Seroprevalence of a “new” bacterium, Simkania negevensis, in renal transplant recipients and in hemodialysis patients

Abstract Background Simkania negevensis is an obligate intracellular bacterium belonging to the family Simkaniaceae in the Chlamydiales order. It is considered an ubiquitous microorganism and aquatic environments may be involved as a source of infection for humans. It was just isolated in samples fr...
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Autor*in:	Andrea Angeletti [verfasserIn] Roberta Biondi [verfasserIn] Giuseppe Battaglino [verfasserIn] Eleonora Cremonini [verfasserIn] Giorgia Comai [verfasserIn] Irene Capelli [verfasserIn] Gabriele Donati [verfasserIn] Roberto Cevenini [verfasserIn] Manuela Donati [verfasserIn] Gaetano La Manna [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Kidney transplantation Chronic hemodialysis Simkania negevensis Chronic inflammation Infection Hemodialysis fluid

Übergeordnetes Werk:	In: BMC Nephrology - BMC, 2003, 18(2017), 1, Seite 8
Übergeordnetes Werk:	volume:18 ; year:2017 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12882-017-0548-z

Katalog-ID:	DOAJ004952715

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520			\|a Abstract Background Simkania negevensis is an obligate intracellular bacterium belonging to the family Simkaniaceae in the Chlamydiales order. It is considered an ubiquitous microorganism and aquatic environments may be involved as a source of infection for humans. It was just isolated in samples from domestic water supplies and from mains water supplies, like spa water or swimming pool water, confirming its ability to resist to the common chlorination treatments. Evidence indicates a possible role of the microorganism in respiratory tract infections, in gastroenteric disorders and in the pathogenesis of cardiovascular disease, furthermore it has hypothesized that it could play a role in lung transplant rejection. Prevalence and possible effects in nephrology are unknown. Methods We examined the occurrence of Simkania negevensis in two differents populations, both characterized by a high susceptibility to infectious complications: 105 hemodialysis patients, 105 renal transplant recipients and 105 healthy subjects through the IgG and IgA response to Simkania negevensis in their sera. Serum antibodies to Simkania negevensis were detected by a homemade ELISA performed according to the Kahane’s protocol. Furthermore water samples from hemodialytic circuit were collected, to evaluate Simkania negevensis resistance to usual treatment of disinfection. Results Our results were unexpected, showing a higher seroprevalence of antibodies against Simkania negevensis in the hemodialysis patients, compared to renal transplant patients (IgG 22% vs 9% - IgA 9% vs 3%). S. negevensis was isolated in all water samples analyzed. Conclusions Our study detected for the first time the occurrence of S. negevensis in hemodialysis and in renal transplant patients. Our findings suggest that water used in hemodialysis could be one of the possible sources of S. negevensis infection, without clinical involvement risk for patients.
650		4	\|a Kidney transplantation
650		4	\|a Chronic hemodialysis
650		4	\|a Simkania negevensis
650		4	\|a Chronic inflammation
650		4	\|a Infection
650		4	\|a Hemodialysis fluid
653		0	\|a Diseases of the genitourinary system. Urology
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700	0		\|a Gaetano La Manna \|e verfasserin \|4 aut
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allfields	10.1186/s12882-017-0548-z doi (DE-627)DOAJ004952715 (DE-599)DOAJ30b27b67adf7498991d9097a2210b6c8 DE-627 ger DE-627 rakwb eng RC870-923 Andrea Angeletti verfasserin aut Seroprevalence of a “new” bacterium, Simkania negevensis, in renal transplant recipients and in hemodialysis patients 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Simkania negevensis is an obligate intracellular bacterium belonging to the family Simkaniaceae in the Chlamydiales order. It is considered an ubiquitous microorganism and aquatic environments may be involved as a source of infection for humans. It was just isolated in samples from domestic water supplies and from mains water supplies, like spa water or swimming pool water, confirming its ability to resist to the common chlorination treatments. Evidence indicates a possible role of the microorganism in respiratory tract infections, in gastroenteric disorders and in the pathogenesis of cardiovascular disease, furthermore it has hypothesized that it could play a role in lung transplant rejection. Prevalence and possible effects in nephrology are unknown. Methods We examined the occurrence of Simkania negevensis in two differents populations, both characterized by a high susceptibility to infectious complications: 105 hemodialysis patients, 105 renal transplant recipients and 105 healthy subjects through the IgG and IgA response to Simkania negevensis in their sera. Serum antibodies to Simkania negevensis were detected by a homemade ELISA performed according to the Kahane’s protocol. Furthermore water samples from hemodialytic circuit were collected, to evaluate Simkania negevensis resistance to usual treatment of disinfection. Results Our results were unexpected, showing a higher seroprevalence of antibodies against Simkania negevensis in the hemodialysis patients, compared to renal transplant patients (IgG 22% vs 9% - IgA 9% vs 3%). S. negevensis was isolated in all water samples analyzed. Conclusions Our study detected for the first time the occurrence of S. negevensis in hemodialysis and in renal transplant patients. Our findings suggest that water used in hemodialysis could be one of the possible sources of S. negevensis infection, without clinical involvement risk for patients. Kidney transplantation Chronic hemodialysis Simkania negevensis Chronic inflammation Infection Hemodialysis fluid Diseases of the genitourinary system. Urology Roberta Biondi verfasserin aut Giuseppe Battaglino verfasserin aut Eleonora Cremonini verfasserin aut Giorgia Comai verfasserin aut Irene Capelli verfasserin aut Gabriele Donati verfasserin aut Roberto Cevenini verfasserin aut Manuela Donati verfasserin aut Gaetano La Manna verfasserin aut In BMC Nephrology BMC, 2003 18(2017), 1, Seite 8 (DE-627)326643672 (DE-600)2041348-8 14712369 nnns volume:18 year:2017 number:1 pages:8 https://doi.org/10.1186/s12882-017-0548-z kostenfrei https://doaj.org/article/30b27b67adf7498991d9097a2210b6c8 kostenfrei http://link.springer.com/article/10.1186/s12882-017-0548-z kostenfrei https://doaj.org/toc/1471-2369 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 8
spelling	10.1186/s12882-017-0548-z doi (DE-627)DOAJ004952715 (DE-599)DOAJ30b27b67adf7498991d9097a2210b6c8 DE-627 ger DE-627 rakwb eng RC870-923 Andrea Angeletti verfasserin aut Seroprevalence of a “new” bacterium, Simkania negevensis, in renal transplant recipients and in hemodialysis patients 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Simkania negevensis is an obligate intracellular bacterium belonging to the family Simkaniaceae in the Chlamydiales order. It is considered an ubiquitous microorganism and aquatic environments may be involved as a source of infection for humans. It was just isolated in samples from domestic water supplies and from mains water supplies, like spa water or swimming pool water, confirming its ability to resist to the common chlorination treatments. Evidence indicates a possible role of the microorganism in respiratory tract infections, in gastroenteric disorders and in the pathogenesis of cardiovascular disease, furthermore it has hypothesized that it could play a role in lung transplant rejection. Prevalence and possible effects in nephrology are unknown. Methods We examined the occurrence of Simkania negevensis in two differents populations, both characterized by a high susceptibility to infectious complications: 105 hemodialysis patients, 105 renal transplant recipients and 105 healthy subjects through the IgG and IgA response to Simkania negevensis in their sera. Serum antibodies to Simkania negevensis were detected by a homemade ELISA performed according to the Kahane’s protocol. Furthermore water samples from hemodialytic circuit were collected, to evaluate Simkania negevensis resistance to usual treatment of disinfection. Results Our results were unexpected, showing a higher seroprevalence of antibodies against Simkania negevensis in the hemodialysis patients, compared to renal transplant patients (IgG 22% vs 9% - IgA 9% vs 3%). S. negevensis was isolated in all water samples analyzed. Conclusions Our study detected for the first time the occurrence of S. negevensis in hemodialysis and in renal transplant patients. Our findings suggest that water used in hemodialysis could be one of the possible sources of S. negevensis infection, without clinical involvement risk for patients. Kidney transplantation Chronic hemodialysis Simkania negevensis Chronic inflammation Infection Hemodialysis fluid Diseases of the genitourinary system. Urology Roberta Biondi verfasserin aut Giuseppe Battaglino verfasserin aut Eleonora Cremonini verfasserin aut Giorgia Comai verfasserin aut Irene Capelli verfasserin aut Gabriele Donati verfasserin aut Roberto Cevenini verfasserin aut Manuela Donati verfasserin aut Gaetano La Manna verfasserin aut In BMC Nephrology BMC, 2003 18(2017), 1, Seite 8 (DE-627)326643672 (DE-600)2041348-8 14712369 nnns volume:18 year:2017 number:1 pages:8 https://doi.org/10.1186/s12882-017-0548-z kostenfrei https://doaj.org/article/30b27b67adf7498991d9097a2210b6c8 kostenfrei http://link.springer.com/article/10.1186/s12882-017-0548-z kostenfrei https://doaj.org/toc/1471-2369 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 8
allfields_unstemmed	10.1186/s12882-017-0548-z doi (DE-627)DOAJ004952715 (DE-599)DOAJ30b27b67adf7498991d9097a2210b6c8 DE-627 ger DE-627 rakwb eng RC870-923 Andrea Angeletti verfasserin aut Seroprevalence of a “new” bacterium, Simkania negevensis, in renal transplant recipients and in hemodialysis patients 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Simkania negevensis is an obligate intracellular bacterium belonging to the family Simkaniaceae in the Chlamydiales order. It is considered an ubiquitous microorganism and aquatic environments may be involved as a source of infection for humans. It was just isolated in samples from domestic water supplies and from mains water supplies, like spa water or swimming pool water, confirming its ability to resist to the common chlorination treatments. Evidence indicates a possible role of the microorganism in respiratory tract infections, in gastroenteric disorders and in the pathogenesis of cardiovascular disease, furthermore it has hypothesized that it could play a role in lung transplant rejection. Prevalence and possible effects in nephrology are unknown. Methods We examined the occurrence of Simkania negevensis in two differents populations, both characterized by a high susceptibility to infectious complications: 105 hemodialysis patients, 105 renal transplant recipients and 105 healthy subjects through the IgG and IgA response to Simkania negevensis in their sera. Serum antibodies to Simkania negevensis were detected by a homemade ELISA performed according to the Kahane’s protocol. Furthermore water samples from hemodialytic circuit were collected, to evaluate Simkania negevensis resistance to usual treatment of disinfection. Results Our results were unexpected, showing a higher seroprevalence of antibodies against Simkania negevensis in the hemodialysis patients, compared to renal transplant patients (IgG 22% vs 9% - IgA 9% vs 3%). S. negevensis was isolated in all water samples analyzed. Conclusions Our study detected for the first time the occurrence of S. negevensis in hemodialysis and in renal transplant patients. Our findings suggest that water used in hemodialysis could be one of the possible sources of S. negevensis infection, without clinical involvement risk for patients. Kidney transplantation Chronic hemodialysis Simkania negevensis Chronic inflammation Infection Hemodialysis fluid Diseases of the genitourinary system. Urology Roberta Biondi verfasserin aut Giuseppe Battaglino verfasserin aut Eleonora Cremonini verfasserin aut Giorgia Comai verfasserin aut Irene Capelli verfasserin aut Gabriele Donati verfasserin aut Roberto Cevenini verfasserin aut Manuela Donati verfasserin aut Gaetano La Manna verfasserin aut In BMC Nephrology BMC, 2003 18(2017), 1, Seite 8 (DE-627)326643672 (DE-600)2041348-8 14712369 nnns volume:18 year:2017 number:1 pages:8 https://doi.org/10.1186/s12882-017-0548-z kostenfrei https://doaj.org/article/30b27b67adf7498991d9097a2210b6c8 kostenfrei http://link.springer.com/article/10.1186/s12882-017-0548-z kostenfrei https://doaj.org/toc/1471-2369 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 8
allfieldsGer	10.1186/s12882-017-0548-z doi (DE-627)DOAJ004952715 (DE-599)DOAJ30b27b67adf7498991d9097a2210b6c8 DE-627 ger DE-627 rakwb eng RC870-923 Andrea Angeletti verfasserin aut Seroprevalence of a “new” bacterium, Simkania negevensis, in renal transplant recipients and in hemodialysis patients 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Simkania negevensis is an obligate intracellular bacterium belonging to the family Simkaniaceae in the Chlamydiales order. It is considered an ubiquitous microorganism and aquatic environments may be involved as a source of infection for humans. It was just isolated in samples from domestic water supplies and from mains water supplies, like spa water or swimming pool water, confirming its ability to resist to the common chlorination treatments. Evidence indicates a possible role of the microorganism in respiratory tract infections, in gastroenteric disorders and in the pathogenesis of cardiovascular disease, furthermore it has hypothesized that it could play a role in lung transplant rejection. Prevalence and possible effects in nephrology are unknown. Methods We examined the occurrence of Simkania negevensis in two differents populations, both characterized by a high susceptibility to infectious complications: 105 hemodialysis patients, 105 renal transplant recipients and 105 healthy subjects through the IgG and IgA response to Simkania negevensis in their sera. Serum antibodies to Simkania negevensis were detected by a homemade ELISA performed according to the Kahane’s protocol. Furthermore water samples from hemodialytic circuit were collected, to evaluate Simkania negevensis resistance to usual treatment of disinfection. Results Our results were unexpected, showing a higher seroprevalence of antibodies against Simkania negevensis in the hemodialysis patients, compared to renal transplant patients (IgG 22% vs 9% - IgA 9% vs 3%). S. negevensis was isolated in all water samples analyzed. Conclusions Our study detected for the first time the occurrence of S. negevensis in hemodialysis and in renal transplant patients. Our findings suggest that water used in hemodialysis could be one of the possible sources of S. negevensis infection, without clinical involvement risk for patients. Kidney transplantation Chronic hemodialysis Simkania negevensis Chronic inflammation Infection Hemodialysis fluid Diseases of the genitourinary system. Urology Roberta Biondi verfasserin aut Giuseppe Battaglino verfasserin aut Eleonora Cremonini verfasserin aut Giorgia Comai verfasserin aut Irene Capelli verfasserin aut Gabriele Donati verfasserin aut Roberto Cevenini verfasserin aut Manuela Donati verfasserin aut Gaetano La Manna verfasserin aut In BMC Nephrology BMC, 2003 18(2017), 1, Seite 8 (DE-627)326643672 (DE-600)2041348-8 14712369 nnns volume:18 year:2017 number:1 pages:8 https://doi.org/10.1186/s12882-017-0548-z kostenfrei https://doaj.org/article/30b27b67adf7498991d9097a2210b6c8 kostenfrei http://link.springer.com/article/10.1186/s12882-017-0548-z kostenfrei https://doaj.org/toc/1471-2369 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 8
allfieldsSound	10.1186/s12882-017-0548-z doi (DE-627)DOAJ004952715 (DE-599)DOAJ30b27b67adf7498991d9097a2210b6c8 DE-627 ger DE-627 rakwb eng RC870-923 Andrea Angeletti verfasserin aut Seroprevalence of a “new” bacterium, Simkania negevensis, in renal transplant recipients and in hemodialysis patients 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Simkania negevensis is an obligate intracellular bacterium belonging to the family Simkaniaceae in the Chlamydiales order. It is considered an ubiquitous microorganism and aquatic environments may be involved as a source of infection for humans. It was just isolated in samples from domestic water supplies and from mains water supplies, like spa water or swimming pool water, confirming its ability to resist to the common chlorination treatments. Evidence indicates a possible role of the microorganism in respiratory tract infections, in gastroenteric disorders and in the pathogenesis of cardiovascular disease, furthermore it has hypothesized that it could play a role in lung transplant rejection. Prevalence and possible effects in nephrology are unknown. Methods We examined the occurrence of Simkania negevensis in two differents populations, both characterized by a high susceptibility to infectious complications: 105 hemodialysis patients, 105 renal transplant recipients and 105 healthy subjects through the IgG and IgA response to Simkania negevensis in their sera. Serum antibodies to Simkania negevensis were detected by a homemade ELISA performed according to the Kahane’s protocol. Furthermore water samples from hemodialytic circuit were collected, to evaluate Simkania negevensis resistance to usual treatment of disinfection. Results Our results were unexpected, showing a higher seroprevalence of antibodies against Simkania negevensis in the hemodialysis patients, compared to renal transplant patients (IgG 22% vs 9% - IgA 9% vs 3%). S. negevensis was isolated in all water samples analyzed. Conclusions Our study detected for the first time the occurrence of S. negevensis in hemodialysis and in renal transplant patients. Our findings suggest that water used in hemodialysis could be one of the possible sources of S. negevensis infection, without clinical involvement risk for patients. Kidney transplantation Chronic hemodialysis Simkania negevensis Chronic inflammation Infection Hemodialysis fluid Diseases of the genitourinary system. Urology Roberta Biondi verfasserin aut Giuseppe Battaglino verfasserin aut Eleonora Cremonini verfasserin aut Giorgia Comai verfasserin aut Irene Capelli verfasserin aut Gabriele Donati verfasserin aut Roberto Cevenini verfasserin aut Manuela Donati verfasserin aut Gaetano La Manna verfasserin aut In BMC Nephrology BMC, 2003 18(2017), 1, Seite 8 (DE-627)326643672 (DE-600)2041348-8 14712369 nnns volume:18 year:2017 number:1 pages:8 https://doi.org/10.1186/s12882-017-0548-z kostenfrei https://doaj.org/article/30b27b67adf7498991d9097a2210b6c8 kostenfrei http://link.springer.com/article/10.1186/s12882-017-0548-z kostenfrei https://doaj.org/toc/1471-2369 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 8
language	English
source	In BMC Nephrology 18(2017), 1, Seite 8 volume:18 year:2017 number:1 pages:8
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topic_facet	Kidney transplantation Chronic hemodialysis Simkania negevensis Chronic inflammation Infection Hemodialysis fluid Diseases of the genitourinary system. Urology
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authorswithroles_txt_mv	Andrea Angeletti @@aut@@ Roberta Biondi @@aut@@ Giuseppe Battaglino @@aut@@ Eleonora Cremonini @@aut@@ Giorgia Comai @@aut@@ Irene Capelli @@aut@@ Gabriele Donati @@aut@@ Roberto Cevenini @@aut@@ Manuela Donati @@aut@@ Gaetano La Manna @@aut@@
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topic_title	RC870-923 Seroprevalence of a “new” bacterium, Simkania negevensis, in renal transplant recipients and in hemodialysis patients Kidney transplantation Chronic hemodialysis Simkania negevensis Chronic inflammation Infection Hemodialysis fluid
topic	misc RC870-923 misc Kidney transplantation misc Chronic hemodialysis misc Simkania negevensis misc Chronic inflammation misc Infection misc Hemodialysis fluid misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RC870-923 misc Kidney transplantation misc Chronic hemodialysis misc Simkania negevensis misc Chronic inflammation misc Infection misc Hemodialysis fluid misc Diseases of the genitourinary system. Urology
topic_browse	misc RC870-923 misc Kidney transplantation misc Chronic hemodialysis misc Simkania negevensis misc Chronic inflammation misc Infection misc Hemodialysis fluid misc Diseases of the genitourinary system. Urology
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title	Seroprevalence of a “new” bacterium, Simkania negevensis, in renal transplant recipients and in hemodialysis patients
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title_full	Seroprevalence of a “new” bacterium, Simkania negevensis, in renal transplant recipients and in hemodialysis patients
author_sort	Andrea Angeletti
journal	BMC Nephrology
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author_browse	Andrea Angeletti Roberta Biondi Giuseppe Battaglino Eleonora Cremonini Giorgia Comai Irene Capelli Gabriele Donati Roberto Cevenini Manuela Donati Gaetano La Manna
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class	RC870-923
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title_sort	seroprevalence of a “new” bacterium, simkania negevensis, in renal transplant recipients and in hemodialysis patients
callnumber	RC870-923
title_auth	Seroprevalence of a “new” bacterium, Simkania negevensis, in renal transplant recipients and in hemodialysis patients
abstract	Abstract Background Simkania negevensis is an obligate intracellular bacterium belonging to the family Simkaniaceae in the Chlamydiales order. It is considered an ubiquitous microorganism and aquatic environments may be involved as a source of infection for humans. It was just isolated in samples from domestic water supplies and from mains water supplies, like spa water or swimming pool water, confirming its ability to resist to the common chlorination treatments. Evidence indicates a possible role of the microorganism in respiratory tract infections, in gastroenteric disorders and in the pathogenesis of cardiovascular disease, furthermore it has hypothesized that it could play a role in lung transplant rejection. Prevalence and possible effects in nephrology are unknown. Methods We examined the occurrence of Simkania negevensis in two differents populations, both characterized by a high susceptibility to infectious complications: 105 hemodialysis patients, 105 renal transplant recipients and 105 healthy subjects through the IgG and IgA response to Simkania negevensis in their sera. Serum antibodies to Simkania negevensis were detected by a homemade ELISA performed according to the Kahane’s protocol. Furthermore water samples from hemodialytic circuit were collected, to evaluate Simkania negevensis resistance to usual treatment of disinfection. Results Our results were unexpected, showing a higher seroprevalence of antibodies against Simkania negevensis in the hemodialysis patients, compared to renal transplant patients (IgG 22% vs 9% - IgA 9% vs 3%). S. negevensis was isolated in all water samples analyzed. Conclusions Our study detected for the first time the occurrence of S. negevensis in hemodialysis and in renal transplant patients. Our findings suggest that water used in hemodialysis could be one of the possible sources of S. negevensis infection, without clinical involvement risk for patients.
abstractGer	Abstract Background Simkania negevensis is an obligate intracellular bacterium belonging to the family Simkaniaceae in the Chlamydiales order. It is considered an ubiquitous microorganism and aquatic environments may be involved as a source of infection for humans. It was just isolated in samples from domestic water supplies and from mains water supplies, like spa water or swimming pool water, confirming its ability to resist to the common chlorination treatments. Evidence indicates a possible role of the microorganism in respiratory tract infections, in gastroenteric disorders and in the pathogenesis of cardiovascular disease, furthermore it has hypothesized that it could play a role in lung transplant rejection. Prevalence and possible effects in nephrology are unknown. Methods We examined the occurrence of Simkania negevensis in two differents populations, both characterized by a high susceptibility to infectious complications: 105 hemodialysis patients, 105 renal transplant recipients and 105 healthy subjects through the IgG and IgA response to Simkania negevensis in their sera. Serum antibodies to Simkania negevensis were detected by a homemade ELISA performed according to the Kahane’s protocol. Furthermore water samples from hemodialytic circuit were collected, to evaluate Simkania negevensis resistance to usual treatment of disinfection. Results Our results were unexpected, showing a higher seroprevalence of antibodies against Simkania negevensis in the hemodialysis patients, compared to renal transplant patients (IgG 22% vs 9% - IgA 9% vs 3%). S. negevensis was isolated in all water samples analyzed. Conclusions Our study detected for the first time the occurrence of S. negevensis in hemodialysis and in renal transplant patients. Our findings suggest that water used in hemodialysis could be one of the possible sources of S. negevensis infection, without clinical involvement risk for patients.
abstract_unstemmed	Abstract Background Simkania negevensis is an obligate intracellular bacterium belonging to the family Simkaniaceae in the Chlamydiales order. It is considered an ubiquitous microorganism and aquatic environments may be involved as a source of infection for humans. It was just isolated in samples from domestic water supplies and from mains water supplies, like spa water or swimming pool water, confirming its ability to resist to the common chlorination treatments. Evidence indicates a possible role of the microorganism in respiratory tract infections, in gastroenteric disorders and in the pathogenesis of cardiovascular disease, furthermore it has hypothesized that it could play a role in lung transplant rejection. Prevalence and possible effects in nephrology are unknown. Methods We examined the occurrence of Simkania negevensis in two differents populations, both characterized by a high susceptibility to infectious complications: 105 hemodialysis patients, 105 renal transplant recipients and 105 healthy subjects through the IgG and IgA response to Simkania negevensis in their sera. Serum antibodies to Simkania negevensis were detected by a homemade ELISA performed according to the Kahane’s protocol. Furthermore water samples from hemodialytic circuit were collected, to evaluate Simkania negevensis resistance to usual treatment of disinfection. Results Our results were unexpected, showing a higher seroprevalence of antibodies against Simkania negevensis in the hemodialysis patients, compared to renal transplant patients (IgG 22% vs 9% - IgA 9% vs 3%). S. negevensis was isolated in all water samples analyzed. Conclusions Our study detected for the first time the occurrence of S. negevensis in hemodialysis and in renal transplant patients. Our findings suggest that water used in hemodialysis could be one of the possible sources of S. negevensis infection, without clinical involvement risk for patients.
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title_short	Seroprevalence of a “new” bacterium, Simkania negevensis, in renal transplant recipients and in hemodialysis patients
url	https://doi.org/10.1186/s12882-017-0548-z https://doaj.org/article/30b27b67adf7498991d9097a2210b6c8 http://link.springer.com/article/10.1186/s12882-017-0548-z https://doaj.org/toc/1471-2369
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author2	Roberta Biondi Giuseppe Battaglino Eleonora Cremonini Giorgia Comai Irene Capelli Gabriele Donati Roberto Cevenini Manuela Donati Gaetano La Manna
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up_date	2024-07-04T01:47:36.188Z
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