Black box of phage–bacterium interactions: exploring alternative phage infection strategies

The canonical lytic–lysogenic binary has been challenged in recent years, as more evidence has emerged on alternative bacteriophage infection strategies. These infection modes are little studied, and yet they appear to be more abundant and ubiquitous in nature than previously recognized, and can pla...
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Autor*in:	Sari Mäntynen [verfasserIn] Elina Laanto [verfasserIn] Hanna M. Oksanen [verfasserIn] Minna M. Poranen [verfasserIn] Samuel L. Díaz-Muñoz [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	bacteriophage phage infection pseudolysogeny carrier state chronic infection

Übergeordnetes Werk:	In: Open Biology - The Royal Society, 2012, 11(2021), 9
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1098/rsob.210188

Katalog-ID:	DOAJ004475852

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allfields	10.1098/rsob.210188 doi (DE-627)DOAJ004475852 (DE-599)DOAJ75977f259357423084f868a619c89e92 DE-627 ger DE-627 rakwb eng QH301-705.5 Sari Mäntynen verfasserin aut Black box of phage–bacterium interactions: exploring alternative phage infection strategies 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The canonical lytic–lysogenic binary has been challenged in recent years, as more evidence has emerged on alternative bacteriophage infection strategies. These infection modes are little studied, and yet they appear to be more abundant and ubiquitous in nature than previously recognized, and can play a significant role in the ecology and evolution of their bacterial hosts. In this review, we discuss the extent, causes and consequences of alternative phage lifestyles, and clarify conceptual and terminological confusion to facilitate research progress. We propose distinct definitions for the terms ‘pseudolysogeny’ and ‘productive or non-productive chronic infection’, and distinguish them from the carrier state life cycle, which describes a population-level phenomenon. Our review also finds that phages may change their infection modes in response to environmental conditions or the physiological state of the host cell. We outline known molecular mechanisms underlying the alternative phage–host interactions, including specific genetic pathways and their considerable biotechnological potential. Moreover, we discuss potential implications of the alternative phage lifestyles for microbial biology and ecosystem functioning, as well as applied topics such as phage therapy. bacteriophage phage infection pseudolysogeny carrier state chronic infection Biology (General) Elina Laanto verfasserin aut Hanna M. Oksanen verfasserin aut Minna M. Poranen verfasserin aut Samuel L. Díaz-Muñoz verfasserin aut In Open Biology The Royal Society, 2012 11(2021), 9 (DE-627)669884146 (DE-600)2630944-0 20462441 nnns volume:11 year:2021 number:9 https://doi.org/10.1098/rsob.210188 kostenfrei https://doaj.org/article/75977f259357423084f868a619c89e92 kostenfrei https://royalsocietypublishing.org/doi/10.1098/rsob.210188 kostenfrei https://doaj.org/toc/2046-2441 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 9
spelling	10.1098/rsob.210188 doi (DE-627)DOAJ004475852 (DE-599)DOAJ75977f259357423084f868a619c89e92 DE-627 ger DE-627 rakwb eng QH301-705.5 Sari Mäntynen verfasserin aut Black box of phage–bacterium interactions: exploring alternative phage infection strategies 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The canonical lytic–lysogenic binary has been challenged in recent years, as more evidence has emerged on alternative bacteriophage infection strategies. These infection modes are little studied, and yet they appear to be more abundant and ubiquitous in nature than previously recognized, and can play a significant role in the ecology and evolution of their bacterial hosts. In this review, we discuss the extent, causes and consequences of alternative phage lifestyles, and clarify conceptual and terminological confusion to facilitate research progress. We propose distinct definitions for the terms ‘pseudolysogeny’ and ‘productive or non-productive chronic infection’, and distinguish them from the carrier state life cycle, which describes a population-level phenomenon. Our review also finds that phages may change their infection modes in response to environmental conditions or the physiological state of the host cell. We outline known molecular mechanisms underlying the alternative phage–host interactions, including specific genetic pathways and their considerable biotechnological potential. Moreover, we discuss potential implications of the alternative phage lifestyles for microbial biology and ecosystem functioning, as well as applied topics such as phage therapy. bacteriophage phage infection pseudolysogeny carrier state chronic infection Biology (General) Elina Laanto verfasserin aut Hanna M. Oksanen verfasserin aut Minna M. Poranen verfasserin aut Samuel L. Díaz-Muñoz verfasserin aut In Open Biology The Royal Society, 2012 11(2021), 9 (DE-627)669884146 (DE-600)2630944-0 20462441 nnns volume:11 year:2021 number:9 https://doi.org/10.1098/rsob.210188 kostenfrei https://doaj.org/article/75977f259357423084f868a619c89e92 kostenfrei https://royalsocietypublishing.org/doi/10.1098/rsob.210188 kostenfrei https://doaj.org/toc/2046-2441 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 9
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allfieldsSound	10.1098/rsob.210188 doi (DE-627)DOAJ004475852 (DE-599)DOAJ75977f259357423084f868a619c89e92 DE-627 ger DE-627 rakwb eng QH301-705.5 Sari Mäntynen verfasserin aut Black box of phage–bacterium interactions: exploring alternative phage infection strategies 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The canonical lytic–lysogenic binary has been challenged in recent years, as more evidence has emerged on alternative bacteriophage infection strategies. These infection modes are little studied, and yet they appear to be more abundant and ubiquitous in nature than previously recognized, and can play a significant role in the ecology and evolution of their bacterial hosts. In this review, we discuss the extent, causes and consequences of alternative phage lifestyles, and clarify conceptual and terminological confusion to facilitate research progress. We propose distinct definitions for the terms ‘pseudolysogeny’ and ‘productive or non-productive chronic infection’, and distinguish them from the carrier state life cycle, which describes a population-level phenomenon. Our review also finds that phages may change their infection modes in response to environmental conditions or the physiological state of the host cell. We outline known molecular mechanisms underlying the alternative phage–host interactions, including specific genetic pathways and their considerable biotechnological potential. Moreover, we discuss potential implications of the alternative phage lifestyles for microbial biology and ecosystem functioning, as well as applied topics such as phage therapy. bacteriophage phage infection pseudolysogeny carrier state chronic infection Biology (General) Elina Laanto verfasserin aut Hanna M. Oksanen verfasserin aut Minna M. Poranen verfasserin aut Samuel L. Díaz-Muñoz verfasserin aut In Open Biology The Royal Society, 2012 11(2021), 9 (DE-627)669884146 (DE-600)2630944-0 20462441 nnns volume:11 year:2021 number:9 https://doi.org/10.1098/rsob.210188 kostenfrei https://doaj.org/article/75977f259357423084f868a619c89e92 kostenfrei https://royalsocietypublishing.org/doi/10.1098/rsob.210188 kostenfrei https://doaj.org/toc/2046-2441 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 9
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topic_facet	bacteriophage phage infection pseudolysogeny carrier state chronic infection Biology (General)
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authorswithroles_txt_mv	Sari Mäntynen @@aut@@ Elina Laanto @@aut@@ Hanna M. Oksanen @@aut@@ Minna M. Poranen @@aut@@ Samuel L. Díaz-Muñoz @@aut@@
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title	Black box of phage–bacterium interactions: exploring alternative phage infection strategies
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title_auth	Black box of phage–bacterium interactions: exploring alternative phage infection strategies
abstract	The canonical lytic–lysogenic binary has been challenged in recent years, as more evidence has emerged on alternative bacteriophage infection strategies. These infection modes are little studied, and yet they appear to be more abundant and ubiquitous in nature than previously recognized, and can play a significant role in the ecology and evolution of their bacterial hosts. In this review, we discuss the extent, causes and consequences of alternative phage lifestyles, and clarify conceptual and terminological confusion to facilitate research progress. We propose distinct definitions for the terms ‘pseudolysogeny’ and ‘productive or non-productive chronic infection’, and distinguish them from the carrier state life cycle, which describes a population-level phenomenon. Our review also finds that phages may change their infection modes in response to environmental conditions or the physiological state of the host cell. We outline known molecular mechanisms underlying the alternative phage–host interactions, including specific genetic pathways and their considerable biotechnological potential. Moreover, we discuss potential implications of the alternative phage lifestyles for microbial biology and ecosystem functioning, as well as applied topics such as phage therapy.
abstractGer	The canonical lytic–lysogenic binary has been challenged in recent years, as more evidence has emerged on alternative bacteriophage infection strategies. These infection modes are little studied, and yet they appear to be more abundant and ubiquitous in nature than previously recognized, and can play a significant role in the ecology and evolution of their bacterial hosts. In this review, we discuss the extent, causes and consequences of alternative phage lifestyles, and clarify conceptual and terminological confusion to facilitate research progress. We propose distinct definitions for the terms ‘pseudolysogeny’ and ‘productive or non-productive chronic infection’, and distinguish them from the carrier state life cycle, which describes a population-level phenomenon. Our review also finds that phages may change their infection modes in response to environmental conditions or the physiological state of the host cell. We outline known molecular mechanisms underlying the alternative phage–host interactions, including specific genetic pathways and their considerable biotechnological potential. Moreover, we discuss potential implications of the alternative phage lifestyles for microbial biology and ecosystem functioning, as well as applied topics such as phage therapy.
abstract_unstemmed	The canonical lytic–lysogenic binary has been challenged in recent years, as more evidence has emerged on alternative bacteriophage infection strategies. These infection modes are little studied, and yet they appear to be more abundant and ubiquitous in nature than previously recognized, and can play a significant role in the ecology and evolution of their bacterial hosts. In this review, we discuss the extent, causes and consequences of alternative phage lifestyles, and clarify conceptual and terminological confusion to facilitate research progress. We propose distinct definitions for the terms ‘pseudolysogeny’ and ‘productive or non-productive chronic infection’, and distinguish them from the carrier state life cycle, which describes a population-level phenomenon. Our review also finds that phages may change their infection modes in response to environmental conditions or the physiological state of the host cell. We outline known molecular mechanisms underlying the alternative phage–host interactions, including specific genetic pathways and their considerable biotechnological potential. Moreover, we discuss potential implications of the alternative phage lifestyles for microbial biology and ecosystem functioning, as well as applied topics such as phage therapy.
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title_short	Black box of phage–bacterium interactions: exploring alternative phage infection strategies
url	https://doi.org/10.1098/rsob.210188 https://doaj.org/article/75977f259357423084f868a619c89e92 https://royalsocietypublishing.org/doi/10.1098/rsob.210188 https://doaj.org/toc/2046-2441
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