Neuromodulation as a new avenue for resuscitation in hemorrhagic shock

Abstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these op...
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Autor*in:	Keren Powell [verfasserIn] Kevin Shah [verfasserIn] Caleb Hao [verfasserIn] Yi-Chen Wu [verfasserIn] Aashish John [verfasserIn] Raj K. Narayan [verfasserIn] Chunyan Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Hemorrhagic shock Neuromodulation Vagus nerve stimulation Trigeminal nerve stimulation Phrenic nerve stimulation Electroacupuncture

Übergeordnetes Werk:	In: Bioelectronic Medicine - BMC, 2018, 5(2019), 1, Seite 7
Übergeordnetes Werk:	volume:5 ; year:2019 ; number:1 ; pages:7

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s42234-019-0033-z

Katalog-ID:	DOAJ004288238

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520			\|a Abstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future.
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allfields	10.1186/s42234-019-0033-z doi (DE-627)DOAJ004288238 (DE-599)DOAJ7ccc4b6c85da40aa93930c1de42b4469 DE-627 ger DE-627 rakwb eng R855-855.5 Keren Powell verfasserin aut Neuromodulation as a new avenue for resuscitation in hemorrhagic shock 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future. Hemorrhagic shock Neuromodulation Vagus nerve stimulation Trigeminal nerve stimulation Phrenic nerve stimulation Electroacupuncture Medical technology Kevin Shah verfasserin aut Caleb Hao verfasserin aut Yi-Chen Wu verfasserin aut Aashish John verfasserin aut Raj K. Narayan verfasserin aut Chunyan Li verfasserin aut In Bioelectronic Medicine BMC, 2018 5(2019), 1, Seite 7 (DE-627)1022213903 23328886 nnns volume:5 year:2019 number:1 pages:7 https://doi.org/10.1186/s42234-019-0033-z kostenfrei https://doaj.org/article/7ccc4b6c85da40aa93930c1de42b4469 kostenfrei http://link.springer.com/article/10.1186/s42234-019-0033-z kostenfrei https://doaj.org/toc/2332-8886 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2019 1 7
spelling	10.1186/s42234-019-0033-z doi (DE-627)DOAJ004288238 (DE-599)DOAJ7ccc4b6c85da40aa93930c1de42b4469 DE-627 ger DE-627 rakwb eng R855-855.5 Keren Powell verfasserin aut Neuromodulation as a new avenue for resuscitation in hemorrhagic shock 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future. Hemorrhagic shock Neuromodulation Vagus nerve stimulation Trigeminal nerve stimulation Phrenic nerve stimulation Electroacupuncture Medical technology Kevin Shah verfasserin aut Caleb Hao verfasserin aut Yi-Chen Wu verfasserin aut Aashish John verfasserin aut Raj K. Narayan verfasserin aut Chunyan Li verfasserin aut In Bioelectronic Medicine BMC, 2018 5(2019), 1, Seite 7 (DE-627)1022213903 23328886 nnns volume:5 year:2019 number:1 pages:7 https://doi.org/10.1186/s42234-019-0033-z kostenfrei https://doaj.org/article/7ccc4b6c85da40aa93930c1de42b4469 kostenfrei http://link.springer.com/article/10.1186/s42234-019-0033-z kostenfrei https://doaj.org/toc/2332-8886 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2019 1 7
allfields_unstemmed	10.1186/s42234-019-0033-z doi (DE-627)DOAJ004288238 (DE-599)DOAJ7ccc4b6c85da40aa93930c1de42b4469 DE-627 ger DE-627 rakwb eng R855-855.5 Keren Powell verfasserin aut Neuromodulation as a new avenue for resuscitation in hemorrhagic shock 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future. Hemorrhagic shock Neuromodulation Vagus nerve stimulation Trigeminal nerve stimulation Phrenic nerve stimulation Electroacupuncture Medical technology Kevin Shah verfasserin aut Caleb Hao verfasserin aut Yi-Chen Wu verfasserin aut Aashish John verfasserin aut Raj K. Narayan verfasserin aut Chunyan Li verfasserin aut In Bioelectronic Medicine BMC, 2018 5(2019), 1, Seite 7 (DE-627)1022213903 23328886 nnns volume:5 year:2019 number:1 pages:7 https://doi.org/10.1186/s42234-019-0033-z kostenfrei https://doaj.org/article/7ccc4b6c85da40aa93930c1de42b4469 kostenfrei http://link.springer.com/article/10.1186/s42234-019-0033-z kostenfrei https://doaj.org/toc/2332-8886 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2019 1 7
allfieldsGer	10.1186/s42234-019-0033-z doi (DE-627)DOAJ004288238 (DE-599)DOAJ7ccc4b6c85da40aa93930c1de42b4469 DE-627 ger DE-627 rakwb eng R855-855.5 Keren Powell verfasserin aut Neuromodulation as a new avenue for resuscitation in hemorrhagic shock 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future. Hemorrhagic shock Neuromodulation Vagus nerve stimulation Trigeminal nerve stimulation Phrenic nerve stimulation Electroacupuncture Medical technology Kevin Shah verfasserin aut Caleb Hao verfasserin aut Yi-Chen Wu verfasserin aut Aashish John verfasserin aut Raj K. Narayan verfasserin aut Chunyan Li verfasserin aut In Bioelectronic Medicine BMC, 2018 5(2019), 1, Seite 7 (DE-627)1022213903 23328886 nnns volume:5 year:2019 number:1 pages:7 https://doi.org/10.1186/s42234-019-0033-z kostenfrei https://doaj.org/article/7ccc4b6c85da40aa93930c1de42b4469 kostenfrei http://link.springer.com/article/10.1186/s42234-019-0033-z kostenfrei https://doaj.org/toc/2332-8886 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2019 1 7
allfieldsSound	10.1186/s42234-019-0033-z doi (DE-627)DOAJ004288238 (DE-599)DOAJ7ccc4b6c85da40aa93930c1de42b4469 DE-627 ger DE-627 rakwb eng R855-855.5 Keren Powell verfasserin aut Neuromodulation as a new avenue for resuscitation in hemorrhagic shock 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future. Hemorrhagic shock Neuromodulation Vagus nerve stimulation Trigeminal nerve stimulation Phrenic nerve stimulation Electroacupuncture Medical technology Kevin Shah verfasserin aut Caleb Hao verfasserin aut Yi-Chen Wu verfasserin aut Aashish John verfasserin aut Raj K. Narayan verfasserin aut Chunyan Li verfasserin aut In Bioelectronic Medicine BMC, 2018 5(2019), 1, Seite 7 (DE-627)1022213903 23328886 nnns volume:5 year:2019 number:1 pages:7 https://doi.org/10.1186/s42234-019-0033-z kostenfrei https://doaj.org/article/7ccc4b6c85da40aa93930c1de42b4469 kostenfrei http://link.springer.com/article/10.1186/s42234-019-0033-z kostenfrei https://doaj.org/toc/2332-8886 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2019 1 7
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source	In Bioelectronic Medicine 5(2019), 1, Seite 7 volume:5 year:2019 number:1 pages:7
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topic_facet	Hemorrhagic shock Neuromodulation Vagus nerve stimulation Trigeminal nerve stimulation Phrenic nerve stimulation Electroacupuncture Medical technology
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callnumber-first	R - Medicine
author	Keren Powell
spellingShingle	Keren Powell misc R855-855.5 misc Hemorrhagic shock misc Neuromodulation misc Vagus nerve stimulation misc Trigeminal nerve stimulation misc Phrenic nerve stimulation misc Electroacupuncture misc Medical technology Neuromodulation as a new avenue for resuscitation in hemorrhagic shock
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topic_title	R855-855.5 Neuromodulation as a new avenue for resuscitation in hemorrhagic shock Hemorrhagic shock Neuromodulation Vagus nerve stimulation Trigeminal nerve stimulation Phrenic nerve stimulation Electroacupuncture
topic	misc R855-855.5 misc Hemorrhagic shock misc Neuromodulation misc Vagus nerve stimulation misc Trigeminal nerve stimulation misc Phrenic nerve stimulation misc Electroacupuncture misc Medical technology
topic_unstemmed	misc R855-855.5 misc Hemorrhagic shock misc Neuromodulation misc Vagus nerve stimulation misc Trigeminal nerve stimulation misc Phrenic nerve stimulation misc Electroacupuncture misc Medical technology
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title	Neuromodulation as a new avenue for resuscitation in hemorrhagic shock
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title_full	Neuromodulation as a new avenue for resuscitation in hemorrhagic shock
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title_sort	neuromodulation as a new avenue for resuscitation in hemorrhagic shock
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title_auth	Neuromodulation as a new avenue for resuscitation in hemorrhagic shock
abstract	Abstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future.
abstractGer	Abstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future.
abstract_unstemmed	Abstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future.
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title_short	Neuromodulation as a new avenue for resuscitation in hemorrhagic shock
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Neuromodulation as a new avenue for resuscitation in hemorrhagic shock

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