Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice

In the present work, we investigated the protective effect of schisandrin, a major and representative lignin from the fruits of Schisandra chinensis Baill., on streptozotocin combining with high fat diet (STZ/HFD)-induced diabetic nephropathy (DN) in mice. All mice were divided into five groups as f...
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Autor*in:	Yu-zhuo Zhang [verfasserIn] Mei-ling Fan [verfasserIn] Wei-zhe Zhang [verfasserIn] Wei Liu [verfasserIn] Hui-ping Li [verfasserIn] Shen Ren [verfasserIn] Shuang Jiang [verfasserIn] Ming-jie Song [verfasserIn] Zi Wang [verfasserIn] Wei Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Schisandrin Diabetic Nephropathy PI3K/Akt NF-κB Inflammation

Übergeordnetes Werk:	In: Journal of Functional Foods - Elsevier, 2021, 100(2023), Seite 105376-
Übergeordnetes Werk:	volume:100 ; year:2023 ; pages:105376-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jff.2022.105376

Katalog-ID:	DOAJ003329577

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allfields	10.1016/j.jff.2022.105376 doi (DE-627)DOAJ003329577 (DE-599)DOAJ3aea0673b1244f01b19bbe41b431547b DE-627 ger DE-627 rakwb eng TX341-641 Yu-zhuo Zhang verfasserin aut Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present work, we investigated the protective effect of schisandrin, a major and representative lignin from the fruits of Schisandra chinensis Baill., on streptozotocin combining with high fat diet (STZ/HFD)-induced diabetic nephropathy (DN) in mice. All mice were divided into five groups as follows: normal group, diabetes mellitus (DM) group, Metformin group, DM + schisandrin (10 and 20 mg/kg). Schisandrin were administered intragastrically to mice for 8 weeks. Schisandrin prevented DN-induced injuries as determined by significantly decreasing levels of fast blood glucose, advanced glycation end products (AGEs), lipid Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), creatinine (CRE), and blood urea nitrogen (BUN) and increasing level of high-density lipoprotein cholesterol (HDL-C), which correlated with inhibited TGF-β1 and α-SMA at protein and transcriptional levels. In addition, schisandrin treatment reduced protein expression levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2), suggesting a suppressed inflammatory response. This suppression was afforded by inhibiting nuclear factor-κB (NF-κB) and activating phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) signaling. In summary, these findings highlight the nephroprotective effect of schisandrin against STZ/HFD-induced DN through inhibiting the renal inflammation and fibrosis in mice. Schisandrin Diabetic Nephropathy PI3K/Akt NF-κB Inflammation Nutrition. Foods and food supply Mei-ling Fan verfasserin aut Wei-zhe Zhang verfasserin aut Wei Liu verfasserin aut Hui-ping Li verfasserin aut Shen Ren verfasserin aut Shuang Jiang verfasserin aut Ming-jie Song verfasserin aut Zi Wang verfasserin aut Wei Li verfasserin aut In Journal of Functional Foods Elsevier, 2021 100(2023), Seite 105376- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:100 year:2023 pages:105376- https://doi.org/10.1016/j.jff.2022.105376 kostenfrei https://doaj.org/article/3aea0673b1244f01b19bbe41b431547b kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464622004467 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 100 2023 105376-
spelling	10.1016/j.jff.2022.105376 doi (DE-627)DOAJ003329577 (DE-599)DOAJ3aea0673b1244f01b19bbe41b431547b DE-627 ger DE-627 rakwb eng TX341-641 Yu-zhuo Zhang verfasserin aut Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present work, we investigated the protective effect of schisandrin, a major and representative lignin from the fruits of Schisandra chinensis Baill., on streptozotocin combining with high fat diet (STZ/HFD)-induced diabetic nephropathy (DN) in mice. All mice were divided into five groups as follows: normal group, diabetes mellitus (DM) group, Metformin group, DM + schisandrin (10 and 20 mg/kg). Schisandrin were administered intragastrically to mice for 8 weeks. Schisandrin prevented DN-induced injuries as determined by significantly decreasing levels of fast blood glucose, advanced glycation end products (AGEs), lipid Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), creatinine (CRE), and blood urea nitrogen (BUN) and increasing level of high-density lipoprotein cholesterol (HDL-C), which correlated with inhibited TGF-β1 and α-SMA at protein and transcriptional levels. In addition, schisandrin treatment reduced protein expression levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2), suggesting a suppressed inflammatory response. This suppression was afforded by inhibiting nuclear factor-κB (NF-κB) and activating phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) signaling. In summary, these findings highlight the nephroprotective effect of schisandrin against STZ/HFD-induced DN through inhibiting the renal inflammation and fibrosis in mice. Schisandrin Diabetic Nephropathy PI3K/Akt NF-κB Inflammation Nutrition. Foods and food supply Mei-ling Fan verfasserin aut Wei-zhe Zhang verfasserin aut Wei Liu verfasserin aut Hui-ping Li verfasserin aut Shen Ren verfasserin aut Shuang Jiang verfasserin aut Ming-jie Song verfasserin aut Zi Wang verfasserin aut Wei Li verfasserin aut In Journal of Functional Foods Elsevier, 2021 100(2023), Seite 105376- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:100 year:2023 pages:105376- https://doi.org/10.1016/j.jff.2022.105376 kostenfrei https://doaj.org/article/3aea0673b1244f01b19bbe41b431547b kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464622004467 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 100 2023 105376-
allfields_unstemmed	10.1016/j.jff.2022.105376 doi (DE-627)DOAJ003329577 (DE-599)DOAJ3aea0673b1244f01b19bbe41b431547b DE-627 ger DE-627 rakwb eng TX341-641 Yu-zhuo Zhang verfasserin aut Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present work, we investigated the protective effect of schisandrin, a major and representative lignin from the fruits of Schisandra chinensis Baill., on streptozotocin combining with high fat diet (STZ/HFD)-induced diabetic nephropathy (DN) in mice. All mice were divided into five groups as follows: normal group, diabetes mellitus (DM) group, Metformin group, DM + schisandrin (10 and 20 mg/kg). Schisandrin were administered intragastrically to mice for 8 weeks. Schisandrin prevented DN-induced injuries as determined by significantly decreasing levels of fast blood glucose, advanced glycation end products (AGEs), lipid Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), creatinine (CRE), and blood urea nitrogen (BUN) and increasing level of high-density lipoprotein cholesterol (HDL-C), which correlated with inhibited TGF-β1 and α-SMA at protein and transcriptional levels. In addition, schisandrin treatment reduced protein expression levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2), suggesting a suppressed inflammatory response. This suppression was afforded by inhibiting nuclear factor-κB (NF-κB) and activating phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) signaling. In summary, these findings highlight the nephroprotective effect of schisandrin against STZ/HFD-induced DN through inhibiting the renal inflammation and fibrosis in mice. Schisandrin Diabetic Nephropathy PI3K/Akt NF-κB Inflammation Nutrition. Foods and food supply Mei-ling Fan verfasserin aut Wei-zhe Zhang verfasserin aut Wei Liu verfasserin aut Hui-ping Li verfasserin aut Shen Ren verfasserin aut Shuang Jiang verfasserin aut Ming-jie Song verfasserin aut Zi Wang verfasserin aut Wei Li verfasserin aut In Journal of Functional Foods Elsevier, 2021 100(2023), Seite 105376- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:100 year:2023 pages:105376- https://doi.org/10.1016/j.jff.2022.105376 kostenfrei https://doaj.org/article/3aea0673b1244f01b19bbe41b431547b kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464622004467 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 100 2023 105376-
allfieldsGer	10.1016/j.jff.2022.105376 doi (DE-627)DOAJ003329577 (DE-599)DOAJ3aea0673b1244f01b19bbe41b431547b DE-627 ger DE-627 rakwb eng TX341-641 Yu-zhuo Zhang verfasserin aut Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present work, we investigated the protective effect of schisandrin, a major and representative lignin from the fruits of Schisandra chinensis Baill., on streptozotocin combining with high fat diet (STZ/HFD)-induced diabetic nephropathy (DN) in mice. All mice were divided into five groups as follows: normal group, diabetes mellitus (DM) group, Metformin group, DM + schisandrin (10 and 20 mg/kg). Schisandrin were administered intragastrically to mice for 8 weeks. Schisandrin prevented DN-induced injuries as determined by significantly decreasing levels of fast blood glucose, advanced glycation end products (AGEs), lipid Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), creatinine (CRE), and blood urea nitrogen (BUN) and increasing level of high-density lipoprotein cholesterol (HDL-C), which correlated with inhibited TGF-β1 and α-SMA at protein and transcriptional levels. In addition, schisandrin treatment reduced protein expression levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2), suggesting a suppressed inflammatory response. This suppression was afforded by inhibiting nuclear factor-κB (NF-κB) and activating phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) signaling. In summary, these findings highlight the nephroprotective effect of schisandrin against STZ/HFD-induced DN through inhibiting the renal inflammation and fibrosis in mice. Schisandrin Diabetic Nephropathy PI3K/Akt NF-κB Inflammation Nutrition. Foods and food supply Mei-ling Fan verfasserin aut Wei-zhe Zhang verfasserin aut Wei Liu verfasserin aut Hui-ping Li verfasserin aut Shen Ren verfasserin aut Shuang Jiang verfasserin aut Ming-jie Song verfasserin aut Zi Wang verfasserin aut Wei Li verfasserin aut In Journal of Functional Foods Elsevier, 2021 100(2023), Seite 105376- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:100 year:2023 pages:105376- https://doi.org/10.1016/j.jff.2022.105376 kostenfrei https://doaj.org/article/3aea0673b1244f01b19bbe41b431547b kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464622004467 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 100 2023 105376-
allfieldsSound	10.1016/j.jff.2022.105376 doi (DE-627)DOAJ003329577 (DE-599)DOAJ3aea0673b1244f01b19bbe41b431547b DE-627 ger DE-627 rakwb eng TX341-641 Yu-zhuo Zhang verfasserin aut Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present work, we investigated the protective effect of schisandrin, a major and representative lignin from the fruits of Schisandra chinensis Baill., on streptozotocin combining with high fat diet (STZ/HFD)-induced diabetic nephropathy (DN) in mice. All mice were divided into five groups as follows: normal group, diabetes mellitus (DM) group, Metformin group, DM + schisandrin (10 and 20 mg/kg). Schisandrin were administered intragastrically to mice for 8 weeks. Schisandrin prevented DN-induced injuries as determined by significantly decreasing levels of fast blood glucose, advanced glycation end products (AGEs), lipid Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), creatinine (CRE), and blood urea nitrogen (BUN) and increasing level of high-density lipoprotein cholesterol (HDL-C), which correlated with inhibited TGF-β1 and α-SMA at protein and transcriptional levels. In addition, schisandrin treatment reduced protein expression levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2), suggesting a suppressed inflammatory response. This suppression was afforded by inhibiting nuclear factor-κB (NF-κB) and activating phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) signaling. In summary, these findings highlight the nephroprotective effect of schisandrin against STZ/HFD-induced DN through inhibiting the renal inflammation and fibrosis in mice. Schisandrin Diabetic Nephropathy PI3K/Akt NF-κB Inflammation Nutrition. Foods and food supply Mei-ling Fan verfasserin aut Wei-zhe Zhang verfasserin aut Wei Liu verfasserin aut Hui-ping Li verfasserin aut Shen Ren verfasserin aut Shuang Jiang verfasserin aut Ming-jie Song verfasserin aut Zi Wang verfasserin aut Wei Li verfasserin aut In Journal of Functional Foods Elsevier, 2021 100(2023), Seite 105376- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:100 year:2023 pages:105376- https://doi.org/10.1016/j.jff.2022.105376 kostenfrei https://doaj.org/article/3aea0673b1244f01b19bbe41b431547b kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464622004467 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 100 2023 105376-
language	English
source	In Journal of Functional Foods 100(2023), Seite 105376- volume:100 year:2023 pages:105376-
sourceStr	In Journal of Functional Foods 100(2023), Seite 105376- volume:100 year:2023 pages:105376-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Schisandrin Diabetic Nephropathy PI3K/Akt NF-κB Inflammation Nutrition. Foods and food supply
isfreeaccess_bool	true
container_title	Journal of Functional Foods
authorswithroles_txt_mv	Yu-zhuo Zhang @@aut@@ Mei-ling Fan @@aut@@ Wei-zhe Zhang @@aut@@ Wei Liu @@aut@@ Hui-ping Li @@aut@@ Shen Ren @@aut@@ Shuang Jiang @@aut@@ Ming-jie Song @@aut@@ Zi Wang @@aut@@ Wei Li @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	587138432
id	DOAJ003329577
language_de	englisch
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callnumber-first	T - Technology
author	Yu-zhuo Zhang
spellingShingle	Yu-zhuo Zhang misc TX341-641 misc Schisandrin misc Diabetic Nephropathy misc PI3K/Akt misc NF-κB misc Inflammation misc Nutrition. Foods and food supply Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice
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topic_title	TX341-641 Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice Schisandrin Diabetic Nephropathy PI3K/Akt NF-κB Inflammation
topic	misc TX341-641 misc Schisandrin misc Diabetic Nephropathy misc PI3K/Akt misc NF-κB misc Inflammation misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc Schisandrin misc Diabetic Nephropathy misc PI3K/Akt misc NF-κB misc Inflammation misc Nutrition. Foods and food supply
topic_browse	misc TX341-641 misc Schisandrin misc Diabetic Nephropathy misc PI3K/Akt misc NF-κB misc Inflammation misc Nutrition. Foods and food supply
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title	Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice
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title_full	Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice
author_sort	Yu-zhuo Zhang
journal	Journal of Functional Foods
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author_browse	Yu-zhuo Zhang Mei-ling Fan Wei-zhe Zhang Wei Liu Hui-ping Li Shen Ren Shuang Jiang Ming-jie Song Zi Wang Wei Li
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title_sort	schisandrin ameliorates diabetic nephropathy via regulating of pi3k/akt/nf-κb-mediated inflammation and tgf-β1-induced fibrosis in hfd/stz-induced c57bl/6j mice
callnumber	TX341-641
title_auth	Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice
abstract	In the present work, we investigated the protective effect of schisandrin, a major and representative lignin from the fruits of Schisandra chinensis Baill., on streptozotocin combining with high fat diet (STZ/HFD)-induced diabetic nephropathy (DN) in mice. All mice were divided into five groups as follows: normal group, diabetes mellitus (DM) group, Metformin group, DM + schisandrin (10 and 20 mg/kg). Schisandrin were administered intragastrically to mice for 8 weeks. Schisandrin prevented DN-induced injuries as determined by significantly decreasing levels of fast blood glucose, advanced glycation end products (AGEs), lipid Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), creatinine (CRE), and blood urea nitrogen (BUN) and increasing level of high-density lipoprotein cholesterol (HDL-C), which correlated with inhibited TGF-β1 and α-SMA at protein and transcriptional levels. In addition, schisandrin treatment reduced protein expression levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2), suggesting a suppressed inflammatory response. This suppression was afforded by inhibiting nuclear factor-κB (NF-κB) and activating phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) signaling. In summary, these findings highlight the nephroprotective effect of schisandrin against STZ/HFD-induced DN through inhibiting the renal inflammation and fibrosis in mice.
abstractGer	In the present work, we investigated the protective effect of schisandrin, a major and representative lignin from the fruits of Schisandra chinensis Baill., on streptozotocin combining with high fat diet (STZ/HFD)-induced diabetic nephropathy (DN) in mice. All mice were divided into five groups as follows: normal group, diabetes mellitus (DM) group, Metformin group, DM + schisandrin (10 and 20 mg/kg). Schisandrin were administered intragastrically to mice for 8 weeks. Schisandrin prevented DN-induced injuries as determined by significantly decreasing levels of fast blood glucose, advanced glycation end products (AGEs), lipid Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), creatinine (CRE), and blood urea nitrogen (BUN) and increasing level of high-density lipoprotein cholesterol (HDL-C), which correlated with inhibited TGF-β1 and α-SMA at protein and transcriptional levels. In addition, schisandrin treatment reduced protein expression levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2), suggesting a suppressed inflammatory response. This suppression was afforded by inhibiting nuclear factor-κB (NF-κB) and activating phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) signaling. In summary, these findings highlight the nephroprotective effect of schisandrin against STZ/HFD-induced DN through inhibiting the renal inflammation and fibrosis in mice.
abstract_unstemmed	In the present work, we investigated the protective effect of schisandrin, a major and representative lignin from the fruits of Schisandra chinensis Baill., on streptozotocin combining with high fat diet (STZ/HFD)-induced diabetic nephropathy (DN) in mice. All mice were divided into five groups as follows: normal group, diabetes mellitus (DM) group, Metformin group, DM + schisandrin (10 and 20 mg/kg). Schisandrin were administered intragastrically to mice for 8 weeks. Schisandrin prevented DN-induced injuries as determined by significantly decreasing levels of fast blood glucose, advanced glycation end products (AGEs), lipid Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), creatinine (CRE), and blood urea nitrogen (BUN) and increasing level of high-density lipoprotein cholesterol (HDL-C), which correlated with inhibited TGF-β1 and α-SMA at protein and transcriptional levels. In addition, schisandrin treatment reduced protein expression levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2), suggesting a suppressed inflammatory response. This suppression was afforded by inhibiting nuclear factor-κB (NF-κB) and activating phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) signaling. In summary, these findings highlight the nephroprotective effect of schisandrin against STZ/HFD-induced DN through inhibiting the renal inflammation and fibrosis in mice.
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title_short	Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice
url	https://doi.org/10.1016/j.jff.2022.105376 https://doaj.org/article/3aea0673b1244f01b19bbe41b431547b http://www.sciencedirect.com/science/article/pii/S1756464622004467 https://doaj.org/toc/1756-4646
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up_date	2024-07-03T17:21:19.817Z
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Schisandrin ameliorates diabetic nephropathy via regulating of PI3K/Akt/NF-κB-mediated inflammation and TGF-β1-induced fibrosis in HFD/STZ-induced C57BL/6J mice

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