Cerebral sterile inflammation in neurodegenerative diseases

Abstract Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of the detailed molecular and cellular mechanisms of neuroinflammation in each CNS dis...
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Autor*in:	Kento Otani [verfasserIn] Takashi Shichita [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Neuroinflammation Alzheimer’s disease Parkinson’s disease Amyotrophic lateral sclerosis

Übergeordnetes Werk:	In: Inflammation and Regeneration - BMC, 2016, 40(2020), 1, Seite 8
Übergeordnetes Werk:	volume:40 ; year:2020 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s41232-020-00137-4

Katalog-ID:	DOAJ004353056

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allfieldsGer	10.1186/s41232-020-00137-4 doi (DE-627)DOAJ004353056 (DE-599)DOAJfba99888f1a64e64afb54d19421822f5 DE-627 ger DE-627 rakwb eng RB1-214 Kento Otani verfasserin aut Cerebral sterile inflammation in neurodegenerative diseases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of the detailed molecular and cellular mechanisms of neuroinflammation in each CNS disease is necessary for the development of therapeutics. Since the brain is a sterile organ, neuroinflammation in Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) is triggered by cerebral cellular damage or the abnormal accumulation of inflammatogenic molecules in CNS tissue through the activation of innate and acquired immunity. Inflammation and CNS pathologies worsen each other through various cellular and molecular mechanisms, such as oxidative stress or the accumulation of inflammatogenic molecules induced in the damaged CNS tissue. In this review, we summarize the recent evidence regarding sterile immune responses in neurodegenerative diseases. Neuroinflammation Alzheimer’s disease Parkinson’s disease Amyotrophic lateral sclerosis Pathology Takashi Shichita verfasserin aut In Inflammation and Regeneration BMC, 2016 40(2020), 1, Seite 8 (DE-627)559080913 (DE-600)2411877-1 18808190 nnns volume:40 year:2020 number:1 pages:8 https://doi.org/10.1186/s41232-020-00137-4 kostenfrei https://doaj.org/article/fba99888f1a64e64afb54d19421822f5 kostenfrei https://doi.org/10.1186/s41232-020-00137-4 kostenfrei https://doaj.org/toc/1880-8190 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 40 2020 1 8
allfieldsSound	10.1186/s41232-020-00137-4 doi (DE-627)DOAJ004353056 (DE-599)DOAJfba99888f1a64e64afb54d19421822f5 DE-627 ger DE-627 rakwb eng RB1-214 Kento Otani verfasserin aut Cerebral sterile inflammation in neurodegenerative diseases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of the detailed molecular and cellular mechanisms of neuroinflammation in each CNS disease is necessary for the development of therapeutics. Since the brain is a sterile organ, neuroinflammation in Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) is triggered by cerebral cellular damage or the abnormal accumulation of inflammatogenic molecules in CNS tissue through the activation of innate and acquired immunity. Inflammation and CNS pathologies worsen each other through various cellular and molecular mechanisms, such as oxidative stress or the accumulation of inflammatogenic molecules induced in the damaged CNS tissue. In this review, we summarize the recent evidence regarding sterile immune responses in neurodegenerative diseases. Neuroinflammation Alzheimer’s disease Parkinson’s disease Amyotrophic lateral sclerosis Pathology Takashi Shichita verfasserin aut In Inflammation and Regeneration BMC, 2016 40(2020), 1, Seite 8 (DE-627)559080913 (DE-600)2411877-1 18808190 nnns volume:40 year:2020 number:1 pages:8 https://doi.org/10.1186/s41232-020-00137-4 kostenfrei https://doaj.org/article/fba99888f1a64e64afb54d19421822f5 kostenfrei https://doi.org/10.1186/s41232-020-00137-4 kostenfrei https://doaj.org/toc/1880-8190 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 40 2020 1 8
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container_title	Inflammation and Regeneration
authorswithroles_txt_mv	Kento Otani @@aut@@ Takashi Shichita @@aut@@
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topic_title	RB1-214 Cerebral sterile inflammation in neurodegenerative diseases Neuroinflammation Alzheimer’s disease Parkinson’s disease Amyotrophic lateral sclerosis
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title	Cerebral sterile inflammation in neurodegenerative diseases
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title_auth	Cerebral sterile inflammation in neurodegenerative diseases
abstract	Abstract Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of the detailed molecular and cellular mechanisms of neuroinflammation in each CNS disease is necessary for the development of therapeutics. Since the brain is a sterile organ, neuroinflammation in Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) is triggered by cerebral cellular damage or the abnormal accumulation of inflammatogenic molecules in CNS tissue through the activation of innate and acquired immunity. Inflammation and CNS pathologies worsen each other through various cellular and molecular mechanisms, such as oxidative stress or the accumulation of inflammatogenic molecules induced in the damaged CNS tissue. In this review, we summarize the recent evidence regarding sterile immune responses in neurodegenerative diseases.
abstractGer	Abstract Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of the detailed molecular and cellular mechanisms of neuroinflammation in each CNS disease is necessary for the development of therapeutics. Since the brain is a sterile organ, neuroinflammation in Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) is triggered by cerebral cellular damage or the abnormal accumulation of inflammatogenic molecules in CNS tissue through the activation of innate and acquired immunity. Inflammation and CNS pathologies worsen each other through various cellular and molecular mechanisms, such as oxidative stress or the accumulation of inflammatogenic molecules induced in the damaged CNS tissue. In this review, we summarize the recent evidence regarding sterile immune responses in neurodegenerative diseases.
abstract_unstemmed	Abstract Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of the detailed molecular and cellular mechanisms of neuroinflammation in each CNS disease is necessary for the development of therapeutics. Since the brain is a sterile organ, neuroinflammation in Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) is triggered by cerebral cellular damage or the abnormal accumulation of inflammatogenic molecules in CNS tissue through the activation of innate and acquired immunity. Inflammation and CNS pathologies worsen each other through various cellular and molecular mechanisms, such as oxidative stress or the accumulation of inflammatogenic molecules induced in the damaged CNS tissue. In this review, we summarize the recent evidence regarding sterile immune responses in neurodegenerative diseases.
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