Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery

A “smart” coreshell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesopor...
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Autor*in:	Bo Sang Kim [verfasserIn] Yi-Ting Chen [verfasserIn] Pannaree Srinoi [verfasserIn] Maria D. Marquez [verfasserIn] T. Randall Lee [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	drug delivery temperature-responsive gold nanoshell hydrogel coating

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 20(2019), 14, p 3422
Übergeordnetes Werk:	volume:20 ; year:2019 ; number:14, p 3422

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms20143422

Katalog-ID:	DOAJ004253124

Internformat


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allfields	10.3390/ijms20143422 doi (DE-627)DOAJ004253124 (DE-599)DOAJfedde904cd104716a2c134318fe5a0f3 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Bo Sang Kim verfasserin aut Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A “smart” coreshell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (<i<m</i<-) silica layer (<i<m</i<-SiO<sub<2</sub<). The GNS@<i<m</i<-SiO<sub<2</sub< nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a <i<m</i<-SiO<sub<2</sub< layer providing additional non-collapsible space for drug storage. The influence of the <i<m</i<-SiO<sub<2</sub< layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The “smart” core@shell composite NPs having a <i<m</i<-SiO<sub<2</sub< layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no <i<m</i<-SiO<sub<2</sub< shell. Additionally, an efficient response by the composite NPs was successfully induced by the thermal energy generated from the gold nanoshell core upon exposure to near infrared (NIR) stimulation. drug delivery temperature-responsive gold nanoshell hydrogel coating Biology (General) Chemistry Yi-Ting Chen verfasserin aut Pannaree Srinoi verfasserin aut Maria D. Marquez verfasserin aut T. Randall Lee verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 14, p 3422 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:14, p 3422 https://doi.org/10.3390/ijms20143422 kostenfrei https://doaj.org/article/fedde904cd104716a2c134318fe5a0f3 kostenfrei https://www.mdpi.com/1422-0067/20/14/3422 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 14, p 3422
spelling	10.3390/ijms20143422 doi (DE-627)DOAJ004253124 (DE-599)DOAJfedde904cd104716a2c134318fe5a0f3 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Bo Sang Kim verfasserin aut Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A “smart” coreshell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (<i<m</i<-) silica layer (<i<m</i<-SiO<sub<2</sub<). The GNS@<i<m</i<-SiO<sub<2</sub< nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a <i<m</i<-SiO<sub<2</sub< layer providing additional non-collapsible space for drug storage. The influence of the <i<m</i<-SiO<sub<2</sub< layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The “smart” core@shell composite NPs having a <i<m</i<-SiO<sub<2</sub< layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no <i<m</i<-SiO<sub<2</sub< shell. Additionally, an efficient response by the composite NPs was successfully induced by the thermal energy generated from the gold nanoshell core upon exposure to near infrared (NIR) stimulation. drug delivery temperature-responsive gold nanoshell hydrogel coating Biology (General) Chemistry Yi-Ting Chen verfasserin aut Pannaree Srinoi verfasserin aut Maria D. Marquez verfasserin aut T. Randall Lee verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 14, p 3422 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:14, p 3422 https://doi.org/10.3390/ijms20143422 kostenfrei https://doaj.org/article/fedde904cd104716a2c134318fe5a0f3 kostenfrei https://www.mdpi.com/1422-0067/20/14/3422 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 14, p 3422
allfields_unstemmed	10.3390/ijms20143422 doi (DE-627)DOAJ004253124 (DE-599)DOAJfedde904cd104716a2c134318fe5a0f3 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Bo Sang Kim verfasserin aut Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A “smart” coreshell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (<i<m</i<-) silica layer (<i<m</i<-SiO<sub<2</sub<). The GNS@<i<m</i<-SiO<sub<2</sub< nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a <i<m</i<-SiO<sub<2</sub< layer providing additional non-collapsible space for drug storage. The influence of the <i<m</i<-SiO<sub<2</sub< layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The “smart” core@shell composite NPs having a <i<m</i<-SiO<sub<2</sub< layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no <i<m</i<-SiO<sub<2</sub< shell. Additionally, an efficient response by the composite NPs was successfully induced by the thermal energy generated from the gold nanoshell core upon exposure to near infrared (NIR) stimulation. drug delivery temperature-responsive gold nanoshell hydrogel coating Biology (General) Chemistry Yi-Ting Chen verfasserin aut Pannaree Srinoi verfasserin aut Maria D. Marquez verfasserin aut T. Randall Lee verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 14, p 3422 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:14, p 3422 https://doi.org/10.3390/ijms20143422 kostenfrei https://doaj.org/article/fedde904cd104716a2c134318fe5a0f3 kostenfrei https://www.mdpi.com/1422-0067/20/14/3422 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 14, p 3422
allfieldsGer	10.3390/ijms20143422 doi (DE-627)DOAJ004253124 (DE-599)DOAJfedde904cd104716a2c134318fe5a0f3 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Bo Sang Kim verfasserin aut Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A “smart” coreshell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (<i<m</i<-) silica layer (<i<m</i<-SiO<sub<2</sub<). The GNS@<i<m</i<-SiO<sub<2</sub< nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a <i<m</i<-SiO<sub<2</sub< layer providing additional non-collapsible space for drug storage. The influence of the <i<m</i<-SiO<sub<2</sub< layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The “smart” core@shell composite NPs having a <i<m</i<-SiO<sub<2</sub< layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no <i<m</i<-SiO<sub<2</sub< shell. Additionally, an efficient response by the composite NPs was successfully induced by the thermal energy generated from the gold nanoshell core upon exposure to near infrared (NIR) stimulation. drug delivery temperature-responsive gold nanoshell hydrogel coating Biology (General) Chemistry Yi-Ting Chen verfasserin aut Pannaree Srinoi verfasserin aut Maria D. Marquez verfasserin aut T. Randall Lee verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 14, p 3422 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:14, p 3422 https://doi.org/10.3390/ijms20143422 kostenfrei https://doaj.org/article/fedde904cd104716a2c134318fe5a0f3 kostenfrei https://www.mdpi.com/1422-0067/20/14/3422 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 14, p 3422
allfieldsSound	10.3390/ijms20143422 doi (DE-627)DOAJ004253124 (DE-599)DOAJfedde904cd104716a2c134318fe5a0f3 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Bo Sang Kim verfasserin aut Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A “smart” coreshell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (<i<m</i<-) silica layer (<i<m</i<-SiO<sub<2</sub<). The GNS@<i<m</i<-SiO<sub<2</sub< nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a <i<m</i<-SiO<sub<2</sub< layer providing additional non-collapsible space for drug storage. The influence of the <i<m</i<-SiO<sub<2</sub< layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The “smart” core@shell composite NPs having a <i<m</i<-SiO<sub<2</sub< layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no <i<m</i<-SiO<sub<2</sub< shell. Additionally, an efficient response by the composite NPs was successfully induced by the thermal energy generated from the gold nanoshell core upon exposure to near infrared (NIR) stimulation. drug delivery temperature-responsive gold nanoshell hydrogel coating Biology (General) Chemistry Yi-Ting Chen verfasserin aut Pannaree Srinoi verfasserin aut Maria D. Marquez verfasserin aut T. Randall Lee verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 14, p 3422 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:14, p 3422 https://doi.org/10.3390/ijms20143422 kostenfrei https://doaj.org/article/fedde904cd104716a2c134318fe5a0f3 kostenfrei https://www.mdpi.com/1422-0067/20/14/3422 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 14, p 3422
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callnumber-first	Q - Science
author	Bo Sang Kim
spellingShingle	Bo Sang Kim misc QH301-705.5 misc QD1-999 misc drug delivery misc temperature-responsive misc gold nanoshell misc hydrogel coating misc Biology (General) misc Chemistry Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery
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topic_title	QH301-705.5 QD1-999 Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery drug delivery temperature-responsive gold nanoshell hydrogel coating
topic	misc QH301-705.5 misc QD1-999 misc drug delivery misc temperature-responsive misc gold nanoshell misc hydrogel coating misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc drug delivery misc temperature-responsive misc gold nanoshell misc hydrogel coating misc Biology (General) misc Chemistry
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title	Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery
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title_full	Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery
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title_sort	hydrogel-encapsulated mesoporous silica-coated gold nanoshells for smart drug delivery
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title_auth	Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery
abstract	A “smart” coreshell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (<i<m</i<-) silica layer (<i<m</i<-SiO<sub<2</sub<). The GNS@<i<m</i<-SiO<sub<2</sub< nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a <i<m</i<-SiO<sub<2</sub< layer providing additional non-collapsible space for drug storage. The influence of the <i<m</i<-SiO<sub<2</sub< layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The “smart” core@shell composite NPs having a <i<m</i<-SiO<sub<2</sub< layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no <i<m</i<-SiO<sub<2</sub< shell. Additionally, an efficient response by the composite NPs was successfully induced by the thermal energy generated from the gold nanoshell core upon exposure to near infrared (NIR) stimulation.
abstractGer	A “smart” coreshell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (<i<m</i<-) silica layer (<i<m</i<-SiO<sub<2</sub<). The GNS@<i<m</i<-SiO<sub<2</sub< nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a <i<m</i<-SiO<sub<2</sub< layer providing additional non-collapsible space for drug storage. The influence of the <i<m</i<-SiO<sub<2</sub< layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The “smart” core@shell composite NPs having a <i<m</i<-SiO<sub<2</sub< layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no <i<m</i<-SiO<sub<2</sub< shell. Additionally, an efficient response by the composite NPs was successfully induced by the thermal energy generated from the gold nanoshell core upon exposure to near infrared (NIR) stimulation.
abstract_unstemmed	A “smart” coreshell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (<i<m</i<-) silica layer (<i<m</i<-SiO<sub<2</sub<). The GNS@<i<m</i<-SiO<sub<2</sub< nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a <i<m</i<-SiO<sub<2</sub< layer providing additional non-collapsible space for drug storage. The influence of the <i<m</i<-SiO<sub<2</sub< layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The “smart” core@shell composite NPs having a <i<m</i<-SiO<sub<2</sub< layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no <i<m</i<-SiO<sub<2</sub< shell. Additionally, an efficient response by the composite NPs was successfully induced by the thermal energy generated from the gold nanoshell core upon exposure to near infrared (NIR) stimulation.
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title_short	Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery
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These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (<i<m</i<-) silica layer (<i<m</i<-SiO<sub<2</sub<). The GNS@<i<m</i<-SiO<sub<2</sub< nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a <i<m</i<-SiO<sub<2</sub< layer providing additional non-collapsible space for drug storage. The influence of the <i<m</i<-SiO<sub<2</sub< layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The “smart” core@shell composite NPs having a <i<m</i<-SiO<sub<2</sub< layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no <i<m</i<-SiO<sub<2</sub< shell. 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