Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration

To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration. The MS HNSs showed a phototh...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hongshi Ma [verfasserIn] Qingqing Yu [verfasserIn] Yu Qu [verfasserIn] Yufang Zhu [verfasserIn] Chengtie Wu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Manganese silicate hollow nanospheres Composite hydrogel Starvation therapy Photothermal therapy Tissue regeneration

Übergeordnetes Werk:	In: Bioactive Materials - KeAi Communications Co., Ltd., 2017, 6(2021), 12, Seite 4558-4567
Übergeordnetes Werk:	volume:6 ; year:2021 ; number:12 ; pages:4558-4567

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.bioactmat.2021.04.042

Katalog-ID:	DOAJ004920813

Internformat


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520			\|a To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration. The MS HNSs showed a photothermal conversion efficiency of 38.5%, and endowed composite hydrogels with satisfactory photothermal effect. Taking advantage of the catalytic activity of Mn ions, the composite hydrogels could decompose hydrogen peroxide (H2O2) into oxygen (O2), which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor starvation. Meanwhile, hyperthermia triggered by near infrared (NIR) irradiation could not only accelerate the reaction rate of H2O2 decomposition by MS HNSs and glucose consumption by GOx, but also ablate tumor cells. The anti-tumor results showed that synergistic effect of starvation-photothermal therapy led to the highest death rate of tumor cells among all groups, and its anti-tumor effect was obviously improved as compared with that of single photothermal treatment or starvation treatment. Interestingly, the introduction of MS HNSs into hydrogels could distinctly promote the epithelialization of the wound beds by releasing Mn ions as compared with the hydrogels without MS HNSs. It is expected that such a multifunctional platform with starvation-photothermal therapy will be promising for treating tumor-caused skin defects in combination of its regeneration bioactivity in the future.
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allfields	10.1016/j.bioactmat.2021.04.042 doi (DE-627)DOAJ004920813 (DE-599)DOAJe935c49539b94fc3887179dfe2cb271a DE-627 ger DE-627 rakwb eng TA401-492 QH301-705.5 Hongshi Ma verfasserin aut Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration. The MS HNSs showed a photothermal conversion efficiency of 38.5%, and endowed composite hydrogels with satisfactory photothermal effect. Taking advantage of the catalytic activity of Mn ions, the composite hydrogels could decompose hydrogen peroxide (H2O2) into oxygen (O2), which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor starvation. Meanwhile, hyperthermia triggered by near infrared (NIR) irradiation could not only accelerate the reaction rate of H2O2 decomposition by MS HNSs and glucose consumption by GOx, but also ablate tumor cells. The anti-tumor results showed that synergistic effect of starvation-photothermal therapy led to the highest death rate of tumor cells among all groups, and its anti-tumor effect was obviously improved as compared with that of single photothermal treatment or starvation treatment. Interestingly, the introduction of MS HNSs into hydrogels could distinctly promote the epithelialization of the wound beds by releasing Mn ions as compared with the hydrogels without MS HNSs. It is expected that such a multifunctional platform with starvation-photothermal therapy will be promising for treating tumor-caused skin defects in combination of its regeneration bioactivity in the future. Manganese silicate hollow nanospheres Composite hydrogel Starvation therapy Photothermal therapy Tissue regeneration Materials of engineering and construction. Mechanics of materials Biology (General) Qingqing Yu verfasserin aut Yu Qu verfasserin aut Yufang Zhu verfasserin aut Chengtie Wu verfasserin aut In Bioactive Materials KeAi Communications Co., Ltd., 2017 6(2021), 12, Seite 4558-4567 (DE-627)1663654956 (DE-600)2970496-0 2452199X nnns volume:6 year:2021 number:12 pages:4558-4567 https://doi.org/10.1016/j.bioactmat.2021.04.042 kostenfrei https://doaj.org/article/e935c49539b94fc3887179dfe2cb271a kostenfrei http://www.sciencedirect.com/science/article/pii/S2452199X21002188 kostenfrei https://doaj.org/toc/2452-199X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 12 4558-4567
spelling	10.1016/j.bioactmat.2021.04.042 doi (DE-627)DOAJ004920813 (DE-599)DOAJe935c49539b94fc3887179dfe2cb271a DE-627 ger DE-627 rakwb eng TA401-492 QH301-705.5 Hongshi Ma verfasserin aut Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration. The MS HNSs showed a photothermal conversion efficiency of 38.5%, and endowed composite hydrogels with satisfactory photothermal effect. Taking advantage of the catalytic activity of Mn ions, the composite hydrogels could decompose hydrogen peroxide (H2O2) into oxygen (O2), which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor starvation. Meanwhile, hyperthermia triggered by near infrared (NIR) irradiation could not only accelerate the reaction rate of H2O2 decomposition by MS HNSs and glucose consumption by GOx, but also ablate tumor cells. The anti-tumor results showed that synergistic effect of starvation-photothermal therapy led to the highest death rate of tumor cells among all groups, and its anti-tumor effect was obviously improved as compared with that of single photothermal treatment or starvation treatment. Interestingly, the introduction of MS HNSs into hydrogels could distinctly promote the epithelialization of the wound beds by releasing Mn ions as compared with the hydrogels without MS HNSs. It is expected that such a multifunctional platform with starvation-photothermal therapy will be promising for treating tumor-caused skin defects in combination of its regeneration bioactivity in the future. Manganese silicate hollow nanospheres Composite hydrogel Starvation therapy Photothermal therapy Tissue regeneration Materials of engineering and construction. Mechanics of materials Biology (General) Qingqing Yu verfasserin aut Yu Qu verfasserin aut Yufang Zhu verfasserin aut Chengtie Wu verfasserin aut In Bioactive Materials KeAi Communications Co., Ltd., 2017 6(2021), 12, Seite 4558-4567 (DE-627)1663654956 (DE-600)2970496-0 2452199X nnns volume:6 year:2021 number:12 pages:4558-4567 https://doi.org/10.1016/j.bioactmat.2021.04.042 kostenfrei https://doaj.org/article/e935c49539b94fc3887179dfe2cb271a kostenfrei http://www.sciencedirect.com/science/article/pii/S2452199X21002188 kostenfrei https://doaj.org/toc/2452-199X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 12 4558-4567
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allfieldsGer	10.1016/j.bioactmat.2021.04.042 doi (DE-627)DOAJ004920813 (DE-599)DOAJe935c49539b94fc3887179dfe2cb271a DE-627 ger DE-627 rakwb eng TA401-492 QH301-705.5 Hongshi Ma verfasserin aut Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration. The MS HNSs showed a photothermal conversion efficiency of 38.5%, and endowed composite hydrogels with satisfactory photothermal effect. Taking advantage of the catalytic activity of Mn ions, the composite hydrogels could decompose hydrogen peroxide (H2O2) into oxygen (O2), which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor starvation. Meanwhile, hyperthermia triggered by near infrared (NIR) irradiation could not only accelerate the reaction rate of H2O2 decomposition by MS HNSs and glucose consumption by GOx, but also ablate tumor cells. The anti-tumor results showed that synergistic effect of starvation-photothermal therapy led to the highest death rate of tumor cells among all groups, and its anti-tumor effect was obviously improved as compared with that of single photothermal treatment or starvation treatment. Interestingly, the introduction of MS HNSs into hydrogels could distinctly promote the epithelialization of the wound beds by releasing Mn ions as compared with the hydrogels without MS HNSs. It is expected that such a multifunctional platform with starvation-photothermal therapy will be promising for treating tumor-caused skin defects in combination of its regeneration bioactivity in the future. Manganese silicate hollow nanospheres Composite hydrogel Starvation therapy Photothermal therapy Tissue regeneration Materials of engineering and construction. Mechanics of materials Biology (General) Qingqing Yu verfasserin aut Yu Qu verfasserin aut Yufang Zhu verfasserin aut Chengtie Wu verfasserin aut In Bioactive Materials KeAi Communications Co., Ltd., 2017 6(2021), 12, Seite 4558-4567 (DE-627)1663654956 (DE-600)2970496-0 2452199X nnns volume:6 year:2021 number:12 pages:4558-4567 https://doi.org/10.1016/j.bioactmat.2021.04.042 kostenfrei https://doaj.org/article/e935c49539b94fc3887179dfe2cb271a kostenfrei http://www.sciencedirect.com/science/article/pii/S2452199X21002188 kostenfrei https://doaj.org/toc/2452-199X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 12 4558-4567
allfieldsSound	10.1016/j.bioactmat.2021.04.042 doi (DE-627)DOAJ004920813 (DE-599)DOAJe935c49539b94fc3887179dfe2cb271a DE-627 ger DE-627 rakwb eng TA401-492 QH301-705.5 Hongshi Ma verfasserin aut Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration. The MS HNSs showed a photothermal conversion efficiency of 38.5%, and endowed composite hydrogels with satisfactory photothermal effect. Taking advantage of the catalytic activity of Mn ions, the composite hydrogels could decompose hydrogen peroxide (H2O2) into oxygen (O2), which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor starvation. Meanwhile, hyperthermia triggered by near infrared (NIR) irradiation could not only accelerate the reaction rate of H2O2 decomposition by MS HNSs and glucose consumption by GOx, but also ablate tumor cells. The anti-tumor results showed that synergistic effect of starvation-photothermal therapy led to the highest death rate of tumor cells among all groups, and its anti-tumor effect was obviously improved as compared with that of single photothermal treatment or starvation treatment. Interestingly, the introduction of MS HNSs into hydrogels could distinctly promote the epithelialization of the wound beds by releasing Mn ions as compared with the hydrogels without MS HNSs. It is expected that such a multifunctional platform with starvation-photothermal therapy will be promising for treating tumor-caused skin defects in combination of its regeneration bioactivity in the future. Manganese silicate hollow nanospheres Composite hydrogel Starvation therapy Photothermal therapy Tissue regeneration Materials of engineering and construction. Mechanics of materials Biology (General) Qingqing Yu verfasserin aut Yu Qu verfasserin aut Yufang Zhu verfasserin aut Chengtie Wu verfasserin aut In Bioactive Materials KeAi Communications Co., Ltd., 2017 6(2021), 12, Seite 4558-4567 (DE-627)1663654956 (DE-600)2970496-0 2452199X nnns volume:6 year:2021 number:12 pages:4558-4567 https://doi.org/10.1016/j.bioactmat.2021.04.042 kostenfrei https://doaj.org/article/e935c49539b94fc3887179dfe2cb271a kostenfrei http://www.sciencedirect.com/science/article/pii/S2452199X21002188 kostenfrei https://doaj.org/toc/2452-199X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 12 4558-4567
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source	In Bioactive Materials 6(2021), 12, Seite 4558-4567 volume:6 year:2021 number:12 pages:4558-4567
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topic_facet	Manganese silicate hollow nanospheres Composite hydrogel Starvation therapy Photothermal therapy Tissue regeneration Materials of engineering and construction. Mechanics of materials Biology (General)
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callnumber-first	T - Technology
author	Hongshi Ma
spellingShingle	Hongshi Ma misc TA401-492 misc QH301-705.5 misc Manganese silicate hollow nanospheres misc Composite hydrogel misc Starvation therapy misc Photothermal therapy misc Tissue regeneration misc Materials of engineering and construction. Mechanics of materials misc Biology (General) Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration
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topic_title	TA401-492 QH301-705.5 Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration Manganese silicate hollow nanospheres Composite hydrogel Starvation therapy Photothermal therapy Tissue regeneration
topic	misc TA401-492 misc QH301-705.5 misc Manganese silicate hollow nanospheres misc Composite hydrogel misc Starvation therapy misc Photothermal therapy misc Tissue regeneration misc Materials of engineering and construction. Mechanics of materials misc Biology (General)
topic_unstemmed	misc TA401-492 misc QH301-705.5 misc Manganese silicate hollow nanospheres misc Composite hydrogel misc Starvation therapy misc Photothermal therapy misc Tissue regeneration misc Materials of engineering and construction. Mechanics of materials misc Biology (General)
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title	Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration
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title_full	Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration
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title_sort	manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration
callnumber	TA401-492
title_auth	Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration
abstract	To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration. The MS HNSs showed a photothermal conversion efficiency of 38.5%, and endowed composite hydrogels with satisfactory photothermal effect. Taking advantage of the catalytic activity of Mn ions, the composite hydrogels could decompose hydrogen peroxide (H2O2) into oxygen (O2), which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor starvation. Meanwhile, hyperthermia triggered by near infrared (NIR) irradiation could not only accelerate the reaction rate of H2O2 decomposition by MS HNSs and glucose consumption by GOx, but also ablate tumor cells. The anti-tumor results showed that synergistic effect of starvation-photothermal therapy led to the highest death rate of tumor cells among all groups, and its anti-tumor effect was obviously improved as compared with that of single photothermal treatment or starvation treatment. Interestingly, the introduction of MS HNSs into hydrogels could distinctly promote the epithelialization of the wound beds by releasing Mn ions as compared with the hydrogels without MS HNSs. It is expected that such a multifunctional platform with starvation-photothermal therapy will be promising for treating tumor-caused skin defects in combination of its regeneration bioactivity in the future.
abstractGer	To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration. The MS HNSs showed a photothermal conversion efficiency of 38.5%, and endowed composite hydrogels with satisfactory photothermal effect. Taking advantage of the catalytic activity of Mn ions, the composite hydrogels could decompose hydrogen peroxide (H2O2) into oxygen (O2), which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor starvation. Meanwhile, hyperthermia triggered by near infrared (NIR) irradiation could not only accelerate the reaction rate of H2O2 decomposition by MS HNSs and glucose consumption by GOx, but also ablate tumor cells. The anti-tumor results showed that synergistic effect of starvation-photothermal therapy led to the highest death rate of tumor cells among all groups, and its anti-tumor effect was obviously improved as compared with that of single photothermal treatment or starvation treatment. Interestingly, the introduction of MS HNSs into hydrogels could distinctly promote the epithelialization of the wound beds by releasing Mn ions as compared with the hydrogels without MS HNSs. It is expected that such a multifunctional platform with starvation-photothermal therapy will be promising for treating tumor-caused skin defects in combination of its regeneration bioactivity in the future.
abstract_unstemmed	To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration. The MS HNSs showed a photothermal conversion efficiency of 38.5%, and endowed composite hydrogels with satisfactory photothermal effect. Taking advantage of the catalytic activity of Mn ions, the composite hydrogels could decompose hydrogen peroxide (H2O2) into oxygen (O2), which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor starvation. Meanwhile, hyperthermia triggered by near infrared (NIR) irradiation could not only accelerate the reaction rate of H2O2 decomposition by MS HNSs and glucose consumption by GOx, but also ablate tumor cells. The anti-tumor results showed that synergistic effect of starvation-photothermal therapy led to the highest death rate of tumor cells among all groups, and its anti-tumor effect was obviously improved as compared with that of single photothermal treatment or starvation treatment. Interestingly, the introduction of MS HNSs into hydrogels could distinctly promote the epithelialization of the wound beds by releasing Mn ions as compared with the hydrogels without MS HNSs. It is expected that such a multifunctional platform with starvation-photothermal therapy will be promising for treating tumor-caused skin defects in combination of its regeneration bioactivity in the future.
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title_short	Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration
url	https://doi.org/10.1016/j.bioactmat.2021.04.042 https://doaj.org/article/e935c49539b94fc3887179dfe2cb271a http://www.sciencedirect.com/science/article/pii/S2452199X21002188 https://doaj.org/toc/2452-199X
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author2	Qingqing Yu Yu Qu Yufang Zhu Chengtie Wu
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up_date	2024-07-04T01:40:08.250Z
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Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration

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