Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa
Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex. Engl. (Bignoniaceae) is reported to possess antioxidant, anti-inflammatory and anticancer activities. Objective: The antifungal and antiproliferative properties of endophytic fungi extracts and fra...
Ausführliche Beschreibung
Autor*in: |
Mutiat Ibrahim [verfasserIn] Nutan Kaushik [verfasserIn] Abimbola Sowemimo [verfasserIn] Hemraj Chhipa [verfasserIn] Trevor Koekemoer [verfasserIn] Maryna van de Venter [verfasserIn] Olukemi A. Odukoya [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2017 |
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In: Pharmaceutical Biology - Taylor & Francis Group, 2017, 55(2017), 1, Seite 590-595 |
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Übergeordnetes Werk: |
volume:55 ; year:2017 ; number:1 ; pages:590-595 |
Links: |
Link aufrufen |
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DOI / URN: |
10.1080/13880209.2016.1263671 |
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Katalog-ID: |
DOAJ003456285 |
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520 | |a Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex. Engl. (Bignoniaceae) is reported to possess antioxidant, anti-inflammatory and anticancer activities. Objective: The antifungal and antiproliferative properties of endophytic fungi extracts and fractions from M. tomentosa were evaluated. Material and methods: Endophytic fungi were isolated from the leaves of M. tomentosa and identified by ITS-rDNA sequence analysis. The antagonistic effect of the fungal strains was investigated against pathogenic fungi viz, Fusarium oxysporum, Sclerotinia sclerotiorium, Rhizoctonia solani, and Botrytis cinerea using the dual culture assay for 5–7 days. Antiproliferative effect of the fungal extracts and fractions (3.91–250 μg/mL) on HeLa cancer cell line was tested and IC50 was calculated. Poisoning food assay and antifeedant activity against the pathogenic fungi and Spodoptera litura larvae, for 7 days and 2 h, respectively, was also tested at concentrations of 250, 500 and 1000 μg/mL. Results: Fungal endophytes Trichoderma longibrachiatum and Syncephalastrum racemosum were isolated from the leaves of M. tomentosa. Isolated endophytic fungal strains and solvent extracts showed MIC value of 1000 μg/mL against tested pathogenic fungi in the dual culture and poisoning food assays. Methanol fraction of S. racemosum isolate showed the most effective antiproliferative activity with IC50 of 43.56 μg/mL. Minimal feeding deterrent activity against S. litura larvae was also observed. Discussion and conclusion: These findings showed that the leaves of Markhamia tomentosa harbor strains of endophytic fungi with promising health benefits, and suggest their antifungal and antiproliferative effects against pathogenic fungi and HeLa cancer cell line. | ||
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700 | 0 | |a Olukemi A. Odukoya |e verfasserin |4 aut | |
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10.1080/13880209.2016.1263671 doi (DE-627)DOAJ003456285 (DE-599)DOAJadfe640f311d4eb98a892b7d93a22c90 DE-627 ger DE-627 rakwb eng RM1-950 Mutiat Ibrahim verfasserin aut Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex. Engl. (Bignoniaceae) is reported to possess antioxidant, anti-inflammatory and anticancer activities. Objective: The antifungal and antiproliferative properties of endophytic fungi extracts and fractions from M. tomentosa were evaluated. Material and methods: Endophytic fungi were isolated from the leaves of M. tomentosa and identified by ITS-rDNA sequence analysis. The antagonistic effect of the fungal strains was investigated against pathogenic fungi viz, Fusarium oxysporum, Sclerotinia sclerotiorium, Rhizoctonia solani, and Botrytis cinerea using the dual culture assay for 5–7 days. Antiproliferative effect of the fungal extracts and fractions (3.91–250 μg/mL) on HeLa cancer cell line was tested and IC50 was calculated. Poisoning food assay and antifeedant activity against the pathogenic fungi and Spodoptera litura larvae, for 7 days and 2 h, respectively, was also tested at concentrations of 250, 500 and 1000 μg/mL. Results: Fungal endophytes Trichoderma longibrachiatum and Syncephalastrum racemosum were isolated from the leaves of M. tomentosa. Isolated endophytic fungal strains and solvent extracts showed MIC value of 1000 μg/mL against tested pathogenic fungi in the dual culture and poisoning food assays. Methanol fraction of S. racemosum isolate showed the most effective antiproliferative activity with IC50 of 43.56 μg/mL. Minimal feeding deterrent activity against S. litura larvae was also observed. Discussion and conclusion: These findings showed that the leaves of Markhamia tomentosa harbor strains of endophytic fungi with promising health benefits, and suggest their antifungal and antiproliferative effects against pathogenic fungi and HeLa cancer cell line. trichoderma longibrachiatum syncephalastrum racemosum pathogenic fungi hela cancer cell line spodoptera litura larvae Therapeutics. Pharmacology Nutan Kaushik verfasserin aut Abimbola Sowemimo verfasserin aut Hemraj Chhipa verfasserin aut Trevor Koekemoer verfasserin aut Maryna van de Venter verfasserin aut Olukemi A. Odukoya verfasserin aut In Pharmaceutical Biology Taylor & Francis Group, 2017 55(2017), 1, Seite 590-595 (DE-627)300595905 (DE-600)1483151-X 17445116 nnns volume:55 year:2017 number:1 pages:590-595 https://doi.org/10.1080/13880209.2016.1263671 kostenfrei https://doaj.org/article/adfe640f311d4eb98a892b7d93a22c90 kostenfrei http://dx.doi.org/10.1080/13880209.2016.1263671 kostenfrei https://doaj.org/toc/1388-0209 Journal toc kostenfrei https://doaj.org/toc/1744-5116 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2017 1 590-595 |
spelling |
10.1080/13880209.2016.1263671 doi (DE-627)DOAJ003456285 (DE-599)DOAJadfe640f311d4eb98a892b7d93a22c90 DE-627 ger DE-627 rakwb eng RM1-950 Mutiat Ibrahim verfasserin aut Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex. Engl. (Bignoniaceae) is reported to possess antioxidant, anti-inflammatory and anticancer activities. Objective: The antifungal and antiproliferative properties of endophytic fungi extracts and fractions from M. tomentosa were evaluated. Material and methods: Endophytic fungi were isolated from the leaves of M. tomentosa and identified by ITS-rDNA sequence analysis. The antagonistic effect of the fungal strains was investigated against pathogenic fungi viz, Fusarium oxysporum, Sclerotinia sclerotiorium, Rhizoctonia solani, and Botrytis cinerea using the dual culture assay for 5–7 days. Antiproliferative effect of the fungal extracts and fractions (3.91–250 μg/mL) on HeLa cancer cell line was tested and IC50 was calculated. Poisoning food assay and antifeedant activity against the pathogenic fungi and Spodoptera litura larvae, for 7 days and 2 h, respectively, was also tested at concentrations of 250, 500 and 1000 μg/mL. Results: Fungal endophytes Trichoderma longibrachiatum and Syncephalastrum racemosum were isolated from the leaves of M. tomentosa. Isolated endophytic fungal strains and solvent extracts showed MIC value of 1000 μg/mL against tested pathogenic fungi in the dual culture and poisoning food assays. Methanol fraction of S. racemosum isolate showed the most effective antiproliferative activity with IC50 of 43.56 μg/mL. Minimal feeding deterrent activity against S. litura larvae was also observed. Discussion and conclusion: These findings showed that the leaves of Markhamia tomentosa harbor strains of endophytic fungi with promising health benefits, and suggest their antifungal and antiproliferative effects against pathogenic fungi and HeLa cancer cell line. trichoderma longibrachiatum syncephalastrum racemosum pathogenic fungi hela cancer cell line spodoptera litura larvae Therapeutics. Pharmacology Nutan Kaushik verfasserin aut Abimbola Sowemimo verfasserin aut Hemraj Chhipa verfasserin aut Trevor Koekemoer verfasserin aut Maryna van de Venter verfasserin aut Olukemi A. Odukoya verfasserin aut In Pharmaceutical Biology Taylor & Francis Group, 2017 55(2017), 1, Seite 590-595 (DE-627)300595905 (DE-600)1483151-X 17445116 nnns volume:55 year:2017 number:1 pages:590-595 https://doi.org/10.1080/13880209.2016.1263671 kostenfrei https://doaj.org/article/adfe640f311d4eb98a892b7d93a22c90 kostenfrei http://dx.doi.org/10.1080/13880209.2016.1263671 kostenfrei https://doaj.org/toc/1388-0209 Journal toc kostenfrei https://doaj.org/toc/1744-5116 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2017 1 590-595 |
allfields_unstemmed |
10.1080/13880209.2016.1263671 doi (DE-627)DOAJ003456285 (DE-599)DOAJadfe640f311d4eb98a892b7d93a22c90 DE-627 ger DE-627 rakwb eng RM1-950 Mutiat Ibrahim verfasserin aut Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex. Engl. (Bignoniaceae) is reported to possess antioxidant, anti-inflammatory and anticancer activities. Objective: The antifungal and antiproliferative properties of endophytic fungi extracts and fractions from M. tomentosa were evaluated. Material and methods: Endophytic fungi were isolated from the leaves of M. tomentosa and identified by ITS-rDNA sequence analysis. The antagonistic effect of the fungal strains was investigated against pathogenic fungi viz, Fusarium oxysporum, Sclerotinia sclerotiorium, Rhizoctonia solani, and Botrytis cinerea using the dual culture assay for 5–7 days. Antiproliferative effect of the fungal extracts and fractions (3.91–250 μg/mL) on HeLa cancer cell line was tested and IC50 was calculated. Poisoning food assay and antifeedant activity against the pathogenic fungi and Spodoptera litura larvae, for 7 days and 2 h, respectively, was also tested at concentrations of 250, 500 and 1000 μg/mL. Results: Fungal endophytes Trichoderma longibrachiatum and Syncephalastrum racemosum were isolated from the leaves of M. tomentosa. Isolated endophytic fungal strains and solvent extracts showed MIC value of 1000 μg/mL against tested pathogenic fungi in the dual culture and poisoning food assays. Methanol fraction of S. racemosum isolate showed the most effective antiproliferative activity with IC50 of 43.56 μg/mL. Minimal feeding deterrent activity against S. litura larvae was also observed. Discussion and conclusion: These findings showed that the leaves of Markhamia tomentosa harbor strains of endophytic fungi with promising health benefits, and suggest their antifungal and antiproliferative effects against pathogenic fungi and HeLa cancer cell line. trichoderma longibrachiatum syncephalastrum racemosum pathogenic fungi hela cancer cell line spodoptera litura larvae Therapeutics. Pharmacology Nutan Kaushik verfasserin aut Abimbola Sowemimo verfasserin aut Hemraj Chhipa verfasserin aut Trevor Koekemoer verfasserin aut Maryna van de Venter verfasserin aut Olukemi A. Odukoya verfasserin aut In Pharmaceutical Biology Taylor & Francis Group, 2017 55(2017), 1, Seite 590-595 (DE-627)300595905 (DE-600)1483151-X 17445116 nnns volume:55 year:2017 number:1 pages:590-595 https://doi.org/10.1080/13880209.2016.1263671 kostenfrei https://doaj.org/article/adfe640f311d4eb98a892b7d93a22c90 kostenfrei http://dx.doi.org/10.1080/13880209.2016.1263671 kostenfrei https://doaj.org/toc/1388-0209 Journal toc kostenfrei https://doaj.org/toc/1744-5116 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2017 1 590-595 |
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10.1080/13880209.2016.1263671 doi (DE-627)DOAJ003456285 (DE-599)DOAJadfe640f311d4eb98a892b7d93a22c90 DE-627 ger DE-627 rakwb eng RM1-950 Mutiat Ibrahim verfasserin aut Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex. Engl. (Bignoniaceae) is reported to possess antioxidant, anti-inflammatory and anticancer activities. Objective: The antifungal and antiproliferative properties of endophytic fungi extracts and fractions from M. tomentosa were evaluated. Material and methods: Endophytic fungi were isolated from the leaves of M. tomentosa and identified by ITS-rDNA sequence analysis. The antagonistic effect of the fungal strains was investigated against pathogenic fungi viz, Fusarium oxysporum, Sclerotinia sclerotiorium, Rhizoctonia solani, and Botrytis cinerea using the dual culture assay for 5–7 days. Antiproliferative effect of the fungal extracts and fractions (3.91–250 μg/mL) on HeLa cancer cell line was tested and IC50 was calculated. Poisoning food assay and antifeedant activity against the pathogenic fungi and Spodoptera litura larvae, for 7 days and 2 h, respectively, was also tested at concentrations of 250, 500 and 1000 μg/mL. Results: Fungal endophytes Trichoderma longibrachiatum and Syncephalastrum racemosum were isolated from the leaves of M. tomentosa. Isolated endophytic fungal strains and solvent extracts showed MIC value of 1000 μg/mL against tested pathogenic fungi in the dual culture and poisoning food assays. Methanol fraction of S. racemosum isolate showed the most effective antiproliferative activity with IC50 of 43.56 μg/mL. Minimal feeding deterrent activity against S. litura larvae was also observed. Discussion and conclusion: These findings showed that the leaves of Markhamia tomentosa harbor strains of endophytic fungi with promising health benefits, and suggest their antifungal and antiproliferative effects against pathogenic fungi and HeLa cancer cell line. trichoderma longibrachiatum syncephalastrum racemosum pathogenic fungi hela cancer cell line spodoptera litura larvae Therapeutics. Pharmacology Nutan Kaushik verfasserin aut Abimbola Sowemimo verfasserin aut Hemraj Chhipa verfasserin aut Trevor Koekemoer verfasserin aut Maryna van de Venter verfasserin aut Olukemi A. Odukoya verfasserin aut In Pharmaceutical Biology Taylor & Francis Group, 2017 55(2017), 1, Seite 590-595 (DE-627)300595905 (DE-600)1483151-X 17445116 nnns volume:55 year:2017 number:1 pages:590-595 https://doi.org/10.1080/13880209.2016.1263671 kostenfrei https://doaj.org/article/adfe640f311d4eb98a892b7d93a22c90 kostenfrei http://dx.doi.org/10.1080/13880209.2016.1263671 kostenfrei https://doaj.org/toc/1388-0209 Journal toc kostenfrei https://doaj.org/toc/1744-5116 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2017 1 590-595 |
allfieldsSound |
10.1080/13880209.2016.1263671 doi (DE-627)DOAJ003456285 (DE-599)DOAJadfe640f311d4eb98a892b7d93a22c90 DE-627 ger DE-627 rakwb eng RM1-950 Mutiat Ibrahim verfasserin aut Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex. Engl. (Bignoniaceae) is reported to possess antioxidant, anti-inflammatory and anticancer activities. Objective: The antifungal and antiproliferative properties of endophytic fungi extracts and fractions from M. tomentosa were evaluated. Material and methods: Endophytic fungi were isolated from the leaves of M. tomentosa and identified by ITS-rDNA sequence analysis. The antagonistic effect of the fungal strains was investigated against pathogenic fungi viz, Fusarium oxysporum, Sclerotinia sclerotiorium, Rhizoctonia solani, and Botrytis cinerea using the dual culture assay for 5–7 days. Antiproliferative effect of the fungal extracts and fractions (3.91–250 μg/mL) on HeLa cancer cell line was tested and IC50 was calculated. Poisoning food assay and antifeedant activity against the pathogenic fungi and Spodoptera litura larvae, for 7 days and 2 h, respectively, was also tested at concentrations of 250, 500 and 1000 μg/mL. Results: Fungal endophytes Trichoderma longibrachiatum and Syncephalastrum racemosum were isolated from the leaves of M. tomentosa. Isolated endophytic fungal strains and solvent extracts showed MIC value of 1000 μg/mL against tested pathogenic fungi in the dual culture and poisoning food assays. Methanol fraction of S. racemosum isolate showed the most effective antiproliferative activity with IC50 of 43.56 μg/mL. Minimal feeding deterrent activity against S. litura larvae was also observed. Discussion and conclusion: These findings showed that the leaves of Markhamia tomentosa harbor strains of endophytic fungi with promising health benefits, and suggest their antifungal and antiproliferative effects against pathogenic fungi and HeLa cancer cell line. trichoderma longibrachiatum syncephalastrum racemosum pathogenic fungi hela cancer cell line spodoptera litura larvae Therapeutics. Pharmacology Nutan Kaushik verfasserin aut Abimbola Sowemimo verfasserin aut Hemraj Chhipa verfasserin aut Trevor Koekemoer verfasserin aut Maryna van de Venter verfasserin aut Olukemi A. Odukoya verfasserin aut In Pharmaceutical Biology Taylor & Francis Group, 2017 55(2017), 1, Seite 590-595 (DE-627)300595905 (DE-600)1483151-X 17445116 nnns volume:55 year:2017 number:1 pages:590-595 https://doi.org/10.1080/13880209.2016.1263671 kostenfrei https://doaj.org/article/adfe640f311d4eb98a892b7d93a22c90 kostenfrei http://dx.doi.org/10.1080/13880209.2016.1263671 kostenfrei https://doaj.org/toc/1388-0209 Journal toc kostenfrei https://doaj.org/toc/1744-5116 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2017 1 590-595 |
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Mutiat Ibrahim misc RM1-950 misc trichoderma longibrachiatum misc syncephalastrum racemosum misc pathogenic fungi misc hela cancer cell line misc spodoptera litura larvae misc Therapeutics. Pharmacology Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa |
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RM1-950 Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa trichoderma longibrachiatum syncephalastrum racemosum pathogenic fungi hela cancer cell line spodoptera litura larvae |
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Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa |
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Mutiat Ibrahim Nutan Kaushik Abimbola Sowemimo Hemraj Chhipa Trevor Koekemoer Maryna van de Venter Olukemi A. Odukoya |
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antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of markhamia tomentosa |
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Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa |
abstract |
Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex. Engl. (Bignoniaceae) is reported to possess antioxidant, anti-inflammatory and anticancer activities. Objective: The antifungal and antiproliferative properties of endophytic fungi extracts and fractions from M. tomentosa were evaluated. Material and methods: Endophytic fungi were isolated from the leaves of M. tomentosa and identified by ITS-rDNA sequence analysis. The antagonistic effect of the fungal strains was investigated against pathogenic fungi viz, Fusarium oxysporum, Sclerotinia sclerotiorium, Rhizoctonia solani, and Botrytis cinerea using the dual culture assay for 5–7 days. Antiproliferative effect of the fungal extracts and fractions (3.91–250 μg/mL) on HeLa cancer cell line was tested and IC50 was calculated. Poisoning food assay and antifeedant activity against the pathogenic fungi and Spodoptera litura larvae, for 7 days and 2 h, respectively, was also tested at concentrations of 250, 500 and 1000 μg/mL. Results: Fungal endophytes Trichoderma longibrachiatum and Syncephalastrum racemosum were isolated from the leaves of M. tomentosa. Isolated endophytic fungal strains and solvent extracts showed MIC value of 1000 μg/mL against tested pathogenic fungi in the dual culture and poisoning food assays. Methanol fraction of S. racemosum isolate showed the most effective antiproliferative activity with IC50 of 43.56 μg/mL. Minimal feeding deterrent activity against S. litura larvae was also observed. Discussion and conclusion: These findings showed that the leaves of Markhamia tomentosa harbor strains of endophytic fungi with promising health benefits, and suggest their antifungal and antiproliferative effects against pathogenic fungi and HeLa cancer cell line. |
abstractGer |
Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex. Engl. (Bignoniaceae) is reported to possess antioxidant, anti-inflammatory and anticancer activities. Objective: The antifungal and antiproliferative properties of endophytic fungi extracts and fractions from M. tomentosa were evaluated. Material and methods: Endophytic fungi were isolated from the leaves of M. tomentosa and identified by ITS-rDNA sequence analysis. The antagonistic effect of the fungal strains was investigated against pathogenic fungi viz, Fusarium oxysporum, Sclerotinia sclerotiorium, Rhizoctonia solani, and Botrytis cinerea using the dual culture assay for 5–7 days. Antiproliferative effect of the fungal extracts and fractions (3.91–250 μg/mL) on HeLa cancer cell line was tested and IC50 was calculated. Poisoning food assay and antifeedant activity against the pathogenic fungi and Spodoptera litura larvae, for 7 days and 2 h, respectively, was also tested at concentrations of 250, 500 and 1000 μg/mL. Results: Fungal endophytes Trichoderma longibrachiatum and Syncephalastrum racemosum were isolated from the leaves of M. tomentosa. Isolated endophytic fungal strains and solvent extracts showed MIC value of 1000 μg/mL against tested pathogenic fungi in the dual culture and poisoning food assays. Methanol fraction of S. racemosum isolate showed the most effective antiproliferative activity with IC50 of 43.56 μg/mL. Minimal feeding deterrent activity against S. litura larvae was also observed. Discussion and conclusion: These findings showed that the leaves of Markhamia tomentosa harbor strains of endophytic fungi with promising health benefits, and suggest their antifungal and antiproliferative effects against pathogenic fungi and HeLa cancer cell line. |
abstract_unstemmed |
Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex. Engl. (Bignoniaceae) is reported to possess antioxidant, anti-inflammatory and anticancer activities. Objective: The antifungal and antiproliferative properties of endophytic fungi extracts and fractions from M. tomentosa were evaluated. Material and methods: Endophytic fungi were isolated from the leaves of M. tomentosa and identified by ITS-rDNA sequence analysis. The antagonistic effect of the fungal strains was investigated against pathogenic fungi viz, Fusarium oxysporum, Sclerotinia sclerotiorium, Rhizoctonia solani, and Botrytis cinerea using the dual culture assay for 5–7 days. Antiproliferative effect of the fungal extracts and fractions (3.91–250 μg/mL) on HeLa cancer cell line was tested and IC50 was calculated. Poisoning food assay and antifeedant activity against the pathogenic fungi and Spodoptera litura larvae, for 7 days and 2 h, respectively, was also tested at concentrations of 250, 500 and 1000 μg/mL. Results: Fungal endophytes Trichoderma longibrachiatum and Syncephalastrum racemosum were isolated from the leaves of M. tomentosa. Isolated endophytic fungal strains and solvent extracts showed MIC value of 1000 μg/mL against tested pathogenic fungi in the dual culture and poisoning food assays. Methanol fraction of S. racemosum isolate showed the most effective antiproliferative activity with IC50 of 43.56 μg/mL. Minimal feeding deterrent activity against S. litura larvae was also observed. Discussion and conclusion: These findings showed that the leaves of Markhamia tomentosa harbor strains of endophytic fungi with promising health benefits, and suggest their antifungal and antiproliferative effects against pathogenic fungi and HeLa cancer cell line. |
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Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa |
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https://doi.org/10.1080/13880209.2016.1263671 https://doaj.org/article/adfe640f311d4eb98a892b7d93a22c90 http://dx.doi.org/10.1080/13880209.2016.1263671 https://doaj.org/toc/1388-0209 https://doaj.org/toc/1744-5116 |
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