Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge

Tuberculosis (TB) has varied manifestations, but autoimmune hemolytic anemia (AIHA) due to TB is rare. Direct antibody test (DAT) or Coombs negative AIHA is also rare. We report a case of a 14-year-old boy who presented with hemolytic anemia and pneumonia. The Coombs test was repeatedly negative. Af...
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Autor*in:	Agarwal Sheetal [verfasserIn] Singh Ruby [verfasserIn] P Singh Dhirendra [verfasserIn] Gupta Anubhav [verfasserIn] Nandan Devki [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	autoimmune hemolytic anemia coombs negative pediatric tuberculosis

Übergeordnetes Werk:	In: Asian Journal of Transfusion Science - Wolters Kluwer Medknow Publications, 2007, 16(2022), 2, Seite 280-282
Übergeordnetes Werk:	volume:16 ; year:2022 ; number:2 ; pages:280-282

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/ajts.AJTS_75_20

Katalog-ID:	DOAJ004396707

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520			\|a Tuberculosis (TB) has varied manifestations, but autoimmune hemolytic anemia (AIHA) due to TB is rare. Direct antibody test (DAT) or Coombs negative AIHA is also rare. We report a case of a 14-year-old boy who presented with hemolytic anemia and pneumonia. The Coombs test was repeatedly negative. After ruling out the possible infectious and noninfectious causes by extensive investigations, he was diagnosed as DAT-negative AIHA by monospecific antibody test with 4°C low ionic strength saline washes and column agglutination method which revealed the presence of IgG-2+ antibodies. Bronchoalveolar lavage fluid for acid-fast bacilli and gene Xpert was also positive. It is important to recognize TB as a cause of AIHA in South Asian countries where its incidence is high.
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topic_facet	autoimmune hemolytic anemia coombs negative pediatric tuberculosis Diseases of the blood and blood-forming organs
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callnumber-first	R - Medicine
author	Agarwal Sheetal
spellingShingle	Agarwal Sheetal misc RC633-647.5 misc autoimmune hemolytic anemia misc coombs negative misc pediatric misc tuberculosis misc Diseases of the blood and blood-forming organs Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge
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topic_title	RC633-647.5 Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge autoimmune hemolytic anemia coombs negative pediatric tuberculosis
topic	misc RC633-647.5 misc autoimmune hemolytic anemia misc coombs negative misc pediatric misc tuberculosis misc Diseases of the blood and blood-forming organs
topic_unstemmed	misc RC633-647.5 misc autoimmune hemolytic anemia misc coombs negative misc pediatric misc tuberculosis misc Diseases of the blood and blood-forming organs
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title	Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge
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title_full	Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge
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author_browse	Agarwal Sheetal Singh Ruby P Singh Dhirendra Gupta Anubhav Nandan Devki
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title_sort	direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: a diagnostic challenge
callnumber	RC633-647.5
title_auth	Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge
abstract	Tuberculosis (TB) has varied manifestations, but autoimmune hemolytic anemia (AIHA) due to TB is rare. Direct antibody test (DAT) or Coombs negative AIHA is also rare. We report a case of a 14-year-old boy who presented with hemolytic anemia and pneumonia. The Coombs test was repeatedly negative. After ruling out the possible infectious and noninfectious causes by extensive investigations, he was diagnosed as DAT-negative AIHA by monospecific antibody test with 4°C low ionic strength saline washes and column agglutination method which revealed the presence of IgG-2+ antibodies. Bronchoalveolar lavage fluid for acid-fast bacilli and gene Xpert was also positive. It is important to recognize TB as a cause of AIHA in South Asian countries where its incidence is high.
abstractGer	Tuberculosis (TB) has varied manifestations, but autoimmune hemolytic anemia (AIHA) due to TB is rare. Direct antibody test (DAT) or Coombs negative AIHA is also rare. We report a case of a 14-year-old boy who presented with hemolytic anemia and pneumonia. The Coombs test was repeatedly negative. After ruling out the possible infectious and noninfectious causes by extensive investigations, he was diagnosed as DAT-negative AIHA by monospecific antibody test with 4°C low ionic strength saline washes and column agglutination method which revealed the presence of IgG-2+ antibodies. Bronchoalveolar lavage fluid for acid-fast bacilli and gene Xpert was also positive. It is important to recognize TB as a cause of AIHA in South Asian countries where its incidence is high.
abstract_unstemmed	Tuberculosis (TB) has varied manifestations, but autoimmune hemolytic anemia (AIHA) due to TB is rare. Direct antibody test (DAT) or Coombs negative AIHA is also rare. We report a case of a 14-year-old boy who presented with hemolytic anemia and pneumonia. The Coombs test was repeatedly negative. After ruling out the possible infectious and noninfectious causes by extensive investigations, he was diagnosed as DAT-negative AIHA by monospecific antibody test with 4°C low ionic strength saline washes and column agglutination method which revealed the presence of IgG-2+ antibodies. Bronchoalveolar lavage fluid for acid-fast bacilli and gene Xpert was also positive. It is important to recognize TB as a cause of AIHA in South Asian countries where its incidence is high.
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title_short	Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge
url	https://doi.org/10.4103/ajts.AJTS_75_20 https://doaj.org/article/c3df1ca55762429badae85a1c4345131 http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=2;spage=280;epage=282;aulast=Sheetal https://doaj.org/toc/0973-6247 https://doaj.org/toc/1998-3565
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up_date	2024-07-03T23:31:44.426Z
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