Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment

Summary: Regulatory T cells (Treg cells) are critical mediators of self-tolerance, but they can also limit effective anti-tumor immunity. Although under homeostasis a small fraction of Treg cells in lymphoid organs express the putative checkpoint molecule Tim-3, this protein is expressed by a much l...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Hridesh Banerjee [verfasserIn]

Hector Nieves-Rosado [verfasserIn]

Aditi Kulkarni [verfasserIn]

Benjamin Murter [verfasserIn]

Kyle V. McGrath [verfasserIn]

Uma R. Chandran [verfasserIn]

Alexander Chang [verfasserIn]

Andrea L. Szymczak-Workman [verfasserIn]

Lazar Vujanovic [verfasserIn]

Greg M. Delgoffe [verfasserIn]

Robert L. Ferris [verfasserIn]

Lawrence P. Kane [verfasserIn]

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2021

Schlagwörter:

regulatory T cells (Treg)

T cell immunoglobulin and mucin 3 (Tim-3)

cellular signaling

cellular metabolism

tumor immunology

immunosuppression

Übergeordnetes Werk:

In: Cell Reports - Elsevier, 2015, 36(2021), 11, Seite 109699-

Übergeordnetes Werk:

volume:36 ; year:2021 ; number:11 ; pages:109699-

Links:

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Journal toc

DOI / URN:

10.1016/j.celrep.2021.109699

Katalog-ID:

DOAJ005220769

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