The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology’s multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about th...
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Autor*in:	Ledyane Taynara Marton [verfasserIn] Laís Maria Pescinini-e-Salzedas [verfasserIn] Maria Eduarda Côrtes Camargo [verfasserIn] Sandra M. Barbalho [verfasserIn] Jesselina F. dos Santos Haber [verfasserIn] Renata Vargas Sinatora [verfasserIn] Claudia Rucco Penteado Detregiachi [verfasserIn] Raul J. S. Girio [verfasserIn] Daniela Vieira Buchaim [verfasserIn] Patricia Cincotto dos Santos Bueno [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Curcuma longa curcumin curcuminoids diabetes type 2 diabetes mellitus

Übergeordnetes Werk:	In: Frontiers in Endocrinology - Frontiers Media S.A., 2011, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fendo.2021.669448

Katalog-ID:	DOAJ005396905

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spelling	10.3389/fendo.2021.669448 doi (DE-627)DOAJ005396905 (DE-599)DOAJffb33e17ea834c0f9afb0969d764126e DE-627 ger DE-627 rakwb eng RC648-665 Ledyane Taynara Marton verfasserin aut The Effects of Curcumin on Diabetes Mellitus: A Systematic Review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology’s multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about the effectiveness of using herbal supplements in preventing and controlling DM. Curcumin is a bioactive component found Curcuma longa, which exhibits several physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-diabetic activities. For these reasons, our objective is to systematically review the effects of Curcuma longa or curcumin on DM. Databases such as PUBMED and EMBASE were searched, and the final selection included sixteen studies that fulfilled the inclusion criteria. The results showed that curcumin’s anti-diabetic activity might be due to its capacity to suppress oxidative stress and inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, and body mass index. Nanocurcumin is also associated with a significant reduction in triglycerides, VLDL-c, total cholesterol, LDL-c, HDL-c, serum C reactive protein, and plasma malonaldehyde. Therefore, it can be considered in the therapeutic approach of patients with DM. Curcuma longa curcumin curcuminoids diabetes type 2 diabetes mellitus Diseases of the endocrine glands. Clinical endocrinology Laís Maria Pescinini-e-Salzedas verfasserin aut Maria Eduarda Côrtes Camargo verfasserin aut Sandra M. Barbalho verfasserin aut Sandra M. Barbalho verfasserin aut Sandra M. Barbalho verfasserin aut Jesselina F. dos Santos Haber verfasserin aut Renata Vargas Sinatora verfasserin aut Claudia Rucco Penteado Detregiachi verfasserin aut Raul J. S. Girio verfasserin aut Daniela Vieira Buchaim verfasserin aut Daniela Vieira Buchaim verfasserin aut Patricia Cincotto dos Santos Bueno verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 12(2021) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:12 year:2021 https://doi.org/10.3389/fendo.2021.669448 kostenfrei https://doaj.org/article/ffb33e17ea834c0f9afb0969d764126e kostenfrei https://www.frontiersin.org/articles/10.3389/fendo.2021.669448/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfields_unstemmed	10.3389/fendo.2021.669448 doi (DE-627)DOAJ005396905 (DE-599)DOAJffb33e17ea834c0f9afb0969d764126e DE-627 ger DE-627 rakwb eng RC648-665 Ledyane Taynara Marton verfasserin aut The Effects of Curcumin on Diabetes Mellitus: A Systematic Review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology’s multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about the effectiveness of using herbal supplements in preventing and controlling DM. Curcumin is a bioactive component found Curcuma longa, which exhibits several physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-diabetic activities. For these reasons, our objective is to systematically review the effects of Curcuma longa or curcumin on DM. Databases such as PUBMED and EMBASE were searched, and the final selection included sixteen studies that fulfilled the inclusion criteria. The results showed that curcumin’s anti-diabetic activity might be due to its capacity to suppress oxidative stress and inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, and body mass index. Nanocurcumin is also associated with a significant reduction in triglycerides, VLDL-c, total cholesterol, LDL-c, HDL-c, serum C reactive protein, and plasma malonaldehyde. Therefore, it can be considered in the therapeutic approach of patients with DM. Curcuma longa curcumin curcuminoids diabetes type 2 diabetes mellitus Diseases of the endocrine glands. Clinical endocrinology Laís Maria Pescinini-e-Salzedas verfasserin aut Maria Eduarda Côrtes Camargo verfasserin aut Sandra M. Barbalho verfasserin aut Sandra M. Barbalho verfasserin aut Sandra M. Barbalho verfasserin aut Jesselina F. dos Santos Haber verfasserin aut Renata Vargas Sinatora verfasserin aut Claudia Rucco Penteado Detregiachi verfasserin aut Raul J. S. Girio verfasserin aut Daniela Vieira Buchaim verfasserin aut Daniela Vieira Buchaim verfasserin aut Patricia Cincotto dos Santos Bueno verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 12(2021) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:12 year:2021 https://doi.org/10.3389/fendo.2021.669448 kostenfrei https://doaj.org/article/ffb33e17ea834c0f9afb0969d764126e kostenfrei https://www.frontiersin.org/articles/10.3389/fendo.2021.669448/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsGer	10.3389/fendo.2021.669448 doi (DE-627)DOAJ005396905 (DE-599)DOAJffb33e17ea834c0f9afb0969d764126e DE-627 ger DE-627 rakwb eng RC648-665 Ledyane Taynara Marton verfasserin aut The Effects of Curcumin on Diabetes Mellitus: A Systematic Review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology’s multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about the effectiveness of using herbal supplements in preventing and controlling DM. Curcumin is a bioactive component found Curcuma longa, which exhibits several physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-diabetic activities. For these reasons, our objective is to systematically review the effects of Curcuma longa or curcumin on DM. Databases such as PUBMED and EMBASE were searched, and the final selection included sixteen studies that fulfilled the inclusion criteria. The results showed that curcumin’s anti-diabetic activity might be due to its capacity to suppress oxidative stress and inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, and body mass index. Nanocurcumin is also associated with a significant reduction in triglycerides, VLDL-c, total cholesterol, LDL-c, HDL-c, serum C reactive protein, and plasma malonaldehyde. Therefore, it can be considered in the therapeutic approach of patients with DM. Curcuma longa curcumin curcuminoids diabetes type 2 diabetes mellitus Diseases of the endocrine glands. Clinical endocrinology Laís Maria Pescinini-e-Salzedas verfasserin aut Maria Eduarda Côrtes Camargo verfasserin aut Sandra M. Barbalho verfasserin aut Sandra M. Barbalho verfasserin aut Sandra M. Barbalho verfasserin aut Jesselina F. dos Santos Haber verfasserin aut Renata Vargas Sinatora verfasserin aut Claudia Rucco Penteado Detregiachi verfasserin aut Raul J. S. Girio verfasserin aut Daniela Vieira Buchaim verfasserin aut Daniela Vieira Buchaim verfasserin aut Patricia Cincotto dos Santos Bueno verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 12(2021) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:12 year:2021 https://doi.org/10.3389/fendo.2021.669448 kostenfrei https://doaj.org/article/ffb33e17ea834c0f9afb0969d764126e kostenfrei https://www.frontiersin.org/articles/10.3389/fendo.2021.669448/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsSound	10.3389/fendo.2021.669448 doi (DE-627)DOAJ005396905 (DE-599)DOAJffb33e17ea834c0f9afb0969d764126e DE-627 ger DE-627 rakwb eng RC648-665 Ledyane Taynara Marton verfasserin aut The Effects of Curcumin on Diabetes Mellitus: A Systematic Review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology’s multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about the effectiveness of using herbal supplements in preventing and controlling DM. Curcumin is a bioactive component found Curcuma longa, which exhibits several physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-diabetic activities. For these reasons, our objective is to systematically review the effects of Curcuma longa or curcumin on DM. Databases such as PUBMED and EMBASE were searched, and the final selection included sixteen studies that fulfilled the inclusion criteria. The results showed that curcumin’s anti-diabetic activity might be due to its capacity to suppress oxidative stress and inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, and body mass index. Nanocurcumin is also associated with a significant reduction in triglycerides, VLDL-c, total cholesterol, LDL-c, HDL-c, serum C reactive protein, and plasma malonaldehyde. Therefore, it can be considered in the therapeutic approach of patients with DM. Curcuma longa curcumin curcuminoids diabetes type 2 diabetes mellitus Diseases of the endocrine glands. Clinical endocrinology Laís Maria Pescinini-e-Salzedas verfasserin aut Maria Eduarda Côrtes Camargo verfasserin aut Sandra M. Barbalho verfasserin aut Sandra M. Barbalho verfasserin aut Sandra M. Barbalho verfasserin aut Jesselina F. dos Santos Haber verfasserin aut Renata Vargas Sinatora verfasserin aut Claudia Rucco Penteado Detregiachi verfasserin aut Raul J. S. Girio verfasserin aut Daniela Vieira Buchaim verfasserin aut Daniela Vieira Buchaim verfasserin aut Patricia Cincotto dos Santos Bueno verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 12(2021) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:12 year:2021 https://doi.org/10.3389/fendo.2021.669448 kostenfrei https://doaj.org/article/ffb33e17ea834c0f9afb0969d764126e kostenfrei https://www.frontiersin.org/articles/10.3389/fendo.2021.669448/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
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author	Ledyane Taynara Marton
spellingShingle	Ledyane Taynara Marton misc RC648-665 misc Curcuma longa misc curcumin misc curcuminoids misc diabetes misc type 2 diabetes mellitus misc Diseases of the endocrine glands. Clinical endocrinology The Effects of Curcumin on Diabetes Mellitus: A Systematic Review
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topic_title	RC648-665 The Effects of Curcumin on Diabetes Mellitus: A Systematic Review Curcuma longa curcumin curcuminoids diabetes type 2 diabetes mellitus
topic	misc RC648-665 misc Curcuma longa misc curcumin misc curcuminoids misc diabetes misc type 2 diabetes mellitus misc Diseases of the endocrine glands. Clinical endocrinology
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title	The Effects of Curcumin on Diabetes Mellitus: A Systematic Review
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title_sort	effects of curcumin on diabetes mellitus: a systematic review
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title_auth	The Effects of Curcumin on Diabetes Mellitus: A Systematic Review
abstract	Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology’s multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about the effectiveness of using herbal supplements in preventing and controlling DM. Curcumin is a bioactive component found Curcuma longa, which exhibits several physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-diabetic activities. For these reasons, our objective is to systematically review the effects of Curcuma longa or curcumin on DM. Databases such as PUBMED and EMBASE were searched, and the final selection included sixteen studies that fulfilled the inclusion criteria. The results showed that curcumin’s anti-diabetic activity might be due to its capacity to suppress oxidative stress and inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, and body mass index. Nanocurcumin is also associated with a significant reduction in triglycerides, VLDL-c, total cholesterol, LDL-c, HDL-c, serum C reactive protein, and plasma malonaldehyde. Therefore, it can be considered in the therapeutic approach of patients with DM.
abstractGer	Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology’s multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about the effectiveness of using herbal supplements in preventing and controlling DM. Curcumin is a bioactive component found Curcuma longa, which exhibits several physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-diabetic activities. For these reasons, our objective is to systematically review the effects of Curcuma longa or curcumin on DM. Databases such as PUBMED and EMBASE were searched, and the final selection included sixteen studies that fulfilled the inclusion criteria. The results showed that curcumin’s anti-diabetic activity might be due to its capacity to suppress oxidative stress and inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, and body mass index. Nanocurcumin is also associated with a significant reduction in triglycerides, VLDL-c, total cholesterol, LDL-c, HDL-c, serum C reactive protein, and plasma malonaldehyde. Therefore, it can be considered in the therapeutic approach of patients with DM.
abstract_unstemmed	Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology’s multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about the effectiveness of using herbal supplements in preventing and controlling DM. Curcumin is a bioactive component found Curcuma longa, which exhibits several physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-diabetic activities. For these reasons, our objective is to systematically review the effects of Curcuma longa or curcumin on DM. Databases such as PUBMED and EMBASE were searched, and the final selection included sixteen studies that fulfilled the inclusion criteria. The results showed that curcumin’s anti-diabetic activity might be due to its capacity to suppress oxidative stress and inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, and body mass index. Nanocurcumin is also associated with a significant reduction in triglycerides, VLDL-c, total cholesterol, LDL-c, HDL-c, serum C reactive protein, and plasma malonaldehyde. Therefore, it can be considered in the therapeutic approach of patients with DM.
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title_short	The Effects of Curcumin on Diabetes Mellitus: A Systematic Review
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up_date	2024-07-03T14:46:17.318Z
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