Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study

Abstract Aims/Introduction Studies have shown that sodium–glucose cotransporter 2 (SGLT2) inhibitors increased time‐in‐range (TIR; percentage of time glucose level remains between 3.9 and 10.0 mmol/L [70–180 mg/dL]) and decreased glycemic variability in patients with type 1 diabetes. The aim of this...
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Autor*in:	Daisuke Suzuki [verfasserIn] Hodaka Yamada [verfasserIn] Masashi Yoshida [verfasserIn] Shunsuke Funazaki [verfasserIn] Misato Amamoto [verfasserIn] Jun Morimoto [verfasserIn] Kazuo Hara [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Sodium–glucose cotransporter 2 inhibitors Time‐in‐range Type 1 diabetes

Übergeordnetes Werk:	In: Journal of Diabetes Investigation - Wiley, 2014, 11(2020), 5, Seite 1230-1237
Übergeordnetes Werk:	volume:11 ; year:2020 ; number:5 ; pages:1230-1237

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1111/jdi.13240

Katalog-ID:	DOAJ00431252X

Internformat


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245	1	0	\|a Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study
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520			\|a Abstract Aims/Introduction Studies have shown that sodium–glucose cotransporter 2 (SGLT2) inhibitors increased time‐in‐range (TIR; percentage of time glucose level remains between 3.9 and 10.0 mmol/L [70–180 mg/dL]) and decreased glycemic variability in patients with type 1 diabetes. The aim of this study was to investigate the effects of SGLT2 inhibitors on TIR, glycemic variability and glucose control in Japanese patients with type 1 diabetes in a real clinical setting. Materials and Methods We designed a single‐arm, retrospective cohort study to analyze data from patients starting to use ipragliflozin or dapagliflozin and who used a sensor‐based flash glucose monitoring system between February 2019 and August 2019. We measured TIR, time above range <180 mg/dL (percentage of time with glucose level of <180 mg/dL or <10.0 mmol/L), time below range <70 mg/dL (percentage of time with glucose level of <70 mg/dL or <3.9 mmol/L), mean glucose and standard deviation, and coefficient of variation for glycemic variability, and then compared the data before and after SGLT2 inhibitors treatments. Results We enrolled 15 patients in the study. The total dosages of basal insulin decreased significantly, but the total doses of bolus insulin did not change significantly. TIR increased significantly by approximately 11.6%; the time below range <70 mg/dL remained unchanged; and the mean glucose and standard deviation decreased significantly, whereas the coefficients of variation did not. Conclusions SGLT2 inhibitors improved TIR and the mean glucose level and standard deviation without increasing the time below range <70 mg/dL in patients with type 1 diabetes.
650		4	\|a Sodium–glucose cotransporter 2 inhibitors
650		4	\|a Time‐in‐range
650		4	\|a Type 1 diabetes
653		0	\|a Diseases of the endocrine glands. Clinical endocrinology
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700	0		\|a Masashi Yoshida \|e verfasserin \|4 aut
700	0		\|a Shunsuke Funazaki \|e verfasserin \|4 aut
700	0		\|a Misato Amamoto \|e verfasserin \|4 aut
700	0		\|a Jun Morimoto \|e verfasserin \|4 aut
700	0		\|a Kazuo Hara \|e verfasserin \|4 aut
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allfields	10.1111/jdi.13240 doi (DE-627)DOAJ00431252X (DE-599)DOAJ4a130768dee841788813414329e5c5f9 DE-627 ger DE-627 rakwb eng RC648-665 Daisuke Suzuki verfasserin aut Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Aims/Introduction Studies have shown that sodium–glucose cotransporter 2 (SGLT2) inhibitors increased time‐in‐range (TIR; percentage of time glucose level remains between 3.9 and 10.0 mmol/L [70–180 mg/dL]) and decreased glycemic variability in patients with type 1 diabetes. The aim of this study was to investigate the effects of SGLT2 inhibitors on TIR, glycemic variability and glucose control in Japanese patients with type 1 diabetes in a real clinical setting. Materials and Methods We designed a single‐arm, retrospective cohort study to analyze data from patients starting to use ipragliflozin or dapagliflozin and who used a sensor‐based flash glucose monitoring system between February 2019 and August 2019. We measured TIR, time above range <180 mg/dL (percentage of time with glucose level of <180 mg/dL or <10.0 mmol/L), time below range <70 mg/dL (percentage of time with glucose level of <70 mg/dL or <3.9 mmol/L), mean glucose and standard deviation, and coefficient of variation for glycemic variability, and then compared the data before and after SGLT2 inhibitors treatments. Results We enrolled 15 patients in the study. The total dosages of basal insulin decreased significantly, but the total doses of bolus insulin did not change significantly. TIR increased significantly by approximately 11.6%; the time below range <70 mg/dL remained unchanged; and the mean glucose and standard deviation decreased significantly, whereas the coefficients of variation did not. Conclusions SGLT2 inhibitors improved TIR and the mean glucose level and standard deviation without increasing the time below range <70 mg/dL in patients with type 1 diabetes. Sodium–glucose cotransporter 2 inhibitors Time‐in‐range Type 1 diabetes Diseases of the endocrine glands. Clinical endocrinology Hodaka Yamada verfasserin aut Masashi Yoshida verfasserin aut Shunsuke Funazaki verfasserin aut Misato Amamoto verfasserin aut Jun Morimoto verfasserin aut Kazuo Hara verfasserin aut In Journal of Diabetes Investigation Wiley, 2014 11(2020), 5, Seite 1230-1237 (DE-627)620769297 (DE-600)2542077-X 20401124 nnns volume:11 year:2020 number:5 pages:1230-1237 https://doi.org/10.1111/jdi.13240 kostenfrei https://doaj.org/article/4a130768dee841788813414329e5c5f9 kostenfrei https://doi.org/10.1111/jdi.13240 kostenfrei https://doaj.org/toc/2040-1116 Journal toc kostenfrei https://doaj.org/toc/2040-1124 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 5 1230-1237
spelling	10.1111/jdi.13240 doi (DE-627)DOAJ00431252X (DE-599)DOAJ4a130768dee841788813414329e5c5f9 DE-627 ger DE-627 rakwb eng RC648-665 Daisuke Suzuki verfasserin aut Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Aims/Introduction Studies have shown that sodium–glucose cotransporter 2 (SGLT2) inhibitors increased time‐in‐range (TIR; percentage of time glucose level remains between 3.9 and 10.0 mmol/L [70–180 mg/dL]) and decreased glycemic variability in patients with type 1 diabetes. The aim of this study was to investigate the effects of SGLT2 inhibitors on TIR, glycemic variability and glucose control in Japanese patients with type 1 diabetes in a real clinical setting. Materials and Methods We designed a single‐arm, retrospective cohort study to analyze data from patients starting to use ipragliflozin or dapagliflozin and who used a sensor‐based flash glucose monitoring system between February 2019 and August 2019. We measured TIR, time above range <180 mg/dL (percentage of time with glucose level of <180 mg/dL or <10.0 mmol/L), time below range <70 mg/dL (percentage of time with glucose level of <70 mg/dL or <3.9 mmol/L), mean glucose and standard deviation, and coefficient of variation for glycemic variability, and then compared the data before and after SGLT2 inhibitors treatments. Results We enrolled 15 patients in the study. The total dosages of basal insulin decreased significantly, but the total doses of bolus insulin did not change significantly. TIR increased significantly by approximately 11.6%; the time below range <70 mg/dL remained unchanged; and the mean glucose and standard deviation decreased significantly, whereas the coefficients of variation did not. Conclusions SGLT2 inhibitors improved TIR and the mean glucose level and standard deviation without increasing the time below range <70 mg/dL in patients with type 1 diabetes. Sodium–glucose cotransporter 2 inhibitors Time‐in‐range Type 1 diabetes Diseases of the endocrine glands. Clinical endocrinology Hodaka Yamada verfasserin aut Masashi Yoshida verfasserin aut Shunsuke Funazaki verfasserin aut Misato Amamoto verfasserin aut Jun Morimoto verfasserin aut Kazuo Hara verfasserin aut In Journal of Diabetes Investigation Wiley, 2014 11(2020), 5, Seite 1230-1237 (DE-627)620769297 (DE-600)2542077-X 20401124 nnns volume:11 year:2020 number:5 pages:1230-1237 https://doi.org/10.1111/jdi.13240 kostenfrei https://doaj.org/article/4a130768dee841788813414329e5c5f9 kostenfrei https://doi.org/10.1111/jdi.13240 kostenfrei https://doaj.org/toc/2040-1116 Journal toc kostenfrei https://doaj.org/toc/2040-1124 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 5 1230-1237
allfields_unstemmed	10.1111/jdi.13240 doi (DE-627)DOAJ00431252X (DE-599)DOAJ4a130768dee841788813414329e5c5f9 DE-627 ger DE-627 rakwb eng RC648-665 Daisuke Suzuki verfasserin aut Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Aims/Introduction Studies have shown that sodium–glucose cotransporter 2 (SGLT2) inhibitors increased time‐in‐range (TIR; percentage of time glucose level remains between 3.9 and 10.0 mmol/L [70–180 mg/dL]) and decreased glycemic variability in patients with type 1 diabetes. The aim of this study was to investigate the effects of SGLT2 inhibitors on TIR, glycemic variability and glucose control in Japanese patients with type 1 diabetes in a real clinical setting. Materials and Methods We designed a single‐arm, retrospective cohort study to analyze data from patients starting to use ipragliflozin or dapagliflozin and who used a sensor‐based flash glucose monitoring system between February 2019 and August 2019. We measured TIR, time above range <180 mg/dL (percentage of time with glucose level of <180 mg/dL or <10.0 mmol/L), time below range <70 mg/dL (percentage of time with glucose level of <70 mg/dL or <3.9 mmol/L), mean glucose and standard deviation, and coefficient of variation for glycemic variability, and then compared the data before and after SGLT2 inhibitors treatments. Results We enrolled 15 patients in the study. The total dosages of basal insulin decreased significantly, but the total doses of bolus insulin did not change significantly. TIR increased significantly by approximately 11.6%; the time below range <70 mg/dL remained unchanged; and the mean glucose and standard deviation decreased significantly, whereas the coefficients of variation did not. Conclusions SGLT2 inhibitors improved TIR and the mean glucose level and standard deviation without increasing the time below range <70 mg/dL in patients with type 1 diabetes. Sodium–glucose cotransporter 2 inhibitors Time‐in‐range Type 1 diabetes Diseases of the endocrine glands. Clinical endocrinology Hodaka Yamada verfasserin aut Masashi Yoshida verfasserin aut Shunsuke Funazaki verfasserin aut Misato Amamoto verfasserin aut Jun Morimoto verfasserin aut Kazuo Hara verfasserin aut In Journal of Diabetes Investigation Wiley, 2014 11(2020), 5, Seite 1230-1237 (DE-627)620769297 (DE-600)2542077-X 20401124 nnns volume:11 year:2020 number:5 pages:1230-1237 https://doi.org/10.1111/jdi.13240 kostenfrei https://doaj.org/article/4a130768dee841788813414329e5c5f9 kostenfrei https://doi.org/10.1111/jdi.13240 kostenfrei https://doaj.org/toc/2040-1116 Journal toc kostenfrei https://doaj.org/toc/2040-1124 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 5 1230-1237
allfieldsGer	10.1111/jdi.13240 doi (DE-627)DOAJ00431252X (DE-599)DOAJ4a130768dee841788813414329e5c5f9 DE-627 ger DE-627 rakwb eng RC648-665 Daisuke Suzuki verfasserin aut Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Aims/Introduction Studies have shown that sodium–glucose cotransporter 2 (SGLT2) inhibitors increased time‐in‐range (TIR; percentage of time glucose level remains between 3.9 and 10.0 mmol/L [70–180 mg/dL]) and decreased glycemic variability in patients with type 1 diabetes. The aim of this study was to investigate the effects of SGLT2 inhibitors on TIR, glycemic variability and glucose control in Japanese patients with type 1 diabetes in a real clinical setting. Materials and Methods We designed a single‐arm, retrospective cohort study to analyze data from patients starting to use ipragliflozin or dapagliflozin and who used a sensor‐based flash glucose monitoring system between February 2019 and August 2019. We measured TIR, time above range <180 mg/dL (percentage of time with glucose level of <180 mg/dL or <10.0 mmol/L), time below range <70 mg/dL (percentage of time with glucose level of <70 mg/dL or <3.9 mmol/L), mean glucose and standard deviation, and coefficient of variation for glycemic variability, and then compared the data before and after SGLT2 inhibitors treatments. Results We enrolled 15 patients in the study. The total dosages of basal insulin decreased significantly, but the total doses of bolus insulin did not change significantly. TIR increased significantly by approximately 11.6%; the time below range <70 mg/dL remained unchanged; and the mean glucose and standard deviation decreased significantly, whereas the coefficients of variation did not. Conclusions SGLT2 inhibitors improved TIR and the mean glucose level and standard deviation without increasing the time below range <70 mg/dL in patients with type 1 diabetes. Sodium–glucose cotransporter 2 inhibitors Time‐in‐range Type 1 diabetes Diseases of the endocrine glands. Clinical endocrinology Hodaka Yamada verfasserin aut Masashi Yoshida verfasserin aut Shunsuke Funazaki verfasserin aut Misato Amamoto verfasserin aut Jun Morimoto verfasserin aut Kazuo Hara verfasserin aut In Journal of Diabetes Investigation Wiley, 2014 11(2020), 5, Seite 1230-1237 (DE-627)620769297 (DE-600)2542077-X 20401124 nnns volume:11 year:2020 number:5 pages:1230-1237 https://doi.org/10.1111/jdi.13240 kostenfrei https://doaj.org/article/4a130768dee841788813414329e5c5f9 kostenfrei https://doi.org/10.1111/jdi.13240 kostenfrei https://doaj.org/toc/2040-1116 Journal toc kostenfrei https://doaj.org/toc/2040-1124 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 5 1230-1237
allfieldsSound	10.1111/jdi.13240 doi (DE-627)DOAJ00431252X (DE-599)DOAJ4a130768dee841788813414329e5c5f9 DE-627 ger DE-627 rakwb eng RC648-665 Daisuke Suzuki verfasserin aut Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Aims/Introduction Studies have shown that sodium–glucose cotransporter 2 (SGLT2) inhibitors increased time‐in‐range (TIR; percentage of time glucose level remains between 3.9 and 10.0 mmol/L [70–180 mg/dL]) and decreased glycemic variability in patients with type 1 diabetes. The aim of this study was to investigate the effects of SGLT2 inhibitors on TIR, glycemic variability and glucose control in Japanese patients with type 1 diabetes in a real clinical setting. Materials and Methods We designed a single‐arm, retrospective cohort study to analyze data from patients starting to use ipragliflozin or dapagliflozin and who used a sensor‐based flash glucose monitoring system between February 2019 and August 2019. We measured TIR, time above range <180 mg/dL (percentage of time with glucose level of <180 mg/dL or <10.0 mmol/L), time below range <70 mg/dL (percentage of time with glucose level of <70 mg/dL or <3.9 mmol/L), mean glucose and standard deviation, and coefficient of variation for glycemic variability, and then compared the data before and after SGLT2 inhibitors treatments. Results We enrolled 15 patients in the study. The total dosages of basal insulin decreased significantly, but the total doses of bolus insulin did not change significantly. TIR increased significantly by approximately 11.6%; the time below range <70 mg/dL remained unchanged; and the mean glucose and standard deviation decreased significantly, whereas the coefficients of variation did not. Conclusions SGLT2 inhibitors improved TIR and the mean glucose level and standard deviation without increasing the time below range <70 mg/dL in patients with type 1 diabetes. Sodium–glucose cotransporter 2 inhibitors Time‐in‐range Type 1 diabetes Diseases of the endocrine glands. Clinical endocrinology Hodaka Yamada verfasserin aut Masashi Yoshida verfasserin aut Shunsuke Funazaki verfasserin aut Misato Amamoto verfasserin aut Jun Morimoto verfasserin aut Kazuo Hara verfasserin aut In Journal of Diabetes Investigation Wiley, 2014 11(2020), 5, Seite 1230-1237 (DE-627)620769297 (DE-600)2542077-X 20401124 nnns volume:11 year:2020 number:5 pages:1230-1237 https://doi.org/10.1111/jdi.13240 kostenfrei https://doaj.org/article/4a130768dee841788813414329e5c5f9 kostenfrei https://doi.org/10.1111/jdi.13240 kostenfrei https://doaj.org/toc/2040-1116 Journal toc kostenfrei https://doaj.org/toc/2040-1124 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 5 1230-1237
language	English
source	In Journal of Diabetes Investigation 11(2020), 5, Seite 1230-1237 volume:11 year:2020 number:5 pages:1230-1237
sourceStr	In Journal of Diabetes Investigation 11(2020), 5, Seite 1230-1237 volume:11 year:2020 number:5 pages:1230-1237
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Sodium–glucose cotransporter 2 inhibitors Time‐in‐range Type 1 diabetes Diseases of the endocrine glands. Clinical endocrinology
isfreeaccess_bool	true
container_title	Journal of Diabetes Investigation
authorswithroles_txt_mv	Daisuke Suzuki @@aut@@ Hodaka Yamada @@aut@@ Masashi Yoshida @@aut@@ Shunsuke Funazaki @@aut@@ Misato Amamoto @@aut@@ Jun Morimoto @@aut@@ Kazuo Hara @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	620769297
id	DOAJ00431252X
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ00431252X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309183338.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/jdi.13240</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ00431252X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ4a130768dee841788813414329e5c5f9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC648-665</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Daisuke Suzuki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Aims/Introduction Studies have shown that sodium–glucose cotransporter 2 (SGLT2) inhibitors increased time‐in‐range (TIR; percentage of time glucose level remains between 3.9 and 10.0 mmol/L [70–180 mg/dL]) and decreased glycemic variability in patients with type 1 diabetes. The aim of this study was to investigate the effects of SGLT2 inhibitors on TIR, glycemic variability and glucose control in Japanese patients with type 1 diabetes in a real clinical setting. Materials and Methods We designed a single‐arm, retrospective cohort study to analyze data from patients starting to use ipragliflozin or dapagliflozin and who used a sensor‐based flash glucose monitoring system between February 2019 and August 2019. We measured TIR, time above range <180 mg/dL (percentage of time with glucose level of <180 mg/dL or <10.0 mmol/L), time below range <70 mg/dL (percentage of time with glucose level of <70 mg/dL or <3.9 mmol/L), mean glucose and standard deviation, and coefficient of variation for glycemic variability, and then compared the data before and after SGLT2 inhibitors treatments. Results We enrolled 15 patients in the study. The total dosages of basal insulin decreased significantly, but the total doses of bolus insulin did not change significantly. TIR increased significantly by approximately 11.6%; the time below range <70 mg/dL remained unchanged; and the mean glucose and standard deviation decreased significantly, whereas the coefficients of variation did not. Conclusions SGLT2 inhibitors improved TIR and the mean glucose level and standard deviation without increasing the time below range <70 mg/dL in patients with type 1 diabetes.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Sodium–glucose cotransporter 2 inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Time‐in‐range</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Type 1 diabetes</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the endocrine glands. 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callnumber-first	R - Medicine
author	Daisuke Suzuki
spellingShingle	Daisuke Suzuki misc RC648-665 misc Sodium–glucose cotransporter 2 inhibitors misc Time‐in‐range misc Type 1 diabetes misc Diseases of the endocrine glands. Clinical endocrinology Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study
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topic_title	RC648-665 Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study Sodium–glucose cotransporter 2 inhibitors Time‐in‐range Type 1 diabetes
topic	misc RC648-665 misc Sodium–glucose cotransporter 2 inhibitors misc Time‐in‐range misc Type 1 diabetes misc Diseases of the endocrine glands. Clinical endocrinology
topic_unstemmed	misc RC648-665 misc Sodium–glucose cotransporter 2 inhibitors misc Time‐in‐range misc Type 1 diabetes misc Diseases of the endocrine glands. Clinical endocrinology
topic_browse	misc RC648-665 misc Sodium–glucose cotransporter 2 inhibitors misc Time‐in‐range misc Type 1 diabetes misc Diseases of the endocrine glands. Clinical endocrinology
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title	Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study
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title_full	Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study
author_sort	Daisuke Suzuki
journal	Journal of Diabetes Investigation
journalStr	Journal of Diabetes Investigation
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author_browse	Daisuke Suzuki Hodaka Yamada Masashi Yoshida Shunsuke Funazaki Misato Amamoto Jun Morimoto Kazuo Hara
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doi_str_mv	10.1111/jdi.13240
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title_sort	sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in japanese patients with type 1 diabetes: a retrospective, single‐center, pilot study
callnumber	RC648-665
title_auth	Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study
abstract	Abstract Aims/Introduction Studies have shown that sodium–glucose cotransporter 2 (SGLT2) inhibitors increased time‐in‐range (TIR; percentage of time glucose level remains between 3.9 and 10.0 mmol/L [70–180 mg/dL]) and decreased glycemic variability in patients with type 1 diabetes. The aim of this study was to investigate the effects of SGLT2 inhibitors on TIR, glycemic variability and glucose control in Japanese patients with type 1 diabetes in a real clinical setting. Materials and Methods We designed a single‐arm, retrospective cohort study to analyze data from patients starting to use ipragliflozin or dapagliflozin and who used a sensor‐based flash glucose monitoring system between February 2019 and August 2019. We measured TIR, time above range <180 mg/dL (percentage of time with glucose level of <180 mg/dL or <10.0 mmol/L), time below range <70 mg/dL (percentage of time with glucose level of <70 mg/dL or <3.9 mmol/L), mean glucose and standard deviation, and coefficient of variation for glycemic variability, and then compared the data before and after SGLT2 inhibitors treatments. Results We enrolled 15 patients in the study. The total dosages of basal insulin decreased significantly, but the total doses of bolus insulin did not change significantly. TIR increased significantly by approximately 11.6%; the time below range <70 mg/dL remained unchanged; and the mean glucose and standard deviation decreased significantly, whereas the coefficients of variation did not. Conclusions SGLT2 inhibitors improved TIR and the mean glucose level and standard deviation without increasing the time below range <70 mg/dL in patients with type 1 diabetes.
abstractGer	Abstract Aims/Introduction Studies have shown that sodium–glucose cotransporter 2 (SGLT2) inhibitors increased time‐in‐range (TIR; percentage of time glucose level remains between 3.9 and 10.0 mmol/L [70–180 mg/dL]) and decreased glycemic variability in patients with type 1 diabetes. The aim of this study was to investigate the effects of SGLT2 inhibitors on TIR, glycemic variability and glucose control in Japanese patients with type 1 diabetes in a real clinical setting. Materials and Methods We designed a single‐arm, retrospective cohort study to analyze data from patients starting to use ipragliflozin or dapagliflozin and who used a sensor‐based flash glucose monitoring system between February 2019 and August 2019. We measured TIR, time above range <180 mg/dL (percentage of time with glucose level of <180 mg/dL or <10.0 mmol/L), time below range <70 mg/dL (percentage of time with glucose level of <70 mg/dL or <3.9 mmol/L), mean glucose and standard deviation, and coefficient of variation for glycemic variability, and then compared the data before and after SGLT2 inhibitors treatments. Results We enrolled 15 patients in the study. The total dosages of basal insulin decreased significantly, but the total doses of bolus insulin did not change significantly. TIR increased significantly by approximately 11.6%; the time below range <70 mg/dL remained unchanged; and the mean glucose and standard deviation decreased significantly, whereas the coefficients of variation did not. Conclusions SGLT2 inhibitors improved TIR and the mean glucose level and standard deviation without increasing the time below range <70 mg/dL in patients with type 1 diabetes.
abstract_unstemmed	Abstract Aims/Introduction Studies have shown that sodium–glucose cotransporter 2 (SGLT2) inhibitors increased time‐in‐range (TIR; percentage of time glucose level remains between 3.9 and 10.0 mmol/L [70–180 mg/dL]) and decreased glycemic variability in patients with type 1 diabetes. The aim of this study was to investigate the effects of SGLT2 inhibitors on TIR, glycemic variability and glucose control in Japanese patients with type 1 diabetes in a real clinical setting. Materials and Methods We designed a single‐arm, retrospective cohort study to analyze data from patients starting to use ipragliflozin or dapagliflozin and who used a sensor‐based flash glucose monitoring system between February 2019 and August 2019. We measured TIR, time above range <180 mg/dL (percentage of time with glucose level of <180 mg/dL or <10.0 mmol/L), time below range <70 mg/dL (percentage of time with glucose level of <70 mg/dL or <3.9 mmol/L), mean glucose and standard deviation, and coefficient of variation for glycemic variability, and then compared the data before and after SGLT2 inhibitors treatments. Results We enrolled 15 patients in the study. The total dosages of basal insulin decreased significantly, but the total doses of bolus insulin did not change significantly. TIR increased significantly by approximately 11.6%; the time below range <70 mg/dL remained unchanged; and the mean glucose and standard deviation decreased significantly, whereas the coefficients of variation did not. Conclusions SGLT2 inhibitors improved TIR and the mean glucose level and standard deviation without increasing the time below range <70 mg/dL in patients with type 1 diabetes.
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title_short	Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study
url	https://doi.org/10.1111/jdi.13240 https://doaj.org/article/4a130768dee841788813414329e5c5f9 https://doaj.org/toc/2040-1116 https://doaj.org/toc/2040-1124
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up_date	2024-07-03T23:07:20.703Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ00431252X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309183338.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/jdi.13240</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ00431252X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ4a130768dee841788813414329e5c5f9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC648-665</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Daisuke Suzuki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Aims/Introduction Studies have shown that sodium–glucose cotransporter 2 (SGLT2) inhibitors increased time‐in‐range (TIR; percentage of time glucose level remains between 3.9 and 10.0 mmol/L [70–180 mg/dL]) and decreased glycemic variability in patients with type 1 diabetes. The aim of this study was to investigate the effects of SGLT2 inhibitors on TIR, glycemic variability and glucose control in Japanese patients with type 1 diabetes in a real clinical setting. Materials and Methods We designed a single‐arm, retrospective cohort study to analyze data from patients starting to use ipragliflozin or dapagliflozin and who used a sensor‐based flash glucose monitoring system between February 2019 and August 2019. We measured TIR, time above range <180 mg/dL (percentage of time with glucose level of <180 mg/dL or <10.0 mmol/L), time below range <70 mg/dL (percentage of time with glucose level of <70 mg/dL or <3.9 mmol/L), mean glucose and standard deviation, and coefficient of variation for glycemic variability, and then compared the data before and after SGLT2 inhibitors treatments. Results We enrolled 15 patients in the study. The total dosages of basal insulin decreased significantly, but the total doses of bolus insulin did not change significantly. TIR increased significantly by approximately 11.6%; the time below range <70 mg/dL remained unchanged; and the mean glucose and standard deviation decreased significantly, whereas the coefficients of variation did not. Conclusions SGLT2 inhibitors improved TIR and the mean glucose level and standard deviation without increasing the time below range <70 mg/dL in patients with type 1 diabetes.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Sodium–glucose cotransporter 2 inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Time‐in‐range</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Type 1 diabetes</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the endocrine glands. 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Sodium–glucose cotransporter 2 inhibitors improved time‐in‐range without increasing hypoglycemia in Japanese patients with type 1 diabetes: A retrospective, single‐center, pilot study

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