Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR

Epistasis effects among amino acids at distal sites within binding pockets can have important impacts on protein fitness landscapes. Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.

Gespeichert in:

Autor*in:	Justin I. Yoo [verfasserIn] Patrick S. Daugherty [verfasserIn] Michelle A. O’Malley [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 11(2020), 1, Seite 12
Übergeordnetes Werk:	volume:11 ; year:2020 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-020-14495-7

Katalog-ID:	DOAJ004935276

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topic_title	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
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title	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
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title_full	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
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title_sort	bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a gpcr
title_auth	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
abstract	Epistasis effects among amino acids at distal sites within binding pockets can have important impacts on protein fitness landscapes. Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.
abstractGer	Epistasis effects among amino acids at distal sites within binding pockets can have important impacts on protein fitness landscapes. Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.
abstract_unstemmed	Epistasis effects among amino acids at distal sites within binding pockets can have important impacts on protein fitness landscapes. Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.
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title_short	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
url	https://doi.org/10.1038/s41467-020-14495-7 https://doaj.org/article/05d4a1f9278e456eb4e1635dc620ccf7 https://doaj.org/toc/2041-1723
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