N-Acetyl-l-Cysteine Inhibits Marble-Burying Behavior in Mice
marble-burying behavior, N-acetyl-l-cysteine, obsessive-compulsive disorder
Gespeichert in:
| Autor*in: |
Nobuaki Egashira [verfasserIn] Atsunori Shirakawa [verfasserIn] Moe Abe [verfasserIn] Tomiko Niki [verfasserIn] Kenichi Mishima [verfasserIn] Katsunori Iwasaki [verfasserIn] Ryozo Oishi [verfasserIn] Michihiro Fujiwara [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Übergeordnetes Werk: |
In: Journal of Pharmacological Sciences - Elsevier, 2017, 119(2012), 1, Seite 97-101 |
|---|---|
| Übergeordnetes Werk: |
volume:119 ; year:2012 ; number:1 ; pages:97-101 |
| Links: |
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| DOI / URN: |
10.1254/jphs.11228SC |
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DOAJ003845893 |
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| 520 | |a In the present study, we examined the effect of N-acetyl-l-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD. Keywords:: marble-burying behavior, N-acetyl-l-cysteine, obsessive-compulsive disorder | ||
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| 700 | 0 | |a Atsunori Shirakawa |e verfasserin |4 aut | |
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| 700 | 0 | |a Ryozo Oishi |e verfasserin |4 aut | |
| 700 | 0 | |a Michihiro Fujiwara |e verfasserin |4 aut | |
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10.1254/jphs.11228SC doi (DE-627)DOAJ003845893 (DE-599)DOAJ7b115403139e48b1ac1e9dcd31a07704 DE-627 ger DE-627 rakwb eng RM1-950 Nobuaki Egashira verfasserin aut N-Acetyl-l-Cysteine Inhibits Marble-Burying Behavior in Mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present study, we examined the effect of N-acetyl-l-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD. Keywords:: marble-burying behavior, N-acetyl-l-cysteine, obsessive-compulsive disorder Therapeutics. Pharmacology Atsunori Shirakawa verfasserin aut Moe Abe verfasserin aut Tomiko Niki verfasserin aut Kenichi Mishima verfasserin aut Katsunori Iwasaki verfasserin aut Ryozo Oishi verfasserin aut Michihiro Fujiwara verfasserin aut In Journal of Pharmacological Sciences Elsevier, 2017 119(2012), 1, Seite 97-101 (DE-627)1760631620 13478613 nnns volume:119 year:2012 number:1 pages:97-101 https://doi.org/10.1254/jphs.11228SC kostenfrei https://doaj.org/article/7b115403139e48b1ac1e9dcd31a07704 kostenfrei http://www.sciencedirect.com/science/article/pii/S1347861319305286 kostenfrei https://doaj.org/toc/1347-8613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 119 2012 1 97-101 |
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10.1254/jphs.11228SC doi (DE-627)DOAJ003845893 (DE-599)DOAJ7b115403139e48b1ac1e9dcd31a07704 DE-627 ger DE-627 rakwb eng RM1-950 Nobuaki Egashira verfasserin aut N-Acetyl-l-Cysteine Inhibits Marble-Burying Behavior in Mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present study, we examined the effect of N-acetyl-l-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD. Keywords:: marble-burying behavior, N-acetyl-l-cysteine, obsessive-compulsive disorder Therapeutics. Pharmacology Atsunori Shirakawa verfasserin aut Moe Abe verfasserin aut Tomiko Niki verfasserin aut Kenichi Mishima verfasserin aut Katsunori Iwasaki verfasserin aut Ryozo Oishi verfasserin aut Michihiro Fujiwara verfasserin aut In Journal of Pharmacological Sciences Elsevier, 2017 119(2012), 1, Seite 97-101 (DE-627)1760631620 13478613 nnns volume:119 year:2012 number:1 pages:97-101 https://doi.org/10.1254/jphs.11228SC kostenfrei https://doaj.org/article/7b115403139e48b1ac1e9dcd31a07704 kostenfrei http://www.sciencedirect.com/science/article/pii/S1347861319305286 kostenfrei https://doaj.org/toc/1347-8613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 119 2012 1 97-101 |
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10.1254/jphs.11228SC doi (DE-627)DOAJ003845893 (DE-599)DOAJ7b115403139e48b1ac1e9dcd31a07704 DE-627 ger DE-627 rakwb eng RM1-950 Nobuaki Egashira verfasserin aut N-Acetyl-l-Cysteine Inhibits Marble-Burying Behavior in Mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present study, we examined the effect of N-acetyl-l-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD. Keywords:: marble-burying behavior, N-acetyl-l-cysteine, obsessive-compulsive disorder Therapeutics. Pharmacology Atsunori Shirakawa verfasserin aut Moe Abe verfasserin aut Tomiko Niki verfasserin aut Kenichi Mishima verfasserin aut Katsunori Iwasaki verfasserin aut Ryozo Oishi verfasserin aut Michihiro Fujiwara verfasserin aut In Journal of Pharmacological Sciences Elsevier, 2017 119(2012), 1, Seite 97-101 (DE-627)1760631620 13478613 nnns volume:119 year:2012 number:1 pages:97-101 https://doi.org/10.1254/jphs.11228SC kostenfrei https://doaj.org/article/7b115403139e48b1ac1e9dcd31a07704 kostenfrei http://www.sciencedirect.com/science/article/pii/S1347861319305286 kostenfrei https://doaj.org/toc/1347-8613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 119 2012 1 97-101 |
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10.1254/jphs.11228SC doi (DE-627)DOAJ003845893 (DE-599)DOAJ7b115403139e48b1ac1e9dcd31a07704 DE-627 ger DE-627 rakwb eng RM1-950 Nobuaki Egashira verfasserin aut N-Acetyl-l-Cysteine Inhibits Marble-Burying Behavior in Mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present study, we examined the effect of N-acetyl-l-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD. Keywords:: marble-burying behavior, N-acetyl-l-cysteine, obsessive-compulsive disorder Therapeutics. Pharmacology Atsunori Shirakawa verfasserin aut Moe Abe verfasserin aut Tomiko Niki verfasserin aut Kenichi Mishima verfasserin aut Katsunori Iwasaki verfasserin aut Ryozo Oishi verfasserin aut Michihiro Fujiwara verfasserin aut In Journal of Pharmacological Sciences Elsevier, 2017 119(2012), 1, Seite 97-101 (DE-627)1760631620 13478613 nnns volume:119 year:2012 number:1 pages:97-101 https://doi.org/10.1254/jphs.11228SC kostenfrei https://doaj.org/article/7b115403139e48b1ac1e9dcd31a07704 kostenfrei http://www.sciencedirect.com/science/article/pii/S1347861319305286 kostenfrei https://doaj.org/toc/1347-8613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 119 2012 1 97-101 |
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10.1254/jphs.11228SC doi (DE-627)DOAJ003845893 (DE-599)DOAJ7b115403139e48b1ac1e9dcd31a07704 DE-627 ger DE-627 rakwb eng RM1-950 Nobuaki Egashira verfasserin aut N-Acetyl-l-Cysteine Inhibits Marble-Burying Behavior in Mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present study, we examined the effect of N-acetyl-l-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD. Keywords:: marble-burying behavior, N-acetyl-l-cysteine, obsessive-compulsive disorder Therapeutics. Pharmacology Atsunori Shirakawa verfasserin aut Moe Abe verfasserin aut Tomiko Niki verfasserin aut Kenichi Mishima verfasserin aut Katsunori Iwasaki verfasserin aut Ryozo Oishi verfasserin aut Michihiro Fujiwara verfasserin aut In Journal of Pharmacological Sciences Elsevier, 2017 119(2012), 1, Seite 97-101 (DE-627)1760631620 13478613 nnns volume:119 year:2012 number:1 pages:97-101 https://doi.org/10.1254/jphs.11228SC kostenfrei https://doaj.org/article/7b115403139e48b1ac1e9dcd31a07704 kostenfrei http://www.sciencedirect.com/science/article/pii/S1347861319305286 kostenfrei https://doaj.org/toc/1347-8613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 119 2012 1 97-101 |
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In the present study, we examined the effect of N-acetyl-l-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD. Keywords:: marble-burying behavior, N-acetyl-l-cysteine, obsessive-compulsive disorder |
| abstractGer |
In the present study, we examined the effect of N-acetyl-l-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD. Keywords:: marble-burying behavior, N-acetyl-l-cysteine, obsessive-compulsive disorder |
| abstract_unstemmed |
In the present study, we examined the effect of N-acetyl-l-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD. Keywords:: marble-burying behavior, N-acetyl-l-cysteine, obsessive-compulsive disorder |
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N-Acetyl-l-Cysteine Inhibits Marble-Burying Behavior in Mice |
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https://doi.org/10.1254/jphs.11228SC https://doaj.org/article/7b115403139e48b1ac1e9dcd31a07704 http://www.sciencedirect.com/science/article/pii/S1347861319305286 https://doaj.org/toc/1347-8613 |
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Atsunori Shirakawa Moe Abe Tomiko Niki Kenichi Mishima Katsunori Iwasaki Ryozo Oishi Michihiro Fujiwara |
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Atsunori Shirakawa Moe Abe Tomiko Niki Kenichi Mishima Katsunori Iwasaki Ryozo Oishi Michihiro Fujiwara |
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