Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task

Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first fu...
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Autor*in:	Jie-Yu Chuang [verfasserIn] Cindy C. Hagan [verfasserIn] Graham K. Murray [verfasserIn] Julia M. E. Graham [verfasserIn] Cinly Ooi [verfasserIn] Roger Tait [verfasserIn] Rosemary J. Holt [verfasserIn] Rebecca Elliott [verfasserIn] Adrienne O. van Nieuwenhuizen [verfasserIn] Edward T. Bullmore [verfasserIn] Belinda R. Lennox [verfasserIn] Barbara J. Sahakian [verfasserIn] Ian M. Goodyer [verfasserIn] John Suckling [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference

Übergeordnetes Werk:	In: Frontiers in Psychiatry - Frontiers Media S.A., 2010, 8(2017)
Übergeordnetes Werk:	volume:8 ; year:2017

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fpsyt.2017.00119

Katalog-ID:	DOAJ004783948

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allfields	10.3389/fpsyt.2017.00119 doi (DE-627)DOAJ004783948 (DE-599)DOAJca283673a5944a61afb1878adeba006b DE-627 ger DE-627 rakwb eng RC435-571 Jie-Yu Chuang verfasserin aut Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference Psychiatry Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Julia M. E. Graham verfasserin aut Cinly Ooi verfasserin aut Roger Tait verfasserin aut Rosemary J. Holt verfasserin aut Rebecca Elliott verfasserin aut Adrienne O. van Nieuwenhuizen verfasserin aut Edward T. Bullmore verfasserin aut Belinda R. Lennox verfasserin aut Barbara J. Sahakian verfasserin aut Barbara J. Sahakian verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 8(2017) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:8 year:2017 https://doi.org/10.3389/fpsyt.2017.00119 kostenfrei https://doaj.org/article/ca283673a5944a61afb1878adeba006b kostenfrei http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
spelling	10.3389/fpsyt.2017.00119 doi (DE-627)DOAJ004783948 (DE-599)DOAJca283673a5944a61afb1878adeba006b DE-627 ger DE-627 rakwb eng RC435-571 Jie-Yu Chuang verfasserin aut Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference Psychiatry Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Julia M. E. Graham verfasserin aut Cinly Ooi verfasserin aut Roger Tait verfasserin aut Rosemary J. Holt verfasserin aut Rebecca Elliott verfasserin aut Adrienne O. van Nieuwenhuizen verfasserin aut Edward T. Bullmore verfasserin aut Belinda R. Lennox verfasserin aut Barbara J. Sahakian verfasserin aut Barbara J. Sahakian verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 8(2017) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:8 year:2017 https://doi.org/10.3389/fpsyt.2017.00119 kostenfrei https://doaj.org/article/ca283673a5944a61afb1878adeba006b kostenfrei http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
allfields_unstemmed	10.3389/fpsyt.2017.00119 doi (DE-627)DOAJ004783948 (DE-599)DOAJca283673a5944a61afb1878adeba006b DE-627 ger DE-627 rakwb eng RC435-571 Jie-Yu Chuang verfasserin aut Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference Psychiatry Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Julia M. E. Graham verfasserin aut Cinly Ooi verfasserin aut Roger Tait verfasserin aut Rosemary J. Holt verfasserin aut Rebecca Elliott verfasserin aut Adrienne O. van Nieuwenhuizen verfasserin aut Edward T. Bullmore verfasserin aut Belinda R. Lennox verfasserin aut Barbara J. Sahakian verfasserin aut Barbara J. Sahakian verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 8(2017) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:8 year:2017 https://doi.org/10.3389/fpsyt.2017.00119 kostenfrei https://doaj.org/article/ca283673a5944a61afb1878adeba006b kostenfrei http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
allfieldsGer	10.3389/fpsyt.2017.00119 doi (DE-627)DOAJ004783948 (DE-599)DOAJca283673a5944a61afb1878adeba006b DE-627 ger DE-627 rakwb eng RC435-571 Jie-Yu Chuang verfasserin aut Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference Psychiatry Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Julia M. E. Graham verfasserin aut Cinly Ooi verfasserin aut Roger Tait verfasserin aut Rosemary J. Holt verfasserin aut Rebecca Elliott verfasserin aut Adrienne O. van Nieuwenhuizen verfasserin aut Edward T. Bullmore verfasserin aut Belinda R. Lennox verfasserin aut Barbara J. Sahakian verfasserin aut Barbara J. Sahakian verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 8(2017) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:8 year:2017 https://doi.org/10.3389/fpsyt.2017.00119 kostenfrei https://doaj.org/article/ca283673a5944a61afb1878adeba006b kostenfrei http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
allfieldsSound	10.3389/fpsyt.2017.00119 doi (DE-627)DOAJ004783948 (DE-599)DOAJca283673a5944a61afb1878adeba006b DE-627 ger DE-627 rakwb eng RC435-571 Jie-Yu Chuang verfasserin aut Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference Psychiatry Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Cindy C. Hagan verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Graham K. Murray verfasserin aut Julia M. E. Graham verfasserin aut Cinly Ooi verfasserin aut Roger Tait verfasserin aut Rosemary J. Holt verfasserin aut Rebecca Elliott verfasserin aut Adrienne O. van Nieuwenhuizen verfasserin aut Edward T. Bullmore verfasserin aut Belinda R. Lennox verfasserin aut Barbara J. Sahakian verfasserin aut Barbara J. Sahakian verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut John Suckling verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 8(2017) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:8 year:2017 https://doi.org/10.3389/fpsyt.2017.00119 kostenfrei https://doaj.org/article/ca283673a5944a61afb1878adeba006b kostenfrei http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
language	English
source	In Frontiers in Psychiatry 8(2017) volume:8 year:2017
sourceStr	In Frontiers in Psychiatry 8(2017) volume:8 year:2017
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference Psychiatry
isfreeaccess_bool	true
container_title	Frontiers in Psychiatry
authorswithroles_txt_mv	Jie-Yu Chuang @@aut@@ Cindy C. Hagan @@aut@@ Graham K. Murray @@aut@@ Julia M. E. Graham @@aut@@ Cinly Ooi @@aut@@ Roger Tait @@aut@@ Rosemary J. Holt @@aut@@ Rebecca Elliott @@aut@@ Adrienne O. van Nieuwenhuizen @@aut@@ Edward T. Bullmore @@aut@@ Belinda R. Lennox @@aut@@ Barbara J. Sahakian @@aut@@ Ian M. Goodyer @@aut@@ John Suckling @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	631498796
id	DOAJ004783948
language_de	englisch
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callnumber-first	R - Medicine
author	Jie-Yu Chuang
spellingShingle	Jie-Yu Chuang misc RC435-571 misc adolescent major depressive disorder misc affective go/no-go task misc cerebellum misc supramarginal gyrus misc sex difference misc Psychiatry Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task
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topic_title	RC435-571 Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference
topic	misc RC435-571 misc adolescent major depressive disorder misc affective go/no-go task misc cerebellum misc supramarginal gyrus misc sex difference misc Psychiatry
topic_unstemmed	misc RC435-571 misc adolescent major depressive disorder misc affective go/no-go task misc cerebellum misc supramarginal gyrus misc sex difference misc Psychiatry
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title	Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task
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title_full	Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task
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author_browse	Jie-Yu Chuang Cindy C. Hagan Graham K. Murray Julia M. E. Graham Cinly Ooi Roger Tait Rosemary J. Holt Rebecca Elliott Adrienne O. van Nieuwenhuizen Edward T. Bullmore Belinda R. Lennox Barbara J. Sahakian Ian M. Goodyer John Suckling
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title_sort	adolescent major depressive disorder: neuroimaging evidence of sex difference during an affective go/no-go task
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title_auth	Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task
abstract	Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD.
abstractGer	Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD.
abstract_unstemmed	Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD.
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title_short	Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task
url	https://doi.org/10.3389/fpsyt.2017.00119 https://doaj.org/article/ca283673a5944a61afb1878adeba006b http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full https://doaj.org/toc/1664-0640
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