Trichomonas vaginalis Antimicrobial Drug Resistance in 6 US Cities, STD Surveillance Network, 2009–2010
Nitroimidazoles (metronidazole and tinidazole) are the only recommended drugs for treating Trichomonas vaginalis infection, and previous samples that assessed resistance of such isolates have been limited in geographic scope. We assessed the prevalence of in vitro aerobic metronidazole and tinidazol...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Robert D. Kirkcaldy [verfasserIn] Peter Augostini [verfasserIn] Lenore E. Asbel [verfasserIn] Kyle T. Bernstein [verfasserIn] Roxanne P. Kerani [verfasserIn] Christie J. Mettenbrink [verfasserIn] Preeti Pathela [verfasserIn] Jane R. Schwebke [verfasserIn] W. Evan Secor [verfasserIn] Kimberly A. Workowski [verfasserIn] Darlene Davis [verfasserIn] Jim Braxton [verfasserIn] Hillard S. Weinstock [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Emerging Infectious Diseases - Centers for Disease Control and Prevention, 2003, 18(2012), 6, Seite 939-943 |
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| Übergeordnetes Werk: |
volume:18 ; year:2012 ; number:6 ; pages:939-943 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.3201/eid1806.111590 |
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| Katalog-ID: |
DOAJ003975169 |
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| 520 | |a Nitroimidazoles (metronidazole and tinidazole) are the only recommended drugs for treating Trichomonas vaginalis infection, and previous samples that assessed resistance of such isolates have been limited in geographic scope. We assessed the prevalence of in vitro aerobic metronidazole and tinidazole resistance among T. vaginalis isolates from multiple geographic sites in the United States. Swab specimens were obtained from women who underwent routine pelvic examinations at sexually transmitted disease clinics in 6 US cities. Cultured T. vaginalis isolates were tested for nitroimidazole resistance (aerobic minimum lethal concentration [MLC] <50 µg/mL). Of 538 T. vaginalis isolates, 23 (4.3%) exhibited low-level in vitro metronidazole resistance (minimum lethal concentrations 50–100 µg/mL). No isolates exhibited moderate- to high-level metronidazole resistance or tinidazole resistance. Results highlight the possibility that reliance on a single class of antimicrobial drugs for treating T. vaginalis infections may heighten vulnerability to emergence of resistance. Thus, novel treatment options are needed. | ||
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10.3201/eid1806.111590 doi (DE-627)DOAJ003975169 (DE-599)DOAJc4dd1e0d1813425f84ece71d9d49102d DE-627 ger DE-627 rakwb eng RC109-216 Robert D. Kirkcaldy verfasserin aut Trichomonas vaginalis Antimicrobial Drug Resistance in 6 US Cities, STD Surveillance Network, 2009–2010 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nitroimidazoles (metronidazole and tinidazole) are the only recommended drugs for treating Trichomonas vaginalis infection, and previous samples that assessed resistance of such isolates have been limited in geographic scope. We assessed the prevalence of in vitro aerobic metronidazole and tinidazole resistance among T. vaginalis isolates from multiple geographic sites in the United States. Swab specimens were obtained from women who underwent routine pelvic examinations at sexually transmitted disease clinics in 6 US cities. Cultured T. vaginalis isolates were tested for nitroimidazole resistance (aerobic minimum lethal concentration [MLC] <50 µg/mL). Of 538 T. vaginalis isolates, 23 (4.3%) exhibited low-level in vitro metronidazole resistance (minimum lethal concentrations 50–100 µg/mL). No isolates exhibited moderate- to high-level metronidazole resistance or tinidazole resistance. Results highlight the possibility that reliance on a single class of antimicrobial drugs for treating T. vaginalis infections may heighten vulnerability to emergence of resistance. Thus, novel treatment options are needed. Trichomonas vaginalis drug resistance metronidazole resistance, tinidazole resistance, antimicrobial drug resistance, sexually transmitted diseases, protozoa metronidazole resistance tinidazole resistance antimicrobial drug resistance Medicine R Infectious and parasitic diseases Peter Augostini verfasserin aut Lenore E. Asbel verfasserin aut Kyle T. Bernstein verfasserin aut Roxanne P. Kerani verfasserin aut Christie J. Mettenbrink verfasserin aut Preeti Pathela verfasserin aut Jane R. Schwebke verfasserin aut W. Evan Secor verfasserin aut Kimberly A. Workowski verfasserin aut Darlene Davis verfasserin aut Jim Braxton verfasserin aut Hillard S. Weinstock verfasserin aut In Emerging Infectious Diseases Centers for Disease Control and Prevention, 2003 18(2012), 6, Seite 939-943 (DE-627)320436217 (DE-600)2004375-2 10806059 nnns volume:18 year:2012 number:6 pages:939-943 https://doi.org/10.3201/eid1806.111590 kostenfrei https://doaj.org/article/c4dd1e0d1813425f84ece71d9d49102d kostenfrei https://wwwnc.cdc.gov/eid/article/18/6/11-1590_article kostenfrei https://doaj.org/toc/1080-6040 Journal toc kostenfrei https://doaj.org/toc/1080-6059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2012 6 939-943 |
| spelling |
10.3201/eid1806.111590 doi (DE-627)DOAJ003975169 (DE-599)DOAJc4dd1e0d1813425f84ece71d9d49102d DE-627 ger DE-627 rakwb eng RC109-216 Robert D. Kirkcaldy verfasserin aut Trichomonas vaginalis Antimicrobial Drug Resistance in 6 US Cities, STD Surveillance Network, 2009–2010 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nitroimidazoles (metronidazole and tinidazole) are the only recommended drugs for treating Trichomonas vaginalis infection, and previous samples that assessed resistance of such isolates have been limited in geographic scope. We assessed the prevalence of in vitro aerobic metronidazole and tinidazole resistance among T. vaginalis isolates from multiple geographic sites in the United States. Swab specimens were obtained from women who underwent routine pelvic examinations at sexually transmitted disease clinics in 6 US cities. Cultured T. vaginalis isolates were tested for nitroimidazole resistance (aerobic minimum lethal concentration [MLC] <50 µg/mL). Of 538 T. vaginalis isolates, 23 (4.3%) exhibited low-level in vitro metronidazole resistance (minimum lethal concentrations 50–100 µg/mL). No isolates exhibited moderate- to high-level metronidazole resistance or tinidazole resistance. Results highlight the possibility that reliance on a single class of antimicrobial drugs for treating T. vaginalis infections may heighten vulnerability to emergence of resistance. Thus, novel treatment options are needed. Trichomonas vaginalis drug resistance metronidazole resistance, tinidazole resistance, antimicrobial drug resistance, sexually transmitted diseases, protozoa metronidazole resistance tinidazole resistance antimicrobial drug resistance Medicine R Infectious and parasitic diseases Peter Augostini verfasserin aut Lenore E. Asbel verfasserin aut Kyle T. Bernstein verfasserin aut Roxanne P. Kerani verfasserin aut Christie J. Mettenbrink verfasserin aut Preeti Pathela verfasserin aut Jane R. Schwebke verfasserin aut W. Evan Secor verfasserin aut Kimberly A. Workowski verfasserin aut Darlene Davis verfasserin aut Jim Braxton verfasserin aut Hillard S. Weinstock verfasserin aut In Emerging Infectious Diseases Centers for Disease Control and Prevention, 2003 18(2012), 6, Seite 939-943 (DE-627)320436217 (DE-600)2004375-2 10806059 nnns volume:18 year:2012 number:6 pages:939-943 https://doi.org/10.3201/eid1806.111590 kostenfrei https://doaj.org/article/c4dd1e0d1813425f84ece71d9d49102d kostenfrei https://wwwnc.cdc.gov/eid/article/18/6/11-1590_article kostenfrei https://doaj.org/toc/1080-6040 Journal toc kostenfrei https://doaj.org/toc/1080-6059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2012 6 939-943 |
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10.3201/eid1806.111590 doi (DE-627)DOAJ003975169 (DE-599)DOAJc4dd1e0d1813425f84ece71d9d49102d DE-627 ger DE-627 rakwb eng RC109-216 Robert D. Kirkcaldy verfasserin aut Trichomonas vaginalis Antimicrobial Drug Resistance in 6 US Cities, STD Surveillance Network, 2009–2010 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nitroimidazoles (metronidazole and tinidazole) are the only recommended drugs for treating Trichomonas vaginalis infection, and previous samples that assessed resistance of such isolates have been limited in geographic scope. We assessed the prevalence of in vitro aerobic metronidazole and tinidazole resistance among T. vaginalis isolates from multiple geographic sites in the United States. Swab specimens were obtained from women who underwent routine pelvic examinations at sexually transmitted disease clinics in 6 US cities. Cultured T. vaginalis isolates were tested for nitroimidazole resistance (aerobic minimum lethal concentration [MLC] <50 µg/mL). Of 538 T. vaginalis isolates, 23 (4.3%) exhibited low-level in vitro metronidazole resistance (minimum lethal concentrations 50–100 µg/mL). No isolates exhibited moderate- to high-level metronidazole resistance or tinidazole resistance. Results highlight the possibility that reliance on a single class of antimicrobial drugs for treating T. vaginalis infections may heighten vulnerability to emergence of resistance. Thus, novel treatment options are needed. Trichomonas vaginalis drug resistance metronidazole resistance, tinidazole resistance, antimicrobial drug resistance, sexually transmitted diseases, protozoa metronidazole resistance tinidazole resistance antimicrobial drug resistance Medicine R Infectious and parasitic diseases Peter Augostini verfasserin aut Lenore E. Asbel verfasserin aut Kyle T. Bernstein verfasserin aut Roxanne P. Kerani verfasserin aut Christie J. Mettenbrink verfasserin aut Preeti Pathela verfasserin aut Jane R. Schwebke verfasserin aut W. Evan Secor verfasserin aut Kimberly A. Workowski verfasserin aut Darlene Davis verfasserin aut Jim Braxton verfasserin aut Hillard S. Weinstock verfasserin aut In Emerging Infectious Diseases Centers for Disease Control and Prevention, 2003 18(2012), 6, Seite 939-943 (DE-627)320436217 (DE-600)2004375-2 10806059 nnns volume:18 year:2012 number:6 pages:939-943 https://doi.org/10.3201/eid1806.111590 kostenfrei https://doaj.org/article/c4dd1e0d1813425f84ece71d9d49102d kostenfrei https://wwwnc.cdc.gov/eid/article/18/6/11-1590_article kostenfrei https://doaj.org/toc/1080-6040 Journal toc kostenfrei https://doaj.org/toc/1080-6059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2012 6 939-943 |
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Robert D. Kirkcaldy @@aut@@ Peter Augostini @@aut@@ Lenore E. Asbel @@aut@@ Kyle T. Bernstein @@aut@@ Roxanne P. Kerani @@aut@@ Christie J. Mettenbrink @@aut@@ Preeti Pathela @@aut@@ Jane R. Schwebke @@aut@@ W. Evan Secor @@aut@@ Kimberly A. Workowski @@aut@@ Darlene Davis @@aut@@ Jim Braxton @@aut@@ Hillard S. Weinstock @@aut@@ |
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RC109-216 Trichomonas vaginalis Antimicrobial Drug Resistance in 6 US Cities, STD Surveillance Network, 2009–2010 Trichomonas vaginalis drug resistance metronidazole resistance, tinidazole resistance, antimicrobial drug resistance, sexually transmitted diseases, protozoa metronidazole resistance tinidazole resistance antimicrobial drug resistance |
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Robert D. Kirkcaldy Peter Augostini Lenore E. Asbel Kyle T. Bernstein Roxanne P. Kerani Christie J. Mettenbrink Preeti Pathela Jane R. Schwebke W. Evan Secor Kimberly A. Workowski Darlene Davis Jim Braxton Hillard S. Weinstock |
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Trichomonas vaginalis Antimicrobial Drug Resistance in 6 US Cities, STD Surveillance Network, 2009–2010 |
| abstract |
Nitroimidazoles (metronidazole and tinidazole) are the only recommended drugs for treating Trichomonas vaginalis infection, and previous samples that assessed resistance of such isolates have been limited in geographic scope. We assessed the prevalence of in vitro aerobic metronidazole and tinidazole resistance among T. vaginalis isolates from multiple geographic sites in the United States. Swab specimens were obtained from women who underwent routine pelvic examinations at sexually transmitted disease clinics in 6 US cities. Cultured T. vaginalis isolates were tested for nitroimidazole resistance (aerobic minimum lethal concentration [MLC] <50 µg/mL). Of 538 T. vaginalis isolates, 23 (4.3%) exhibited low-level in vitro metronidazole resistance (minimum lethal concentrations 50–100 µg/mL). No isolates exhibited moderate- to high-level metronidazole resistance or tinidazole resistance. Results highlight the possibility that reliance on a single class of antimicrobial drugs for treating T. vaginalis infections may heighten vulnerability to emergence of resistance. Thus, novel treatment options are needed. |
| abstractGer |
Nitroimidazoles (metronidazole and tinidazole) are the only recommended drugs for treating Trichomonas vaginalis infection, and previous samples that assessed resistance of such isolates have been limited in geographic scope. We assessed the prevalence of in vitro aerobic metronidazole and tinidazole resistance among T. vaginalis isolates from multiple geographic sites in the United States. Swab specimens were obtained from women who underwent routine pelvic examinations at sexually transmitted disease clinics in 6 US cities. Cultured T. vaginalis isolates were tested for nitroimidazole resistance (aerobic minimum lethal concentration [MLC] <50 µg/mL). Of 538 T. vaginalis isolates, 23 (4.3%) exhibited low-level in vitro metronidazole resistance (minimum lethal concentrations 50–100 µg/mL). No isolates exhibited moderate- to high-level metronidazole resistance or tinidazole resistance. Results highlight the possibility that reliance on a single class of antimicrobial drugs for treating T. vaginalis infections may heighten vulnerability to emergence of resistance. Thus, novel treatment options are needed. |
| abstract_unstemmed |
Nitroimidazoles (metronidazole and tinidazole) are the only recommended drugs for treating Trichomonas vaginalis infection, and previous samples that assessed resistance of such isolates have been limited in geographic scope. We assessed the prevalence of in vitro aerobic metronidazole and tinidazole resistance among T. vaginalis isolates from multiple geographic sites in the United States. Swab specimens were obtained from women who underwent routine pelvic examinations at sexually transmitted disease clinics in 6 US cities. Cultured T. vaginalis isolates were tested for nitroimidazole resistance (aerobic minimum lethal concentration [MLC] <50 µg/mL). Of 538 T. vaginalis isolates, 23 (4.3%) exhibited low-level in vitro metronidazole resistance (minimum lethal concentrations 50–100 µg/mL). No isolates exhibited moderate- to high-level metronidazole resistance or tinidazole resistance. Results highlight the possibility that reliance on a single class of antimicrobial drugs for treating T. vaginalis infections may heighten vulnerability to emergence of resistance. Thus, novel treatment options are needed. |
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