Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest

Selecting patients with a high chance of endured benefit from transcatheter aortic valve implantation (TAVI) is becoming relevant with changing indications and increasing number of TAVI being performed. The aim of our study was to investigate the association of the multidimensional prognostic index...
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Autor*in:	Jeannette A. Goudzwaard [verfasserIn] Sadhna Chotkan [verfasserIn] Marjo J. A. G. De Ronde-Tillmans [verfasserIn] Mattie J. Lenzen [verfasserIn] Maarten P. H. van Wiechen [verfasserIn] Joris F. W. Ooms [verfasserIn] Harmke A. Polinder-Bos [verfasserIn] Madelon de Beer-Leentfaar [verfasserIn] Nicolas M. Van Mieghem [verfasserIn] Joost Daemen [verfasserIn] Alberto Pilotto [verfasserIn] Peter P. T. de Jaegere [verfasserIn] Francesco U. S. Mattace-Raso [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	aortic stenosis (AS) transcatheter aortic valve implantation (TAVI) multidimensional prognostic index outcome mortality frailty

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 10(2021), 16, p 3529
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:16, p 3529

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm10163529

Katalog-ID:	DOAJ004998820

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allfields	10.3390/jcm10163529 doi (DE-627)DOAJ004998820 (DE-599)DOAJ5f9672bf216c42adbad6e55d80f1fe2d DE-627 ger DE-627 rakwb eng Jeannette A. Goudzwaard verfasserin aut Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Selecting patients with a high chance of endured benefit from transcatheter aortic valve implantation (TAVI) is becoming relevant with changing indications and increasing number of TAVI being performed. The aim of our study was to investigate the association of the multidimensional prognostic index (MPI) based on a comprehensive geriatric assessment (CGA) on survival. The TAVI Care & Cure program is a prospective, observational registry of patients referred for TAVI at the Erasmus MC University Medical Center. Consecutive patients who underwent a complete CGA and TAVI were included. CGA components were used to calculate the MPI score. The impact of the MPI score on survival was evaluated using Cox regression. Furthermore, 376 patients were included, 143 (38.0%) patients belonged to the MPI-1 group and 233 (61.9%) patients to the MPI-2–3 group. After 3 years, 14.9% of the patients in the MPI-1 group and 30.5% of the patients in the MPI-2–3 group died (<i<p</i< = 0.001). Patients in MPI-1 had increased chances of overall survival in comparison with patients in MPI group 2–3 Hazard Ratio (HR) 0.57, (95% Confidence Interval (CI) 0.33–0.98)). In this study we found that the MPI tool could be useful to assess frailty and to predict which patient will have a higher chance of enduring benefit from a TAVI procedure. aortic stenosis (AS) transcatheter aortic valve implantation (TAVI) multidimensional prognostic index outcome mortality frailty Medicine R Sadhna Chotkan verfasserin aut Marjo J. A. G. De Ronde-Tillmans verfasserin aut Mattie J. Lenzen verfasserin aut Maarten P. H. van Wiechen verfasserin aut Joris F. W. Ooms verfasserin aut Harmke A. Polinder-Bos verfasserin aut Madelon de Beer-Leentfaar verfasserin aut Nicolas M. Van Mieghem verfasserin aut Joost Daemen verfasserin aut Alberto Pilotto verfasserin aut Peter P. T. de Jaegere verfasserin aut Francesco U. S. Mattace-Raso verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 16, p 3529 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:16, p 3529 https://doi.org/10.3390/jcm10163529 kostenfrei https://doaj.org/article/5f9672bf216c42adbad6e55d80f1fe2d kostenfrei https://www.mdpi.com/2077-0383/10/16/3529 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 16, p 3529
spelling	10.3390/jcm10163529 doi (DE-627)DOAJ004998820 (DE-599)DOAJ5f9672bf216c42adbad6e55d80f1fe2d DE-627 ger DE-627 rakwb eng Jeannette A. Goudzwaard verfasserin aut Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Selecting patients with a high chance of endured benefit from transcatheter aortic valve implantation (TAVI) is becoming relevant with changing indications and increasing number of TAVI being performed. The aim of our study was to investigate the association of the multidimensional prognostic index (MPI) based on a comprehensive geriatric assessment (CGA) on survival. The TAVI Care & Cure program is a prospective, observational registry of patients referred for TAVI at the Erasmus MC University Medical Center. Consecutive patients who underwent a complete CGA and TAVI were included. CGA components were used to calculate the MPI score. The impact of the MPI score on survival was evaluated using Cox regression. Furthermore, 376 patients were included, 143 (38.0%) patients belonged to the MPI-1 group and 233 (61.9%) patients to the MPI-2–3 group. After 3 years, 14.9% of the patients in the MPI-1 group and 30.5% of the patients in the MPI-2–3 group died (<i<p</i< = 0.001). Patients in MPI-1 had increased chances of overall survival in comparison with patients in MPI group 2–3 Hazard Ratio (HR) 0.57, (95% Confidence Interval (CI) 0.33–0.98)). In this study we found that the MPI tool could be useful to assess frailty and to predict which patient will have a higher chance of enduring benefit from a TAVI procedure. aortic stenosis (AS) transcatheter aortic valve implantation (TAVI) multidimensional prognostic index outcome mortality frailty Medicine R Sadhna Chotkan verfasserin aut Marjo J. A. G. De Ronde-Tillmans verfasserin aut Mattie J. Lenzen verfasserin aut Maarten P. H. van Wiechen verfasserin aut Joris F. W. Ooms verfasserin aut Harmke A. Polinder-Bos verfasserin aut Madelon de Beer-Leentfaar verfasserin aut Nicolas M. Van Mieghem verfasserin aut Joost Daemen verfasserin aut Alberto Pilotto verfasserin aut Peter P. T. de Jaegere verfasserin aut Francesco U. S. Mattace-Raso verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 16, p 3529 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:16, p 3529 https://doi.org/10.3390/jcm10163529 kostenfrei https://doaj.org/article/5f9672bf216c42adbad6e55d80f1fe2d kostenfrei https://www.mdpi.com/2077-0383/10/16/3529 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 16, p 3529
allfields_unstemmed	10.3390/jcm10163529 doi (DE-627)DOAJ004998820 (DE-599)DOAJ5f9672bf216c42adbad6e55d80f1fe2d DE-627 ger DE-627 rakwb eng Jeannette A. Goudzwaard verfasserin aut Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Selecting patients with a high chance of endured benefit from transcatheter aortic valve implantation (TAVI) is becoming relevant with changing indications and increasing number of TAVI being performed. The aim of our study was to investigate the association of the multidimensional prognostic index (MPI) based on a comprehensive geriatric assessment (CGA) on survival. The TAVI Care & Cure program is a prospective, observational registry of patients referred for TAVI at the Erasmus MC University Medical Center. Consecutive patients who underwent a complete CGA and TAVI were included. CGA components were used to calculate the MPI score. The impact of the MPI score on survival was evaluated using Cox regression. Furthermore, 376 patients were included, 143 (38.0%) patients belonged to the MPI-1 group and 233 (61.9%) patients to the MPI-2–3 group. After 3 years, 14.9% of the patients in the MPI-1 group and 30.5% of the patients in the MPI-2–3 group died (<i<p</i< = 0.001). Patients in MPI-1 had increased chances of overall survival in comparison with patients in MPI group 2–3 Hazard Ratio (HR) 0.57, (95% Confidence Interval (CI) 0.33–0.98)). In this study we found that the MPI tool could be useful to assess frailty and to predict which patient will have a higher chance of enduring benefit from a TAVI procedure. aortic stenosis (AS) transcatheter aortic valve implantation (TAVI) multidimensional prognostic index outcome mortality frailty Medicine R Sadhna Chotkan verfasserin aut Marjo J. A. G. De Ronde-Tillmans verfasserin aut Mattie J. Lenzen verfasserin aut Maarten P. H. van Wiechen verfasserin aut Joris F. W. Ooms verfasserin aut Harmke A. Polinder-Bos verfasserin aut Madelon de Beer-Leentfaar verfasserin aut Nicolas M. Van Mieghem verfasserin aut Joost Daemen verfasserin aut Alberto Pilotto verfasserin aut Peter P. T. de Jaegere verfasserin aut Francesco U. S. Mattace-Raso verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 16, p 3529 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:16, p 3529 https://doi.org/10.3390/jcm10163529 kostenfrei https://doaj.org/article/5f9672bf216c42adbad6e55d80f1fe2d kostenfrei https://www.mdpi.com/2077-0383/10/16/3529 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 16, p 3529
allfieldsGer	10.3390/jcm10163529 doi (DE-627)DOAJ004998820 (DE-599)DOAJ5f9672bf216c42adbad6e55d80f1fe2d DE-627 ger DE-627 rakwb eng Jeannette A. Goudzwaard verfasserin aut Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Selecting patients with a high chance of endured benefit from transcatheter aortic valve implantation (TAVI) is becoming relevant with changing indications and increasing number of TAVI being performed. The aim of our study was to investigate the association of the multidimensional prognostic index (MPI) based on a comprehensive geriatric assessment (CGA) on survival. The TAVI Care & Cure program is a prospective, observational registry of patients referred for TAVI at the Erasmus MC University Medical Center. Consecutive patients who underwent a complete CGA and TAVI were included. CGA components were used to calculate the MPI score. The impact of the MPI score on survival was evaluated using Cox regression. Furthermore, 376 patients were included, 143 (38.0%) patients belonged to the MPI-1 group and 233 (61.9%) patients to the MPI-2–3 group. After 3 years, 14.9% of the patients in the MPI-1 group and 30.5% of the patients in the MPI-2–3 group died (<i<p</i< = 0.001). Patients in MPI-1 had increased chances of overall survival in comparison with patients in MPI group 2–3 Hazard Ratio (HR) 0.57, (95% Confidence Interval (CI) 0.33–0.98)). In this study we found that the MPI tool could be useful to assess frailty and to predict which patient will have a higher chance of enduring benefit from a TAVI procedure. aortic stenosis (AS) transcatheter aortic valve implantation (TAVI) multidimensional prognostic index outcome mortality frailty Medicine R Sadhna Chotkan verfasserin aut Marjo J. A. G. De Ronde-Tillmans verfasserin aut Mattie J. Lenzen verfasserin aut Maarten P. H. van Wiechen verfasserin aut Joris F. W. Ooms verfasserin aut Harmke A. Polinder-Bos verfasserin aut Madelon de Beer-Leentfaar verfasserin aut Nicolas M. Van Mieghem verfasserin aut Joost Daemen verfasserin aut Alberto Pilotto verfasserin aut Peter P. T. de Jaegere verfasserin aut Francesco U. S. Mattace-Raso verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 16, p 3529 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:16, p 3529 https://doi.org/10.3390/jcm10163529 kostenfrei https://doaj.org/article/5f9672bf216c42adbad6e55d80f1fe2d kostenfrei https://www.mdpi.com/2077-0383/10/16/3529 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 16, p 3529
allfieldsSound	10.3390/jcm10163529 doi (DE-627)DOAJ004998820 (DE-599)DOAJ5f9672bf216c42adbad6e55d80f1fe2d DE-627 ger DE-627 rakwb eng Jeannette A. Goudzwaard verfasserin aut Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Selecting patients with a high chance of endured benefit from transcatheter aortic valve implantation (TAVI) is becoming relevant with changing indications and increasing number of TAVI being performed. The aim of our study was to investigate the association of the multidimensional prognostic index (MPI) based on a comprehensive geriatric assessment (CGA) on survival. The TAVI Care & Cure program is a prospective, observational registry of patients referred for TAVI at the Erasmus MC University Medical Center. Consecutive patients who underwent a complete CGA and TAVI were included. CGA components were used to calculate the MPI score. The impact of the MPI score on survival was evaluated using Cox regression. Furthermore, 376 patients were included, 143 (38.0%) patients belonged to the MPI-1 group and 233 (61.9%) patients to the MPI-2–3 group. After 3 years, 14.9% of the patients in the MPI-1 group and 30.5% of the patients in the MPI-2–3 group died (<i<p</i< = 0.001). Patients in MPI-1 had increased chances of overall survival in comparison with patients in MPI group 2–3 Hazard Ratio (HR) 0.57, (95% Confidence Interval (CI) 0.33–0.98)). In this study we found that the MPI tool could be useful to assess frailty and to predict which patient will have a higher chance of enduring benefit from a TAVI procedure. aortic stenosis (AS) transcatheter aortic valve implantation (TAVI) multidimensional prognostic index outcome mortality frailty Medicine R Sadhna Chotkan verfasserin aut Marjo J. A. G. De Ronde-Tillmans verfasserin aut Mattie J. Lenzen verfasserin aut Maarten P. H. van Wiechen verfasserin aut Joris F. W. Ooms verfasserin aut Harmke A. Polinder-Bos verfasserin aut Madelon de Beer-Leentfaar verfasserin aut Nicolas M. Van Mieghem verfasserin aut Joost Daemen verfasserin aut Alberto Pilotto verfasserin aut Peter P. T. de Jaegere verfasserin aut Francesco U. S. Mattace-Raso verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 16, p 3529 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:16, p 3529 https://doi.org/10.3390/jcm10163529 kostenfrei https://doaj.org/article/5f9672bf216c42adbad6e55d80f1fe2d kostenfrei https://www.mdpi.com/2077-0383/10/16/3529 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 16, p 3529
language	English
source	In Journal of Clinical Medicine 10(2021), 16, p 3529 volume:10 year:2021 number:16, p 3529
sourceStr	In Journal of Clinical Medicine 10(2021), 16, p 3529 volume:10 year:2021 number:16, p 3529
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	aortic stenosis (AS) transcatheter aortic valve implantation (TAVI) multidimensional prognostic index outcome mortality frailty Medicine R
isfreeaccess_bool	true
container_title	Journal of Clinical Medicine
authorswithroles_txt_mv	Jeannette A. Goudzwaard @@aut@@ Sadhna Chotkan @@aut@@ Marjo J. A. G. De Ronde-Tillmans @@aut@@ Mattie J. Lenzen @@aut@@ Maarten P. H. van Wiechen @@aut@@ Joris F. W. Ooms @@aut@@ Harmke A. Polinder-Bos @@aut@@ Madelon de Beer-Leentfaar @@aut@@ Nicolas M. Van Mieghem @@aut@@ Joost Daemen @@aut@@ Alberto Pilotto @@aut@@ Peter P. T. de Jaegere @@aut@@ Francesco U. S. Mattace-Raso @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	718632478
id	DOAJ004998820
language_de	englisch
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author	Jeannette A. Goudzwaard
spellingShingle	Jeannette A. Goudzwaard misc aortic stenosis (AS) misc transcatheter aortic valve implantation (TAVI) misc multidimensional prognostic index misc outcome misc mortality misc frailty misc Medicine misc R Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest
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topic_title	Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest aortic stenosis (AS) transcatheter aortic valve implantation (TAVI) multidimensional prognostic index outcome mortality frailty
topic	misc aortic stenosis (AS) misc transcatheter aortic valve implantation (TAVI) misc multidimensional prognostic index misc outcome misc mortality misc frailty misc Medicine misc R
topic_unstemmed	misc aortic stenosis (AS) misc transcatheter aortic valve implantation (TAVI) misc multidimensional prognostic index misc outcome misc mortality misc frailty misc Medicine misc R
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title	Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest
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title_full	Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest
author_sort	Jeannette A. Goudzwaard
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author_browse	Jeannette A. Goudzwaard Sadhna Chotkan Marjo J. A. G. De Ronde-Tillmans Mattie J. Lenzen Maarten P. H. van Wiechen Joris F. W. Ooms Harmke A. Polinder-Bos Madelon de Beer-Leentfaar Nicolas M. Van Mieghem Joost Daemen Alberto Pilotto Peter P. T. de Jaegere Francesco U. S. Mattace-Raso
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title_sort	multidimensional prognostic index and outcomes in older patients undergoing transcatheter aortic valve implantation: survival of the fittest
title_auth	Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest
abstract	Selecting patients with a high chance of endured benefit from transcatheter aortic valve implantation (TAVI) is becoming relevant with changing indications and increasing number of TAVI being performed. The aim of our study was to investigate the association of the multidimensional prognostic index (MPI) based on a comprehensive geriatric assessment (CGA) on survival. The TAVI Care & Cure program is a prospective, observational registry of patients referred for TAVI at the Erasmus MC University Medical Center. Consecutive patients who underwent a complete CGA and TAVI were included. CGA components were used to calculate the MPI score. The impact of the MPI score on survival was evaluated using Cox regression. Furthermore, 376 patients were included, 143 (38.0%) patients belonged to the MPI-1 group and 233 (61.9%) patients to the MPI-2–3 group. After 3 years, 14.9% of the patients in the MPI-1 group and 30.5% of the patients in the MPI-2–3 group died (<i<p</i< = 0.001). Patients in MPI-1 had increased chances of overall survival in comparison with patients in MPI group 2–3 Hazard Ratio (HR) 0.57, (95% Confidence Interval (CI) 0.33–0.98)). In this study we found that the MPI tool could be useful to assess frailty and to predict which patient will have a higher chance of enduring benefit from a TAVI procedure.
abstractGer	Selecting patients with a high chance of endured benefit from transcatheter aortic valve implantation (TAVI) is becoming relevant with changing indications and increasing number of TAVI being performed. The aim of our study was to investigate the association of the multidimensional prognostic index (MPI) based on a comprehensive geriatric assessment (CGA) on survival. The TAVI Care & Cure program is a prospective, observational registry of patients referred for TAVI at the Erasmus MC University Medical Center. Consecutive patients who underwent a complete CGA and TAVI were included. CGA components were used to calculate the MPI score. The impact of the MPI score on survival was evaluated using Cox regression. Furthermore, 376 patients were included, 143 (38.0%) patients belonged to the MPI-1 group and 233 (61.9%) patients to the MPI-2–3 group. After 3 years, 14.9% of the patients in the MPI-1 group and 30.5% of the patients in the MPI-2–3 group died (<i<p</i< = 0.001). Patients in MPI-1 had increased chances of overall survival in comparison with patients in MPI group 2–3 Hazard Ratio (HR) 0.57, (95% Confidence Interval (CI) 0.33–0.98)). In this study we found that the MPI tool could be useful to assess frailty and to predict which patient will have a higher chance of enduring benefit from a TAVI procedure.
abstract_unstemmed	Selecting patients with a high chance of endured benefit from transcatheter aortic valve implantation (TAVI) is becoming relevant with changing indications and increasing number of TAVI being performed. The aim of our study was to investigate the association of the multidimensional prognostic index (MPI) based on a comprehensive geriatric assessment (CGA) on survival. The TAVI Care & Cure program is a prospective, observational registry of patients referred for TAVI at the Erasmus MC University Medical Center. Consecutive patients who underwent a complete CGA and TAVI were included. CGA components were used to calculate the MPI score. The impact of the MPI score on survival was evaluated using Cox regression. Furthermore, 376 patients were included, 143 (38.0%) patients belonged to the MPI-1 group and 233 (61.9%) patients to the MPI-2–3 group. After 3 years, 14.9% of the patients in the MPI-1 group and 30.5% of the patients in the MPI-2–3 group died (<i<p</i< = 0.001). Patients in MPI-1 had increased chances of overall survival in comparison with patients in MPI group 2–3 Hazard Ratio (HR) 0.57, (95% Confidence Interval (CI) 0.33–0.98)). In this study we found that the MPI tool could be useful to assess frailty and to predict which patient will have a higher chance of enduring benefit from a TAVI procedure.
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title_short	Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest
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