Early Auditory Event Related Potentials Distinguish Higher-Order From First-Order Aversive Conditioning

Stimuli in reality rarely co-occur with primary reward or punishment to allow direct associative learning of value. Instead, value is thought to be inferred through complex higher-order associations. Rodent research has demonstrated that the formation and maintenance of first-order and higher-order...
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Gespeichert in:

Autor*in:	Prateek Dhamija [verfasserIn] Allison Wong [verfasserIn] Asaf Gilboa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	EEG ventromedial prefrontal cortex (vmPFC) second-order conditioning value learning model-based choice

Übergeordnetes Werk:	In: Frontiers in Behavioral Neuroscience - Frontiers Media S.A., 2008, 16(2022)
Übergeordnetes Werk:	volume:16 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnbeh.2022.751274

Katalog-ID:	DOAJ00341969X

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callnumber-first	R - Medicine
author	Prateek Dhamija
spellingShingle	Prateek Dhamija misc RC321-571 misc EEG misc ventromedial prefrontal cortex (vmPFC) misc second-order conditioning misc value misc learning misc model-based choice misc Neurosciences. Biological psychiatry. Neuropsychiatry Early Auditory Event Related Potentials Distinguish Higher-Order From First-Order Aversive Conditioning
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topic_title	RC321-571 Early Auditory Event Related Potentials Distinguish Higher-Order From First-Order Aversive Conditioning EEG ventromedial prefrontal cortex (vmPFC) second-order conditioning value learning model-based choice
topic	misc RC321-571 misc EEG misc ventromedial prefrontal cortex (vmPFC) misc second-order conditioning misc value misc learning misc model-based choice misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc EEG misc ventromedial prefrontal cortex (vmPFC) misc second-order conditioning misc value misc learning misc model-based choice misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Early Auditory Event Related Potentials Distinguish Higher-Order From First-Order Aversive Conditioning
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title_full	Early Auditory Event Related Potentials Distinguish Higher-Order From First-Order Aversive Conditioning
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title_sort	early auditory event related potentials distinguish higher-order from first-order aversive conditioning
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title_auth	Early Auditory Event Related Potentials Distinguish Higher-Order From First-Order Aversive Conditioning
abstract	Stimuli in reality rarely co-occur with primary reward or punishment to allow direct associative learning of value. Instead, value is thought to be inferred through complex higher-order associations. Rodent research has demonstrated that the formation and maintenance of first-order and higher-order associations are supported by distinct neural substrates. In this study, we explored whether this pattern of findings held true for humans. Participants underwent first-order and subsequent higher-order conditioning using an aversive burst of white noise or neutral tone as the unconditioned stimuli. Four distinct tones, initially neutral, served as first-order and higher-order conditioned stimuli. Autonomic and neural responses were indexed by pupillometry and evoked response potentials (ERPs) respectively. Conditioned aversive values of first-order and higher-order stimuli led to increased autonomic responses, as indexed by pupil dilation. Distinct temporo-spatial auditory evoked response potentials were elicited by first-order and high-order conditioned stimuli. Conditioned first-order responses peaked around 260 ms and source estimation suggested a primary medial prefrontal and amygdala source. Conversely, conditioned higher-order responses peaked around 120 ms with an estimated source in the medial temporal lobe. Interestingly, pupillometry responses to first-order conditioned stimuli were diminished after higher order training, possibly signifying concomitant incidental extinction, while responses to higher-order stimuli remained. This suggests that once formed, higher order associations are at least partially independent of first order conditioned representations. This experiment demonstrates that first-order and higher-order conditioned associations have distinct neural signatures, and like rodents, the medial temporal lobe may be specifically involved with higher-order conditioning.
abstractGer	Stimuli in reality rarely co-occur with primary reward or punishment to allow direct associative learning of value. Instead, value is thought to be inferred through complex higher-order associations. Rodent research has demonstrated that the formation and maintenance of first-order and higher-order associations are supported by distinct neural substrates. In this study, we explored whether this pattern of findings held true for humans. Participants underwent first-order and subsequent higher-order conditioning using an aversive burst of white noise or neutral tone as the unconditioned stimuli. Four distinct tones, initially neutral, served as first-order and higher-order conditioned stimuli. Autonomic and neural responses were indexed by pupillometry and evoked response potentials (ERPs) respectively. Conditioned aversive values of first-order and higher-order stimuli led to increased autonomic responses, as indexed by pupil dilation. Distinct temporo-spatial auditory evoked response potentials were elicited by first-order and high-order conditioned stimuli. Conditioned first-order responses peaked around 260 ms and source estimation suggested a primary medial prefrontal and amygdala source. Conversely, conditioned higher-order responses peaked around 120 ms with an estimated source in the medial temporal lobe. Interestingly, pupillometry responses to first-order conditioned stimuli were diminished after higher order training, possibly signifying concomitant incidental extinction, while responses to higher-order stimuli remained. This suggests that once formed, higher order associations are at least partially independent of first order conditioned representations. This experiment demonstrates that first-order and higher-order conditioned associations have distinct neural signatures, and like rodents, the medial temporal lobe may be specifically involved with higher-order conditioning.
abstract_unstemmed	Stimuli in reality rarely co-occur with primary reward or punishment to allow direct associative learning of value. Instead, value is thought to be inferred through complex higher-order associations. Rodent research has demonstrated that the formation and maintenance of first-order and higher-order associations are supported by distinct neural substrates. In this study, we explored whether this pattern of findings held true for humans. Participants underwent first-order and subsequent higher-order conditioning using an aversive burst of white noise or neutral tone as the unconditioned stimuli. Four distinct tones, initially neutral, served as first-order and higher-order conditioned stimuli. Autonomic and neural responses were indexed by pupillometry and evoked response potentials (ERPs) respectively. Conditioned aversive values of first-order and higher-order stimuli led to increased autonomic responses, as indexed by pupil dilation. Distinct temporo-spatial auditory evoked response potentials were elicited by first-order and high-order conditioned stimuli. Conditioned first-order responses peaked around 260 ms and source estimation suggested a primary medial prefrontal and amygdala source. Conversely, conditioned higher-order responses peaked around 120 ms with an estimated source in the medial temporal lobe. Interestingly, pupillometry responses to first-order conditioned stimuli were diminished after higher order training, possibly signifying concomitant incidental extinction, while responses to higher-order stimuli remained. This suggests that once formed, higher order associations are at least partially independent of first order conditioned representations. This experiment demonstrates that first-order and higher-order conditioned associations have distinct neural signatures, and like rodents, the medial temporal lobe may be specifically involved with higher-order conditioning.
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title_short	Early Auditory Event Related Potentials Distinguish Higher-Order From First-Order Aversive Conditioning
url	https://doi.org/10.3389/fnbeh.2022.751274 https://doaj.org/article/36bee62af7ab4e3581b00d1488d7e711 https://www.frontiersin.org/articles/10.3389/fnbeh.2022.751274/full https://doaj.org/toc/1662-5153
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up_date	2024-07-03T17:53:37.105Z
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Early Auditory Event Related Potentials Distinguish Higher-Order From First-Order Aversive Conditioning

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