Amine Metabolism Is Influenced by Dietary Protein Source

Growth in world population will inevitably leads to increased demand for protein for humans and animals. Protein from insects and blood plasma are being considered as possible alternatives, but more research on their nutritional quality and health effects is needed. Here, we studied the effect of di...
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Autor*in:	Soumya K. Kar [verfasserIn] Alfons J. M. Jansman [verfasserIn] Dirkjan Schokker [verfasserIn] Leo Kruijt [verfasserIn] Amy C. Harms [verfasserIn] Jerry M. Wells [verfasserIn] Mari A. Smits [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	1-methylhistidine alpha-aminobutyric acid amine metabolites dietary protein source endophenotype metabolomics

Übergeordnetes Werk:	In: Frontiers in Nutrition - Frontiers Media S.A., 2014, 4(2017)
Übergeordnetes Werk:	volume:4 ; year:2017

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnut.2017.00041

Katalog-ID:	DOAJ003718026

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callnumber-first	T - Technology
author	Soumya K. Kar
spellingShingle	Soumya K. Kar misc TX341-641 misc 1-methylhistidine misc alpha-aminobutyric acid misc amine metabolites misc dietary protein source misc endophenotype misc metabolomics misc Nutrition. Foods and food supply Amine Metabolism Is Influenced by Dietary Protein Source
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topic_title	TX341-641 Amine Metabolism Is Influenced by Dietary Protein Source 1-methylhistidine alpha-aminobutyric acid amine metabolites dietary protein source endophenotype metabolomics
topic	misc TX341-641 misc 1-methylhistidine misc alpha-aminobutyric acid misc amine metabolites misc dietary protein source misc endophenotype misc metabolomics misc Nutrition. Foods and food supply
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title	Amine Metabolism Is Influenced by Dietary Protein Source
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title_sort	amine metabolism is influenced by dietary protein source
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title_auth	Amine Metabolism Is Influenced by Dietary Protein Source
abstract	Growth in world population will inevitably leads to increased demand for protein for humans and animals. Protein from insects and blood plasma are being considered as possible alternatives, but more research on their nutritional quality and health effects is needed. Here, we studied the effect of dietary protein source on metabolism and metabolic amine profiles in serum and urine of mice. Groups of mice were fed semi-purified diets containing 300 g/kg of soybean meal, casein, partially delactosed whey powder, spray-dried plasma protein, wheat gluten meal, and yellow mealworm. Feed and water intake as well as body weight gain were measured for 28 days. After 14 and 28 days, serum and urine samples were collected for measurement of a large panel of amine metabolites. MetaboAnalyst 3.0 was used for analysis of the raw metabolic data. Out of 68 targeted amine metabolites, we could detect 54 in urine and 41 in blood serum. Dietary protein sources were found to have profound effects on host metabolism, particularly in systemic amine profiles, considered here as an endophenotype. We recommend serum over urine to screen for the amine metabolic endophenotype based on partial least squares discriminant analysis. We concluded that metabolites like alpha-aminobutyric acid and 1-methylhistidine are sensitive indicators of too much or too little availability of specific amino acids in the different protein diets. Furthermore, we concluded that amine metabolic profiles can be useful for assessing the nutritional quality of different protein sources.
abstractGer	Growth in world population will inevitably leads to increased demand for protein for humans and animals. Protein from insects and blood plasma are being considered as possible alternatives, but more research on their nutritional quality and health effects is needed. Here, we studied the effect of dietary protein source on metabolism and metabolic amine profiles in serum and urine of mice. Groups of mice were fed semi-purified diets containing 300 g/kg of soybean meal, casein, partially delactosed whey powder, spray-dried plasma protein, wheat gluten meal, and yellow mealworm. Feed and water intake as well as body weight gain were measured for 28 days. After 14 and 28 days, serum and urine samples were collected for measurement of a large panel of amine metabolites. MetaboAnalyst 3.0 was used for analysis of the raw metabolic data. Out of 68 targeted amine metabolites, we could detect 54 in urine and 41 in blood serum. Dietary protein sources were found to have profound effects on host metabolism, particularly in systemic amine profiles, considered here as an endophenotype. We recommend serum over urine to screen for the amine metabolic endophenotype based on partial least squares discriminant analysis. We concluded that metabolites like alpha-aminobutyric acid and 1-methylhistidine are sensitive indicators of too much or too little availability of specific amino acids in the different protein diets. Furthermore, we concluded that amine metabolic profiles can be useful for assessing the nutritional quality of different protein sources.
abstract_unstemmed	Growth in world population will inevitably leads to increased demand for protein for humans and animals. Protein from insects and blood plasma are being considered as possible alternatives, but more research on their nutritional quality and health effects is needed. Here, we studied the effect of dietary protein source on metabolism and metabolic amine profiles in serum and urine of mice. Groups of mice were fed semi-purified diets containing 300 g/kg of soybean meal, casein, partially delactosed whey powder, spray-dried plasma protein, wheat gluten meal, and yellow mealworm. Feed and water intake as well as body weight gain were measured for 28 days. After 14 and 28 days, serum and urine samples were collected for measurement of a large panel of amine metabolites. MetaboAnalyst 3.0 was used for analysis of the raw metabolic data. Out of 68 targeted amine metabolites, we could detect 54 in urine and 41 in blood serum. Dietary protein sources were found to have profound effects on host metabolism, particularly in systemic amine profiles, considered here as an endophenotype. We recommend serum over urine to screen for the amine metabolic endophenotype based on partial least squares discriminant analysis. We concluded that metabolites like alpha-aminobutyric acid and 1-methylhistidine are sensitive indicators of too much or too little availability of specific amino acids in the different protein diets. Furthermore, we concluded that amine metabolic profiles can be useful for assessing the nutritional quality of different protein sources.
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title_short	Amine Metabolism Is Influenced by Dietary Protein Source
url	https://doi.org/10.3389/fnut.2017.00041 https://doaj.org/article/c86eaf39b9d6425d8e13dc4b5181987f http://journal.frontiersin.org/article/10.3389/fnut.2017.00041/full https://doaj.org/toc/2296-861X
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