Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task
Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first fu...
Ausführliche Beschreibung
Autor*in: |
Jie-Yu Chuang [verfasserIn] Cindy C. Hagan [verfasserIn] Graham K. Murray [verfasserIn] Julia M. E. Graham [verfasserIn] Cinly Ooi [verfasserIn] Roger Tait [verfasserIn] Rosemary J. Holt [verfasserIn] Rebecca Elliott [verfasserIn] Adrienne O. van Nieuwenhuizen [verfasserIn] Edward T. Bullmore [verfasserIn] Belinda R. Lennox [verfasserIn] Barbara J. Sahakian [verfasserIn] Ian M. Goodyer [verfasserIn] John Suckling [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2017 |
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Übergeordnetes Werk: |
In: Frontiers in Psychiatry - Frontiers Media S.A., 2010, 8(2017) |
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Übergeordnetes Werk: |
volume:8 ; year:2017 |
Links: |
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DOI / URN: |
10.3389/fpsyt.2017.00119 |
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Katalog-ID: |
DOAJ004783948 |
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10.3389/fpsyt.2017.00119 doi (DE-627)DOAJ004783948 (DE-599)DOAJca283673a5944a61afb1878adeba006b DE-627 ger DE-627 rakwb eng RC435-571 Jie-Yu Chuang verfasserin aut Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference Psychiatry Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Julia M. E. Graham verfasserin aut Cinly Ooi verfasserin aut Roger Tait verfasserin aut Rosemary J. Holt verfasserin aut Rebecca Elliott verfasserin aut Adrienne O. van Nieuwenhuizen verfasserin aut Edward T. Bullmore verfasserin aut Belinda R. Lennox verfasserin aut Barbara J. Sahakian verfasserin aut Barbara J. Sahakian verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 8(2017) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:8 year:2017 https://doi.org/10.3389/fpsyt.2017.00119 kostenfrei https://doaj.org/article/ca283673a5944a61afb1878adeba006b kostenfrei http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 |
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10.3389/fpsyt.2017.00119 doi (DE-627)DOAJ004783948 (DE-599)DOAJca283673a5944a61afb1878adeba006b DE-627 ger DE-627 rakwb eng RC435-571 Jie-Yu Chuang verfasserin aut Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference Psychiatry Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Julia M. E. Graham verfasserin aut Cinly Ooi verfasserin aut Roger Tait verfasserin aut Rosemary J. Holt verfasserin aut Rebecca Elliott verfasserin aut Adrienne O. van Nieuwenhuizen verfasserin aut Edward T. Bullmore verfasserin aut Belinda R. Lennox verfasserin aut Barbara J. Sahakian verfasserin aut Barbara J. Sahakian verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 8(2017) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:8 year:2017 https://doi.org/10.3389/fpsyt.2017.00119 kostenfrei https://doaj.org/article/ca283673a5944a61afb1878adeba006b kostenfrei http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 |
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10.3389/fpsyt.2017.00119 doi (DE-627)DOAJ004783948 (DE-599)DOAJca283673a5944a61afb1878adeba006b DE-627 ger DE-627 rakwb eng RC435-571 Jie-Yu Chuang verfasserin aut Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference Psychiatry Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Julia M. E. Graham verfasserin aut Cinly Ooi verfasserin aut Roger Tait verfasserin aut Rosemary J. Holt verfasserin aut Rebecca Elliott verfasserin aut Adrienne O. van Nieuwenhuizen verfasserin aut Edward T. Bullmore verfasserin aut Belinda R. Lennox verfasserin aut Barbara J. Sahakian verfasserin aut Barbara J. Sahakian verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 8(2017) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:8 year:2017 https://doi.org/10.3389/fpsyt.2017.00119 kostenfrei https://doaj.org/article/ca283673a5944a61afb1878adeba006b kostenfrei http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 |
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10.3389/fpsyt.2017.00119 doi (DE-627)DOAJ004783948 (DE-599)DOAJca283673a5944a61afb1878adeba006b DE-627 ger DE-627 rakwb eng RC435-571 Jie-Yu Chuang verfasserin aut Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference Psychiatry Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Julia M. E. Graham verfasserin aut Cinly Ooi verfasserin aut Roger Tait verfasserin aut Rosemary J. Holt verfasserin aut Rebecca Elliott verfasserin aut Adrienne O. van Nieuwenhuizen verfasserin aut Edward T. Bullmore verfasserin aut Belinda R. Lennox verfasserin aut Barbara J. Sahakian verfasserin aut Barbara J. Sahakian verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 8(2017) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:8 year:2017 https://doi.org/10.3389/fpsyt.2017.00119 kostenfrei https://doaj.org/article/ca283673a5944a61afb1878adeba006b kostenfrei http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 |
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10.3389/fpsyt.2017.00119 doi (DE-627)DOAJ004783948 (DE-599)DOAJca283673a5944a61afb1878adeba006b DE-627 ger DE-627 rakwb eng RC435-571 Jie-Yu Chuang verfasserin aut Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference Psychiatry Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Julia M. E. Graham verfasserin aut Cinly Ooi verfasserin aut Roger Tait verfasserin aut Rosemary J. Holt verfasserin aut Rebecca Elliott verfasserin aut Adrienne O. van Nieuwenhuizen verfasserin aut Edward T. Bullmore verfasserin aut Belinda R. Lennox verfasserin aut Barbara J. Sahakian verfasserin aut Barbara J. Sahakian verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 8(2017) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:8 year:2017 https://doi.org/10.3389/fpsyt.2017.00119 kostenfrei https://doaj.org/article/ca283673a5944a61afb1878adeba006b kostenfrei http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 |
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adolescent major depressive disorder: neuroimaging evidence of sex difference during an affective go/no-go task |
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title_auth |
Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task |
abstract |
Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. |
abstractGer |
Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. |
abstract_unstemmed |
Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. |
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title_short |
Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task |
url |
https://doi.org/10.3389/fpsyt.2017.00119 https://doaj.org/article/ca283673a5944a61afb1878adeba006b http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full https://doaj.org/toc/1664-0640 |
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Cindy C. Hagan Graham K. Murray Julia M. E. Graham Cinly Ooi Roger Tait Rosemary J. Holt Rebecca Elliott Adrienne O. van Nieuwenhuizen Edward T. Bullmore Belinda R. Lennox Barbara J. Sahakian Ian M. Goodyer John Suckling |
author2Str |
Cindy C. Hagan Graham K. Murray Julia M. E. Graham Cinly Ooi Roger Tait Rosemary J. Holt Rebecca Elliott Adrienne O. van Nieuwenhuizen Edward T. Bullmore Belinda R. Lennox Barbara J. Sahakian Ian M. Goodyer John Suckling |
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callnumber-a |
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up_date |
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