Epidemiology and burden of multidrug-resistant bacterial infection in a developing country

Little is known about the excess mortality caused by multidrug-resistant (MDR) bacterial infection in low- and middle-income countries (LMICs). We retrospectively obtained microbiology laboratory and hospital databases of nine public hospitals in northeast Thailand from 2004 to 2010, and linked thes...
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Autor*in:	Cherry Lim [verfasserIn] Emi Takahashi [verfasserIn] Maliwan Hongsuwan [verfasserIn] Vanaporn Wuthiekanun [verfasserIn] Visanu Thamlikitkul [verfasserIn] Soawapak Hinjoy [verfasserIn] Nicholas PJ Day [verfasserIn] Sharon J Peacock [verfasserIn] Direk Limmathurotsakul [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	antimicrobial resistant Staphylococcus aureus K. pneumoniae P. aeruginosa Enterococcus Acinetobacter

Übergeordnetes Werk:	In: eLife - eLife Sciences Publications Ltd, 2013, 5(2016)
Übergeordnetes Werk:	volume:5 ; year:2016

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7554/eLife.18082

Katalog-ID:	DOAJ004398416

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allfieldsSound	10.7554/eLife.18082 doi (DE-627)DOAJ004398416 (DE-599)DOAJc3ab47c975324adf971d8dd5e0b813bd DE-627 ger DE-627 rakwb eng QH301-705.5 Cherry Lim verfasserin aut Epidemiology and burden of multidrug-resistant bacterial infection in a developing country 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Little is known about the excess mortality caused by multidrug-resistant (MDR) bacterial infection in low- and middle-income countries (LMICs). We retrospectively obtained microbiology laboratory and hospital databases of nine public hospitals in northeast Thailand from 2004 to 2010, and linked these with the national death registry to obtain the 30-day mortality outcome. The 30-day mortality in those with MDR community-acquired bacteraemia, healthcare-associated bacteraemia, and hospital-acquired bacteraemia were 35% (549/1555), 49% (247/500), and 53% (640/1198), respectively. We estimate that 19,122 of 45,209 (43%) deaths in patients with hospital-acquired infection due to MDR bacteria in Thailand in 2010 represented excess mortality caused by MDR. We demonstrate that national statistics on the epidemiology and burden of MDR in LMICs could be improved by integrating information from readily available databases. The prevalence and mortality attributable to MDR in Thailand are high. This is likely to reflect the situation in other LMICs. antimicrobial resistant Staphylococcus aureus K. pneumoniae P. aeruginosa Enterococcus Acinetobacter Medicine R Science Q Biology (General) Emi Takahashi verfasserin aut Maliwan Hongsuwan verfasserin aut Vanaporn Wuthiekanun verfasserin aut Visanu Thamlikitkul verfasserin aut Soawapak Hinjoy verfasserin aut Nicholas PJ Day verfasserin aut Sharon J Peacock verfasserin aut Direk Limmathurotsakul verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 5(2016) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:5 year:2016 https://doi.org/10.7554/eLife.18082 kostenfrei https://doaj.org/article/c3ab47c975324adf971d8dd5e0b813bd kostenfrei https://elifesciences.org/articles/18082 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2016
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container_title	eLife
authorswithroles_txt_mv	Cherry Lim @@aut@@ Emi Takahashi @@aut@@ Maliwan Hongsuwan @@aut@@ Vanaporn Wuthiekanun @@aut@@ Visanu Thamlikitkul @@aut@@ Soawapak Hinjoy @@aut@@ Nicholas PJ Day @@aut@@ Sharon J Peacock @@aut@@ Direk Limmathurotsakul @@aut@@
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spellingShingle	Cherry Lim misc QH301-705.5 misc antimicrobial resistant misc Staphylococcus aureus misc K. pneumoniae misc P. aeruginosa misc Enterococcus misc Acinetobacter misc Medicine misc R misc Science misc Q misc Biology (General) Epidemiology and burden of multidrug-resistant bacterial infection in a developing country
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topic_title	QH301-705.5 Epidemiology and burden of multidrug-resistant bacterial infection in a developing country antimicrobial resistant Staphylococcus aureus K. pneumoniae P. aeruginosa Enterococcus Acinetobacter
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title	Epidemiology and burden of multidrug-resistant bacterial infection in a developing country
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title_auth	Epidemiology and burden of multidrug-resistant bacterial infection in a developing country
abstract	Little is known about the excess mortality caused by multidrug-resistant (MDR) bacterial infection in low- and middle-income countries (LMICs). We retrospectively obtained microbiology laboratory and hospital databases of nine public hospitals in northeast Thailand from 2004 to 2010, and linked these with the national death registry to obtain the 30-day mortality outcome. The 30-day mortality in those with MDR community-acquired bacteraemia, healthcare-associated bacteraemia, and hospital-acquired bacteraemia were 35% (549/1555), 49% (247/500), and 53% (640/1198), respectively. We estimate that 19,122 of 45,209 (43%) deaths in patients with hospital-acquired infection due to MDR bacteria in Thailand in 2010 represented excess mortality caused by MDR. We demonstrate that national statistics on the epidemiology and burden of MDR in LMICs could be improved by integrating information from readily available databases. The prevalence and mortality attributable to MDR in Thailand are high. This is likely to reflect the situation in other LMICs.
abstractGer	Little is known about the excess mortality caused by multidrug-resistant (MDR) bacterial infection in low- and middle-income countries (LMICs). We retrospectively obtained microbiology laboratory and hospital databases of nine public hospitals in northeast Thailand from 2004 to 2010, and linked these with the national death registry to obtain the 30-day mortality outcome. The 30-day mortality in those with MDR community-acquired bacteraemia, healthcare-associated bacteraemia, and hospital-acquired bacteraemia were 35% (549/1555), 49% (247/500), and 53% (640/1198), respectively. We estimate that 19,122 of 45,209 (43%) deaths in patients with hospital-acquired infection due to MDR bacteria in Thailand in 2010 represented excess mortality caused by MDR. We demonstrate that national statistics on the epidemiology and burden of MDR in LMICs could be improved by integrating information from readily available databases. The prevalence and mortality attributable to MDR in Thailand are high. This is likely to reflect the situation in other LMICs.
abstract_unstemmed	Little is known about the excess mortality caused by multidrug-resistant (MDR) bacterial infection in low- and middle-income countries (LMICs). We retrospectively obtained microbiology laboratory and hospital databases of nine public hospitals in northeast Thailand from 2004 to 2010, and linked these with the national death registry to obtain the 30-day mortality outcome. The 30-day mortality in those with MDR community-acquired bacteraemia, healthcare-associated bacteraemia, and hospital-acquired bacteraemia were 35% (549/1555), 49% (247/500), and 53% (640/1198), respectively. We estimate that 19,122 of 45,209 (43%) deaths in patients with hospital-acquired infection due to MDR bacteria in Thailand in 2010 represented excess mortality caused by MDR. We demonstrate that national statistics on the epidemiology and burden of MDR in LMICs could be improved by integrating information from readily available databases. The prevalence and mortality attributable to MDR in Thailand are high. This is likely to reflect the situation in other LMICs.
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title_short	Epidemiology and burden of multidrug-resistant bacterial infection in a developing country
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