Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis
Summary: Background: Burkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission...
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| Autor*in: |
Philip L Bulterys, PhD [verfasserIn] Michelle A Bulterys, BA [verfasserIn] Koukeo Phommasone, MSc [verfasserIn] Manophab Luangraj, MD [verfasserIn] Mayfong Mayxay, MD [verfasserIn] Sabine Kloprogge, MSc [verfasserIn] Thyl Miliya, MD [verfasserIn] Manivanh Vongsouvath, MSc [verfasserIn] Paul N Newton, ProfMRCP [verfasserIn] Rattanaphone Phetsouvanh, MD [verfasserIn] Christopher T French, PhD [verfasserIn] Jeff F Miller, ProfPhD [verfasserIn] Paul Turner, FRCPath [verfasserIn] David A B Dance, ProfFRCPath [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Übergeordnetes Werk: |
In: The Lancet Planetary Health - Elsevier, 2018, 2(2018), 8, Seite e334-e343 |
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| Übergeordnetes Werk: |
volume:2 ; year:2018 ; number:8 ; pages:e334-e343 |
| Links: |
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| DOI / URN: |
10.1016/S2542-5196(18)30172-4 |
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| Katalog-ID: |
DOAJ003637875 |
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| 520 | |a Summary: Background: Burkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies. Methods: We examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between February, 2009, and December, 2013. We also examined local temperature, humidity, precipitation, visibility, and wind data for the corresponding time periods. We estimated the B pseudomallei incubation period by examining profile likelihoods for hypothetical exposure-to-presentation delays. Findings: 870 patients were diagnosed with melioidosis in Laos and 173 patients were diagnosed with melioidosis in Cambodia during the study periods. Melioidosis cases were significantly associated with humidity (p<0·0001), low visibility (p<0·0001), and maximum wind speeds (p<0·0001) in Laos, and humidity (p=0·010), rainy days (p=0·015), and maximum wind speed (p=0·0070) in Cambodia. Compared with adults, children were at significantly higher odds of infection during highly humid months (odds ratio 2·79, 95% CI 1·83–4·26). Lung and disseminated infections were more common during windy months. The maximum likelihood estimate of the incubation period was 1 week (95% CI 0–2). Interpretation: The results of this study demonstrate a significant seasonal burden of melioidosis among adults and children in Laos and Cambodia. Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for increased awareness among at-risk individuals, such as children. Funding: Wellcome Trust. | ||
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| 700 | 0 | |a Michelle A Bulterys, BA |e verfasserin |4 aut | |
| 700 | 0 | |a Koukeo Phommasone, MSc |e verfasserin |4 aut | |
| 700 | 0 | |a Manophab Luangraj, MD |e verfasserin |4 aut | |
| 700 | 0 | |a Mayfong Mayxay, MD |e verfasserin |4 aut | |
| 700 | 0 | |a Sabine Kloprogge, MSc |e verfasserin |4 aut | |
| 700 | 0 | |a Thyl Miliya, MD |e verfasserin |4 aut | |
| 700 | 0 | |a Manivanh Vongsouvath, MSc |e verfasserin |4 aut | |
| 700 | 0 | |a Paul N Newton, ProfMRCP |e verfasserin |4 aut | |
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| 700 | 0 | |a Jeff F Miller, ProfPhD |e verfasserin |4 aut | |
| 700 | 0 | |a Paul Turner, FRCPath |e verfasserin |4 aut | |
| 700 | 0 | |a David A B Dance, ProfFRCPath |e verfasserin |4 aut | |
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10.1016/S2542-5196(18)30172-4 doi (DE-627)DOAJ003637875 (DE-599)DOAJ10678ad042334e49b3effde2a16507d8 DE-627 ger DE-627 rakwb eng GE1-350 Philip L Bulterys, PhD verfasserin aut Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Burkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies. Methods: We examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between February, 2009, and December, 2013. We also examined local temperature, humidity, precipitation, visibility, and wind data for the corresponding time periods. We estimated the B pseudomallei incubation period by examining profile likelihoods for hypothetical exposure-to-presentation delays. Findings: 870 patients were diagnosed with melioidosis in Laos and 173 patients were diagnosed with melioidosis in Cambodia during the study periods. Melioidosis cases were significantly associated with humidity (p<0·0001), low visibility (p<0·0001), and maximum wind speeds (p<0·0001) in Laos, and humidity (p=0·010), rainy days (p=0·015), and maximum wind speed (p=0·0070) in Cambodia. Compared with adults, children were at significantly higher odds of infection during highly humid months (odds ratio 2·79, 95% CI 1·83–4·26). Lung and disseminated infections were more common during windy months. The maximum likelihood estimate of the incubation period was 1 week (95% CI 0–2). Interpretation: The results of this study demonstrate a significant seasonal burden of melioidosis among adults and children in Laos and Cambodia. Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for increased awareness among at-risk individuals, such as children. Funding: Wellcome Trust. Environmental sciences Michelle A Bulterys, BA verfasserin aut Koukeo Phommasone, MSc verfasserin aut Manophab Luangraj, MD verfasserin aut Mayfong Mayxay, MD verfasserin aut Sabine Kloprogge, MSc verfasserin aut Thyl Miliya, MD verfasserin aut Manivanh Vongsouvath, MSc verfasserin aut Paul N Newton, ProfMRCP verfasserin aut Rattanaphone Phetsouvanh, MD verfasserin aut Christopher T French, PhD verfasserin aut Jeff F Miller, ProfPhD verfasserin aut Paul Turner, FRCPath verfasserin aut David A B Dance, ProfFRCPath verfasserin aut In The Lancet Planetary Health Elsevier, 2018 2(2018), 8, Seite e334-e343 (DE-627)895241757 (DE-600)2902154-6 25425196 nnns volume:2 year:2018 number:8 pages:e334-e343 https://doi.org/10.1016/S2542-5196(18)30172-4 kostenfrei https://doaj.org/article/10678ad042334e49b3effde2a16507d8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2542519618301724 kostenfrei https://doaj.org/toc/2542-5196 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2018 8 e334-e343 |
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10.1016/S2542-5196(18)30172-4 doi (DE-627)DOAJ003637875 (DE-599)DOAJ10678ad042334e49b3effde2a16507d8 DE-627 ger DE-627 rakwb eng GE1-350 Philip L Bulterys, PhD verfasserin aut Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Burkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies. Methods: We examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between February, 2009, and December, 2013. We also examined local temperature, humidity, precipitation, visibility, and wind data for the corresponding time periods. We estimated the B pseudomallei incubation period by examining profile likelihoods for hypothetical exposure-to-presentation delays. Findings: 870 patients were diagnosed with melioidosis in Laos and 173 patients were diagnosed with melioidosis in Cambodia during the study periods. Melioidosis cases were significantly associated with humidity (p<0·0001), low visibility (p<0·0001), and maximum wind speeds (p<0·0001) in Laos, and humidity (p=0·010), rainy days (p=0·015), and maximum wind speed (p=0·0070) in Cambodia. Compared with adults, children were at significantly higher odds of infection during highly humid months (odds ratio 2·79, 95% CI 1·83–4·26). Lung and disseminated infections were more common during windy months. The maximum likelihood estimate of the incubation period was 1 week (95% CI 0–2). Interpretation: The results of this study demonstrate a significant seasonal burden of melioidosis among adults and children in Laos and Cambodia. Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for increased awareness among at-risk individuals, such as children. Funding: Wellcome Trust. Environmental sciences Michelle A Bulterys, BA verfasserin aut Koukeo Phommasone, MSc verfasserin aut Manophab Luangraj, MD verfasserin aut Mayfong Mayxay, MD verfasserin aut Sabine Kloprogge, MSc verfasserin aut Thyl Miliya, MD verfasserin aut Manivanh Vongsouvath, MSc verfasserin aut Paul N Newton, ProfMRCP verfasserin aut Rattanaphone Phetsouvanh, MD verfasserin aut Christopher T French, PhD verfasserin aut Jeff F Miller, ProfPhD verfasserin aut Paul Turner, FRCPath verfasserin aut David A B Dance, ProfFRCPath verfasserin aut In The Lancet Planetary Health Elsevier, 2018 2(2018), 8, Seite e334-e343 (DE-627)895241757 (DE-600)2902154-6 25425196 nnns volume:2 year:2018 number:8 pages:e334-e343 https://doi.org/10.1016/S2542-5196(18)30172-4 kostenfrei https://doaj.org/article/10678ad042334e49b3effde2a16507d8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2542519618301724 kostenfrei https://doaj.org/toc/2542-5196 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2018 8 e334-e343 |
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10.1016/S2542-5196(18)30172-4 doi (DE-627)DOAJ003637875 (DE-599)DOAJ10678ad042334e49b3effde2a16507d8 DE-627 ger DE-627 rakwb eng GE1-350 Philip L Bulterys, PhD verfasserin aut Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Burkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies. Methods: We examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between February, 2009, and December, 2013. We also examined local temperature, humidity, precipitation, visibility, and wind data for the corresponding time periods. We estimated the B pseudomallei incubation period by examining profile likelihoods for hypothetical exposure-to-presentation delays. Findings: 870 patients were diagnosed with melioidosis in Laos and 173 patients were diagnosed with melioidosis in Cambodia during the study periods. Melioidosis cases were significantly associated with humidity (p<0·0001), low visibility (p<0·0001), and maximum wind speeds (p<0·0001) in Laos, and humidity (p=0·010), rainy days (p=0·015), and maximum wind speed (p=0·0070) in Cambodia. Compared with adults, children were at significantly higher odds of infection during highly humid months (odds ratio 2·79, 95% CI 1·83–4·26). Lung and disseminated infections were more common during windy months. The maximum likelihood estimate of the incubation period was 1 week (95% CI 0–2). Interpretation: The results of this study demonstrate a significant seasonal burden of melioidosis among adults and children in Laos and Cambodia. Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for increased awareness among at-risk individuals, such as children. Funding: Wellcome Trust. Environmental sciences Michelle A Bulterys, BA verfasserin aut Koukeo Phommasone, MSc verfasserin aut Manophab Luangraj, MD verfasserin aut Mayfong Mayxay, MD verfasserin aut Sabine Kloprogge, MSc verfasserin aut Thyl Miliya, MD verfasserin aut Manivanh Vongsouvath, MSc verfasserin aut Paul N Newton, ProfMRCP verfasserin aut Rattanaphone Phetsouvanh, MD verfasserin aut Christopher T French, PhD verfasserin aut Jeff F Miller, ProfPhD verfasserin aut Paul Turner, FRCPath verfasserin aut David A B Dance, ProfFRCPath verfasserin aut In The Lancet Planetary Health Elsevier, 2018 2(2018), 8, Seite e334-e343 (DE-627)895241757 (DE-600)2902154-6 25425196 nnns volume:2 year:2018 number:8 pages:e334-e343 https://doi.org/10.1016/S2542-5196(18)30172-4 kostenfrei https://doaj.org/article/10678ad042334e49b3effde2a16507d8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2542519618301724 kostenfrei https://doaj.org/toc/2542-5196 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2018 8 e334-e343 |
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10.1016/S2542-5196(18)30172-4 doi (DE-627)DOAJ003637875 (DE-599)DOAJ10678ad042334e49b3effde2a16507d8 DE-627 ger DE-627 rakwb eng GE1-350 Philip L Bulterys, PhD verfasserin aut Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Burkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies. Methods: We examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between February, 2009, and December, 2013. We also examined local temperature, humidity, precipitation, visibility, and wind data for the corresponding time periods. We estimated the B pseudomallei incubation period by examining profile likelihoods for hypothetical exposure-to-presentation delays. Findings: 870 patients were diagnosed with melioidosis in Laos and 173 patients were diagnosed with melioidosis in Cambodia during the study periods. Melioidosis cases were significantly associated with humidity (p<0·0001), low visibility (p<0·0001), and maximum wind speeds (p<0·0001) in Laos, and humidity (p=0·010), rainy days (p=0·015), and maximum wind speed (p=0·0070) in Cambodia. Compared with adults, children were at significantly higher odds of infection during highly humid months (odds ratio 2·79, 95% CI 1·83–4·26). Lung and disseminated infections were more common during windy months. The maximum likelihood estimate of the incubation period was 1 week (95% CI 0–2). Interpretation: The results of this study demonstrate a significant seasonal burden of melioidosis among adults and children in Laos and Cambodia. Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for increased awareness among at-risk individuals, such as children. Funding: Wellcome Trust. Environmental sciences Michelle A Bulterys, BA verfasserin aut Koukeo Phommasone, MSc verfasserin aut Manophab Luangraj, MD verfasserin aut Mayfong Mayxay, MD verfasserin aut Sabine Kloprogge, MSc verfasserin aut Thyl Miliya, MD verfasserin aut Manivanh Vongsouvath, MSc verfasserin aut Paul N Newton, ProfMRCP verfasserin aut Rattanaphone Phetsouvanh, MD verfasserin aut Christopher T French, PhD verfasserin aut Jeff F Miller, ProfPhD verfasserin aut Paul Turner, FRCPath verfasserin aut David A B Dance, ProfFRCPath verfasserin aut In The Lancet Planetary Health Elsevier, 2018 2(2018), 8, Seite e334-e343 (DE-627)895241757 (DE-600)2902154-6 25425196 nnns volume:2 year:2018 number:8 pages:e334-e343 https://doi.org/10.1016/S2542-5196(18)30172-4 kostenfrei https://doaj.org/article/10678ad042334e49b3effde2a16507d8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2542519618301724 kostenfrei https://doaj.org/toc/2542-5196 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2018 8 e334-e343 |
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10.1016/S2542-5196(18)30172-4 doi (DE-627)DOAJ003637875 (DE-599)DOAJ10678ad042334e49b3effde2a16507d8 DE-627 ger DE-627 rakwb eng GE1-350 Philip L Bulterys, PhD verfasserin aut Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Burkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies. Methods: We examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between February, 2009, and December, 2013. We also examined local temperature, humidity, precipitation, visibility, and wind data for the corresponding time periods. We estimated the B pseudomallei incubation period by examining profile likelihoods for hypothetical exposure-to-presentation delays. Findings: 870 patients were diagnosed with melioidosis in Laos and 173 patients were diagnosed with melioidosis in Cambodia during the study periods. Melioidosis cases were significantly associated with humidity (p<0·0001), low visibility (p<0·0001), and maximum wind speeds (p<0·0001) in Laos, and humidity (p=0·010), rainy days (p=0·015), and maximum wind speed (p=0·0070) in Cambodia. Compared with adults, children were at significantly higher odds of infection during highly humid months (odds ratio 2·79, 95% CI 1·83–4·26). Lung and disseminated infections were more common during windy months. The maximum likelihood estimate of the incubation period was 1 week (95% CI 0–2). Interpretation: The results of this study demonstrate a significant seasonal burden of melioidosis among adults and children in Laos and Cambodia. Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for increased awareness among at-risk individuals, such as children. Funding: Wellcome Trust. Environmental sciences Michelle A Bulterys, BA verfasserin aut Koukeo Phommasone, MSc verfasserin aut Manophab Luangraj, MD verfasserin aut Mayfong Mayxay, MD verfasserin aut Sabine Kloprogge, MSc verfasserin aut Thyl Miliya, MD verfasserin aut Manivanh Vongsouvath, MSc verfasserin aut Paul N Newton, ProfMRCP verfasserin aut Rattanaphone Phetsouvanh, MD verfasserin aut Christopher T French, PhD verfasserin aut Jeff F Miller, ProfPhD verfasserin aut Paul Turner, FRCPath verfasserin aut David A B Dance, ProfFRCPath verfasserin aut In The Lancet Planetary Health Elsevier, 2018 2(2018), 8, Seite e334-e343 (DE-627)895241757 (DE-600)2902154-6 25425196 nnns volume:2 year:2018 number:8 pages:e334-e343 https://doi.org/10.1016/S2542-5196(18)30172-4 kostenfrei https://doaj.org/article/10678ad042334e49b3effde2a16507d8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2542519618301724 kostenfrei https://doaj.org/toc/2542-5196 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2018 8 e334-e343 |
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Philip L Bulterys, PhD @@aut@@ Michelle A Bulterys, BA @@aut@@ Koukeo Phommasone, MSc @@aut@@ Manophab Luangraj, MD @@aut@@ Mayfong Mayxay, MD @@aut@@ Sabine Kloprogge, MSc @@aut@@ Thyl Miliya, MD @@aut@@ Manivanh Vongsouvath, MSc @@aut@@ Paul N Newton, ProfMRCP @@aut@@ Rattanaphone Phetsouvanh, MD @@aut@@ Christopher T French, PhD @@aut@@ Jeff F Miller, ProfPhD @@aut@@ Paul Turner, FRCPath @@aut@@ David A B Dance, ProfFRCPath @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ003637875</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230501174848.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2018 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/S2542-5196(18)30172-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ003637875</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ10678ad042334e49b3effde2a16507d8</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">GE1-350</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Philip L Bulterys, PhD</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary: Background: Burkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies. Methods: We examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between February, 2009, and December, 2013. We also examined local temperature, humidity, precipitation, visibility, and wind data for the corresponding time periods. We estimated the B pseudomallei incubation period by examining profile likelihoods for hypothetical exposure-to-presentation delays. Findings: 870 patients were diagnosed with melioidosis in Laos and 173 patients were diagnosed with melioidosis in Cambodia during the study periods. Melioidosis cases were significantly associated with humidity (p<0·0001), low visibility (p<0·0001), and maximum wind speeds (p<0·0001) in Laos, and humidity (p=0·010), rainy days (p=0·015), and maximum wind speed (p=0·0070) in Cambodia. Compared with adults, children were at significantly higher odds of infection during highly humid months (odds ratio 2·79, 95% CI 1·83–4·26). Lung and disseminated infections were more common during windy months. The maximum likelihood estimate of the incubation period was 1 week (95% CI 0–2). Interpretation: The results of this study demonstrate a significant seasonal burden of melioidosis among adults and children in Laos and Cambodia. Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for increased awareness among at-risk individuals, such as children. 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Philip L Bulterys, PhD |
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GE1-350 Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis |
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Philip L Bulterys, PhD |
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Philip L Bulterys, PhD Michelle A Bulterys, BA Koukeo Phommasone, MSc Manophab Luangraj, MD Mayfong Mayxay, MD Sabine Kloprogge, MSc Thyl Miliya, MD Manivanh Vongsouvath, MSc Paul N Newton, ProfMRCP Rattanaphone Phetsouvanh, MD Christopher T French, PhD Jeff F Miller, ProfPhD Paul Turner, FRCPath David A B Dance, ProfFRCPath |
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climatic drivers of melioidosis in laos and cambodia: a 16-year case series analysis |
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Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis |
| abstract |
Summary: Background: Burkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies. Methods: We examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between February, 2009, and December, 2013. We also examined local temperature, humidity, precipitation, visibility, and wind data for the corresponding time periods. We estimated the B pseudomallei incubation period by examining profile likelihoods for hypothetical exposure-to-presentation delays. Findings: 870 patients were diagnosed with melioidosis in Laos and 173 patients were diagnosed with melioidosis in Cambodia during the study periods. Melioidosis cases were significantly associated with humidity (p<0·0001), low visibility (p<0·0001), and maximum wind speeds (p<0·0001) in Laos, and humidity (p=0·010), rainy days (p=0·015), and maximum wind speed (p=0·0070) in Cambodia. Compared with adults, children were at significantly higher odds of infection during highly humid months (odds ratio 2·79, 95% CI 1·83–4·26). Lung and disseminated infections were more common during windy months. The maximum likelihood estimate of the incubation period was 1 week (95% CI 0–2). Interpretation: The results of this study demonstrate a significant seasonal burden of melioidosis among adults and children in Laos and Cambodia. Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for increased awareness among at-risk individuals, such as children. Funding: Wellcome Trust. |
| abstractGer |
Summary: Background: Burkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies. Methods: We examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between February, 2009, and December, 2013. We also examined local temperature, humidity, precipitation, visibility, and wind data for the corresponding time periods. We estimated the B pseudomallei incubation period by examining profile likelihoods for hypothetical exposure-to-presentation delays. Findings: 870 patients were diagnosed with melioidosis in Laos and 173 patients were diagnosed with melioidosis in Cambodia during the study periods. Melioidosis cases were significantly associated with humidity (p<0·0001), low visibility (p<0·0001), and maximum wind speeds (p<0·0001) in Laos, and humidity (p=0·010), rainy days (p=0·015), and maximum wind speed (p=0·0070) in Cambodia. Compared with adults, children were at significantly higher odds of infection during highly humid months (odds ratio 2·79, 95% CI 1·83–4·26). Lung and disseminated infections were more common during windy months. The maximum likelihood estimate of the incubation period was 1 week (95% CI 0–2). Interpretation: The results of this study demonstrate a significant seasonal burden of melioidosis among adults and children in Laos and Cambodia. Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for increased awareness among at-risk individuals, such as children. Funding: Wellcome Trust. |
| abstract_unstemmed |
Summary: Background: Burkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies. Methods: We examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between February, 2009, and December, 2013. We also examined local temperature, humidity, precipitation, visibility, and wind data for the corresponding time periods. We estimated the B pseudomallei incubation period by examining profile likelihoods for hypothetical exposure-to-presentation delays. Findings: 870 patients were diagnosed with melioidosis in Laos and 173 patients were diagnosed with melioidosis in Cambodia during the study periods. Melioidosis cases were significantly associated with humidity (p<0·0001), low visibility (p<0·0001), and maximum wind speeds (p<0·0001) in Laos, and humidity (p=0·010), rainy days (p=0·015), and maximum wind speed (p=0·0070) in Cambodia. Compared with adults, children were at significantly higher odds of infection during highly humid months (odds ratio 2·79, 95% CI 1·83–4·26). Lung and disseminated infections were more common during windy months. The maximum likelihood estimate of the incubation period was 1 week (95% CI 0–2). Interpretation: The results of this study demonstrate a significant seasonal burden of melioidosis among adults and children in Laos and Cambodia. Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for increased awareness among at-risk individuals, such as children. Funding: Wellcome Trust. |
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Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis |
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https://doi.org/10.1016/S2542-5196(18)30172-4 https://doaj.org/article/10678ad042334e49b3effde2a16507d8 http://www.sciencedirect.com/science/article/pii/S2542519618301724 https://doaj.org/toc/2542-5196 |
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Michelle A Bulterys, BA Koukeo Phommasone, MSc Manophab Luangraj, MD Mayfong Mayxay, MD Sabine Kloprogge, MSc Thyl Miliya, MD Manivanh Vongsouvath, MSc Paul N Newton, ProfMRCP Rattanaphone Phetsouvanh, MD Christopher T French, PhD Jeff F Miller, ProfPhD Paul Turner, FRCPath David A B Dance, ProfFRCPath |
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Michelle A Bulterys, BA Koukeo Phommasone, MSc Manophab Luangraj, MD Mayfong Mayxay, MD Sabine Kloprogge, MSc Thyl Miliya, MD Manivanh Vongsouvath, MSc Paul N Newton, ProfMRCP Rattanaphone Phetsouvanh, MD Christopher T French, PhD Jeff F Miller, ProfPhD Paul Turner, FRCPath David A B Dance, ProfFRCPath |
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GE - Environmental Sciences |
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10.1016/S2542-5196(18)30172-4 |
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GE1-350 |
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2024-07-03T19:12:03.527Z |
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Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies. Methods: We examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between February, 2009, and December, 2013. We also examined local temperature, humidity, precipitation, visibility, and wind data for the corresponding time periods. We estimated the B pseudomallei incubation period by examining profile likelihoods for hypothetical exposure-to-presentation delays. Findings: 870 patients were diagnosed with melioidosis in Laos and 173 patients were diagnosed with melioidosis in Cambodia during the study periods. Melioidosis cases were significantly associated with humidity (p<0·0001), low visibility (p<0·0001), and maximum wind speeds (p<0·0001) in Laos, and humidity (p=0·010), rainy days (p=0·015), and maximum wind speed (p=0·0070) in Cambodia. Compared with adults, children were at significantly higher odds of infection during highly humid months (odds ratio 2·79, 95% CI 1·83–4·26). Lung and disseminated infections were more common during windy months. The maximum likelihood estimate of the incubation period was 1 week (95% CI 0–2). Interpretation: The results of this study demonstrate a significant seasonal burden of melioidosis among adults and children in Laos and Cambodia. Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for increased awareness among at-risk individuals, such as children. 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