Prospects for Comprehensive Analyses of Circulating Tumor Cells in Tumor Biology

The comprehensive analysis of biological and clinical aspects of circulating tumor cells (CTCs) has attracted interest as a means of enabling non-invasive, real-time monitoring of cancer patients and enhancing our fundamental understanding of tumor metastasis. However, CTC populations are extremely...
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Autor*in:	Masahiko Aoki [verfasserIn] Hirokazu Shoji [verfasserIn] Ayumi Kashiro [verfasserIn] Keiko Takeuchi [verfasserIn] Yoshihiro Shimizu [verfasserIn] Kazufumi Honda [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	circulating tumor cells (CTCs) circulating tumor dna (ctDNA) genomics metabolomics heterogeneity single cell

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 12(2020), 5, p 1135
Übergeordnetes Werk:	volume:12 ; year:2020 ; number:5, p 1135

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers12051135

Katalog-ID:	DOAJ003551830

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language	English
source	In Cancers 12(2020), 5, p 1135 volume:12 year:2020 number:5, p 1135
sourceStr	In Cancers 12(2020), 5, p 1135 volume:12 year:2020 number:5, p 1135
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topic_facet	circulating tumor cells (CTCs) circulating tumor dna (ctDNA) genomics metabolomics heterogeneity single cell Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancers
authorswithroles_txt_mv	Masahiko Aoki @@aut@@ Hirokazu Shoji @@aut@@ Ayumi Kashiro @@aut@@ Keiko Takeuchi @@aut@@ Yoshihiro Shimizu @@aut@@ Kazufumi Honda @@aut@@
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callnumber-first	R - Medicine
author	Masahiko Aoki
spellingShingle	Masahiko Aoki misc RC254-282 misc circulating tumor cells (CTCs) misc circulating tumor dna (ctDNA) misc genomics misc metabolomics misc heterogeneity misc single cell misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prospects for Comprehensive Analyses of Circulating Tumor Cells in Tumor Biology
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topic_title	RC254-282 Prospects for Comprehensive Analyses of Circulating Tumor Cells in Tumor Biology circulating tumor cells (CTCs) circulating tumor dna (ctDNA) genomics metabolomics heterogeneity single cell
topic	misc RC254-282 misc circulating tumor cells (CTCs) misc circulating tumor dna (ctDNA) misc genomics misc metabolomics misc heterogeneity misc single cell misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc circulating tumor cells (CTCs) misc circulating tumor dna (ctDNA) misc genomics misc metabolomics misc heterogeneity misc single cell misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Prospects for Comprehensive Analyses of Circulating Tumor Cells in Tumor Biology
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title_full	Prospects for Comprehensive Analyses of Circulating Tumor Cells in Tumor Biology
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author_browse	Masahiko Aoki Hirokazu Shoji Ayumi Kashiro Keiko Takeuchi Yoshihiro Shimizu Kazufumi Honda
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title_sort	prospects for comprehensive analyses of circulating tumor cells in tumor biology
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title_auth	Prospects for Comprehensive Analyses of Circulating Tumor Cells in Tumor Biology
abstract	The comprehensive analysis of biological and clinical aspects of circulating tumor cells (CTCs) has attracted interest as a means of enabling non-invasive, real-time monitoring of cancer patients and enhancing our fundamental understanding of tumor metastasis. However, CTC populations are extremely small when compared to other cell populations in the blood, limiting our comprehension of CTC biology and their clinical utility. Recently developed proteomic and genomic techniques that require only a small amount of sample have attracted much interest and expanded the potential utility of CTCs. Cancer heterogeneity, including specific mutations, greatly impacts disease diagnosis and the choice of available therapeutic strategies. The CTC population consists primarily of cancer stem cells, and CTC subpopulations are thought to undergo epithelial–mesenchymal transition during dissemination. To better characterize tumor cell populations, we demonstrated that changes in genomic profiles identified via next-generation sequencing of liquid biopsy samples could be expanded upon to increase sensitivity without decreasing specificity by using a combination of assays with CTCs and circulating tumor DNA. To enhance our understanding of CTC biology, we developed a metabolome analysis method applicable to single CTCs. Here, we review―omics studies related to CTC analysis and discuss various clinical and biological issues related to CTCs.
abstractGer	The comprehensive analysis of biological and clinical aspects of circulating tumor cells (CTCs) has attracted interest as a means of enabling non-invasive, real-time monitoring of cancer patients and enhancing our fundamental understanding of tumor metastasis. However, CTC populations are extremely small when compared to other cell populations in the blood, limiting our comprehension of CTC biology and their clinical utility. Recently developed proteomic and genomic techniques that require only a small amount of sample have attracted much interest and expanded the potential utility of CTCs. Cancer heterogeneity, including specific mutations, greatly impacts disease diagnosis and the choice of available therapeutic strategies. The CTC population consists primarily of cancer stem cells, and CTC subpopulations are thought to undergo epithelial–mesenchymal transition during dissemination. To better characterize tumor cell populations, we demonstrated that changes in genomic profiles identified via next-generation sequencing of liquid biopsy samples could be expanded upon to increase sensitivity without decreasing specificity by using a combination of assays with CTCs and circulating tumor DNA. To enhance our understanding of CTC biology, we developed a metabolome analysis method applicable to single CTCs. Here, we review―omics studies related to CTC analysis and discuss various clinical and biological issues related to CTCs.
abstract_unstemmed	The comprehensive analysis of biological and clinical aspects of circulating tumor cells (CTCs) has attracted interest as a means of enabling non-invasive, real-time monitoring of cancer patients and enhancing our fundamental understanding of tumor metastasis. However, CTC populations are extremely small when compared to other cell populations in the blood, limiting our comprehension of CTC biology and their clinical utility. Recently developed proteomic and genomic techniques that require only a small amount of sample have attracted much interest and expanded the potential utility of CTCs. Cancer heterogeneity, including specific mutations, greatly impacts disease diagnosis and the choice of available therapeutic strategies. The CTC population consists primarily of cancer stem cells, and CTC subpopulations are thought to undergo epithelial–mesenchymal transition during dissemination. To better characterize tumor cell populations, we demonstrated that changes in genomic profiles identified via next-generation sequencing of liquid biopsy samples could be expanded upon to increase sensitivity without decreasing specificity by using a combination of assays with CTCs and circulating tumor DNA. To enhance our understanding of CTC biology, we developed a metabolome analysis method applicable to single CTCs. Here, we review―omics studies related to CTC analysis and discuss various clinical and biological issues related to CTCs.
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title_short	Prospects for Comprehensive Analyses of Circulating Tumor Cells in Tumor Biology
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