Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios Standardization of echocardiographic parameters of healthy Golden Retriever dogs

A distrofia muscular de Duchenne (DMD) em humanos é uma alteração neuromuscular hereditária, de caráter recessivo, ligada ao cromossomo X e causada pela ausência ou disfunção da distrofina. Clinicamente, caracteriza-se por severa alteração na musculatura esquelética, resultando em morte precoce do indivíduo acometido. Em cães da raça Golden Retriever, a mutação que leva à distrofia muscular ocorre espontaneamente e a extensa homologia entre a patogênese da DMD e da distrofia muscular do Golden Retriever permite qualificar o cão como principal substituto de humanos nos testes clínicos de novas terapias. O miocárdio deficiente em distrofina é mais vulnerável à sobrecarga de pressão e os pacientes com DMD podem desenvolver cardiomiopatia dilatada e hipertensão arterial; à ecocardiografia, verificam-se anormalidades na função diastólica, além de insuficiência sistólica em alguns pacientes mais velhos. No presente estudo, 41 cães da raça Golden Retriever, clinicamente sadios, foram submetidos ao exame ecocardiográfico com a finalidade de se obterem os citados parâmetros na referida raça, o que futuramente poderá servir de referência na identificação de cães portadores ou afetados pela distrofia muscular.<br<The Duchenne's muscular dystrophy (DMD) in humans is a recessive X-linked neuromuscular disease, caused either by the absence or dysfunction of the dystrophin. Clinically it is characterized by severe alteration in the skeletal musculature, resulting in precocious death of the affected patient. In Golden Retriever dogs, the mutation that determines the muscular dystrophy occurs spontaneously and the extensive homology among the pathogenesis of DMD and of Golden Retriever muscular dystrophy allows to qualify the dog as the main substitute of humans in the clinical tests of new therapies. The deficient myocardium in dystrophin is more vulnerable to the pressure overload, and the patients with DMD can develop dilated cardiomyopathy as well as arterial hypertension; in echocardiography, diastolic function abnormalities are verified and systolic inadequacy can be observed in some old patients. In the present study, 41 healthy Golden Retriever dogs were evaluated by echocardiographic exam with the purpose to obtain parameters for the standardization of these cardiovascular characteristics in the refered breed, what hereafter can be used as reference in the identification of bearer or affected dogs by muscular dystrophy. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Arine Pellegrino [verfasserIn] Lilian Caram Petrus [verfasserIn] Guilherme Gonçalves Pereira [verfasserIn] Elaine Cristina Soares [verfasserIn] Ronaldo Jun Yamato [verfasserIn] Eduardo Lipparelli Fernandez [verfasserIn] Maria Helena Matiko Akao Larsson [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Portugiesisch

Erschienen:	2007

Schlagwörter:	ecocardiografia distrofia muscular do Golden Retriever (GRMD) distrofia muscular de Duchenne (DMD) cardiomiopatia de Duchenne cardiomiopatia echocardiography Golden Retriever muscular dystrophy (GRMD) Duchenne's muscular dystrophy (DMD) Duchenne's cardiomyopathy cardiomyopathy

Übergeordnetes Werk:	In: Ciência Rural - Universidade Federal de Santa Maria, 2004, 37(2007), 4, Seite 1039-1044
Übergeordnetes Werk:	volume:37 ; year:2007 ; number:4 ; pages:1039-1044

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1590/S0103-84782007000400019

Katalog-ID:	DOAJ003386031

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520			\|a A distrofia muscular de Duchenne (DMD) em humanos é uma alteração neuromuscular hereditária, de caráter recessivo, ligada ao cromossomo X e causada pela ausência ou disfunção da distrofina. Clinicamente, caracteriza-se por severa alteração na musculatura esquelética, resultando em morte precoce do indivíduo acometido. Em cães da raça Golden Retriever, a mutação que leva à distrofia muscular ocorre espontaneamente e a extensa homologia entre a patogênese da DMD e da distrofia muscular do Golden Retriever permite qualificar o cão como principal substituto de humanos nos testes clínicos de novas terapias. O miocárdio deficiente em distrofina é mais vulnerável à sobrecarga de pressão e os pacientes com DMD podem desenvolver cardiomiopatia dilatada e hipertensão arterial; à ecocardiografia, verificam-se anormalidades na função diastólica, além de insuficiência sistólica em alguns pacientes mais velhos. No presente estudo, 41 cães da raça Golden Retriever, clinicamente sadios, foram submetidos ao exame ecocardiográfico com a finalidade de se obterem os citados parâmetros na referida raça, o que futuramente poderá servir de referência na identificação de cães portadores ou afetados pela distrofia muscular.<br<The Duchenne's muscular dystrophy (DMD) in humans is a recessive X-linked neuromuscular disease, caused either by the absence or dysfunction of the dystrophin. Clinically it is characterized by severe alteration in the skeletal musculature, resulting in precocious death of the affected patient. In Golden Retriever dogs, the mutation that determines the muscular dystrophy occurs spontaneously and the extensive homology among the pathogenesis of DMD and of Golden Retriever muscular dystrophy allows to qualify the dog as the main substitute of humans in the clinical tests of new therapies. The deficient myocardium in dystrophin is more vulnerable to the pressure overload, and the patients with DMD can develop dilated cardiomyopathy as well as arterial hypertension; in echocardiography, diastolic function abnormalities are verified and systolic inadequacy can be observed in some old patients. In the present study, 41 healthy Golden Retriever dogs were evaluated by echocardiographic exam with the purpose to obtain parameters for the standardization of these cardiovascular characteristics in the refered breed, what hereafter can be used as reference in the identification of bearer or affected dogs by muscular dystrophy.
650		4	\|a ecocardiografia
650		4	\|a distrofia muscular do Golden Retriever (GRMD)
650		4	\|a distrofia muscular de Duchenne (DMD)
650		4	\|a cardiomiopatia de Duchenne
650		4	\|a cardiomiopatia
650		4	\|a echocardiography
650		4	\|a Golden Retriever muscular dystrophy (GRMD)
650		4	\|a Duchenne's muscular dystrophy (DMD)
650		4	\|a Duchenne's cardiomyopathy
650		4	\|a cardiomyopathy
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spelling	10.1590/S0103-84782007000400019 doi (DE-627)DOAJ003386031 (DE-599)DOAJ5015d5dcb1434267ac1e5c226e12ccd8 DE-627 ger DE-627 rakwb eng por S1-972 Arine Pellegrino verfasserin aut Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios Standardization of echocardiographic parameters of healthy Golden Retriever dogs 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A distrofia muscular de Duchenne (DMD) em humanos é uma alteração neuromuscular hereditária, de caráter recessivo, ligada ao cromossomo X e causada pela ausência ou disfunção da distrofina. Clinicamente, caracteriza-se por severa alteração na musculatura esquelética, resultando em morte precoce do indivíduo acometido. Em cães da raça Golden Retriever, a mutação que leva à distrofia muscular ocorre espontaneamente e a extensa homologia entre a patogênese da DMD e da distrofia muscular do Golden Retriever permite qualificar o cão como principal substituto de humanos nos testes clínicos de novas terapias. O miocárdio deficiente em distrofina é mais vulnerável à sobrecarga de pressão e os pacientes com DMD podem desenvolver cardiomiopatia dilatada e hipertensão arterial; à ecocardiografia, verificam-se anormalidades na função diastólica, além de insuficiência sistólica em alguns pacientes mais velhos. No presente estudo, 41 cães da raça Golden Retriever, clinicamente sadios, foram submetidos ao exame ecocardiográfico com a finalidade de se obterem os citados parâmetros na referida raça, o que futuramente poderá servir de referência na identificação de cães portadores ou afetados pela distrofia muscular.<br<The Duchenne's muscular dystrophy (DMD) in humans is a recessive X-linked neuromuscular disease, caused either by the absence or dysfunction of the dystrophin. Clinically it is characterized by severe alteration in the skeletal musculature, resulting in precocious death of the affected patient. In Golden Retriever dogs, the mutation that determines the muscular dystrophy occurs spontaneously and the extensive homology among the pathogenesis of DMD and of Golden Retriever muscular dystrophy allows to qualify the dog as the main substitute of humans in the clinical tests of new therapies. The deficient myocardium in dystrophin is more vulnerable to the pressure overload, and the patients with DMD can develop dilated cardiomyopathy as well as arterial hypertension; in echocardiography, diastolic function abnormalities are verified and systolic inadequacy can be observed in some old patients. In the present study, 41 healthy Golden Retriever dogs were evaluated by echocardiographic exam with the purpose to obtain parameters for the standardization of these cardiovascular characteristics in the refered breed, what hereafter can be used as reference in the identification of bearer or affected dogs by muscular dystrophy. ecocardiografia distrofia muscular do Golden Retriever (GRMD) distrofia muscular de Duchenne (DMD) cardiomiopatia de Duchenne cardiomiopatia echocardiography Golden Retriever muscular dystrophy (GRMD) Duchenne's muscular dystrophy (DMD) Duchenne's cardiomyopathy cardiomyopathy Agriculture S Agriculture (General) Lilian Caram Petrus verfasserin aut Guilherme Gonçalves Pereira verfasserin aut Elaine Cristina Soares verfasserin aut Ronaldo Jun Yamato verfasserin aut Eduardo Lipparelli Fernandez verfasserin aut Maria Helena Matiko Akao Larsson verfasserin aut In Ciência Rural Universidade Federal de Santa Maria, 2004 37(2007), 4, Seite 1039-1044 (DE-627)320649970 (DE-600)2025834-3 16784596 nnns volume:37 year:2007 number:4 pages:1039-1044 https://doi.org/10.1590/S0103-84782007000400019 kostenfrei https://doaj.org/article/5015d5dcb1434267ac1e5c226e12ccd8 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000400019 kostenfrei https://doaj.org/toc/0103-8478 Journal toc kostenfrei https://doaj.org/toc/1678-4596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 37 2007 4 1039-1044
allfields_unstemmed	10.1590/S0103-84782007000400019 doi (DE-627)DOAJ003386031 (DE-599)DOAJ5015d5dcb1434267ac1e5c226e12ccd8 DE-627 ger DE-627 rakwb eng por S1-972 Arine Pellegrino verfasserin aut Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios Standardization of echocardiographic parameters of healthy Golden Retriever dogs 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A distrofia muscular de Duchenne (DMD) em humanos é uma alteração neuromuscular hereditária, de caráter recessivo, ligada ao cromossomo X e causada pela ausência ou disfunção da distrofina. Clinicamente, caracteriza-se por severa alteração na musculatura esquelética, resultando em morte precoce do indivíduo acometido. Em cães da raça Golden Retriever, a mutação que leva à distrofia muscular ocorre espontaneamente e a extensa homologia entre a patogênese da DMD e da distrofia muscular do Golden Retriever permite qualificar o cão como principal substituto de humanos nos testes clínicos de novas terapias. O miocárdio deficiente em distrofina é mais vulnerável à sobrecarga de pressão e os pacientes com DMD podem desenvolver cardiomiopatia dilatada e hipertensão arterial; à ecocardiografia, verificam-se anormalidades na função diastólica, além de insuficiência sistólica em alguns pacientes mais velhos. No presente estudo, 41 cães da raça Golden Retriever, clinicamente sadios, foram submetidos ao exame ecocardiográfico com a finalidade de se obterem os citados parâmetros na referida raça, o que futuramente poderá servir de referência na identificação de cães portadores ou afetados pela distrofia muscular.<br<The Duchenne's muscular dystrophy (DMD) in humans is a recessive X-linked neuromuscular disease, caused either by the absence or dysfunction of the dystrophin. Clinically it is characterized by severe alteration in the skeletal musculature, resulting in precocious death of the affected patient. In Golden Retriever dogs, the mutation that determines the muscular dystrophy occurs spontaneously and the extensive homology among the pathogenesis of DMD and of Golden Retriever muscular dystrophy allows to qualify the dog as the main substitute of humans in the clinical tests of new therapies. The deficient myocardium in dystrophin is more vulnerable to the pressure overload, and the patients with DMD can develop dilated cardiomyopathy as well as arterial hypertension; in echocardiography, diastolic function abnormalities are verified and systolic inadequacy can be observed in some old patients. In the present study, 41 healthy Golden Retriever dogs were evaluated by echocardiographic exam with the purpose to obtain parameters for the standardization of these cardiovascular characteristics in the refered breed, what hereafter can be used as reference in the identification of bearer or affected dogs by muscular dystrophy. ecocardiografia distrofia muscular do Golden Retriever (GRMD) distrofia muscular de Duchenne (DMD) cardiomiopatia de Duchenne cardiomiopatia echocardiography Golden Retriever muscular dystrophy (GRMD) Duchenne's muscular dystrophy (DMD) Duchenne's cardiomyopathy cardiomyopathy Agriculture S Agriculture (General) Lilian Caram Petrus verfasserin aut Guilherme Gonçalves Pereira verfasserin aut Elaine Cristina Soares verfasserin aut Ronaldo Jun Yamato verfasserin aut Eduardo Lipparelli Fernandez verfasserin aut Maria Helena Matiko Akao Larsson verfasserin aut In Ciência Rural Universidade Federal de Santa Maria, 2004 37(2007), 4, Seite 1039-1044 (DE-627)320649970 (DE-600)2025834-3 16784596 nnns volume:37 year:2007 number:4 pages:1039-1044 https://doi.org/10.1590/S0103-84782007000400019 kostenfrei https://doaj.org/article/5015d5dcb1434267ac1e5c226e12ccd8 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000400019 kostenfrei https://doaj.org/toc/0103-8478 Journal toc kostenfrei https://doaj.org/toc/1678-4596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 37 2007 4 1039-1044
allfieldsGer	10.1590/S0103-84782007000400019 doi (DE-627)DOAJ003386031 (DE-599)DOAJ5015d5dcb1434267ac1e5c226e12ccd8 DE-627 ger DE-627 rakwb eng por S1-972 Arine Pellegrino verfasserin aut Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios Standardization of echocardiographic parameters of healthy Golden Retriever dogs 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A distrofia muscular de Duchenne (DMD) em humanos é uma alteração neuromuscular hereditária, de caráter recessivo, ligada ao cromossomo X e causada pela ausência ou disfunção da distrofina. Clinicamente, caracteriza-se por severa alteração na musculatura esquelética, resultando em morte precoce do indivíduo acometido. Em cães da raça Golden Retriever, a mutação que leva à distrofia muscular ocorre espontaneamente e a extensa homologia entre a patogênese da DMD e da distrofia muscular do Golden Retriever permite qualificar o cão como principal substituto de humanos nos testes clínicos de novas terapias. O miocárdio deficiente em distrofina é mais vulnerável à sobrecarga de pressão e os pacientes com DMD podem desenvolver cardiomiopatia dilatada e hipertensão arterial; à ecocardiografia, verificam-se anormalidades na função diastólica, além de insuficiência sistólica em alguns pacientes mais velhos. No presente estudo, 41 cães da raça Golden Retriever, clinicamente sadios, foram submetidos ao exame ecocardiográfico com a finalidade de se obterem os citados parâmetros na referida raça, o que futuramente poderá servir de referência na identificação de cães portadores ou afetados pela distrofia muscular.<br<The Duchenne's muscular dystrophy (DMD) in humans is a recessive X-linked neuromuscular disease, caused either by the absence or dysfunction of the dystrophin. Clinically it is characterized by severe alteration in the skeletal musculature, resulting in precocious death of the affected patient. In Golden Retriever dogs, the mutation that determines the muscular dystrophy occurs spontaneously and the extensive homology among the pathogenesis of DMD and of Golden Retriever muscular dystrophy allows to qualify the dog as the main substitute of humans in the clinical tests of new therapies. The deficient myocardium in dystrophin is more vulnerable to the pressure overload, and the patients with DMD can develop dilated cardiomyopathy as well as arterial hypertension; in echocardiography, diastolic function abnormalities are verified and systolic inadequacy can be observed in some old patients. In the present study, 41 healthy Golden Retriever dogs were evaluated by echocardiographic exam with the purpose to obtain parameters for the standardization of these cardiovascular characteristics in the refered breed, what hereafter can be used as reference in the identification of bearer or affected dogs by muscular dystrophy. ecocardiografia distrofia muscular do Golden Retriever (GRMD) distrofia muscular de Duchenne (DMD) cardiomiopatia de Duchenne cardiomiopatia echocardiography Golden Retriever muscular dystrophy (GRMD) Duchenne's muscular dystrophy (DMD) Duchenne's cardiomyopathy cardiomyopathy Agriculture S Agriculture (General) Lilian Caram Petrus verfasserin aut Guilherme Gonçalves Pereira verfasserin aut Elaine Cristina Soares verfasserin aut Ronaldo Jun Yamato verfasserin aut Eduardo Lipparelli Fernandez verfasserin aut Maria Helena Matiko Akao Larsson verfasserin aut In Ciência Rural Universidade Federal de Santa Maria, 2004 37(2007), 4, Seite 1039-1044 (DE-627)320649970 (DE-600)2025834-3 16784596 nnns volume:37 year:2007 number:4 pages:1039-1044 https://doi.org/10.1590/S0103-84782007000400019 kostenfrei https://doaj.org/article/5015d5dcb1434267ac1e5c226e12ccd8 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000400019 kostenfrei https://doaj.org/toc/0103-8478 Journal toc kostenfrei https://doaj.org/toc/1678-4596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 37 2007 4 1039-1044
allfieldsSound	10.1590/S0103-84782007000400019 doi (DE-627)DOAJ003386031 (DE-599)DOAJ5015d5dcb1434267ac1e5c226e12ccd8 DE-627 ger DE-627 rakwb eng por S1-972 Arine Pellegrino verfasserin aut Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios Standardization of echocardiographic parameters of healthy Golden Retriever dogs 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A distrofia muscular de Duchenne (DMD) em humanos é uma alteração neuromuscular hereditária, de caráter recessivo, ligada ao cromossomo X e causada pela ausência ou disfunção da distrofina. Clinicamente, caracteriza-se por severa alteração na musculatura esquelética, resultando em morte precoce do indivíduo acometido. Em cães da raça Golden Retriever, a mutação que leva à distrofia muscular ocorre espontaneamente e a extensa homologia entre a patogênese da DMD e da distrofia muscular do Golden Retriever permite qualificar o cão como principal substituto de humanos nos testes clínicos de novas terapias. O miocárdio deficiente em distrofina é mais vulnerável à sobrecarga de pressão e os pacientes com DMD podem desenvolver cardiomiopatia dilatada e hipertensão arterial; à ecocardiografia, verificam-se anormalidades na função diastólica, além de insuficiência sistólica em alguns pacientes mais velhos. No presente estudo, 41 cães da raça Golden Retriever, clinicamente sadios, foram submetidos ao exame ecocardiográfico com a finalidade de se obterem os citados parâmetros na referida raça, o que futuramente poderá servir de referência na identificação de cães portadores ou afetados pela distrofia muscular.<br<The Duchenne's muscular dystrophy (DMD) in humans is a recessive X-linked neuromuscular disease, caused either by the absence or dysfunction of the dystrophin. Clinically it is characterized by severe alteration in the skeletal musculature, resulting in precocious death of the affected patient. In Golden Retriever dogs, the mutation that determines the muscular dystrophy occurs spontaneously and the extensive homology among the pathogenesis of DMD and of Golden Retriever muscular dystrophy allows to qualify the dog as the main substitute of humans in the clinical tests of new therapies. The deficient myocardium in dystrophin is more vulnerable to the pressure overload, and the patients with DMD can develop dilated cardiomyopathy as well as arterial hypertension; in echocardiography, diastolic function abnormalities are verified and systolic inadequacy can be observed in some old patients. In the present study, 41 healthy Golden Retriever dogs were evaluated by echocardiographic exam with the purpose to obtain parameters for the standardization of these cardiovascular characteristics in the refered breed, what hereafter can be used as reference in the identification of bearer or affected dogs by muscular dystrophy. ecocardiografia distrofia muscular do Golden Retriever (GRMD) distrofia muscular de Duchenne (DMD) cardiomiopatia de Duchenne cardiomiopatia echocardiography Golden Retriever muscular dystrophy (GRMD) Duchenne's muscular dystrophy (DMD) Duchenne's cardiomyopathy cardiomyopathy Agriculture S Agriculture (General) Lilian Caram Petrus verfasserin aut Guilherme Gonçalves Pereira verfasserin aut Elaine Cristina Soares verfasserin aut Ronaldo Jun Yamato verfasserin aut Eduardo Lipparelli Fernandez verfasserin aut Maria Helena Matiko Akao Larsson verfasserin aut In Ciência Rural Universidade Federal de Santa Maria, 2004 37(2007), 4, Seite 1039-1044 (DE-627)320649970 (DE-600)2025834-3 16784596 nnns volume:37 year:2007 number:4 pages:1039-1044 https://doi.org/10.1590/S0103-84782007000400019 kostenfrei https://doaj.org/article/5015d5dcb1434267ac1e5c226e12ccd8 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000400019 kostenfrei https://doaj.org/toc/0103-8478 Journal toc kostenfrei https://doaj.org/toc/1678-4596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 37 2007 4 1039-1044
language	English Portuguese
source	In Ciência Rural 37(2007), 4, Seite 1039-1044 volume:37 year:2007 number:4 pages:1039-1044
sourceStr	In Ciência Rural 37(2007), 4, Seite 1039-1044 volume:37 year:2007 number:4 pages:1039-1044
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	ecocardiografia distrofia muscular do Golden Retriever (GRMD) distrofia muscular de Duchenne (DMD) cardiomiopatia de Duchenne cardiomiopatia echocardiography Golden Retriever muscular dystrophy (GRMD) Duchenne's muscular dystrophy (DMD) Duchenne's cardiomyopathy cardiomyopathy Agriculture S Agriculture (General)
isfreeaccess_bool	true
container_title	Ciência Rural
authorswithroles_txt_mv	Arine Pellegrino @@aut@@ Lilian Caram Petrus @@aut@@ Guilherme Gonçalves Pereira @@aut@@ Elaine Cristina Soares @@aut@@ Ronaldo Jun Yamato @@aut@@ Eduardo Lipparelli Fernandez @@aut@@ Maria Helena Matiko Akao Larsson @@aut@@
publishDateDaySort_date	2007-01-01T00:00:00Z
hierarchy_top_id	320649970
id	DOAJ003386031
language_de	englisch portugiesisch
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Clinicamente, caracteriza-se por severa alteração na musculatura esquelética, resultando em morte precoce do indivíduo acometido. Em cães da raça Golden Retriever, a mutação que leva à distrofia muscular ocorre espontaneamente e a extensa homologia entre a patogênese da DMD e da distrofia muscular do Golden Retriever permite qualificar o cão como principal substituto de humanos nos testes clínicos de novas terapias. O miocárdio deficiente em distrofina é mais vulnerável à sobrecarga de pressão e os pacientes com DMD podem desenvolver cardiomiopatia dilatada e hipertensão arterial; à ecocardiografia, verificam-se anormalidades na função diastólica, além de insuficiência sistólica em alguns pacientes mais velhos. 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callnumber-first	S - Agriculture
author	Arine Pellegrino
spellingShingle	Arine Pellegrino misc S1-972 misc ecocardiografia misc distrofia muscular do Golden Retriever (GRMD) misc distrofia muscular de Duchenne (DMD) misc cardiomiopatia de Duchenne misc cardiomiopatia misc echocardiography misc Golden Retriever muscular dystrophy (GRMD) misc Duchenne's muscular dystrophy (DMD) misc Duchenne's cardiomyopathy misc cardiomyopathy misc Agriculture misc S misc Agriculture (General) Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios Standardization of echocardiographic parameters of healthy Golden Retriever dogs
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topic_title	S1-972 Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios Standardization of echocardiographic parameters of healthy Golden Retriever dogs ecocardiografia distrofia muscular do Golden Retriever (GRMD) distrofia muscular de Duchenne (DMD) cardiomiopatia de Duchenne cardiomiopatia echocardiography Golden Retriever muscular dystrophy (GRMD) Duchenne's muscular dystrophy (DMD) Duchenne's cardiomyopathy cardiomyopathy
topic	misc S1-972 misc ecocardiografia misc distrofia muscular do Golden Retriever (GRMD) misc distrofia muscular de Duchenne (DMD) misc cardiomiopatia de Duchenne misc cardiomiopatia misc echocardiography misc Golden Retriever muscular dystrophy (GRMD) misc Duchenne's muscular dystrophy (DMD) misc Duchenne's cardiomyopathy misc cardiomyopathy misc Agriculture misc S misc Agriculture (General)
topic_unstemmed	misc S1-972 misc ecocardiografia misc distrofia muscular do Golden Retriever (GRMD) misc distrofia muscular de Duchenne (DMD) misc cardiomiopatia de Duchenne misc cardiomiopatia misc echocardiography misc Golden Retriever muscular dystrophy (GRMD) misc Duchenne's muscular dystrophy (DMD) misc Duchenne's cardiomyopathy misc cardiomyopathy misc Agriculture misc S misc Agriculture (General)
topic_browse	misc S1-972 misc ecocardiografia misc distrofia muscular do Golden Retriever (GRMD) misc distrofia muscular de Duchenne (DMD) misc cardiomiopatia de Duchenne misc cardiomiopatia misc echocardiography misc Golden Retriever muscular dystrophy (GRMD) misc Duchenne's muscular dystrophy (DMD) misc Duchenne's cardiomyopathy misc cardiomyopathy misc Agriculture misc S misc Agriculture (General)
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title	Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios Standardization of echocardiographic parameters of healthy Golden Retriever dogs
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title_full	Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios Standardization of echocardiographic parameters of healthy Golden Retriever dogs
author_sort	Arine Pellegrino
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title_sort	padronização de parâmetros ecocardiográficos de cães da raça golden retriever clinicamente sadios standardization of echocardiographic parameters of healthy golden retriever dogs
callnumber	S1-972
title_auth	Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios Standardization of echocardiographic parameters of healthy Golden Retriever dogs
abstract	A distrofia muscular de Duchenne (DMD) em humanos é uma alteração neuromuscular hereditária, de caráter recessivo, ligada ao cromossomo X e causada pela ausência ou disfunção da distrofina. Clinicamente, caracteriza-se por severa alteração na musculatura esquelética, resultando em morte precoce do indivíduo acometido. Em cães da raça Golden Retriever, a mutação que leva à distrofia muscular ocorre espontaneamente e a extensa homologia entre a patogênese da DMD e da distrofia muscular do Golden Retriever permite qualificar o cão como principal substituto de humanos nos testes clínicos de novas terapias. O miocárdio deficiente em distrofina é mais vulnerável à sobrecarga de pressão e os pacientes com DMD podem desenvolver cardiomiopatia dilatada e hipertensão arterial; à ecocardiografia, verificam-se anormalidades na função diastólica, além de insuficiência sistólica em alguns pacientes mais velhos. No presente estudo, 41 cães da raça Golden Retriever, clinicamente sadios, foram submetidos ao exame ecocardiográfico com a finalidade de se obterem os citados parâmetros na referida raça, o que futuramente poderá servir de referência na identificação de cães portadores ou afetados pela distrofia muscular.<br<The Duchenne's muscular dystrophy (DMD) in humans is a recessive X-linked neuromuscular disease, caused either by the absence or dysfunction of the dystrophin. Clinically it is characterized by severe alteration in the skeletal musculature, resulting in precocious death of the affected patient. In Golden Retriever dogs, the mutation that determines the muscular dystrophy occurs spontaneously and the extensive homology among the pathogenesis of DMD and of Golden Retriever muscular dystrophy allows to qualify the dog as the main substitute of humans in the clinical tests of new therapies. The deficient myocardium in dystrophin is more vulnerable to the pressure overload, and the patients with DMD can develop dilated cardiomyopathy as well as arterial hypertension; in echocardiography, diastolic function abnormalities are verified and systolic inadequacy can be observed in some old patients. In the present study, 41 healthy Golden Retriever dogs were evaluated by echocardiographic exam with the purpose to obtain parameters for the standardization of these cardiovascular characteristics in the refered breed, what hereafter can be used as reference in the identification of bearer or affected dogs by muscular dystrophy.
abstractGer	A distrofia muscular de Duchenne (DMD) em humanos é uma alteração neuromuscular hereditária, de caráter recessivo, ligada ao cromossomo X e causada pela ausência ou disfunção da distrofina. Clinicamente, caracteriza-se por severa alteração na musculatura esquelética, resultando em morte precoce do indivíduo acometido. Em cães da raça Golden Retriever, a mutação que leva à distrofia muscular ocorre espontaneamente e a extensa homologia entre a patogênese da DMD e da distrofia muscular do Golden Retriever permite qualificar o cão como principal substituto de humanos nos testes clínicos de novas terapias. O miocárdio deficiente em distrofina é mais vulnerável à sobrecarga de pressão e os pacientes com DMD podem desenvolver cardiomiopatia dilatada e hipertensão arterial; à ecocardiografia, verificam-se anormalidades na função diastólica, além de insuficiência sistólica em alguns pacientes mais velhos. No presente estudo, 41 cães da raça Golden Retriever, clinicamente sadios, foram submetidos ao exame ecocardiográfico com a finalidade de se obterem os citados parâmetros na referida raça, o que futuramente poderá servir de referência na identificação de cães portadores ou afetados pela distrofia muscular.<br<The Duchenne's muscular dystrophy (DMD) in humans is a recessive X-linked neuromuscular disease, caused either by the absence or dysfunction of the dystrophin. Clinically it is characterized by severe alteration in the skeletal musculature, resulting in precocious death of the affected patient. In Golden Retriever dogs, the mutation that determines the muscular dystrophy occurs spontaneously and the extensive homology among the pathogenesis of DMD and of Golden Retriever muscular dystrophy allows to qualify the dog as the main substitute of humans in the clinical tests of new therapies. The deficient myocardium in dystrophin is more vulnerable to the pressure overload, and the patients with DMD can develop dilated cardiomyopathy as well as arterial hypertension; in echocardiography, diastolic function abnormalities are verified and systolic inadequacy can be observed in some old patients. In the present study, 41 healthy Golden Retriever dogs were evaluated by echocardiographic exam with the purpose to obtain parameters for the standardization of these cardiovascular characteristics in the refered breed, what hereafter can be used as reference in the identification of bearer or affected dogs by muscular dystrophy.
abstract_unstemmed	A distrofia muscular de Duchenne (DMD) em humanos é uma alteração neuromuscular hereditária, de caráter recessivo, ligada ao cromossomo X e causada pela ausência ou disfunção da distrofina. Clinicamente, caracteriza-se por severa alteração na musculatura esquelética, resultando em morte precoce do indivíduo acometido. Em cães da raça Golden Retriever, a mutação que leva à distrofia muscular ocorre espontaneamente e a extensa homologia entre a patogênese da DMD e da distrofia muscular do Golden Retriever permite qualificar o cão como principal substituto de humanos nos testes clínicos de novas terapias. O miocárdio deficiente em distrofina é mais vulnerável à sobrecarga de pressão e os pacientes com DMD podem desenvolver cardiomiopatia dilatada e hipertensão arterial; à ecocardiografia, verificam-se anormalidades na função diastólica, além de insuficiência sistólica em alguns pacientes mais velhos. No presente estudo, 41 cães da raça Golden Retriever, clinicamente sadios, foram submetidos ao exame ecocardiográfico com a finalidade de se obterem os citados parâmetros na referida raça, o que futuramente poderá servir de referência na identificação de cães portadores ou afetados pela distrofia muscular.<br<The Duchenne's muscular dystrophy (DMD) in humans is a recessive X-linked neuromuscular disease, caused either by the absence or dysfunction of the dystrophin. Clinically it is characterized by severe alteration in the skeletal musculature, resulting in precocious death of the affected patient. In Golden Retriever dogs, the mutation that determines the muscular dystrophy occurs spontaneously and the extensive homology among the pathogenesis of DMD and of Golden Retriever muscular dystrophy allows to qualify the dog as the main substitute of humans in the clinical tests of new therapies. The deficient myocardium in dystrophin is more vulnerable to the pressure overload, and the patients with DMD can develop dilated cardiomyopathy as well as arterial hypertension; in echocardiography, diastolic function abnormalities are verified and systolic inadequacy can be observed in some old patients. In the present study, 41 healthy Golden Retriever dogs were evaluated by echocardiographic exam with the purpose to obtain parameters for the standardization of these cardiovascular characteristics in the refered breed, what hereafter can be used as reference in the identification of bearer or affected dogs by muscular dystrophy.
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title_short	Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios Standardization of echocardiographic parameters of healthy Golden Retriever dogs
url	https://doi.org/10.1590/S0103-84782007000400019 https://doaj.org/article/5015d5dcb1434267ac1e5c226e12ccd8 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000400019 https://doaj.org/toc/0103-8478 https://doaj.org/toc/1678-4596
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Clinicamente, caracteriza-se por severa alteração na musculatura esquelética, resultando em morte precoce do indivíduo acometido. Em cães da raça Golden Retriever, a mutação que leva à distrofia muscular ocorre espontaneamente e a extensa homologia entre a patogênese da DMD e da distrofia muscular do Golden Retriever permite qualificar o cão como principal substituto de humanos nos testes clínicos de novas terapias. O miocárdio deficiente em distrofina é mais vulnerável à sobrecarga de pressão e os pacientes com DMD podem desenvolver cardiomiopatia dilatada e hipertensão arterial; à ecocardiografia, verificam-se anormalidades na função diastólica, além de insuficiência sistólica em alguns pacientes mais velhos. No presente estudo, 41 cães da raça Golden Retriever, clinicamente sadios, foram submetidos ao exame ecocardiográfico com a finalidade de se obterem os citados parâmetros na referida raça, o que futuramente poderá servir de referência na identificação de cães portadores ou afetados pela distrofia muscular.<br<The Duchenne's muscular dystrophy (DMD) in humans is a recessive X-linked neuromuscular disease, caused either by the absence or dysfunction of the dystrophin. Clinically it is characterized by severe alteration in the skeletal musculature, resulting in precocious death of the affected patient. In Golden Retriever dogs, the mutation that determines the muscular dystrophy occurs spontaneously and the extensive homology among the pathogenesis of DMD and of Golden Retriever muscular dystrophy allows to qualify the dog as the main substitute of humans in the clinical tests of new therapies. The deficient myocardium in dystrophin is more vulnerable to the pressure overload, and the patients with DMD can develop dilated cardiomyopathy as well as arterial hypertension; in echocardiography, diastolic function abnormalities are verified and systolic inadequacy can be observed in some old patients. In the present study, 41 healthy Golden Retriever dogs were evaluated by echocardiographic exam with the purpose to obtain parameters for the standardization of these cardiovascular characteristics in the refered breed, what hereafter can be used as reference in the identification of bearer or affected dogs by muscular dystrophy.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ecocardiografia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">distrofia muscular do Golden Retriever (GRMD)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">distrofia muscular de Duchenne (DMD)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cardiomiopatia de Duchenne</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cardiomiopatia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield 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Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios Standardization of echocardiographic parameters of healthy Golden Retriever dogs

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