strowig Josef Kamphues Klaus Jung Christian Visscher
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up_date	2024-07-03T17:00:16.892Z
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Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection

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