Statement on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and assessment of the risk to humans
Abstract The European Commission requested EFSA to provide scientific advice on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and, if applicable, for a revision of the assessment of the risk to humans by its metabolite 2,3‐deepoxy‐2,...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
EFSA Panel on Plant Protection Products and their Residues (PPR) [verfasserIn] Antonio F Hernandez‐Jerez [verfasserIn] Paulien Adriaanse [verfasserIn] Annette Aldrich [verfasserIn] Philippe Berny [verfasserIn] Tamara Coja [verfasserIn] Sabine Duquesne [verfasserIn] Marina Marinovich [verfasserIn] Maurice Millet [verfasserIn] Olavi Pelkonen [verfasserIn] Silvia Pieper [verfasserIn] Aaldrik Tiktak [verfasserIn] Christopher J Topping [verfasserIn] Gerrit Wolterink [verfasserIn] Lieve Herman [verfasserIn] Arianna Chiusolo [verfasserIn] José Oriol Magrans [verfasserIn] Anneli Widenfalk [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: EFSA Journal - Wiley, 2018, 18(2020), 10, Seite n/a-n/a |
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| Übergeordnetes Werk: |
volume:18 ; year:2020 ; number:10 ; pages:n/a-n/a |
| Links: |
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| DOI / URN: |
10.2903/j.efsa.2020.6276 |
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| Katalog-ID: |
DOAJ005161770 |
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| 520 | |a Abstract The European Commission requested EFSA to provide scientific advice on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and, if applicable, for a revision of the assessment of the risk to humans by its metabolite 2,3‐deepoxy‐2,3‐didehydro‐rhizoxin (DDR) and this based on the evidence available in the dossier for renewal of the approval. The information from other P. chlororaphis strains than MA342 was taken into account with care, because the studies available in the dossier did not confirm the identity of the strain MA342 as belonging to the species P. chlororaphis. It has been concluded that there is a potential for translocation of P. chlororaphis MA342 to edible plant parts following seed treatment till an estimated concentration up to about 105 cfu/g and some exposure can be assumed by consumption of fresh commodities. Also, production of the metabolite DDR in the plant cannot be excluded. Regarding levels of DDR in the raw agricultural commodities, exposure estimates based on the limit of quantification (LOQ) for DDR in cereals cannot be further refined while there is no information on the levels of DDR in peas in the dossier. As regards genotoxicity, DDR induced chromosomal damage; however, it was not possible to conclude whether it is through an aneugenic or clastogenic mechanism. Hence, it is not possible to draw a reliable conclusion that DDR is producing an aneugenic effect nor to determine a threshold dose for aneugenicity. Thus, it is not possible to revise the human risk assessment as regards exposure to DDR. The concerns identified in the EFSA conclusion of 2017 remain. | ||
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| 650 | 4 | |a aneugenicity | |
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| 653 | 0 | |a Nutrition. Foods and food supply | |
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| 700 | 0 | |a Antonio F Hernandez‐Jerez |e verfasserin |4 aut | |
| 700 | 0 | |a Paulien Adriaanse |e verfasserin |4 aut | |
| 700 | 0 | |a Annette Aldrich |e verfasserin |4 aut | |
| 700 | 0 | |a Philippe Berny |e verfasserin |4 aut | |
| 700 | 0 | |a Tamara Coja |e verfasserin |4 aut | |
| 700 | 0 | |a Sabine Duquesne |e verfasserin |4 aut | |
| 700 | 0 | |a Marina Marinovich |e verfasserin |4 aut | |
| 700 | 0 | |a Maurice Millet |e verfasserin |4 aut | |
| 700 | 0 | |a Olavi Pelkonen |e verfasserin |4 aut | |
| 700 | 0 | |a Silvia Pieper |e verfasserin |4 aut | |
| 700 | 0 | |a Aaldrik Tiktak |e verfasserin |4 aut | |
| 700 | 0 | |a Christopher J Topping |e verfasserin |4 aut | |
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| 700 | 0 | |a Arianna Chiusolo |e verfasserin |4 aut | |
| 700 | 0 | |a José Oriol Magrans |e verfasserin |4 aut | |
| 700 | 0 | |a Anneli Widenfalk |e verfasserin |4 aut | |
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10.2903/j.efsa.2020.6276 doi (DE-627)DOAJ005161770 (DE-599)DOAJf1c0cc4aab5c462fb158c4b977242af4 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Plant Protection Products and their Residues (PPR) verfasserin aut Statement on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and assessment of the risk to humans 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The European Commission requested EFSA to provide scientific advice on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and, if applicable, for a revision of the assessment of the risk to humans by its metabolite 2,3‐deepoxy‐2,3‐didehydro‐rhizoxin (DDR) and this based on the evidence available in the dossier for renewal of the approval. The information from other P. chlororaphis strains than MA342 was taken into account with care, because the studies available in the dossier did not confirm the identity of the strain MA342 as belonging to the species P. chlororaphis. It has been concluded that there is a potential for translocation of P. chlororaphis MA342 to edible plant parts following seed treatment till an estimated concentration up to about 105 cfu/g and some exposure can be assumed by consumption of fresh commodities. Also, production of the metabolite DDR in the plant cannot be excluded. Regarding levels of DDR in the raw agricultural commodities, exposure estimates based on the limit of quantification (LOQ) for DDR in cereals cannot be further refined while there is no information on the levels of DDR in peas in the dossier. As regards genotoxicity, DDR induced chromosomal damage; however, it was not possible to conclude whether it is through an aneugenic or clastogenic mechanism. Hence, it is not possible to draw a reliable conclusion that DDR is producing an aneugenic effect nor to determine a threshold dose for aneugenicity. Thus, it is not possible to revise the human risk assessment as regards exposure to DDR. The concerns identified in the EFSA conclusion of 2017 remain. Pseudomonas chlororaphis MA342 metabolite DDR genotoxicity aneugenicity seed treatment Nutrition. Foods and food supply Chemical technology Antonio F Hernandez‐Jerez verfasserin aut Paulien Adriaanse verfasserin aut Annette Aldrich verfasserin aut Philippe Berny verfasserin aut Tamara Coja verfasserin aut Sabine Duquesne verfasserin aut Marina Marinovich verfasserin aut Maurice Millet verfasserin aut Olavi Pelkonen verfasserin aut Silvia Pieper verfasserin aut Aaldrik Tiktak verfasserin aut Christopher J Topping verfasserin aut Gerrit Wolterink verfasserin aut Lieve Herman verfasserin aut Arianna Chiusolo verfasserin aut José Oriol Magrans verfasserin aut Anneli Widenfalk verfasserin aut In EFSA Journal Wiley, 2018 18(2020), 10, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:18 year:2020 number:10 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2020.6276 kostenfrei https://doaj.org/article/f1c0cc4aab5c462fb158c4b977242af4 kostenfrei https://doi.org/10.2903/j.efsa.2020.6276 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 10 n/a-n/a |
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10.2903/j.efsa.2020.6276 doi (DE-627)DOAJ005161770 (DE-599)DOAJf1c0cc4aab5c462fb158c4b977242af4 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Plant Protection Products and their Residues (PPR) verfasserin aut Statement on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and assessment of the risk to humans 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The European Commission requested EFSA to provide scientific advice on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and, if applicable, for a revision of the assessment of the risk to humans by its metabolite 2,3‐deepoxy‐2,3‐didehydro‐rhizoxin (DDR) and this based on the evidence available in the dossier for renewal of the approval. The information from other P. chlororaphis strains than MA342 was taken into account with care, because the studies available in the dossier did not confirm the identity of the strain MA342 as belonging to the species P. chlororaphis. It has been concluded that there is a potential for translocation of P. chlororaphis MA342 to edible plant parts following seed treatment till an estimated concentration up to about 105 cfu/g and some exposure can be assumed by consumption of fresh commodities. Also, production of the metabolite DDR in the plant cannot be excluded. Regarding levels of DDR in the raw agricultural commodities, exposure estimates based on the limit of quantification (LOQ) for DDR in cereals cannot be further refined while there is no information on the levels of DDR in peas in the dossier. As regards genotoxicity, DDR induced chromosomal damage; however, it was not possible to conclude whether it is through an aneugenic or clastogenic mechanism. Hence, it is not possible to draw a reliable conclusion that DDR is producing an aneugenic effect nor to determine a threshold dose for aneugenicity. Thus, it is not possible to revise the human risk assessment as regards exposure to DDR. The concerns identified in the EFSA conclusion of 2017 remain. Pseudomonas chlororaphis MA342 metabolite DDR genotoxicity aneugenicity seed treatment Nutrition. Foods and food supply Chemical technology Antonio F Hernandez‐Jerez verfasserin aut Paulien Adriaanse verfasserin aut Annette Aldrich verfasserin aut Philippe Berny verfasserin aut Tamara Coja verfasserin aut Sabine Duquesne verfasserin aut Marina Marinovich verfasserin aut Maurice Millet verfasserin aut Olavi Pelkonen verfasserin aut Silvia Pieper verfasserin aut Aaldrik Tiktak verfasserin aut Christopher J Topping verfasserin aut Gerrit Wolterink verfasserin aut Lieve Herman verfasserin aut Arianna Chiusolo verfasserin aut José Oriol Magrans verfasserin aut Anneli Widenfalk verfasserin aut In EFSA Journal Wiley, 2018 18(2020), 10, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:18 year:2020 number:10 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2020.6276 kostenfrei https://doaj.org/article/f1c0cc4aab5c462fb158c4b977242af4 kostenfrei https://doi.org/10.2903/j.efsa.2020.6276 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 10 n/a-n/a |
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10.2903/j.efsa.2020.6276 doi (DE-627)DOAJ005161770 (DE-599)DOAJf1c0cc4aab5c462fb158c4b977242af4 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Plant Protection Products and their Residues (PPR) verfasserin aut Statement on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and assessment of the risk to humans 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The European Commission requested EFSA to provide scientific advice on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and, if applicable, for a revision of the assessment of the risk to humans by its metabolite 2,3‐deepoxy‐2,3‐didehydro‐rhizoxin (DDR) and this based on the evidence available in the dossier for renewal of the approval. The information from other P. chlororaphis strains than MA342 was taken into account with care, because the studies available in the dossier did not confirm the identity of the strain MA342 as belonging to the species P. chlororaphis. It has been concluded that there is a potential for translocation of P. chlororaphis MA342 to edible plant parts following seed treatment till an estimated concentration up to about 105 cfu/g and some exposure can be assumed by consumption of fresh commodities. Also, production of the metabolite DDR in the plant cannot be excluded. Regarding levels of DDR in the raw agricultural commodities, exposure estimates based on the limit of quantification (LOQ) for DDR in cereals cannot be further refined while there is no information on the levels of DDR in peas in the dossier. As regards genotoxicity, DDR induced chromosomal damage; however, it was not possible to conclude whether it is through an aneugenic or clastogenic mechanism. Hence, it is not possible to draw a reliable conclusion that DDR is producing an aneugenic effect nor to determine a threshold dose for aneugenicity. Thus, it is not possible to revise the human risk assessment as regards exposure to DDR. The concerns identified in the EFSA conclusion of 2017 remain. Pseudomonas chlororaphis MA342 metabolite DDR genotoxicity aneugenicity seed treatment Nutrition. Foods and food supply Chemical technology Antonio F Hernandez‐Jerez verfasserin aut Paulien Adriaanse verfasserin aut Annette Aldrich verfasserin aut Philippe Berny verfasserin aut Tamara Coja verfasserin aut Sabine Duquesne verfasserin aut Marina Marinovich verfasserin aut Maurice Millet verfasserin aut Olavi Pelkonen verfasserin aut Silvia Pieper verfasserin aut Aaldrik Tiktak verfasserin aut Christopher J Topping verfasserin aut Gerrit Wolterink verfasserin aut Lieve Herman verfasserin aut Arianna Chiusolo verfasserin aut José Oriol Magrans verfasserin aut Anneli Widenfalk verfasserin aut In EFSA Journal Wiley, 2018 18(2020), 10, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:18 year:2020 number:10 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2020.6276 kostenfrei https://doaj.org/article/f1c0cc4aab5c462fb158c4b977242af4 kostenfrei https://doi.org/10.2903/j.efsa.2020.6276 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 10 n/a-n/a |
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10.2903/j.efsa.2020.6276 doi (DE-627)DOAJ005161770 (DE-599)DOAJf1c0cc4aab5c462fb158c4b977242af4 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Plant Protection Products and their Residues (PPR) verfasserin aut Statement on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and assessment of the risk to humans 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The European Commission requested EFSA to provide scientific advice on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and, if applicable, for a revision of the assessment of the risk to humans by its metabolite 2,3‐deepoxy‐2,3‐didehydro‐rhizoxin (DDR) and this based on the evidence available in the dossier for renewal of the approval. The information from other P. chlororaphis strains than MA342 was taken into account with care, because the studies available in the dossier did not confirm the identity of the strain MA342 as belonging to the species P. chlororaphis. It has been concluded that there is a potential for translocation of P. chlororaphis MA342 to edible plant parts following seed treatment till an estimated concentration up to about 105 cfu/g and some exposure can be assumed by consumption of fresh commodities. Also, production of the metabolite DDR in the plant cannot be excluded. Regarding levels of DDR in the raw agricultural commodities, exposure estimates based on the limit of quantification (LOQ) for DDR in cereals cannot be further refined while there is no information on the levels of DDR in peas in the dossier. As regards genotoxicity, DDR induced chromosomal damage; however, it was not possible to conclude whether it is through an aneugenic or clastogenic mechanism. Hence, it is not possible to draw a reliable conclusion that DDR is producing an aneugenic effect nor to determine a threshold dose for aneugenicity. Thus, it is not possible to revise the human risk assessment as regards exposure to DDR. The concerns identified in the EFSA conclusion of 2017 remain. Pseudomonas chlororaphis MA342 metabolite DDR genotoxicity aneugenicity seed treatment Nutrition. Foods and food supply Chemical technology Antonio F Hernandez‐Jerez verfasserin aut Paulien Adriaanse verfasserin aut Annette Aldrich verfasserin aut Philippe Berny verfasserin aut Tamara Coja verfasserin aut Sabine Duquesne verfasserin aut Marina Marinovich verfasserin aut Maurice Millet verfasserin aut Olavi Pelkonen verfasserin aut Silvia Pieper verfasserin aut Aaldrik Tiktak verfasserin aut Christopher J Topping verfasserin aut Gerrit Wolterink verfasserin aut Lieve Herman verfasserin aut Arianna Chiusolo verfasserin aut José Oriol Magrans verfasserin aut Anneli Widenfalk verfasserin aut In EFSA Journal Wiley, 2018 18(2020), 10, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:18 year:2020 number:10 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2020.6276 kostenfrei https://doaj.org/article/f1c0cc4aab5c462fb158c4b977242af4 kostenfrei https://doi.org/10.2903/j.efsa.2020.6276 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 10 n/a-n/a |
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10.2903/j.efsa.2020.6276 doi (DE-627)DOAJ005161770 (DE-599)DOAJf1c0cc4aab5c462fb158c4b977242af4 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Plant Protection Products and their Residues (PPR) verfasserin aut Statement on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and assessment of the risk to humans 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The European Commission requested EFSA to provide scientific advice on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and, if applicable, for a revision of the assessment of the risk to humans by its metabolite 2,3‐deepoxy‐2,3‐didehydro‐rhizoxin (DDR) and this based on the evidence available in the dossier for renewal of the approval. The information from other P. chlororaphis strains than MA342 was taken into account with care, because the studies available in the dossier did not confirm the identity of the strain MA342 as belonging to the species P. chlororaphis. It has been concluded that there is a potential for translocation of P. chlororaphis MA342 to edible plant parts following seed treatment till an estimated concentration up to about 105 cfu/g and some exposure can be assumed by consumption of fresh commodities. Also, production of the metabolite DDR in the plant cannot be excluded. Regarding levels of DDR in the raw agricultural commodities, exposure estimates based on the limit of quantification (LOQ) for DDR in cereals cannot be further refined while there is no information on the levels of DDR in peas in the dossier. As regards genotoxicity, DDR induced chromosomal damage; however, it was not possible to conclude whether it is through an aneugenic or clastogenic mechanism. Hence, it is not possible to draw a reliable conclusion that DDR is producing an aneugenic effect nor to determine a threshold dose for aneugenicity. Thus, it is not possible to revise the human risk assessment as regards exposure to DDR. The concerns identified in the EFSA conclusion of 2017 remain. Pseudomonas chlororaphis MA342 metabolite DDR genotoxicity aneugenicity seed treatment Nutrition. Foods and food supply Chemical technology Antonio F Hernandez‐Jerez verfasserin aut Paulien Adriaanse verfasserin aut Annette Aldrich verfasserin aut Philippe Berny verfasserin aut Tamara Coja verfasserin aut Sabine Duquesne verfasserin aut Marina Marinovich verfasserin aut Maurice Millet verfasserin aut Olavi Pelkonen verfasserin aut Silvia Pieper verfasserin aut Aaldrik Tiktak verfasserin aut Christopher J Topping verfasserin aut Gerrit Wolterink verfasserin aut Lieve Herman verfasserin aut Arianna Chiusolo verfasserin aut José Oriol Magrans verfasserin aut Anneli Widenfalk verfasserin aut In EFSA Journal Wiley, 2018 18(2020), 10, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:18 year:2020 number:10 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2020.6276 kostenfrei https://doaj.org/article/f1c0cc4aab5c462fb158c4b977242af4 kostenfrei https://doi.org/10.2903/j.efsa.2020.6276 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 10 n/a-n/a |
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EFSA Panel on Plant Protection Products and their Residues (PPR) @@aut@@ Antonio F Hernandez‐Jerez @@aut@@ Paulien Adriaanse @@aut@@ Annette Aldrich @@aut@@ Philippe Berny @@aut@@ Tamara Coja @@aut@@ Sabine Duquesne @@aut@@ Marina Marinovich @@aut@@ Maurice Millet @@aut@@ Olavi Pelkonen @@aut@@ Silvia Pieper @@aut@@ Aaldrik Tiktak @@aut@@ Christopher J Topping @@aut@@ Gerrit Wolterink @@aut@@ Lieve Herman @@aut@@ Arianna Chiusolo @@aut@@ José Oriol Magrans @@aut@@ Anneli Widenfalk @@aut@@ |
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The information from other P. chlororaphis strains than MA342 was taken into account with care, because the studies available in the dossier did not confirm the identity of the strain MA342 as belonging to the species P. chlororaphis. It has been concluded that there is a potential for translocation of P. chlororaphis MA342 to edible plant parts following seed treatment till an estimated concentration up to about 105 cfu/g and some exposure can be assumed by consumption of fresh commodities. Also, production of the metabolite DDR in the plant cannot be excluded. Regarding levels of DDR in the raw agricultural commodities, exposure estimates based on the limit of quantification (LOQ) for DDR in cereals cannot be further refined while there is no information on the levels of DDR in peas in the dossier. As regards genotoxicity, DDR induced chromosomal damage; however, it was not possible to conclude whether it is through an aneugenic or clastogenic mechanism. Hence, it is not possible to draw a reliable conclusion that DDR is producing an aneugenic effect nor to determine a threshold dose for aneugenicity. Thus, it is not possible to revise the human risk assessment as regards exposure to DDR. The concerns identified in the EFSA conclusion of 2017 remain.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pseudomonas chlororaphis MA342</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">metabolite</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DDR</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">genotoxicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">aneugenicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">seed treatment</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Nutrition. 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TX341-641 TP1-1185 Statement on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and assessment of the risk to humans Pseudomonas chlororaphis MA342 metabolite DDR genotoxicity aneugenicity seed treatment |
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EFSA Panel on Plant Protection Products and their Residues (PPR) Antonio F Hernandez‐Jerez Paulien Adriaanse Annette Aldrich Philippe Berny Tamara Coja Sabine Duquesne Marina Marinovich Maurice Millet Olavi Pelkonen Silvia Pieper Aaldrik Tiktak Christopher J Topping Gerrit Wolterink Lieve Herman Arianna Chiusolo José Oriol Magrans Anneli Widenfalk |
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statement on the translocation potential by pseudomonas chlororaphis ma342 in plants after seed treatment of cereals and peas and assessment of the risk to humans |
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Statement on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and assessment of the risk to humans |
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Abstract The European Commission requested EFSA to provide scientific advice on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and, if applicable, for a revision of the assessment of the risk to humans by its metabolite 2,3‐deepoxy‐2,3‐didehydro‐rhizoxin (DDR) and this based on the evidence available in the dossier for renewal of the approval. The information from other P. chlororaphis strains than MA342 was taken into account with care, because the studies available in the dossier did not confirm the identity of the strain MA342 as belonging to the species P. chlororaphis. It has been concluded that there is a potential for translocation of P. chlororaphis MA342 to edible plant parts following seed treatment till an estimated concentration up to about 105 cfu/g and some exposure can be assumed by consumption of fresh commodities. Also, production of the metabolite DDR in the plant cannot be excluded. Regarding levels of DDR in the raw agricultural commodities, exposure estimates based on the limit of quantification (LOQ) for DDR in cereals cannot be further refined while there is no information on the levels of DDR in peas in the dossier. As regards genotoxicity, DDR induced chromosomal damage; however, it was not possible to conclude whether it is through an aneugenic or clastogenic mechanism. Hence, it is not possible to draw a reliable conclusion that DDR is producing an aneugenic effect nor to determine a threshold dose for aneugenicity. Thus, it is not possible to revise the human risk assessment as regards exposure to DDR. The concerns identified in the EFSA conclusion of 2017 remain. |
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Abstract The European Commission requested EFSA to provide scientific advice on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and, if applicable, for a revision of the assessment of the risk to humans by its metabolite 2,3‐deepoxy‐2,3‐didehydro‐rhizoxin (DDR) and this based on the evidence available in the dossier for renewal of the approval. The information from other P. chlororaphis strains than MA342 was taken into account with care, because the studies available in the dossier did not confirm the identity of the strain MA342 as belonging to the species P. chlororaphis. It has been concluded that there is a potential for translocation of P. chlororaphis MA342 to edible plant parts following seed treatment till an estimated concentration up to about 105 cfu/g and some exposure can be assumed by consumption of fresh commodities. Also, production of the metabolite DDR in the plant cannot be excluded. Regarding levels of DDR in the raw agricultural commodities, exposure estimates based on the limit of quantification (LOQ) for DDR in cereals cannot be further refined while there is no information on the levels of DDR in peas in the dossier. As regards genotoxicity, DDR induced chromosomal damage; however, it was not possible to conclude whether it is through an aneugenic or clastogenic mechanism. Hence, it is not possible to draw a reliable conclusion that DDR is producing an aneugenic effect nor to determine a threshold dose for aneugenicity. Thus, it is not possible to revise the human risk assessment as regards exposure to DDR. The concerns identified in the EFSA conclusion of 2017 remain. |
| abstract_unstemmed |
Abstract The European Commission requested EFSA to provide scientific advice on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and, if applicable, for a revision of the assessment of the risk to humans by its metabolite 2,3‐deepoxy‐2,3‐didehydro‐rhizoxin (DDR) and this based on the evidence available in the dossier for renewal of the approval. The information from other P. chlororaphis strains than MA342 was taken into account with care, because the studies available in the dossier did not confirm the identity of the strain MA342 as belonging to the species P. chlororaphis. It has been concluded that there is a potential for translocation of P. chlororaphis MA342 to edible plant parts following seed treatment till an estimated concentration up to about 105 cfu/g and some exposure can be assumed by consumption of fresh commodities. Also, production of the metabolite DDR in the plant cannot be excluded. Regarding levels of DDR in the raw agricultural commodities, exposure estimates based on the limit of quantification (LOQ) for DDR in cereals cannot be further refined while there is no information on the levels of DDR in peas in the dossier. As regards genotoxicity, DDR induced chromosomal damage; however, it was not possible to conclude whether it is through an aneugenic or clastogenic mechanism. Hence, it is not possible to draw a reliable conclusion that DDR is producing an aneugenic effect nor to determine a threshold dose for aneugenicity. Thus, it is not possible to revise the human risk assessment as regards exposure to DDR. The concerns identified in the EFSA conclusion of 2017 remain. |
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| title_short |
Statement on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and assessment of the risk to humans |
| url |
https://doi.org/10.2903/j.efsa.2020.6276 https://doaj.org/article/f1c0cc4aab5c462fb158c4b977242af4 https://doaj.org/toc/1831-4732 |
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Antonio F Hernandez‐Jerez Paulien Adriaanse Annette Aldrich Philippe Berny Tamara Coja Sabine Duquesne Marina Marinovich Maurice Millet Olavi Pelkonen Silvia Pieper Aaldrik Tiktak Christopher J Topping Gerrit Wolterink Lieve Herman Arianna Chiusolo José Oriol Magrans Anneli Widenfalk |
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Antonio F Hernandez‐Jerez Paulien Adriaanse Annette Aldrich Philippe Berny Tamara Coja Sabine Duquesne Marina Marinovich Maurice Millet Olavi Pelkonen Silvia Pieper Aaldrik Tiktak Christopher J Topping Gerrit Wolterink Lieve Herman Arianna Chiusolo José Oriol Magrans Anneli Widenfalk |
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2024-07-03T13:20:26.082Z |
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| score |
7.399102 |