Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study

Aim and Objective: The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels. Materials and Methods: The sam...
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Autor*in:	M Kandasamy [verfasserIn] N Jaisanghar [verfasserIn] Ravi David Austin [verfasserIn] Kumar Chandan Srivastava [verfasserIn] G Sai Anusuya [verfasserIn] N Anisa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Hemoglobin immunoglobulin A immunoglobulin G oral squamous cell carcinoma oral submucous fibrosis total serum protein

Übergeordnetes Werk:	In: Journal of Pharmacy and Bioallied Sciences - Wolters Kluwer Medknow Publications, 2009, 8(2016), 5, Seite 126-132
Übergeordnetes Werk:	volume:8 ; year:2016 ; number:5 ; pages:126-132

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4103/0975-7406.191941

Katalog-ID:	DOAJ005201411

Internformat


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245	1	0	\|a Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study
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520			\|a Aim and Objective: The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels. Materials and Methods: The sample for the present study comprised a total of 20 healthy controls, 20 OSMF patients. About 5 ml of blood and 2 ml of saliva were collected. Quantitative analysis of serum and salivary IgG, IgA was done by turbidometric immunoassay. TSP and Hb were estimated by Biuret and cyanmethemoglobin methods, respectively. Results: Serum and salivary IgA and IgG levels were statistically significantly increased (P < 0.001) in OSMF patients when compared to controls. Also serum and salivary IgG and IgA levels showed significantly increased (P < 0.01) in all the three staging of OSMF when compared to control group. Hb levels and TSP levels were significantly decreased (P < 0.001) in OSMF patients when compared to controls. One-way ANOVA, Pearson's correlation, and unpaired t -test were used for statistical analysis. Conclusion: The elevated levels of IgG and IgA are also in favor of polygammapathy, which are nonspecific and nondiagnostic objective reflections of an underlying disease. Decreased TSP is a result of host response and Hb, acts as an indicator of nutritional status plays an important role. It is also observed from the present study that the severity of OSMF was directly proportional to the estimated elevated levels of the major IgG and IgA. A need is also felt for the knowledge of immunoprofile estimation in etiology and pathogenesis that would prove a great asset in the proper assessment of this condition.
650		4	\|a Hemoglobin
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650		4	\|a total serum protein
653		0	\|a Pharmacy and materia medica
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author_variant	m k mk n j nj r d a rda k c s kcs g s a gsa n a na
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allfields	10.4103/0975-7406.191941 doi (DE-627)DOAJ005201411 (DE-599)DOAJd8757f65dcca4b698379ca4dd7dd0ca0 DE-627 ger DE-627 rakwb eng RS1-441 QD71-142 M Kandasamy verfasserin aut Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim and Objective: The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels. Materials and Methods: The sample for the present study comprised a total of 20 healthy controls, 20 OSMF patients. About 5 ml of blood and 2 ml of saliva were collected. Quantitative analysis of serum and salivary IgG, IgA was done by turbidometric immunoassay. TSP and Hb were estimated by Biuret and cyanmethemoglobin methods, respectively. Results: Serum and salivary IgA and IgG levels were statistically significantly increased (P < 0.001) in OSMF patients when compared to controls. Also serum and salivary IgG and IgA levels showed significantly increased (P < 0.01) in all the three staging of OSMF when compared to control group. Hb levels and TSP levels were significantly decreased (P < 0.001) in OSMF patients when compared to controls. One-way ANOVA, Pearson's correlation, and unpaired t -test were used for statistical analysis. Conclusion: The elevated levels of IgG and IgA are also in favor of polygammapathy, which are nonspecific and nondiagnostic objective reflections of an underlying disease. Decreased TSP is a result of host response and Hb, acts as an indicator of nutritional status plays an important role. It is also observed from the present study that the severity of OSMF was directly proportional to the estimated elevated levels of the major IgG and IgA. A need is also felt for the knowledge of immunoprofile estimation in etiology and pathogenesis that would prove a great asset in the proper assessment of this condition. Hemoglobin immunoglobulin A immunoglobulin G oral squamous cell carcinoma oral submucous fibrosis total serum protein Pharmacy and materia medica Analytical chemistry N Jaisanghar verfasserin aut Ravi David Austin verfasserin aut Kumar Chandan Srivastava verfasserin aut G Sai Anusuya verfasserin aut N Anisa verfasserin aut In Journal of Pharmacy and Bioallied Sciences Wolters Kluwer Medknow Publications, 2009 8(2016), 5, Seite 126-132 (DE-627)635603888 (DE-600)2573569-X 09757406 nnns volume:8 year:2016 number:5 pages:126-132 https://doi.org/10.4103/0975-7406.191941 kostenfrei https://doaj.org/article/d8757f65dcca4b698379ca4dd7dd0ca0 kostenfrei http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2016;volume=8;issue=5;spage=126;epage=132;aulast=Kandasamy kostenfrei https://doaj.org/toc/0975-7406 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 5 126-132
spelling	10.4103/0975-7406.191941 doi (DE-627)DOAJ005201411 (DE-599)DOAJd8757f65dcca4b698379ca4dd7dd0ca0 DE-627 ger DE-627 rakwb eng RS1-441 QD71-142 M Kandasamy verfasserin aut Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim and Objective: The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels. Materials and Methods: The sample for the present study comprised a total of 20 healthy controls, 20 OSMF patients. About 5 ml of blood and 2 ml of saliva were collected. Quantitative analysis of serum and salivary IgG, IgA was done by turbidometric immunoassay. TSP and Hb were estimated by Biuret and cyanmethemoglobin methods, respectively. Results: Serum and salivary IgA and IgG levels were statistically significantly increased (P < 0.001) in OSMF patients when compared to controls. Also serum and salivary IgG and IgA levels showed significantly increased (P < 0.01) in all the three staging of OSMF when compared to control group. Hb levels and TSP levels were significantly decreased (P < 0.001) in OSMF patients when compared to controls. One-way ANOVA, Pearson's correlation, and unpaired t -test were used for statistical analysis. Conclusion: The elevated levels of IgG and IgA are also in favor of polygammapathy, which are nonspecific and nondiagnostic objective reflections of an underlying disease. Decreased TSP is a result of host response and Hb, acts as an indicator of nutritional status plays an important role. It is also observed from the present study that the severity of OSMF was directly proportional to the estimated elevated levels of the major IgG and IgA. A need is also felt for the knowledge of immunoprofile estimation in etiology and pathogenesis that would prove a great asset in the proper assessment of this condition. Hemoglobin immunoglobulin A immunoglobulin G oral squamous cell carcinoma oral submucous fibrosis total serum protein Pharmacy and materia medica Analytical chemistry N Jaisanghar verfasserin aut Ravi David Austin verfasserin aut Kumar Chandan Srivastava verfasserin aut G Sai Anusuya verfasserin aut N Anisa verfasserin aut In Journal of Pharmacy and Bioallied Sciences Wolters Kluwer Medknow Publications, 2009 8(2016), 5, Seite 126-132 (DE-627)635603888 (DE-600)2573569-X 09757406 nnns volume:8 year:2016 number:5 pages:126-132 https://doi.org/10.4103/0975-7406.191941 kostenfrei https://doaj.org/article/d8757f65dcca4b698379ca4dd7dd0ca0 kostenfrei http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2016;volume=8;issue=5;spage=126;epage=132;aulast=Kandasamy kostenfrei https://doaj.org/toc/0975-7406 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 5 126-132
allfields_unstemmed	10.4103/0975-7406.191941 doi (DE-627)DOAJ005201411 (DE-599)DOAJd8757f65dcca4b698379ca4dd7dd0ca0 DE-627 ger DE-627 rakwb eng RS1-441 QD71-142 M Kandasamy verfasserin aut Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim and Objective: The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels. Materials and Methods: The sample for the present study comprised a total of 20 healthy controls, 20 OSMF patients. About 5 ml of blood and 2 ml of saliva were collected. Quantitative analysis of serum and salivary IgG, IgA was done by turbidometric immunoassay. TSP and Hb were estimated by Biuret and cyanmethemoglobin methods, respectively. Results: Serum and salivary IgA and IgG levels were statistically significantly increased (P < 0.001) in OSMF patients when compared to controls. Also serum and salivary IgG and IgA levels showed significantly increased (P < 0.01) in all the three staging of OSMF when compared to control group. Hb levels and TSP levels were significantly decreased (P < 0.001) in OSMF patients when compared to controls. One-way ANOVA, Pearson's correlation, and unpaired t -test were used for statistical analysis. Conclusion: The elevated levels of IgG and IgA are also in favor of polygammapathy, which are nonspecific and nondiagnostic objective reflections of an underlying disease. Decreased TSP is a result of host response and Hb, acts as an indicator of nutritional status plays an important role. It is also observed from the present study that the severity of OSMF was directly proportional to the estimated elevated levels of the major IgG and IgA. A need is also felt for the knowledge of immunoprofile estimation in etiology and pathogenesis that would prove a great asset in the proper assessment of this condition. Hemoglobin immunoglobulin A immunoglobulin G oral squamous cell carcinoma oral submucous fibrosis total serum protein Pharmacy and materia medica Analytical chemistry N Jaisanghar verfasserin aut Ravi David Austin verfasserin aut Kumar Chandan Srivastava verfasserin aut G Sai Anusuya verfasserin aut N Anisa verfasserin aut In Journal of Pharmacy and Bioallied Sciences Wolters Kluwer Medknow Publications, 2009 8(2016), 5, Seite 126-132 (DE-627)635603888 (DE-600)2573569-X 09757406 nnns volume:8 year:2016 number:5 pages:126-132 https://doi.org/10.4103/0975-7406.191941 kostenfrei https://doaj.org/article/d8757f65dcca4b698379ca4dd7dd0ca0 kostenfrei http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2016;volume=8;issue=5;spage=126;epage=132;aulast=Kandasamy kostenfrei https://doaj.org/toc/0975-7406 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 5 126-132
allfieldsGer	10.4103/0975-7406.191941 doi (DE-627)DOAJ005201411 (DE-599)DOAJd8757f65dcca4b698379ca4dd7dd0ca0 DE-627 ger DE-627 rakwb eng RS1-441 QD71-142 M Kandasamy verfasserin aut Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim and Objective: The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels. Materials and Methods: The sample for the present study comprised a total of 20 healthy controls, 20 OSMF patients. About 5 ml of blood and 2 ml of saliva were collected. Quantitative analysis of serum and salivary IgG, IgA was done by turbidometric immunoassay. TSP and Hb were estimated by Biuret and cyanmethemoglobin methods, respectively. Results: Serum and salivary IgA and IgG levels were statistically significantly increased (P < 0.001) in OSMF patients when compared to controls. Also serum and salivary IgG and IgA levels showed significantly increased (P < 0.01) in all the three staging of OSMF when compared to control group. Hb levels and TSP levels were significantly decreased (P < 0.001) in OSMF patients when compared to controls. One-way ANOVA, Pearson's correlation, and unpaired t -test were used for statistical analysis. Conclusion: The elevated levels of IgG and IgA are also in favor of polygammapathy, which are nonspecific and nondiagnostic objective reflections of an underlying disease. Decreased TSP is a result of host response and Hb, acts as an indicator of nutritional status plays an important role. It is also observed from the present study that the severity of OSMF was directly proportional to the estimated elevated levels of the major IgG and IgA. A need is also felt for the knowledge of immunoprofile estimation in etiology and pathogenesis that would prove a great asset in the proper assessment of this condition. Hemoglobin immunoglobulin A immunoglobulin G oral squamous cell carcinoma oral submucous fibrosis total serum protein Pharmacy and materia medica Analytical chemistry N Jaisanghar verfasserin aut Ravi David Austin verfasserin aut Kumar Chandan Srivastava verfasserin aut G Sai Anusuya verfasserin aut N Anisa verfasserin aut In Journal of Pharmacy and Bioallied Sciences Wolters Kluwer Medknow Publications, 2009 8(2016), 5, Seite 126-132 (DE-627)635603888 (DE-600)2573569-X 09757406 nnns volume:8 year:2016 number:5 pages:126-132 https://doi.org/10.4103/0975-7406.191941 kostenfrei https://doaj.org/article/d8757f65dcca4b698379ca4dd7dd0ca0 kostenfrei http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2016;volume=8;issue=5;spage=126;epage=132;aulast=Kandasamy kostenfrei https://doaj.org/toc/0975-7406 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 5 126-132
allfieldsSound	10.4103/0975-7406.191941 doi (DE-627)DOAJ005201411 (DE-599)DOAJd8757f65dcca4b698379ca4dd7dd0ca0 DE-627 ger DE-627 rakwb eng RS1-441 QD71-142 M Kandasamy verfasserin aut Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim and Objective: The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels. Materials and Methods: The sample for the present study comprised a total of 20 healthy controls, 20 OSMF patients. About 5 ml of blood and 2 ml of saliva were collected. Quantitative analysis of serum and salivary IgG, IgA was done by turbidometric immunoassay. TSP and Hb were estimated by Biuret and cyanmethemoglobin methods, respectively. Results: Serum and salivary IgA and IgG levels were statistically significantly increased (P < 0.001) in OSMF patients when compared to controls. Also serum and salivary IgG and IgA levels showed significantly increased (P < 0.01) in all the three staging of OSMF when compared to control group. Hb levels and TSP levels were significantly decreased (P < 0.001) in OSMF patients when compared to controls. One-way ANOVA, Pearson's correlation, and unpaired t -test were used for statistical analysis. Conclusion: The elevated levels of IgG and IgA are also in favor of polygammapathy, which are nonspecific and nondiagnostic objective reflections of an underlying disease. Decreased TSP is a result of host response and Hb, acts as an indicator of nutritional status plays an important role. It is also observed from the present study that the severity of OSMF was directly proportional to the estimated elevated levels of the major IgG and IgA. A need is also felt for the knowledge of immunoprofile estimation in etiology and pathogenesis that would prove a great asset in the proper assessment of this condition. Hemoglobin immunoglobulin A immunoglobulin G oral squamous cell carcinoma oral submucous fibrosis total serum protein Pharmacy and materia medica Analytical chemistry N Jaisanghar verfasserin aut Ravi David Austin verfasserin aut Kumar Chandan Srivastava verfasserin aut G Sai Anusuya verfasserin aut N Anisa verfasserin aut In Journal of Pharmacy and Bioallied Sciences Wolters Kluwer Medknow Publications, 2009 8(2016), 5, Seite 126-132 (DE-627)635603888 (DE-600)2573569-X 09757406 nnns volume:8 year:2016 number:5 pages:126-132 https://doi.org/10.4103/0975-7406.191941 kostenfrei https://doaj.org/article/d8757f65dcca4b698379ca4dd7dd0ca0 kostenfrei http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2016;volume=8;issue=5;spage=126;epage=132;aulast=Kandasamy kostenfrei https://doaj.org/toc/0975-7406 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 5 126-132
language	English
source	In Journal of Pharmacy and Bioallied Sciences 8(2016), 5, Seite 126-132 volume:8 year:2016 number:5 pages:126-132
sourceStr	In Journal of Pharmacy and Bioallied Sciences 8(2016), 5, Seite 126-132 volume:8 year:2016 number:5 pages:126-132
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institution	findex.gbv.de
topic_facet	Hemoglobin immunoglobulin A immunoglobulin G oral squamous cell carcinoma oral submucous fibrosis total serum protein Pharmacy and materia medica Analytical chemistry
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authorswithroles_txt_mv	M Kandasamy @@aut@@ N Jaisanghar @@aut@@ Ravi David Austin @@aut@@ Kumar Chandan Srivastava @@aut@@ G Sai Anusuya @@aut@@ N Anisa @@aut@@
publishDateDaySort_date	2016-01-01T00:00:00Z
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author	M Kandasamy
spellingShingle	M Kandasamy misc RS1-441 misc QD71-142 misc Hemoglobin misc immunoglobulin A misc immunoglobulin G misc oral squamous cell carcinoma misc oral submucous fibrosis misc total serum protein misc Pharmacy and materia medica misc Analytical chemistry Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study
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topic_title	RS1-441 QD71-142 Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study Hemoglobin immunoglobulin A immunoglobulin G oral squamous cell carcinoma oral submucous fibrosis total serum protein
topic	misc RS1-441 misc QD71-142 misc Hemoglobin misc immunoglobulin A misc immunoglobulin G misc oral squamous cell carcinoma misc oral submucous fibrosis misc total serum protein misc Pharmacy and materia medica misc Analytical chemistry
topic_unstemmed	misc RS1-441 misc QD71-142 misc Hemoglobin misc immunoglobulin A misc immunoglobulin G misc oral squamous cell carcinoma misc oral submucous fibrosis misc total serum protein misc Pharmacy and materia medica misc Analytical chemistry
topic_browse	misc RS1-441 misc QD71-142 misc Hemoglobin misc immunoglobulin A misc immunoglobulin G misc oral squamous cell carcinoma misc oral submucous fibrosis misc total serum protein misc Pharmacy and materia medica misc Analytical chemistry
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title	Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study
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title_full	Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study
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author_browse	M Kandasamy N Jaisanghar Ravi David Austin Kumar Chandan Srivastava G Sai Anusuya N Anisa
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title_sort	comparative evaluation of serum and salivary immunoglobulin g and a levels with total serum protein in oral submucous fibrosis patients: a case control study
callnumber	RS1-441
title_auth	Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study
abstract	Aim and Objective: The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels. Materials and Methods: The sample for the present study comprised a total of 20 healthy controls, 20 OSMF patients. About 5 ml of blood and 2 ml of saliva were collected. Quantitative analysis of serum and salivary IgG, IgA was done by turbidometric immunoassay. TSP and Hb were estimated by Biuret and cyanmethemoglobin methods, respectively. Results: Serum and salivary IgA and IgG levels were statistically significantly increased (P < 0.001) in OSMF patients when compared to controls. Also serum and salivary IgG and IgA levels showed significantly increased (P < 0.01) in all the three staging of OSMF when compared to control group. Hb levels and TSP levels were significantly decreased (P < 0.001) in OSMF patients when compared to controls. One-way ANOVA, Pearson's correlation, and unpaired t -test were used for statistical analysis. Conclusion: The elevated levels of IgG and IgA are also in favor of polygammapathy, which are nonspecific and nondiagnostic objective reflections of an underlying disease. Decreased TSP is a result of host response and Hb, acts as an indicator of nutritional status plays an important role. It is also observed from the present study that the severity of OSMF was directly proportional to the estimated elevated levels of the major IgG and IgA. A need is also felt for the knowledge of immunoprofile estimation in etiology and pathogenesis that would prove a great asset in the proper assessment of this condition.
abstractGer	Aim and Objective: The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels. Materials and Methods: The sample for the present study comprised a total of 20 healthy controls, 20 OSMF patients. About 5 ml of blood and 2 ml of saliva were collected. Quantitative analysis of serum and salivary IgG, IgA was done by turbidometric immunoassay. TSP and Hb were estimated by Biuret and cyanmethemoglobin methods, respectively. Results: Serum and salivary IgA and IgG levels were statistically significantly increased (P < 0.001) in OSMF patients when compared to controls. Also serum and salivary IgG and IgA levels showed significantly increased (P < 0.01) in all the three staging of OSMF when compared to control group. Hb levels and TSP levels were significantly decreased (P < 0.001) in OSMF patients when compared to controls. One-way ANOVA, Pearson's correlation, and unpaired t -test were used for statistical analysis. Conclusion: The elevated levels of IgG and IgA are also in favor of polygammapathy, which are nonspecific and nondiagnostic objective reflections of an underlying disease. Decreased TSP is a result of host response and Hb, acts as an indicator of nutritional status plays an important role. It is also observed from the present study that the severity of OSMF was directly proportional to the estimated elevated levels of the major IgG and IgA. A need is also felt for the knowledge of immunoprofile estimation in etiology and pathogenesis that would prove a great asset in the proper assessment of this condition.
abstract_unstemmed	Aim and Objective: The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels. Materials and Methods: The sample for the present study comprised a total of 20 healthy controls, 20 OSMF patients. About 5 ml of blood and 2 ml of saliva were collected. Quantitative analysis of serum and salivary IgG, IgA was done by turbidometric immunoassay. TSP and Hb were estimated by Biuret and cyanmethemoglobin methods, respectively. Results: Serum and salivary IgA and IgG levels were statistically significantly increased (P < 0.001) in OSMF patients when compared to controls. Also serum and salivary IgG and IgA levels showed significantly increased (P < 0.01) in all the three staging of OSMF when compared to control group. Hb levels and TSP levels were significantly decreased (P < 0.001) in OSMF patients when compared to controls. One-way ANOVA, Pearson's correlation, and unpaired t -test were used for statistical analysis. Conclusion: The elevated levels of IgG and IgA are also in favor of polygammapathy, which are nonspecific and nondiagnostic objective reflections of an underlying disease. Decreased TSP is a result of host response and Hb, acts as an indicator of nutritional status plays an important role. It is also observed from the present study that the severity of OSMF was directly proportional to the estimated elevated levels of the major IgG and IgA. A need is also felt for the knowledge of immunoprofile estimation in etiology and pathogenesis that would prove a great asset in the proper assessment of this condition.
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title_short	Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study
url	https://doi.org/10.4103/0975-7406.191941 https://doaj.org/article/d8757f65dcca4b698379ca4dd7dd0ca0 http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2016;volume=8;issue=5;spage=126;epage=132;aulast=Kandasamy https://doaj.org/toc/0975-7406
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author2	N Jaisanghar Ravi David Austin Kumar Chandan Srivastava G Sai Anusuya N Anisa
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