Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction

Abstract Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen presentation, phagocytosis, and bact...
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Autor*in:	Brandt D. Pence [verfasserIn] Johnathan R. Yarbro [verfasserIn] Russell S. Emmons [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	immune function inflammaging senescence senescence‐associated secretory phenotype

Übergeordnetes Werk:	In: Aging Medicine - Wiley, 2019, 4(2021), 1, Seite 47-52
Übergeordnetes Werk:	volume:4 ; year:2021 ; number:1 ; pages:47-52

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DOI / URN:	10.1002/agm2.12128

Katalog-ID:	DOAJ005033829

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520			\|a Abstract Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen presentation, phagocytosis, and bacterial clearance. Recently, we described an aging effect on several functions in monocytes, including impaired mitochondrial function and reduced inflammatory cytokine gene expression during stimulation with lipopolysaccharide. We hypothesized that circulating factors altered by the aging process underly these changes. Growth differentiation factor‐15 (GDF‐15) is a distant member of the transforming growth factor‐β superfamily that has known anti‐inflammatory effects in macrophages and has been shown to be highly differentially expressed during aging. Methods We used biobanked plasma samples to assay circulating GDF‐15 levels in subjects from our previous studies and examined correlations between GDF‐15 and monocyte function. Results Monocyte interleukin‐6 production due to lipopolysaccharide stimulation was negatively correlated to plasma GDF‐15. Additionally, GDF‐15 was positively correlated to circulating CD16 + monocyte proportions and negatively correlated to monocyte mitochondrial respiratory capacity. Conclusions These results suggest that GDF‐15 is a potential circulating factor affecting a variety of monocyte functions and promoting monocyte immunosenescence and thus may be an attractive candidate for therapeutic intervention to ameliorate this.
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allfields	10.1002/agm2.12128 doi (DE-627)DOAJ005033829 (DE-599)DOAJ98ea022c3b9447968aa7a073947eec06 DE-627 ger DE-627 rakwb eng RC952-954.6 Brandt D. Pence verfasserin aut Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen presentation, phagocytosis, and bacterial clearance. Recently, we described an aging effect on several functions in monocytes, including impaired mitochondrial function and reduced inflammatory cytokine gene expression during stimulation with lipopolysaccharide. We hypothesized that circulating factors altered by the aging process underly these changes. Growth differentiation factor‐15 (GDF‐15) is a distant member of the transforming growth factor‐β superfamily that has known anti‐inflammatory effects in macrophages and has been shown to be highly differentially expressed during aging. Methods We used biobanked plasma samples to assay circulating GDF‐15 levels in subjects from our previous studies and examined correlations between GDF‐15 and monocyte function. Results Monocyte interleukin‐6 production due to lipopolysaccharide stimulation was negatively correlated to plasma GDF‐15. Additionally, GDF‐15 was positively correlated to circulating CD16 + monocyte proportions and negatively correlated to monocyte mitochondrial respiratory capacity. Conclusions These results suggest that GDF‐15 is a potential circulating factor affecting a variety of monocyte functions and promoting monocyte immunosenescence and thus may be an attractive candidate for therapeutic intervention to ameliorate this. immune function inflammaging senescence senescence‐associated secretory phenotype Geriatrics Johnathan R. Yarbro verfasserin aut Russell S. Emmons verfasserin aut In Aging Medicine Wiley, 2019 4(2021), 1, Seite 47-52 (DE-627)1025397770 (DE-600)2934364-1 24750360 nnns volume:4 year:2021 number:1 pages:47-52 https://doi.org/10.1002/agm2.12128 kostenfrei https://doaj.org/article/98ea022c3b9447968aa7a073947eec06 kostenfrei https://doi.org/10.1002/agm2.12128 kostenfrei https://doaj.org/toc/2475-0360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2021 1 47-52
spelling	10.1002/agm2.12128 doi (DE-627)DOAJ005033829 (DE-599)DOAJ98ea022c3b9447968aa7a073947eec06 DE-627 ger DE-627 rakwb eng RC952-954.6 Brandt D. Pence verfasserin aut Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen presentation, phagocytosis, and bacterial clearance. Recently, we described an aging effect on several functions in monocytes, including impaired mitochondrial function and reduced inflammatory cytokine gene expression during stimulation with lipopolysaccharide. We hypothesized that circulating factors altered by the aging process underly these changes. Growth differentiation factor‐15 (GDF‐15) is a distant member of the transforming growth factor‐β superfamily that has known anti‐inflammatory effects in macrophages and has been shown to be highly differentially expressed during aging. Methods We used biobanked plasma samples to assay circulating GDF‐15 levels in subjects from our previous studies and examined correlations between GDF‐15 and monocyte function. Results Monocyte interleukin‐6 production due to lipopolysaccharide stimulation was negatively correlated to plasma GDF‐15. Additionally, GDF‐15 was positively correlated to circulating CD16 + monocyte proportions and negatively correlated to monocyte mitochondrial respiratory capacity. Conclusions These results suggest that GDF‐15 is a potential circulating factor affecting a variety of monocyte functions and promoting monocyte immunosenescence and thus may be an attractive candidate for therapeutic intervention to ameliorate this. immune function inflammaging senescence senescence‐associated secretory phenotype Geriatrics Johnathan R. Yarbro verfasserin aut Russell S. Emmons verfasserin aut In Aging Medicine Wiley, 2019 4(2021), 1, Seite 47-52 (DE-627)1025397770 (DE-600)2934364-1 24750360 nnns volume:4 year:2021 number:1 pages:47-52 https://doi.org/10.1002/agm2.12128 kostenfrei https://doaj.org/article/98ea022c3b9447968aa7a073947eec06 kostenfrei https://doi.org/10.1002/agm2.12128 kostenfrei https://doaj.org/toc/2475-0360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2021 1 47-52
allfields_unstemmed	10.1002/agm2.12128 doi (DE-627)DOAJ005033829 (DE-599)DOAJ98ea022c3b9447968aa7a073947eec06 DE-627 ger DE-627 rakwb eng RC952-954.6 Brandt D. Pence verfasserin aut Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen presentation, phagocytosis, and bacterial clearance. Recently, we described an aging effect on several functions in monocytes, including impaired mitochondrial function and reduced inflammatory cytokine gene expression during stimulation with lipopolysaccharide. We hypothesized that circulating factors altered by the aging process underly these changes. Growth differentiation factor‐15 (GDF‐15) is a distant member of the transforming growth factor‐β superfamily that has known anti‐inflammatory effects in macrophages and has been shown to be highly differentially expressed during aging. Methods We used biobanked plasma samples to assay circulating GDF‐15 levels in subjects from our previous studies and examined correlations between GDF‐15 and monocyte function. Results Monocyte interleukin‐6 production due to lipopolysaccharide stimulation was negatively correlated to plasma GDF‐15. Additionally, GDF‐15 was positively correlated to circulating CD16 + monocyte proportions and negatively correlated to monocyte mitochondrial respiratory capacity. Conclusions These results suggest that GDF‐15 is a potential circulating factor affecting a variety of monocyte functions and promoting monocyte immunosenescence and thus may be an attractive candidate for therapeutic intervention to ameliorate this. immune function inflammaging senescence senescence‐associated secretory phenotype Geriatrics Johnathan R. Yarbro verfasserin aut Russell S. Emmons verfasserin aut In Aging Medicine Wiley, 2019 4(2021), 1, Seite 47-52 (DE-627)1025397770 (DE-600)2934364-1 24750360 nnns volume:4 year:2021 number:1 pages:47-52 https://doi.org/10.1002/agm2.12128 kostenfrei https://doaj.org/article/98ea022c3b9447968aa7a073947eec06 kostenfrei https://doi.org/10.1002/agm2.12128 kostenfrei https://doaj.org/toc/2475-0360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2021 1 47-52
allfieldsGer	10.1002/agm2.12128 doi (DE-627)DOAJ005033829 (DE-599)DOAJ98ea022c3b9447968aa7a073947eec06 DE-627 ger DE-627 rakwb eng RC952-954.6 Brandt D. Pence verfasserin aut Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen presentation, phagocytosis, and bacterial clearance. Recently, we described an aging effect on several functions in monocytes, including impaired mitochondrial function and reduced inflammatory cytokine gene expression during stimulation with lipopolysaccharide. We hypothesized that circulating factors altered by the aging process underly these changes. Growth differentiation factor‐15 (GDF‐15) is a distant member of the transforming growth factor‐β superfamily that has known anti‐inflammatory effects in macrophages and has been shown to be highly differentially expressed during aging. Methods We used biobanked plasma samples to assay circulating GDF‐15 levels in subjects from our previous studies and examined correlations between GDF‐15 and monocyte function. Results Monocyte interleukin‐6 production due to lipopolysaccharide stimulation was negatively correlated to plasma GDF‐15. Additionally, GDF‐15 was positively correlated to circulating CD16 + monocyte proportions and negatively correlated to monocyte mitochondrial respiratory capacity. Conclusions These results suggest that GDF‐15 is a potential circulating factor affecting a variety of monocyte functions and promoting monocyte immunosenescence and thus may be an attractive candidate for therapeutic intervention to ameliorate this. immune function inflammaging senescence senescence‐associated secretory phenotype Geriatrics Johnathan R. Yarbro verfasserin aut Russell S. Emmons verfasserin aut In Aging Medicine Wiley, 2019 4(2021), 1, Seite 47-52 (DE-627)1025397770 (DE-600)2934364-1 24750360 nnns volume:4 year:2021 number:1 pages:47-52 https://doi.org/10.1002/agm2.12128 kostenfrei https://doaj.org/article/98ea022c3b9447968aa7a073947eec06 kostenfrei https://doi.org/10.1002/agm2.12128 kostenfrei https://doaj.org/toc/2475-0360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2021 1 47-52
allfieldsSound	10.1002/agm2.12128 doi (DE-627)DOAJ005033829 (DE-599)DOAJ98ea022c3b9447968aa7a073947eec06 DE-627 ger DE-627 rakwb eng RC952-954.6 Brandt D. Pence verfasserin aut Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen presentation, phagocytosis, and bacterial clearance. Recently, we described an aging effect on several functions in monocytes, including impaired mitochondrial function and reduced inflammatory cytokine gene expression during stimulation with lipopolysaccharide. We hypothesized that circulating factors altered by the aging process underly these changes. Growth differentiation factor‐15 (GDF‐15) is a distant member of the transforming growth factor‐β superfamily that has known anti‐inflammatory effects in macrophages and has been shown to be highly differentially expressed during aging. Methods We used biobanked plasma samples to assay circulating GDF‐15 levels in subjects from our previous studies and examined correlations between GDF‐15 and monocyte function. Results Monocyte interleukin‐6 production due to lipopolysaccharide stimulation was negatively correlated to plasma GDF‐15. Additionally, GDF‐15 was positively correlated to circulating CD16 + monocyte proportions and negatively correlated to monocyte mitochondrial respiratory capacity. Conclusions These results suggest that GDF‐15 is a potential circulating factor affecting a variety of monocyte functions and promoting monocyte immunosenescence and thus may be an attractive candidate for therapeutic intervention to ameliorate this. immune function inflammaging senescence senescence‐associated secretory phenotype Geriatrics Johnathan R. Yarbro verfasserin aut Russell S. Emmons verfasserin aut In Aging Medicine Wiley, 2019 4(2021), 1, Seite 47-52 (DE-627)1025397770 (DE-600)2934364-1 24750360 nnns volume:4 year:2021 number:1 pages:47-52 https://doi.org/10.1002/agm2.12128 kostenfrei https://doaj.org/article/98ea022c3b9447968aa7a073947eec06 kostenfrei https://doi.org/10.1002/agm2.12128 kostenfrei https://doaj.org/toc/2475-0360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2021 1 47-52
language	English
source	In Aging Medicine 4(2021), 1, Seite 47-52 volume:4 year:2021 number:1 pages:47-52
sourceStr	In Aging Medicine 4(2021), 1, Seite 47-52 volume:4 year:2021 number:1 pages:47-52
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	immune function inflammaging senescence senescence‐associated secretory phenotype Geriatrics
isfreeaccess_bool	true
container_title	Aging Medicine
authorswithroles_txt_mv	Brandt D. Pence @@aut@@ Johnathan R. Yarbro @@aut@@ Russell S. Emmons @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	1025397770
id	DOAJ005033829
language_de	englisch
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Pence</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen presentation, phagocytosis, and bacterial clearance. Recently, we described an aging effect on several functions in monocytes, including impaired mitochondrial function and reduced inflammatory cytokine gene expression during stimulation with lipopolysaccharide. We hypothesized that circulating factors altered by the aging process underly these changes. Growth differentiation factor‐15 (GDF‐15) is a distant member of the transforming growth factor‐β superfamily that has known anti‐inflammatory effects in macrophages and has been shown to be highly differentially expressed during aging. Methods We used biobanked plasma samples to assay circulating GDF‐15 levels in subjects from our previous studies and examined correlations between GDF‐15 and monocyte function. Results Monocyte interleukin‐6 production due to lipopolysaccharide stimulation was negatively correlated to plasma GDF‐15. Additionally, GDF‐15 was positively correlated to circulating CD16 + monocyte proportions and negatively correlated to monocyte mitochondrial respiratory capacity. Conclusions These results suggest that GDF‐15 is a potential circulating factor affecting a variety of monocyte functions and promoting monocyte immunosenescence and thus may be an attractive candidate for therapeutic intervention to ameliorate this.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">immune function</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">inflammaging</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">senescence</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">senescence‐associated secretory phenotype</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Geriatrics</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Johnathan R. 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callnumber-first	R - Medicine
author	Brandt D. Pence
spellingShingle	Brandt D. Pence misc RC952-954.6 misc immune function misc inflammaging misc senescence misc senescence‐associated secretory phenotype misc Geriatrics Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction
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topic_title	RC952-954.6 Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction immune function inflammaging senescence senescence‐associated secretory phenotype
topic	misc RC952-954.6 misc immune function misc inflammaging misc senescence misc senescence‐associated secretory phenotype misc Geriatrics
topic_unstemmed	misc RC952-954.6 misc immune function misc inflammaging misc senescence misc senescence‐associated secretory phenotype misc Geriatrics
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title	Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction
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title_full	Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction
author_sort	Brandt D. Pence
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author_browse	Brandt D. Pence Johnathan R. Yarbro Russell S. Emmons
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doi_str_mv	10.1002/agm2.12128
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title_sort	growth differentiation factor‐15 is associated with age‐related monocyte dysfunction
callnumber	RC952-954.6
title_auth	Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction
abstract	Abstract Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen presentation, phagocytosis, and bacterial clearance. Recently, we described an aging effect on several functions in monocytes, including impaired mitochondrial function and reduced inflammatory cytokine gene expression during stimulation with lipopolysaccharide. We hypothesized that circulating factors altered by the aging process underly these changes. Growth differentiation factor‐15 (GDF‐15) is a distant member of the transforming growth factor‐β superfamily that has known anti‐inflammatory effects in macrophages and has been shown to be highly differentially expressed during aging. Methods We used biobanked plasma samples to assay circulating GDF‐15 levels in subjects from our previous studies and examined correlations between GDF‐15 and monocyte function. Results Monocyte interleukin‐6 production due to lipopolysaccharide stimulation was negatively correlated to plasma GDF‐15. Additionally, GDF‐15 was positively correlated to circulating CD16 + monocyte proportions and negatively correlated to monocyte mitochondrial respiratory capacity. Conclusions These results suggest that GDF‐15 is a potential circulating factor affecting a variety of monocyte functions and promoting monocyte immunosenescence and thus may be an attractive candidate for therapeutic intervention to ameliorate this.
abstractGer	Abstract Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen presentation, phagocytosis, and bacterial clearance. Recently, we described an aging effect on several functions in monocytes, including impaired mitochondrial function and reduced inflammatory cytokine gene expression during stimulation with lipopolysaccharide. We hypothesized that circulating factors altered by the aging process underly these changes. Growth differentiation factor‐15 (GDF‐15) is a distant member of the transforming growth factor‐β superfamily that has known anti‐inflammatory effects in macrophages and has been shown to be highly differentially expressed during aging. Methods We used biobanked plasma samples to assay circulating GDF‐15 levels in subjects from our previous studies and examined correlations between GDF‐15 and monocyte function. Results Monocyte interleukin‐6 production due to lipopolysaccharide stimulation was negatively correlated to plasma GDF‐15. Additionally, GDF‐15 was positively correlated to circulating CD16 + monocyte proportions and negatively correlated to monocyte mitochondrial respiratory capacity. Conclusions These results suggest that GDF‐15 is a potential circulating factor affecting a variety of monocyte functions and promoting monocyte immunosenescence and thus may be an attractive candidate for therapeutic intervention to ameliorate this.
abstract_unstemmed	Abstract Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen presentation, phagocytosis, and bacterial clearance. Recently, we described an aging effect on several functions in monocytes, including impaired mitochondrial function and reduced inflammatory cytokine gene expression during stimulation with lipopolysaccharide. We hypothesized that circulating factors altered by the aging process underly these changes. Growth differentiation factor‐15 (GDF‐15) is a distant member of the transforming growth factor‐β superfamily that has known anti‐inflammatory effects in macrophages and has been shown to be highly differentially expressed during aging. Methods We used biobanked plasma samples to assay circulating GDF‐15 levels in subjects from our previous studies and examined correlations between GDF‐15 and monocyte function. Results Monocyte interleukin‐6 production due to lipopolysaccharide stimulation was negatively correlated to plasma GDF‐15. Additionally, GDF‐15 was positively correlated to circulating CD16 + monocyte proportions and negatively correlated to monocyte mitochondrial respiratory capacity. Conclusions These results suggest that GDF‐15 is a potential circulating factor affecting a variety of monocyte functions and promoting monocyte immunosenescence and thus may be an attractive candidate for therapeutic intervention to ameliorate this.
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title_short	Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction
url	https://doi.org/10.1002/agm2.12128 https://doaj.org/article/98ea022c3b9447968aa7a073947eec06 https://doaj.org/toc/2475-0360
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Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction

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