Experimental model of normotrophic pseudarthrosis of a rabbit’s tibia
Background. The formation of a pseudarthrosis is one of the most severe complications of bone fractures. Pseudarthrosis occurs as a result of a disorder in the fracture union, has a poor prognosis and requires long-term treatment and repeated surgeries. A small number of representative pseudarthrosi...
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| Autor*in: |
S. S. Smirnov [verfasserIn] E. A. Shchepkina [verfasserIn] L. A. Shilenko [verfasserIn] E. K. Samsonenko [verfasserIn] N. A. Anikin [verfasserIn] M. V. Mametov [verfasserIn] Z. I. Chepurnoy [verfasserIn] S. E. Voronin [verfasserIn] M. D. Gerko [verfasserIn] D. Yu. Ivkin [verfasserIn] A. A. Karpov [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Russisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Acta Biomedica Scientifica - Scientific Сentre for Family Health and Human Reproduction Problems, 2018, 7(2022), 5-2, Seite 268-279 |
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| Übergeordnetes Werk: |
volume:7 ; year:2022 ; number:5-2 ; pages:268-279 |
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Link aufrufen |
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| DOI / URN: |
10.29413/ABS.2022-7.5-2.27 |
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| Katalog-ID: |
DOAJ003305414 |
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| 245 | 1 | 0 | |a Experimental model of normotrophic pseudarthrosis of a rabbit’s tibia |
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| 520 | |a Background. The formation of a pseudarthrosis is one of the most severe complications of bone fractures. Pseudarthrosis occurs as a result of a disorder in the fracture union, has a poor prognosis and requires long-term treatment and repeated surgeries. A small number of representative pseudarthrosis models makes it difficult to conduct preclinical studies of promising pharmacological substances, bone replacement materials and surgical methods of treatment.The aim. To develop and to validate an experimental model of normotrophic pseudarthrosis of a rabbit’s tibia by creating diastasis between bone fragments, forming local vascularization disturbance and using unstable fixation.Materials and methods. The study was carried out on Soviet Chinchilla rabbits. The animals were divided into 2 groups: in experimental group, we formed tibial pseudarthrosis; in control group, we made a simple transverse tibial fracture. The pseudarthrosis was formed by segmental resection (5 mm) of the middle third of the tibia, bone fragments dilatation for 5 mm, removal of periosteum and bone marrow within 5 mm followed by daily destabilization of a fracture in an external fixation device. The duration of the experiment was 6 weeks. X-ray examination of the fracture area was carried out weekly, multi-layer spiral computed tomography (MSCT) and histological examinations were carried out at the end of the experiment.Results. The survival value in the experiment was 100 %. According to weekly X-ray examination, fracture union was registered only in the control group and occurred on average on the 22,8 ± 5,1 day, while the formation of pseudarthrosis was observed only in the experimental group, and radiographic signs of a pseudarthrosis were noted on average on the 33,6 ± 3,5 day. The formation of a pseudarthrosis by the end of the experiment was confirmed by MSCT and histological studies.Conclusions. The developed model of the normotrophic pseudarthrosis of a rabbit’s tibia can be used for experimental tests of various factors for stimulating reparative regeneration and methods for treatment of the pseudarthrosis. | ||
| 650 | 4 | |a experimental model | |
| 650 | 4 | |a pseudarthrosis | |
| 650 | 4 | |a rabbits | |
| 650 | 4 | |a fracture | |
| 650 | 4 | |a tibia | |
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| 700 | 0 | |a E. A. Shchepkina |e verfasserin |4 aut | |
| 700 | 0 | |a L. A. Shilenko |e verfasserin |4 aut | |
| 700 | 0 | |a E. K. Samsonenko |e verfasserin |4 aut | |
| 700 | 0 | |a N. A. Anikin |e verfasserin |4 aut | |
| 700 | 0 | |a M. V. Mametov |e verfasserin |4 aut | |
| 700 | 0 | |a Z. I. Chepurnoy |e verfasserin |4 aut | |
| 700 | 0 | |a S. E. Voronin |e verfasserin |4 aut | |
| 700 | 0 | |a M. D. Gerko |e verfasserin |4 aut | |
| 700 | 0 | |a D. Yu. Ivkin |e verfasserin |4 aut | |
| 700 | 0 | |a A. A. Karpov |e verfasserin |4 aut | |
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10.29413/ABS.2022-7.5-2.27 doi (DE-627)DOAJ003305414 (DE-599)DOAJfb756405939f4bb3b571f70023e693e2 DE-627 ger DE-627 rakwb rus S. S. Smirnov verfasserin aut Experimental model of normotrophic pseudarthrosis of a rabbit’s tibia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The formation of a pseudarthrosis is one of the most severe complications of bone fractures. Pseudarthrosis occurs as a result of a disorder in the fracture union, has a poor prognosis and requires long-term treatment and repeated surgeries. A small number of representative pseudarthrosis models makes it difficult to conduct preclinical studies of promising pharmacological substances, bone replacement materials and surgical methods of treatment.The aim. To develop and to validate an experimental model of normotrophic pseudarthrosis of a rabbit’s tibia by creating diastasis between bone fragments, forming local vascularization disturbance and using unstable fixation.Materials and methods. The study was carried out on Soviet Chinchilla rabbits. The animals were divided into 2 groups: in experimental group, we formed tibial pseudarthrosis; in control group, we made a simple transverse tibial fracture. The pseudarthrosis was formed by segmental resection (5 mm) of the middle third of the tibia, bone fragments dilatation for 5 mm, removal of periosteum and bone marrow within 5 mm followed by daily destabilization of a fracture in an external fixation device. The duration of the experiment was 6 weeks. X-ray examination of the fracture area was carried out weekly, multi-layer spiral computed tomography (MSCT) and histological examinations were carried out at the end of the experiment.Results. The survival value in the experiment was 100 %. According to weekly X-ray examination, fracture union was registered only in the control group and occurred on average on the 22,8 ± 5,1 day, while the formation of pseudarthrosis was observed only in the experimental group, and radiographic signs of a pseudarthrosis were noted on average on the 33,6 ± 3,5 day. The formation of a pseudarthrosis by the end of the experiment was confirmed by MSCT and histological studies.Conclusions. The developed model of the normotrophic pseudarthrosis of a rabbit’s tibia can be used for experimental tests of various factors for stimulating reparative regeneration and methods for treatment of the pseudarthrosis. experimental model pseudarthrosis rabbits fracture tibia Science Q E. A. Shchepkina verfasserin aut L. A. Shilenko verfasserin aut E. K. Samsonenko verfasserin aut N. A. Anikin verfasserin aut M. V. Mametov verfasserin aut Z. I. Chepurnoy verfasserin aut S. E. Voronin verfasserin aut M. D. Gerko verfasserin aut D. Yu. Ivkin verfasserin aut A. A. Karpov verfasserin aut In Acta Biomedica Scientifica Scientific Сentre for Family Health and Human Reproduction Problems, 2018 7(2022), 5-2, Seite 268-279 (DE-627)1760606928 25879596 nnns volume:7 year:2022 number:5-2 pages:268-279 https://doi.org/10.29413/ABS.2022-7.5-2.27 kostenfrei https://doaj.org/article/fb756405939f4bb3b571f70023e693e2 kostenfrei https://www.actabiomedica.ru/jour/article/view/3848 kostenfrei https://doaj.org/toc/2541-9420 Journal toc kostenfrei https://doaj.org/toc/2587-9596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 7 2022 5-2 268-279 |
| spelling |
10.29413/ABS.2022-7.5-2.27 doi (DE-627)DOAJ003305414 (DE-599)DOAJfb756405939f4bb3b571f70023e693e2 DE-627 ger DE-627 rakwb rus S. S. Smirnov verfasserin aut Experimental model of normotrophic pseudarthrosis of a rabbit’s tibia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The formation of a pseudarthrosis is one of the most severe complications of bone fractures. Pseudarthrosis occurs as a result of a disorder in the fracture union, has a poor prognosis and requires long-term treatment and repeated surgeries. A small number of representative pseudarthrosis models makes it difficult to conduct preclinical studies of promising pharmacological substances, bone replacement materials and surgical methods of treatment.The aim. To develop and to validate an experimental model of normotrophic pseudarthrosis of a rabbit’s tibia by creating diastasis between bone fragments, forming local vascularization disturbance and using unstable fixation.Materials and methods. The study was carried out on Soviet Chinchilla rabbits. The animals were divided into 2 groups: in experimental group, we formed tibial pseudarthrosis; in control group, we made a simple transverse tibial fracture. The pseudarthrosis was formed by segmental resection (5 mm) of the middle third of the tibia, bone fragments dilatation for 5 mm, removal of periosteum and bone marrow within 5 mm followed by daily destabilization of a fracture in an external fixation device. The duration of the experiment was 6 weeks. X-ray examination of the fracture area was carried out weekly, multi-layer spiral computed tomography (MSCT) and histological examinations were carried out at the end of the experiment.Results. The survival value in the experiment was 100 %. According to weekly X-ray examination, fracture union was registered only in the control group and occurred on average on the 22,8 ± 5,1 day, while the formation of pseudarthrosis was observed only in the experimental group, and radiographic signs of a pseudarthrosis were noted on average on the 33,6 ± 3,5 day. The formation of a pseudarthrosis by the end of the experiment was confirmed by MSCT and histological studies.Conclusions. The developed model of the normotrophic pseudarthrosis of a rabbit’s tibia can be used for experimental tests of various factors for stimulating reparative regeneration and methods for treatment of the pseudarthrosis. experimental model pseudarthrosis rabbits fracture tibia Science Q E. A. Shchepkina verfasserin aut L. A. Shilenko verfasserin aut E. K. Samsonenko verfasserin aut N. A. Anikin verfasserin aut M. V. Mametov verfasserin aut Z. I. Chepurnoy verfasserin aut S. E. Voronin verfasserin aut M. D. Gerko verfasserin aut D. Yu. Ivkin verfasserin aut A. A. Karpov verfasserin aut In Acta Biomedica Scientifica Scientific Сentre for Family Health and Human Reproduction Problems, 2018 7(2022), 5-2, Seite 268-279 (DE-627)1760606928 25879596 nnns volume:7 year:2022 number:5-2 pages:268-279 https://doi.org/10.29413/ABS.2022-7.5-2.27 kostenfrei https://doaj.org/article/fb756405939f4bb3b571f70023e693e2 kostenfrei https://www.actabiomedica.ru/jour/article/view/3848 kostenfrei https://doaj.org/toc/2541-9420 Journal toc kostenfrei https://doaj.org/toc/2587-9596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 7 2022 5-2 268-279 |
| allfields_unstemmed |
10.29413/ABS.2022-7.5-2.27 doi (DE-627)DOAJ003305414 (DE-599)DOAJfb756405939f4bb3b571f70023e693e2 DE-627 ger DE-627 rakwb rus S. S. Smirnov verfasserin aut Experimental model of normotrophic pseudarthrosis of a rabbit’s tibia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The formation of a pseudarthrosis is one of the most severe complications of bone fractures. Pseudarthrosis occurs as a result of a disorder in the fracture union, has a poor prognosis and requires long-term treatment and repeated surgeries. A small number of representative pseudarthrosis models makes it difficult to conduct preclinical studies of promising pharmacological substances, bone replacement materials and surgical methods of treatment.The aim. To develop and to validate an experimental model of normotrophic pseudarthrosis of a rabbit’s tibia by creating diastasis between bone fragments, forming local vascularization disturbance and using unstable fixation.Materials and methods. The study was carried out on Soviet Chinchilla rabbits. The animals were divided into 2 groups: in experimental group, we formed tibial pseudarthrosis; in control group, we made a simple transverse tibial fracture. The pseudarthrosis was formed by segmental resection (5 mm) of the middle third of the tibia, bone fragments dilatation for 5 mm, removal of periosteum and bone marrow within 5 mm followed by daily destabilization of a fracture in an external fixation device. The duration of the experiment was 6 weeks. X-ray examination of the fracture area was carried out weekly, multi-layer spiral computed tomography (MSCT) and histological examinations were carried out at the end of the experiment.Results. The survival value in the experiment was 100 %. According to weekly X-ray examination, fracture union was registered only in the control group and occurred on average on the 22,8 ± 5,1 day, while the formation of pseudarthrosis was observed only in the experimental group, and radiographic signs of a pseudarthrosis were noted on average on the 33,6 ± 3,5 day. The formation of a pseudarthrosis by the end of the experiment was confirmed by MSCT and histological studies.Conclusions. The developed model of the normotrophic pseudarthrosis of a rabbit’s tibia can be used for experimental tests of various factors for stimulating reparative regeneration and methods for treatment of the pseudarthrosis. experimental model pseudarthrosis rabbits fracture tibia Science Q E. A. Shchepkina verfasserin aut L. A. Shilenko verfasserin aut E. K. Samsonenko verfasserin aut N. A. Anikin verfasserin aut M. V. Mametov verfasserin aut Z. I. Chepurnoy verfasserin aut S. E. Voronin verfasserin aut M. D. Gerko verfasserin aut D. Yu. Ivkin verfasserin aut A. A. Karpov verfasserin aut In Acta Biomedica Scientifica Scientific Сentre for Family Health and Human Reproduction Problems, 2018 7(2022), 5-2, Seite 268-279 (DE-627)1760606928 25879596 nnns volume:7 year:2022 number:5-2 pages:268-279 https://doi.org/10.29413/ABS.2022-7.5-2.27 kostenfrei https://doaj.org/article/fb756405939f4bb3b571f70023e693e2 kostenfrei https://www.actabiomedica.ru/jour/article/view/3848 kostenfrei https://doaj.org/toc/2541-9420 Journal toc kostenfrei https://doaj.org/toc/2587-9596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 7 2022 5-2 268-279 |
| allfieldsGer |
10.29413/ABS.2022-7.5-2.27 doi (DE-627)DOAJ003305414 (DE-599)DOAJfb756405939f4bb3b571f70023e693e2 DE-627 ger DE-627 rakwb rus S. S. Smirnov verfasserin aut Experimental model of normotrophic pseudarthrosis of a rabbit’s tibia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The formation of a pseudarthrosis is one of the most severe complications of bone fractures. Pseudarthrosis occurs as a result of a disorder in the fracture union, has a poor prognosis and requires long-term treatment and repeated surgeries. A small number of representative pseudarthrosis models makes it difficult to conduct preclinical studies of promising pharmacological substances, bone replacement materials and surgical methods of treatment.The aim. To develop and to validate an experimental model of normotrophic pseudarthrosis of a rabbit’s tibia by creating diastasis between bone fragments, forming local vascularization disturbance and using unstable fixation.Materials and methods. The study was carried out on Soviet Chinchilla rabbits. The animals were divided into 2 groups: in experimental group, we formed tibial pseudarthrosis; in control group, we made a simple transverse tibial fracture. The pseudarthrosis was formed by segmental resection (5 mm) of the middle third of the tibia, bone fragments dilatation for 5 mm, removal of periosteum and bone marrow within 5 mm followed by daily destabilization of a fracture in an external fixation device. The duration of the experiment was 6 weeks. X-ray examination of the fracture area was carried out weekly, multi-layer spiral computed tomography (MSCT) and histological examinations were carried out at the end of the experiment.Results. The survival value in the experiment was 100 %. According to weekly X-ray examination, fracture union was registered only in the control group and occurred on average on the 22,8 ± 5,1 day, while the formation of pseudarthrosis was observed only in the experimental group, and radiographic signs of a pseudarthrosis were noted on average on the 33,6 ± 3,5 day. The formation of a pseudarthrosis by the end of the experiment was confirmed by MSCT and histological studies.Conclusions. The developed model of the normotrophic pseudarthrosis of a rabbit’s tibia can be used for experimental tests of various factors for stimulating reparative regeneration and methods for treatment of the pseudarthrosis. experimental model pseudarthrosis rabbits fracture tibia Science Q E. A. Shchepkina verfasserin aut L. A. Shilenko verfasserin aut E. K. Samsonenko verfasserin aut N. A. Anikin verfasserin aut M. V. Mametov verfasserin aut Z. I. Chepurnoy verfasserin aut S. E. Voronin verfasserin aut M. D. Gerko verfasserin aut D. Yu. Ivkin verfasserin aut A. A. Karpov verfasserin aut In Acta Biomedica Scientifica Scientific Сentre for Family Health and Human Reproduction Problems, 2018 7(2022), 5-2, Seite 268-279 (DE-627)1760606928 25879596 nnns volume:7 year:2022 number:5-2 pages:268-279 https://doi.org/10.29413/ABS.2022-7.5-2.27 kostenfrei https://doaj.org/article/fb756405939f4bb3b571f70023e693e2 kostenfrei https://www.actabiomedica.ru/jour/article/view/3848 kostenfrei https://doaj.org/toc/2541-9420 Journal toc kostenfrei https://doaj.org/toc/2587-9596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 7 2022 5-2 268-279 |
| allfieldsSound |
10.29413/ABS.2022-7.5-2.27 doi (DE-627)DOAJ003305414 (DE-599)DOAJfb756405939f4bb3b571f70023e693e2 DE-627 ger DE-627 rakwb rus S. S. Smirnov verfasserin aut Experimental model of normotrophic pseudarthrosis of a rabbit’s tibia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The formation of a pseudarthrosis is one of the most severe complications of bone fractures. Pseudarthrosis occurs as a result of a disorder in the fracture union, has a poor prognosis and requires long-term treatment and repeated surgeries. A small number of representative pseudarthrosis models makes it difficult to conduct preclinical studies of promising pharmacological substances, bone replacement materials and surgical methods of treatment.The aim. To develop and to validate an experimental model of normotrophic pseudarthrosis of a rabbit’s tibia by creating diastasis between bone fragments, forming local vascularization disturbance and using unstable fixation.Materials and methods. The study was carried out on Soviet Chinchilla rabbits. The animals were divided into 2 groups: in experimental group, we formed tibial pseudarthrosis; in control group, we made a simple transverse tibial fracture. The pseudarthrosis was formed by segmental resection (5 mm) of the middle third of the tibia, bone fragments dilatation for 5 mm, removal of periosteum and bone marrow within 5 mm followed by daily destabilization of a fracture in an external fixation device. The duration of the experiment was 6 weeks. X-ray examination of the fracture area was carried out weekly, multi-layer spiral computed tomography (MSCT) and histological examinations were carried out at the end of the experiment.Results. The survival value in the experiment was 100 %. According to weekly X-ray examination, fracture union was registered only in the control group and occurred on average on the 22,8 ± 5,1 day, while the formation of pseudarthrosis was observed only in the experimental group, and radiographic signs of a pseudarthrosis were noted on average on the 33,6 ± 3,5 day. The formation of a pseudarthrosis by the end of the experiment was confirmed by MSCT and histological studies.Conclusions. The developed model of the normotrophic pseudarthrosis of a rabbit’s tibia can be used for experimental tests of various factors for stimulating reparative regeneration and methods for treatment of the pseudarthrosis. experimental model pseudarthrosis rabbits fracture tibia Science Q E. A. Shchepkina verfasserin aut L. A. Shilenko verfasserin aut E. K. Samsonenko verfasserin aut N. A. Anikin verfasserin aut M. V. Mametov verfasserin aut Z. I. Chepurnoy verfasserin aut S. E. Voronin verfasserin aut M. D. Gerko verfasserin aut D. Yu. Ivkin verfasserin aut A. A. Karpov verfasserin aut In Acta Biomedica Scientifica Scientific Сentre for Family Health and Human Reproduction Problems, 2018 7(2022), 5-2, Seite 268-279 (DE-627)1760606928 25879596 nnns volume:7 year:2022 number:5-2 pages:268-279 https://doi.org/10.29413/ABS.2022-7.5-2.27 kostenfrei https://doaj.org/article/fb756405939f4bb3b571f70023e693e2 kostenfrei https://www.actabiomedica.ru/jour/article/view/3848 kostenfrei https://doaj.org/toc/2541-9420 Journal toc kostenfrei https://doaj.org/toc/2587-9596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 7 2022 5-2 268-279 |
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S. Smirnov</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Experimental model of normotrophic pseudarthrosis of a rabbit’s tibia</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background. The formation of a pseudarthrosis is one of the most severe complications of bone fractures. Pseudarthrosis occurs as a result of a disorder in the fracture union, has a poor prognosis and requires long-term treatment and repeated surgeries. A small number of representative pseudarthrosis models makes it difficult to conduct preclinical studies of promising pharmacological substances, bone replacement materials and surgical methods of treatment.The aim. To develop and to validate an experimental model of normotrophic pseudarthrosis of a rabbit’s tibia by creating diastasis between bone fragments, forming local vascularization disturbance and using unstable fixation.Materials and methods. The study was carried out on Soviet Chinchilla rabbits. The animals were divided into 2 groups: in experimental group, we formed tibial pseudarthrosis; in control group, we made a simple transverse tibial fracture. The pseudarthrosis was formed by segmental resection (5 mm) of the middle third of the tibia, bone fragments dilatation for 5 mm, removal of periosteum and bone marrow within 5 mm followed by daily destabilization of a fracture in an external fixation device. The duration of the experiment was 6 weeks. X-ray examination of the fracture area was carried out weekly, multi-layer spiral computed tomography (MSCT) and histological examinations were carried out at the end of the experiment.Results. The survival value in the experiment was 100 %. According to weekly X-ray examination, fracture union was registered only in the control group and occurred on average on the 22,8 ± 5,1 day, while the formation of pseudarthrosis was observed only in the experimental group, and radiographic signs of a pseudarthrosis were noted on average on the 33,6 ± 3,5 day. The formation of a pseudarthrosis by the end of the experiment was confirmed by MSCT and histological studies.Conclusions. 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S. S. Smirnov E. A. Shchepkina L. A. Shilenko E. K. Samsonenko N. A. Anikin M. V. Mametov Z. I. Chepurnoy S. E. Voronin M. D. Gerko D. Yu. Ivkin A. A. Karpov |
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experimental model of normotrophic pseudarthrosis of a rabbit’s tibia |
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Experimental model of normotrophic pseudarthrosis of a rabbit’s tibia |
| abstract |
Background. The formation of a pseudarthrosis is one of the most severe complications of bone fractures. Pseudarthrosis occurs as a result of a disorder in the fracture union, has a poor prognosis and requires long-term treatment and repeated surgeries. A small number of representative pseudarthrosis models makes it difficult to conduct preclinical studies of promising pharmacological substances, bone replacement materials and surgical methods of treatment.The aim. To develop and to validate an experimental model of normotrophic pseudarthrosis of a rabbit’s tibia by creating diastasis between bone fragments, forming local vascularization disturbance and using unstable fixation.Materials and methods. The study was carried out on Soviet Chinchilla rabbits. The animals were divided into 2 groups: in experimental group, we formed tibial pseudarthrosis; in control group, we made a simple transverse tibial fracture. The pseudarthrosis was formed by segmental resection (5 mm) of the middle third of the tibia, bone fragments dilatation for 5 mm, removal of periosteum and bone marrow within 5 mm followed by daily destabilization of a fracture in an external fixation device. The duration of the experiment was 6 weeks. X-ray examination of the fracture area was carried out weekly, multi-layer spiral computed tomography (MSCT) and histological examinations were carried out at the end of the experiment.Results. The survival value in the experiment was 100 %. According to weekly X-ray examination, fracture union was registered only in the control group and occurred on average on the 22,8 ± 5,1 day, while the formation of pseudarthrosis was observed only in the experimental group, and radiographic signs of a pseudarthrosis were noted on average on the 33,6 ± 3,5 day. The formation of a pseudarthrosis by the end of the experiment was confirmed by MSCT and histological studies.Conclusions. The developed model of the normotrophic pseudarthrosis of a rabbit’s tibia can be used for experimental tests of various factors for stimulating reparative regeneration and methods for treatment of the pseudarthrosis. |
| abstractGer |
Background. The formation of a pseudarthrosis is one of the most severe complications of bone fractures. Pseudarthrosis occurs as a result of a disorder in the fracture union, has a poor prognosis and requires long-term treatment and repeated surgeries. A small number of representative pseudarthrosis models makes it difficult to conduct preclinical studies of promising pharmacological substances, bone replacement materials and surgical methods of treatment.The aim. To develop and to validate an experimental model of normotrophic pseudarthrosis of a rabbit’s tibia by creating diastasis between bone fragments, forming local vascularization disturbance and using unstable fixation.Materials and methods. The study was carried out on Soviet Chinchilla rabbits. The animals were divided into 2 groups: in experimental group, we formed tibial pseudarthrosis; in control group, we made a simple transverse tibial fracture. The pseudarthrosis was formed by segmental resection (5 mm) of the middle third of the tibia, bone fragments dilatation for 5 mm, removal of periosteum and bone marrow within 5 mm followed by daily destabilization of a fracture in an external fixation device. The duration of the experiment was 6 weeks. X-ray examination of the fracture area was carried out weekly, multi-layer spiral computed tomography (MSCT) and histological examinations were carried out at the end of the experiment.Results. The survival value in the experiment was 100 %. According to weekly X-ray examination, fracture union was registered only in the control group and occurred on average on the 22,8 ± 5,1 day, while the formation of pseudarthrosis was observed only in the experimental group, and radiographic signs of a pseudarthrosis were noted on average on the 33,6 ± 3,5 day. The formation of a pseudarthrosis by the end of the experiment was confirmed by MSCT and histological studies.Conclusions. The developed model of the normotrophic pseudarthrosis of a rabbit’s tibia can be used for experimental tests of various factors for stimulating reparative regeneration and methods for treatment of the pseudarthrosis. |
| abstract_unstemmed |
Background. The formation of a pseudarthrosis is one of the most severe complications of bone fractures. Pseudarthrosis occurs as a result of a disorder in the fracture union, has a poor prognosis and requires long-term treatment and repeated surgeries. A small number of representative pseudarthrosis models makes it difficult to conduct preclinical studies of promising pharmacological substances, bone replacement materials and surgical methods of treatment.The aim. To develop and to validate an experimental model of normotrophic pseudarthrosis of a rabbit’s tibia by creating diastasis between bone fragments, forming local vascularization disturbance and using unstable fixation.Materials and methods. The study was carried out on Soviet Chinchilla rabbits. The animals were divided into 2 groups: in experimental group, we formed tibial pseudarthrosis; in control group, we made a simple transverse tibial fracture. The pseudarthrosis was formed by segmental resection (5 mm) of the middle third of the tibia, bone fragments dilatation for 5 mm, removal of periosteum and bone marrow within 5 mm followed by daily destabilization of a fracture in an external fixation device. The duration of the experiment was 6 weeks. X-ray examination of the fracture area was carried out weekly, multi-layer spiral computed tomography (MSCT) and histological examinations were carried out at the end of the experiment.Results. The survival value in the experiment was 100 %. According to weekly X-ray examination, fracture union was registered only in the control group and occurred on average on the 22,8 ± 5,1 day, while the formation of pseudarthrosis was observed only in the experimental group, and radiographic signs of a pseudarthrosis were noted on average on the 33,6 ± 3,5 day. The formation of a pseudarthrosis by the end of the experiment was confirmed by MSCT and histological studies.Conclusions. The developed model of the normotrophic pseudarthrosis of a rabbit’s tibia can be used for experimental tests of various factors for stimulating reparative regeneration and methods for treatment of the pseudarthrosis. |
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