Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells

The study aimed to evaluate the possible modulation of Nrf2, NF-ĸB and STAT3 signaling pathways in the colorectal cancer (CRC) cells line DLD-1 and HCT116 by secondary metabolites of lichens. An attempt was made to indicate the most promising targets in these signaling pathways. Attention was also p...
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Autor*in:	Katarzyna Papierska [verfasserIn] Violetta Krajka-Kuźniak [verfasserIn] Jarosław Paluszczak [verfasserIn] Robert Kleszcz [verfasserIn] Marcin Skalski [verfasserIn] Elżbieta Studzińska-Sroka [verfasserIn] Wanda Baer-Dubowska [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	colorectal cancer lichens NF-κB Nrf2 STAT3

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 26(2021), 16, p 4787
Übergeordnetes Werk:	volume:26 ; year:2021 ; number:16, p 4787

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules26164787

Katalog-ID:	DOAJ004013387

Internformat


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spelling	10.3390/molecules26164787 doi (DE-627)DOAJ004013387 (DE-599)DOAJ39507ddb43b94d6c8cd5135c21b8c6ca DE-627 ger DE-627 rakwb eng QD241-441 Katarzyna Papierska verfasserin aut Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The study aimed to evaluate the possible modulation of Nrf2, NF-ĸB and STAT3 signaling pathways in the colorectal cancer (CRC) cells line DLD-1 and HCT116 by secondary metabolites of lichens. An attempt was made to indicate the most promising targets in these signaling pathways. Attention was also paid to the effects of the compounds tested on CRC cells using anakoinosis—that is, simultaneous analysis of several signaling pathways. The effects of the tested natural compounds on the activity of selected transcriptional factors related to CRC were analyzed by Western blot and RT-PCR assays. The highest activity against CRC cells was shown by physodic and salazinic acids from the studied secondary metabolites of lichens. As a result, an increase in the activation of transcription factor Nrf2 and the expression of its selected target genes was observed. Physodic and salazinic acids induced the opposite effect in relation to the NF-κB and STAT3 pathways. These results confirmed our earlier observations that lichen-derived compounds have the ability to modulate signaling pathway networks. While caperatic acid affected Wnt/β-catenin to the most extent, salazinic acid was the most potent modulator of Nrf2, NF-κB and STAT3 pathways. Physodic acid seemed to affect all the investigated pathways. colorectal cancer lichens NF-κB Nrf2 STAT3 Organic chemistry Violetta Krajka-Kuźniak verfasserin aut Jarosław Paluszczak verfasserin aut Robert Kleszcz verfasserin aut Marcin Skalski verfasserin aut Elżbieta Studzińska-Sroka verfasserin aut Wanda Baer-Dubowska verfasserin aut In Molecules MDPI AG, 2003 26(2021), 16, p 4787 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:16, p 4787 https://doi.org/10.3390/molecules26164787 kostenfrei https://doaj.org/article/39507ddb43b94d6c8cd5135c21b8c6ca kostenfrei https://www.mdpi.com/1420-3049/26/16/4787 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 16, p 4787
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allfieldsSound	10.3390/molecules26164787 doi (DE-627)DOAJ004013387 (DE-599)DOAJ39507ddb43b94d6c8cd5135c21b8c6ca DE-627 ger DE-627 rakwb eng QD241-441 Katarzyna Papierska verfasserin aut Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The study aimed to evaluate the possible modulation of Nrf2, NF-ĸB and STAT3 signaling pathways in the colorectal cancer (CRC) cells line DLD-1 and HCT116 by secondary metabolites of lichens. An attempt was made to indicate the most promising targets in these signaling pathways. Attention was also paid to the effects of the compounds tested on CRC cells using anakoinosis—that is, simultaneous analysis of several signaling pathways. The effects of the tested natural compounds on the activity of selected transcriptional factors related to CRC were analyzed by Western blot and RT-PCR assays. The highest activity against CRC cells was shown by physodic and salazinic acids from the studied secondary metabolites of lichens. As a result, an increase in the activation of transcription factor Nrf2 and the expression of its selected target genes was observed. Physodic and salazinic acids induced the opposite effect in relation to the NF-κB and STAT3 pathways. These results confirmed our earlier observations that lichen-derived compounds have the ability to modulate signaling pathway networks. While caperatic acid affected Wnt/β-catenin to the most extent, salazinic acid was the most potent modulator of Nrf2, NF-κB and STAT3 pathways. Physodic acid seemed to affect all the investigated pathways. colorectal cancer lichens NF-κB Nrf2 STAT3 Organic chemistry Violetta Krajka-Kuźniak verfasserin aut Jarosław Paluszczak verfasserin aut Robert Kleszcz verfasserin aut Marcin Skalski verfasserin aut Elżbieta Studzińska-Sroka verfasserin aut Wanda Baer-Dubowska verfasserin aut In Molecules MDPI AG, 2003 26(2021), 16, p 4787 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:16, p 4787 https://doi.org/10.3390/molecules26164787 kostenfrei https://doaj.org/article/39507ddb43b94d6c8cd5135c21b8c6ca kostenfrei https://www.mdpi.com/1420-3049/26/16/4787 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 16, p 4787
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callnumber-first	Q - Science
author	Katarzyna Papierska
spellingShingle	Katarzyna Papierska misc QD241-441 misc colorectal cancer misc lichens misc NF-κB misc Nrf2 misc STAT3 misc Organic chemistry Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells
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topic_title	QD241-441 Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells colorectal cancer lichens NF-κB Nrf2 STAT3
topic	misc QD241-441 misc colorectal cancer misc lichens misc NF-κB misc Nrf2 misc STAT3 misc Organic chemistry
topic_unstemmed	misc QD241-441 misc colorectal cancer misc lichens misc NF-κB misc Nrf2 misc STAT3 misc Organic chemistry
topic_browse	misc QD241-441 misc colorectal cancer misc lichens misc NF-κB misc Nrf2 misc STAT3 misc Organic chemistry
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title	Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells
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title_full	Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells
author_sort	Katarzyna Papierska
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author_browse	Katarzyna Papierska Violetta Krajka-Kuźniak Jarosław Paluszczak Robert Kleszcz Marcin Skalski Elżbieta Studzińska-Sroka Wanda Baer-Dubowska
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title_sort	lichen-derived depsides and depsidones modulate the nrf2, nf-κb and stat3 signaling pathways in colorectal cancer cells
callnumber	QD241-441
title_auth	Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells
abstract	The study aimed to evaluate the possible modulation of Nrf2, NF-ĸB and STAT3 signaling pathways in the colorectal cancer (CRC) cells line DLD-1 and HCT116 by secondary metabolites of lichens. An attempt was made to indicate the most promising targets in these signaling pathways. Attention was also paid to the effects of the compounds tested on CRC cells using anakoinosis—that is, simultaneous analysis of several signaling pathways. The effects of the tested natural compounds on the activity of selected transcriptional factors related to CRC were analyzed by Western blot and RT-PCR assays. The highest activity against CRC cells was shown by physodic and salazinic acids from the studied secondary metabolites of lichens. As a result, an increase in the activation of transcription factor Nrf2 and the expression of its selected target genes was observed. Physodic and salazinic acids induced the opposite effect in relation to the NF-κB and STAT3 pathways. These results confirmed our earlier observations that lichen-derived compounds have the ability to modulate signaling pathway networks. While caperatic acid affected Wnt/β-catenin to the most extent, salazinic acid was the most potent modulator of Nrf2, NF-κB and STAT3 pathways. Physodic acid seemed to affect all the investigated pathways.
abstractGer	The study aimed to evaluate the possible modulation of Nrf2, NF-ĸB and STAT3 signaling pathways in the colorectal cancer (CRC) cells line DLD-1 and HCT116 by secondary metabolites of lichens. An attempt was made to indicate the most promising targets in these signaling pathways. Attention was also paid to the effects of the compounds tested on CRC cells using anakoinosis—that is, simultaneous analysis of several signaling pathways. The effects of the tested natural compounds on the activity of selected transcriptional factors related to CRC were analyzed by Western blot and RT-PCR assays. The highest activity against CRC cells was shown by physodic and salazinic acids from the studied secondary metabolites of lichens. As a result, an increase in the activation of transcription factor Nrf2 and the expression of its selected target genes was observed. Physodic and salazinic acids induced the opposite effect in relation to the NF-κB and STAT3 pathways. These results confirmed our earlier observations that lichen-derived compounds have the ability to modulate signaling pathway networks. While caperatic acid affected Wnt/β-catenin to the most extent, salazinic acid was the most potent modulator of Nrf2, NF-κB and STAT3 pathways. Physodic acid seemed to affect all the investigated pathways.
abstract_unstemmed	The study aimed to evaluate the possible modulation of Nrf2, NF-ĸB and STAT3 signaling pathways in the colorectal cancer (CRC) cells line DLD-1 and HCT116 by secondary metabolites of lichens. An attempt was made to indicate the most promising targets in these signaling pathways. Attention was also paid to the effects of the compounds tested on CRC cells using anakoinosis—that is, simultaneous analysis of several signaling pathways. The effects of the tested natural compounds on the activity of selected transcriptional factors related to CRC were analyzed by Western blot and RT-PCR assays. The highest activity against CRC cells was shown by physodic and salazinic acids from the studied secondary metabolites of lichens. As a result, an increase in the activation of transcription factor Nrf2 and the expression of its selected target genes was observed. Physodic and salazinic acids induced the opposite effect in relation to the NF-κB and STAT3 pathways. These results confirmed our earlier observations that lichen-derived compounds have the ability to modulate signaling pathway networks. While caperatic acid affected Wnt/β-catenin to the most extent, salazinic acid was the most potent modulator of Nrf2, NF-κB and STAT3 pathways. Physodic acid seemed to affect all the investigated pathways.
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title_short	Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells
url	https://doi.org/10.3390/molecules26164787 https://doaj.org/article/39507ddb43b94d6c8cd5135c21b8c6ca https://www.mdpi.com/1420-3049/26/16/4787 https://doaj.org/toc/1420-3049
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author2	Violetta Krajka-Kuźniak Jarosław Paluszczak Robert Kleszcz Marcin Skalski Elżbieta Studzińska-Sroka Wanda Baer-Dubowska
author2Str	Violetta Krajka-Kuźniak Jarosław Paluszczak Robert Kleszcz Marcin Skalski Elżbieta Studzińska-Sroka Wanda Baer-Dubowska
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doi_str	10.3390/molecules26164787
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up_date	2024-07-03T21:28:44.919Z
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Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells

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