CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients

Abstract The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years. However, cytokine release syndrome (CRS) and clinical efficacy have become the ma...
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Gespeichert in:

Autor*in:	Mengying Ke [verfasserIn] Liqing Kang [verfasserIn] Ling Wang [verfasserIn] Shu Yang [verfasserIn] Yajun Wang [verfasserIn] Haiyan Liu [verfasserIn] Chunyan Gu [verfasserIn] Hongming Huang [verfasserIn] Ye Yang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Platelet-activating factor Multiple myeloma CAR-T therapy Cytokine release syndrome LPCAT1

Übergeordnetes Werk:	In: Journal of Hematology & Oncology - BMC, 2008, 14(2021), 1, Seite 6
Übergeordnetes Werk:	volume:14 ; year:2021 ; number:1 ; pages:6

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13045-021-01101-6

Katalog-ID:	DOAJ003411419

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520			\|a Abstract The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years. However, cytokine release syndrome (CRS) and clinical efficacy have become the major obstacles which limit the application of CAR-T in clinics. To explore the potential biomarkers in plasma for evaluating CRS and clinical efficacy, we performed metabolomic and lipidomic profiling of plasma samples from 17 relapsed or refractory MM patients received CAR-T therapy. Our study showed that glycerophosphocholine (GPC), an intermediate of platelet-activating factor (PAF)-like molecule, was significantly decreased when the participants underwent CRS, and the remarkable elevation of lysophosphatidylcholines (lysoPCs), which were catalyzed by lysoPC acyltransferase (LPCAT) was a distinct metabolism signature of relapsed or refractory MM patients with prognostic value post-CAR-T therapy. Both GPC and lysoPC are involved in platelet-activating factor (PAF) remodeling pathway. Besides, these findings were validated by LPCAT1 expression, a key factor in the PAF pathway, associated with poor outcome in three MM GEP datasets of MM. In conclusion, CAR-T therapy alters PAF synthesis in MM patients, and targeting PAF remodeling may be a promising strategy to enhance MM CAR-T therapy.
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spelling	10.1186/s13045-021-01101-6 doi (DE-627)DOAJ003411419 (DE-599)DOAJ094fff3e045e40109a749fc72c3c2656 DE-627 ger DE-627 rakwb eng RC633-647.5 RC254-282 Mengying Ke verfasserin aut CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years. However, cytokine release syndrome (CRS) and clinical efficacy have become the major obstacles which limit the application of CAR-T in clinics. To explore the potential biomarkers in plasma for evaluating CRS and clinical efficacy, we performed metabolomic and lipidomic profiling of plasma samples from 17 relapsed or refractory MM patients received CAR-T therapy. Our study showed that glycerophosphocholine (GPC), an intermediate of platelet-activating factor (PAF)-like molecule, was significantly decreased when the participants underwent CRS, and the remarkable elevation of lysophosphatidylcholines (lysoPCs), which were catalyzed by lysoPC acyltransferase (LPCAT) was a distinct metabolism signature of relapsed or refractory MM patients with prognostic value post-CAR-T therapy. Both GPC and lysoPC are involved in platelet-activating factor (PAF) remodeling pathway. Besides, these findings were validated by LPCAT1 expression, a key factor in the PAF pathway, associated with poor outcome in three MM GEP datasets of MM. In conclusion, CAR-T therapy alters PAF synthesis in MM patients, and targeting PAF remodeling may be a promising strategy to enhance MM CAR-T therapy. Platelet-activating factor Multiple myeloma CAR-T therapy Cytokine release syndrome LPCAT1 Diseases of the blood and blood-forming organs Neoplasms. Tumors. Oncology. Including cancer and carcinogens Liqing Kang verfasserin aut Ling Wang verfasserin aut Shu Yang verfasserin aut Yajun Wang verfasserin aut Haiyan Liu verfasserin aut Chunyan Gu verfasserin aut Hongming Huang verfasserin aut Ye Yang verfasserin aut In Journal of Hematology & Oncology BMC, 2008 14(2021), 1, Seite 6 (DE-627)568914813 (DE-600)2429631-4 17568722 nnns volume:14 year:2021 number:1 pages:6 https://doi.org/10.1186/s13045-021-01101-6 kostenfrei https://doaj.org/article/094fff3e045e40109a749fc72c3c2656 kostenfrei https://doi.org/10.1186/s13045-021-01101-6 kostenfrei https://doaj.org/toc/1756-8722 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2021 1 6
allfields_unstemmed	10.1186/s13045-021-01101-6 doi (DE-627)DOAJ003411419 (DE-599)DOAJ094fff3e045e40109a749fc72c3c2656 DE-627 ger DE-627 rakwb eng RC633-647.5 RC254-282 Mengying Ke verfasserin aut CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years. However, cytokine release syndrome (CRS) and clinical efficacy have become the major obstacles which limit the application of CAR-T in clinics. To explore the potential biomarkers in plasma for evaluating CRS and clinical efficacy, we performed metabolomic and lipidomic profiling of plasma samples from 17 relapsed or refractory MM patients received CAR-T therapy. Our study showed that glycerophosphocholine (GPC), an intermediate of platelet-activating factor (PAF)-like molecule, was significantly decreased when the participants underwent CRS, and the remarkable elevation of lysophosphatidylcholines (lysoPCs), which were catalyzed by lysoPC acyltransferase (LPCAT) was a distinct metabolism signature of relapsed or refractory MM patients with prognostic value post-CAR-T therapy. Both GPC and lysoPC are involved in platelet-activating factor (PAF) remodeling pathway. Besides, these findings were validated by LPCAT1 expression, a key factor in the PAF pathway, associated with poor outcome in three MM GEP datasets of MM. In conclusion, CAR-T therapy alters PAF synthesis in MM patients, and targeting PAF remodeling may be a promising strategy to enhance MM CAR-T therapy. Platelet-activating factor Multiple myeloma CAR-T therapy Cytokine release syndrome LPCAT1 Diseases of the blood and blood-forming organs Neoplasms. Tumors. Oncology. Including cancer and carcinogens Liqing Kang verfasserin aut Ling Wang verfasserin aut Shu Yang verfasserin aut Yajun Wang verfasserin aut Haiyan Liu verfasserin aut Chunyan Gu verfasserin aut Hongming Huang verfasserin aut Ye Yang verfasserin aut In Journal of Hematology & Oncology BMC, 2008 14(2021), 1, Seite 6 (DE-627)568914813 (DE-600)2429631-4 17568722 nnns volume:14 year:2021 number:1 pages:6 https://doi.org/10.1186/s13045-021-01101-6 kostenfrei https://doaj.org/article/094fff3e045e40109a749fc72c3c2656 kostenfrei https://doi.org/10.1186/s13045-021-01101-6 kostenfrei https://doaj.org/toc/1756-8722 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2021 1 6
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allfieldsSound	10.1186/s13045-021-01101-6 doi (DE-627)DOAJ003411419 (DE-599)DOAJ094fff3e045e40109a749fc72c3c2656 DE-627 ger DE-627 rakwb eng RC633-647.5 RC254-282 Mengying Ke verfasserin aut CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years. However, cytokine release syndrome (CRS) and clinical efficacy have become the major obstacles which limit the application of CAR-T in clinics. To explore the potential biomarkers in plasma for evaluating CRS and clinical efficacy, we performed metabolomic and lipidomic profiling of plasma samples from 17 relapsed or refractory MM patients received CAR-T therapy. Our study showed that glycerophosphocholine (GPC), an intermediate of platelet-activating factor (PAF)-like molecule, was significantly decreased when the participants underwent CRS, and the remarkable elevation of lysophosphatidylcholines (lysoPCs), which were catalyzed by lysoPC acyltransferase (LPCAT) was a distinct metabolism signature of relapsed or refractory MM patients with prognostic value post-CAR-T therapy. Both GPC and lysoPC are involved in platelet-activating factor (PAF) remodeling pathway. Besides, these findings were validated by LPCAT1 expression, a key factor in the PAF pathway, associated with poor outcome in three MM GEP datasets of MM. In conclusion, CAR-T therapy alters PAF synthesis in MM patients, and targeting PAF remodeling may be a promising strategy to enhance MM CAR-T therapy. Platelet-activating factor Multiple myeloma CAR-T therapy Cytokine release syndrome LPCAT1 Diseases of the blood and blood-forming organs Neoplasms. Tumors. Oncology. Including cancer and carcinogens Liqing Kang verfasserin aut Ling Wang verfasserin aut Shu Yang verfasserin aut Yajun Wang verfasserin aut Haiyan Liu verfasserin aut Chunyan Gu verfasserin aut Hongming Huang verfasserin aut Ye Yang verfasserin aut In Journal of Hematology & Oncology BMC, 2008 14(2021), 1, Seite 6 (DE-627)568914813 (DE-600)2429631-4 17568722 nnns volume:14 year:2021 number:1 pages:6 https://doi.org/10.1186/s13045-021-01101-6 kostenfrei https://doaj.org/article/094fff3e045e40109a749fc72c3c2656 kostenfrei https://doi.org/10.1186/s13045-021-01101-6 kostenfrei https://doaj.org/toc/1756-8722 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2021 1 6
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callnumber-first	R - Medicine
author	Mengying Ke
spellingShingle	Mengying Ke misc RC633-647.5 misc RC254-282 misc Platelet-activating factor misc Multiple myeloma misc CAR-T therapy misc Cytokine release syndrome misc LPCAT1 misc Diseases of the blood and blood-forming organs misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients
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topic_title	RC633-647.5 RC254-282 CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients Platelet-activating factor Multiple myeloma CAR-T therapy Cytokine release syndrome LPCAT1
topic	misc RC633-647.5 misc RC254-282 misc Platelet-activating factor misc Multiple myeloma misc CAR-T therapy misc Cytokine release syndrome misc LPCAT1 misc Diseases of the blood and blood-forming organs misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC633-647.5 misc RC254-282 misc Platelet-activating factor misc Multiple myeloma misc CAR-T therapy misc Cytokine release syndrome misc LPCAT1 misc Diseases of the blood and blood-forming organs misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC633-647.5 misc RC254-282 misc Platelet-activating factor misc Multiple myeloma misc CAR-T therapy misc Cytokine release syndrome misc LPCAT1 misc Diseases of the blood and blood-forming organs misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients
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title_full	CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients
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author_browse	Mengying Ke Liqing Kang Ling Wang Shu Yang Yajun Wang Haiyan Liu Chunyan Gu Hongming Huang Ye Yang
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title_sort	car-t therapy alters synthesis of platelet-activating factor in multiple myeloma patients
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title_auth	CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients
abstract	Abstract The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years. However, cytokine release syndrome (CRS) and clinical efficacy have become the major obstacles which limit the application of CAR-T in clinics. To explore the potential biomarkers in plasma for evaluating CRS and clinical efficacy, we performed metabolomic and lipidomic profiling of plasma samples from 17 relapsed or refractory MM patients received CAR-T therapy. Our study showed that glycerophosphocholine (GPC), an intermediate of platelet-activating factor (PAF)-like molecule, was significantly decreased when the participants underwent CRS, and the remarkable elevation of lysophosphatidylcholines (lysoPCs), which were catalyzed by lysoPC acyltransferase (LPCAT) was a distinct metabolism signature of relapsed or refractory MM patients with prognostic value post-CAR-T therapy. Both GPC and lysoPC are involved in platelet-activating factor (PAF) remodeling pathway. Besides, these findings were validated by LPCAT1 expression, a key factor in the PAF pathway, associated with poor outcome in three MM GEP datasets of MM. In conclusion, CAR-T therapy alters PAF synthesis in MM patients, and targeting PAF remodeling may be a promising strategy to enhance MM CAR-T therapy.
abstractGer	Abstract The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years. However, cytokine release syndrome (CRS) and clinical efficacy have become the major obstacles which limit the application of CAR-T in clinics. To explore the potential biomarkers in plasma for evaluating CRS and clinical efficacy, we performed metabolomic and lipidomic profiling of plasma samples from 17 relapsed or refractory MM patients received CAR-T therapy. Our study showed that glycerophosphocholine (GPC), an intermediate of platelet-activating factor (PAF)-like molecule, was significantly decreased when the participants underwent CRS, and the remarkable elevation of lysophosphatidylcholines (lysoPCs), which were catalyzed by lysoPC acyltransferase (LPCAT) was a distinct metabolism signature of relapsed or refractory MM patients with prognostic value post-CAR-T therapy. Both GPC and lysoPC are involved in platelet-activating factor (PAF) remodeling pathway. Besides, these findings were validated by LPCAT1 expression, a key factor in the PAF pathway, associated with poor outcome in three MM GEP datasets of MM. In conclusion, CAR-T therapy alters PAF synthesis in MM patients, and targeting PAF remodeling may be a promising strategy to enhance MM CAR-T therapy.
abstract_unstemmed	Abstract The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years. However, cytokine release syndrome (CRS) and clinical efficacy have become the major obstacles which limit the application of CAR-T in clinics. To explore the potential biomarkers in plasma for evaluating CRS and clinical efficacy, we performed metabolomic and lipidomic profiling of plasma samples from 17 relapsed or refractory MM patients received CAR-T therapy. Our study showed that glycerophosphocholine (GPC), an intermediate of platelet-activating factor (PAF)-like molecule, was significantly decreased when the participants underwent CRS, and the remarkable elevation of lysophosphatidylcholines (lysoPCs), which were catalyzed by lysoPC acyltransferase (LPCAT) was a distinct metabolism signature of relapsed or refractory MM patients with prognostic value post-CAR-T therapy. Both GPC and lysoPC are involved in platelet-activating factor (PAF) remodeling pathway. Besides, these findings were validated by LPCAT1 expression, a key factor in the PAF pathway, associated with poor outcome in three MM GEP datasets of MM. In conclusion, CAR-T therapy alters PAF synthesis in MM patients, and targeting PAF remodeling may be a promising strategy to enhance MM CAR-T therapy.
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title_short	CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients
url	https://doi.org/10.1186/s13045-021-01101-6 https://doaj.org/article/094fff3e045e40109a749fc72c3c2656 https://doaj.org/toc/1756-8722
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author2	Liqing Kang Ling Wang Shu Yang Yajun Wang Haiyan Liu Chunyan Gu Hongming Huang Ye Yang
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up_date	2024-07-03T17:50:43.480Z
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Besides, these findings were validated by LPCAT1 expression, a key factor in the PAF pathway, associated with poor outcome in three MM GEP datasets of MM. 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CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients

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