Mechanisms of Mechanical Force Induced Pulmonary Vascular Endothelial Hyperpermeability

Mechanical ventilation is a supportive therapy for patients with acute respiratory distress syndrome (ARDS). However, it also inevitably produces or aggravates the original lung injury with pathophysiological changes of pulmonary edema caused by increased permeability of alveolar capillaries which c...
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Gespeichert in:

Autor*in:	Yan Lai [verfasserIn] Yongbo Huang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	mechanical ventilation pulmonary vascular endothelium lung injury permeability mechanisms

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2021.714064

Katalog-ID:	DOAJ003960765

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topic_facet	mechanical ventilation pulmonary vascular endothelium lung injury permeability mechanisms Physiology
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authorswithroles_txt_mv	Yan Lai @@aut@@ Yongbo Huang @@aut@@
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callnumber-first	Q - Science
author	Yan Lai
spellingShingle	Yan Lai misc QP1-981 misc mechanical ventilation misc pulmonary vascular endothelium misc lung injury misc permeability misc mechanisms misc Physiology Mechanisms of Mechanical Force Induced Pulmonary Vascular Endothelial Hyperpermeability
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topic_title	QP1-981 Mechanisms of Mechanical Force Induced Pulmonary Vascular Endothelial Hyperpermeability mechanical ventilation pulmonary vascular endothelium lung injury permeability mechanisms
topic	misc QP1-981 misc mechanical ventilation misc pulmonary vascular endothelium misc lung injury misc permeability misc mechanisms misc Physiology
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title	Mechanisms of Mechanical Force Induced Pulmonary Vascular Endothelial Hyperpermeability
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title_full	Mechanisms of Mechanical Force Induced Pulmonary Vascular Endothelial Hyperpermeability
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title_sort	mechanisms of mechanical force induced pulmonary vascular endothelial hyperpermeability
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title_auth	Mechanisms of Mechanical Force Induced Pulmonary Vascular Endothelial Hyperpermeability
abstract	Mechanical ventilation is a supportive therapy for patients with acute respiratory distress syndrome (ARDS). However, it also inevitably produces or aggravates the original lung injury with pathophysiological changes of pulmonary edema caused by increased permeability of alveolar capillaries which composed of microvascular endothelium, alveolar epithelium, and basement membrane. Vascular endothelium forms a semi-selective barrier to regulate body fluid balance. Mechanical ventilation in critically ill patients produces a mechanical force on lung vascular endothelium when the endothelial barrier was destructed. This review aims to provide a comprehensive overview of molecular and signaling mechanisms underlying the endothelial barrier permeability in ventilator-induced lung jury (VILI).
abstractGer	Mechanical ventilation is a supportive therapy for patients with acute respiratory distress syndrome (ARDS). However, it also inevitably produces or aggravates the original lung injury with pathophysiological changes of pulmonary edema caused by increased permeability of alveolar capillaries which composed of microvascular endothelium, alveolar epithelium, and basement membrane. Vascular endothelium forms a semi-selective barrier to regulate body fluid balance. Mechanical ventilation in critically ill patients produces a mechanical force on lung vascular endothelium when the endothelial barrier was destructed. This review aims to provide a comprehensive overview of molecular and signaling mechanisms underlying the endothelial barrier permeability in ventilator-induced lung jury (VILI).
abstract_unstemmed	Mechanical ventilation is a supportive therapy for patients with acute respiratory distress syndrome (ARDS). However, it also inevitably produces or aggravates the original lung injury with pathophysiological changes of pulmonary edema caused by increased permeability of alveolar capillaries which composed of microvascular endothelium, alveolar epithelium, and basement membrane. Vascular endothelium forms a semi-selective barrier to regulate body fluid balance. Mechanical ventilation in critically ill patients produces a mechanical force on lung vascular endothelium when the endothelial barrier was destructed. This review aims to provide a comprehensive overview of molecular and signaling mechanisms underlying the endothelial barrier permeability in ventilator-induced lung jury (VILI).
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title_short	Mechanisms of Mechanical Force Induced Pulmonary Vascular Endothelial Hyperpermeability
url	https://doi.org/10.3389/fphys.2021.714064 https://doaj.org/article/319d66af55d747b3b579396be01e7e0b https://www.frontiersin.org/articles/10.3389/fphys.2021.714064/full https://doaj.org/toc/1664-042X
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