Serum neprilysin levels are elevated in preeclampsia

Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with...
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Autor*in:	Nevin Tüten [verfasserIn] Eduard Malik [verfasserIn] Koray Gök [verfasserIn] Kübra Hamzaoglu [verfasserIn] Melike Makul [verfasserIn] Yahya Özgün Öner [verfasserIn] Huri Bulut [verfasserIn] Abdullah Tüten [verfasserIn] Onur Güralp [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Blood pressure Enkephalinase Endopeptidase Natriuretic peptides Neutral endopeptidase

Übergeordnetes Werk:	In: Taiwanese Journal of Obstetrics & Gynecology - Elsevier, 2017, 60(2021), 5, Seite 869-873
Übergeordnetes Werk:	volume:60 ; year:2021 ; number:5 ; pages:869-873

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.tjog.2021.07.015

Katalog-ID:	DOAJ004652673

Internformat


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245	1	0	\|a Serum neprilysin levels are elevated in preeclampsia
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520			\|a Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia.
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700	0		\|a Yahya Özgün Öner \|e verfasserin \|4 aut
700	0		\|a Huri Bulut \|e verfasserin \|4 aut
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700	0		\|a Onur Güralp \|e verfasserin \|4 aut
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allfields	10.1016/j.tjog.2021.07.015 doi (DE-627)DOAJ004652673 (DE-599)DOAJfcfc12a7be2742b281e9b0d2ed182c15 DE-627 ger DE-627 rakwb eng RG1-991 Nevin Tüten verfasserin aut Serum neprilysin levels are elevated in preeclampsia 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia. Blood pressure Enkephalinase Endopeptidase Natriuretic peptides Neutral endopeptidase Gynecology and obstetrics Eduard Malik verfasserin aut Koray Gök verfasserin aut Kübra Hamzaoglu verfasserin aut Melike Makul verfasserin aut Yahya Özgün Öner verfasserin aut Huri Bulut verfasserin aut Abdullah Tüten verfasserin aut Onur Güralp verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 60(2021), 5, Seite 869-873 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:60 year:2021 number:5 pages:869-873 https://doi.org/10.1016/j.tjog.2021.07.015 kostenfrei https://doaj.org/article/fcfc12a7be2742b281e9b0d2ed182c15 kostenfrei http://www.sciencedirect.com/science/article/pii/S102845592100187X kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2021 5 869-873
spelling	10.1016/j.tjog.2021.07.015 doi (DE-627)DOAJ004652673 (DE-599)DOAJfcfc12a7be2742b281e9b0d2ed182c15 DE-627 ger DE-627 rakwb eng RG1-991 Nevin Tüten verfasserin aut Serum neprilysin levels are elevated in preeclampsia 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia. Blood pressure Enkephalinase Endopeptidase Natriuretic peptides Neutral endopeptidase Gynecology and obstetrics Eduard Malik verfasserin aut Koray Gök verfasserin aut Kübra Hamzaoglu verfasserin aut Melike Makul verfasserin aut Yahya Özgün Öner verfasserin aut Huri Bulut verfasserin aut Abdullah Tüten verfasserin aut Onur Güralp verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 60(2021), 5, Seite 869-873 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:60 year:2021 number:5 pages:869-873 https://doi.org/10.1016/j.tjog.2021.07.015 kostenfrei https://doaj.org/article/fcfc12a7be2742b281e9b0d2ed182c15 kostenfrei http://www.sciencedirect.com/science/article/pii/S102845592100187X kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2021 5 869-873
allfields_unstemmed	10.1016/j.tjog.2021.07.015 doi (DE-627)DOAJ004652673 (DE-599)DOAJfcfc12a7be2742b281e9b0d2ed182c15 DE-627 ger DE-627 rakwb eng RG1-991 Nevin Tüten verfasserin aut Serum neprilysin levels are elevated in preeclampsia 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia. Blood pressure Enkephalinase Endopeptidase Natriuretic peptides Neutral endopeptidase Gynecology and obstetrics Eduard Malik verfasserin aut Koray Gök verfasserin aut Kübra Hamzaoglu verfasserin aut Melike Makul verfasserin aut Yahya Özgün Öner verfasserin aut Huri Bulut verfasserin aut Abdullah Tüten verfasserin aut Onur Güralp verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 60(2021), 5, Seite 869-873 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:60 year:2021 number:5 pages:869-873 https://doi.org/10.1016/j.tjog.2021.07.015 kostenfrei https://doaj.org/article/fcfc12a7be2742b281e9b0d2ed182c15 kostenfrei http://www.sciencedirect.com/science/article/pii/S102845592100187X kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2021 5 869-873
allfieldsGer	10.1016/j.tjog.2021.07.015 doi (DE-627)DOAJ004652673 (DE-599)DOAJfcfc12a7be2742b281e9b0d2ed182c15 DE-627 ger DE-627 rakwb eng RG1-991 Nevin Tüten verfasserin aut Serum neprilysin levels are elevated in preeclampsia 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia. Blood pressure Enkephalinase Endopeptidase Natriuretic peptides Neutral endopeptidase Gynecology and obstetrics Eduard Malik verfasserin aut Koray Gök verfasserin aut Kübra Hamzaoglu verfasserin aut Melike Makul verfasserin aut Yahya Özgün Öner verfasserin aut Huri Bulut verfasserin aut Abdullah Tüten verfasserin aut Onur Güralp verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 60(2021), 5, Seite 869-873 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:60 year:2021 number:5 pages:869-873 https://doi.org/10.1016/j.tjog.2021.07.015 kostenfrei https://doaj.org/article/fcfc12a7be2742b281e9b0d2ed182c15 kostenfrei http://www.sciencedirect.com/science/article/pii/S102845592100187X kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2021 5 869-873
allfieldsSound	10.1016/j.tjog.2021.07.015 doi (DE-627)DOAJ004652673 (DE-599)DOAJfcfc12a7be2742b281e9b0d2ed182c15 DE-627 ger DE-627 rakwb eng RG1-991 Nevin Tüten verfasserin aut Serum neprilysin levels are elevated in preeclampsia 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia. Blood pressure Enkephalinase Endopeptidase Natriuretic peptides Neutral endopeptidase Gynecology and obstetrics Eduard Malik verfasserin aut Koray Gök verfasserin aut Kübra Hamzaoglu verfasserin aut Melike Makul verfasserin aut Yahya Özgün Öner verfasserin aut Huri Bulut verfasserin aut Abdullah Tüten verfasserin aut Onur Güralp verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 60(2021), 5, Seite 869-873 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:60 year:2021 number:5 pages:869-873 https://doi.org/10.1016/j.tjog.2021.07.015 kostenfrei https://doaj.org/article/fcfc12a7be2742b281e9b0d2ed182c15 kostenfrei http://www.sciencedirect.com/science/article/pii/S102845592100187X kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2021 5 869-873
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Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. 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callnumber-first	R - Medicine
author	Nevin Tüten
spellingShingle	Nevin Tüten misc RG1-991 misc Blood pressure misc Enkephalinase misc Endopeptidase misc Natriuretic peptides misc Neutral endopeptidase misc Gynecology and obstetrics Serum neprilysin levels are elevated in preeclampsia
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topic_title	RG1-991 Serum neprilysin levels are elevated in preeclampsia Blood pressure Enkephalinase Endopeptidase Natriuretic peptides Neutral endopeptidase
topic	misc RG1-991 misc Blood pressure misc Enkephalinase misc Endopeptidase misc Natriuretic peptides misc Neutral endopeptidase misc Gynecology and obstetrics
topic_unstemmed	misc RG1-991 misc Blood pressure misc Enkephalinase misc Endopeptidase misc Natriuretic peptides misc Neutral endopeptidase misc Gynecology and obstetrics
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title	Serum neprilysin levels are elevated in preeclampsia
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title_full	Serum neprilysin levels are elevated in preeclampsia
author_sort	Nevin Tüten
journal	Taiwanese Journal of Obstetrics & Gynecology
journalStr	Taiwanese Journal of Obstetrics & Gynecology
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author_browse	Nevin Tüten Eduard Malik Koray Gök Kübra Hamzaoglu Melike Makul Yahya Özgün Öner Huri Bulut Abdullah Tüten Onur Güralp
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doi_str_mv	10.1016/j.tjog.2021.07.015
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title_sort	serum neprilysin levels are elevated in preeclampsia
callnumber	RG1-991
title_auth	Serum neprilysin levels are elevated in preeclampsia
abstract	Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia.
abstractGer	Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia.
abstract_unstemmed	Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia.
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title_short	Serum neprilysin levels are elevated in preeclampsia
url	https://doi.org/10.1016/j.tjog.2021.07.015 https://doaj.org/article/fcfc12a7be2742b281e9b0d2ed182c15 http://www.sciencedirect.com/science/article/pii/S102845592100187X https://doaj.org/toc/1028-4559
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author2	Eduard Malik Koray Gök Kübra Hamzaoglu Melike Makul Yahya Özgün Öner Huri Bulut Abdullah Tüten Onur Güralp
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up_date	2024-07-04T00:35:53.655Z
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Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. 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Serum neprilysin levels are elevated in preeclampsia

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