PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals

The immune checkpoint molecule PD-1 is expressed on a fraction of CD4+ T cells latently infected with HIV, but whether PD-1 plays a functional role in reservoir persistence remains unknown. Here, Fromentin et al. show that PD-1 blockade potentiates latency reversal ex vivo in CD4+ T cells from ART s...
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Autor*in:	Rémi Fromentin [verfasserIn] Sandrina DaFonseca [verfasserIn] Cecilia T. Costiniuk [verfasserIn] Mohamed El-Far [verfasserIn] Francesco Andrea Procopio [verfasserIn] Frederick M. Hecht [verfasserIn] Rebecca Hoh [verfasserIn] Steven G. Deeks [verfasserIn] Daria J. Hazuda [verfasserIn] Sharon R. Lewin [verfasserIn] Jean-Pierre Routy [verfasserIn] Rafick-Pierre Sékaly [verfasserIn] Nicolas Chomont [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 10(2019), 1, Seite 7
Übergeordnetes Werk:	volume:10 ; year:2019 ; number:1 ; pages:7

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-019-08798-7

Katalog-ID:	DOAJ004909747

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spelling	10.1038/s41467-019-08798-7 doi (DE-627)DOAJ004909747 (DE-599)DOAJe996a4e085b845f09a6cdde3b15c9886 DE-627 ger DE-627 rakwb eng Rémi Fromentin verfasserin aut PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The immune checkpoint molecule PD-1 is expressed on a fraction of CD4+ T cells latently infected with HIV, but whether PD-1 plays a functional role in reservoir persistence remains unknown. Here, Fromentin et al. show that PD-1 blockade potentiates latency reversal ex vivo in CD4+ T cells from ART suppressed individuals. Science Q Sandrina DaFonseca verfasserin aut Cecilia T. Costiniuk verfasserin aut Mohamed El-Far verfasserin aut Francesco Andrea Procopio verfasserin aut Frederick M. Hecht verfasserin aut Rebecca Hoh verfasserin aut Steven G. Deeks verfasserin aut Daria J. Hazuda verfasserin aut Sharon R. Lewin verfasserin aut Jean-Pierre Routy verfasserin aut Rafick-Pierre Sékaly verfasserin aut Nicolas Chomont verfasserin aut In Nature Communications Nature Portfolio, 2016 10(2019), 1, Seite 7 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:10 year:2019 number:1 pages:7 https://doi.org/10.1038/s41467-019-08798-7 kostenfrei https://doaj.org/article/e996a4e085b845f09a6cdde3b15c9886 kostenfrei https://doi.org/10.1038/s41467-019-08798-7 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019 1 7
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author	Rémi Fromentin
spellingShingle	Rémi Fromentin misc Science misc Q PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
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topic_title	PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
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title	PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
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title_full	PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
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author_browse	Rémi Fromentin Sandrina DaFonseca Cecilia T. Costiniuk Mohamed El-Far Francesco Andrea Procopio Frederick M. Hecht Rebecca Hoh Steven G. Deeks Daria J. Hazuda Sharon R. Lewin Jean-Pierre Routy Rafick-Pierre Sékaly Nicolas Chomont
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title_sort	pd-1 blockade potentiates hiv latency reversal ex vivo in cd4+ t cells from art-suppressed individuals
title_auth	PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
abstract	The immune checkpoint molecule PD-1 is expressed on a fraction of CD4+ T cells latently infected with HIV, but whether PD-1 plays a functional role in reservoir persistence remains unknown. Here, Fromentin et al. show that PD-1 blockade potentiates latency reversal ex vivo in CD4+ T cells from ART suppressed individuals.
abstractGer	The immune checkpoint molecule PD-1 is expressed on a fraction of CD4+ T cells latently infected with HIV, but whether PD-1 plays a functional role in reservoir persistence remains unknown. Here, Fromentin et al. show that PD-1 blockade potentiates latency reversal ex vivo in CD4+ T cells from ART suppressed individuals.
abstract_unstemmed	The immune checkpoint molecule PD-1 is expressed on a fraction of CD4+ T cells latently infected with HIV, but whether PD-1 plays a functional role in reservoir persistence remains unknown. Here, Fromentin et al. show that PD-1 blockade potentiates latency reversal ex vivo in CD4+ T cells from ART suppressed individuals.
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title_short	PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
url	https://doi.org/10.1038/s41467-019-08798-7 https://doaj.org/article/e996a4e085b845f09a6cdde3b15c9886 https://doaj.org/toc/2041-1723
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PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals

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