Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients

This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequen...
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Autor*in:	Lazarević Ivana [verfasserIn] Ćupić Maja [verfasserIn] Banko Ana [verfasserIn] Karalić Danijela [verfasserIn] Delić D. [verfasserIn] Švirtlih Neda [verfasserIn] Simonović Jasmina [verfasserIn] Jovanović Tanja [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Hepatitis B virus (HBV) lamivudine resistance mutations

Übergeordnetes Werk:	In: Archives of Biological Sciences - University of Belgrade, University of Novi Sad, 2010, 66(2014), 2, Seite 601-608
Übergeordnetes Werk:	volume:66 ; year:2014 ; number:2 ; pages:601-608

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.2298/ABS1402601L

Katalog-ID:	DOAJ005422124

Internformat


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100	0		\|a Lazarević Ivana \|e verfasserin \|4 aut
245	1	0	\|a Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients
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520			\|a This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073]
650		4	\|a Hepatitis B virus (HBV)
650		4	\|a lamivudine
650		4	\|a resistance
650		4	\|a mutations
653		0	\|a Biology (General)
700	0		\|a Ćupić Maja \|e verfasserin \|4 aut
700	0		\|a Banko Ana \|e verfasserin \|4 aut
700	0		\|a Karalić Danijela \|e verfasserin \|4 aut
700	0		\|a Delić D. \|e verfasserin \|4 aut
700	0		\|a Švirtlih Neda \|e verfasserin \|4 aut
700	0		\|a Simonović Jasmina \|e verfasserin \|4 aut
700	0		\|a Jovanović Tanja \|e verfasserin \|4 aut
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912			\|a GBV_USEFLAG_A
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912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 66 \|j 2014 \|e 2 \|h 601-608

Indexfelder

author_variant	l i li ć m ćm b a ba k d kd d d dd š n šn s j sj j t jt
matchkey_str	article:18214339:2014----::rvlnenmttoaptenolmvdnrssatbsrisnhoia
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allfields	10.2298/ABS1402601L doi (DE-627)DOAJ005422124 (DE-599)DOAJ57f7431837d446759b966fd892f3f21c DE-627 ger DE-627 rakwb eng QH301-705.5 Lazarević Ivana verfasserin aut Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] Hepatitis B virus (HBV) lamivudine resistance mutations Biology (General) Ćupić Maja verfasserin aut Banko Ana verfasserin aut Karalić Danijela verfasserin aut Delić D. verfasserin aut Švirtlih Neda verfasserin aut Simonović Jasmina verfasserin aut Jovanović Tanja verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 66(2014), 2, Seite 601-608 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:66 year:2014 number:2 pages:601-608 https://doi.org/10.2298/ABS1402601L kostenfrei https://doaj.org/article/57f7431837d446759b966fd892f3f21c kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402601L.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei https://doaj.org/toc/1821-4339 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 66 2014 2 601-608
spelling	10.2298/ABS1402601L doi (DE-627)DOAJ005422124 (DE-599)DOAJ57f7431837d446759b966fd892f3f21c DE-627 ger DE-627 rakwb eng QH301-705.5 Lazarević Ivana verfasserin aut Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] Hepatitis B virus (HBV) lamivudine resistance mutations Biology (General) Ćupić Maja verfasserin aut Banko Ana verfasserin aut Karalić Danijela verfasserin aut Delić D. verfasserin aut Švirtlih Neda verfasserin aut Simonović Jasmina verfasserin aut Jovanović Tanja verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 66(2014), 2, Seite 601-608 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:66 year:2014 number:2 pages:601-608 https://doi.org/10.2298/ABS1402601L kostenfrei https://doaj.org/article/57f7431837d446759b966fd892f3f21c kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402601L.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei https://doaj.org/toc/1821-4339 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 66 2014 2 601-608
allfields_unstemmed	10.2298/ABS1402601L doi (DE-627)DOAJ005422124 (DE-599)DOAJ57f7431837d446759b966fd892f3f21c DE-627 ger DE-627 rakwb eng QH301-705.5 Lazarević Ivana verfasserin aut Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] Hepatitis B virus (HBV) lamivudine resistance mutations Biology (General) Ćupić Maja verfasserin aut Banko Ana verfasserin aut Karalić Danijela verfasserin aut Delić D. verfasserin aut Švirtlih Neda verfasserin aut Simonović Jasmina verfasserin aut Jovanović Tanja verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 66(2014), 2, Seite 601-608 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:66 year:2014 number:2 pages:601-608 https://doi.org/10.2298/ABS1402601L kostenfrei https://doaj.org/article/57f7431837d446759b966fd892f3f21c kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402601L.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei https://doaj.org/toc/1821-4339 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 66 2014 2 601-608
allfieldsGer	10.2298/ABS1402601L doi (DE-627)DOAJ005422124 (DE-599)DOAJ57f7431837d446759b966fd892f3f21c DE-627 ger DE-627 rakwb eng QH301-705.5 Lazarević Ivana verfasserin aut Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] Hepatitis B virus (HBV) lamivudine resistance mutations Biology (General) Ćupić Maja verfasserin aut Banko Ana verfasserin aut Karalić Danijela verfasserin aut Delić D. verfasserin aut Švirtlih Neda verfasserin aut Simonović Jasmina verfasserin aut Jovanović Tanja verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 66(2014), 2, Seite 601-608 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:66 year:2014 number:2 pages:601-608 https://doi.org/10.2298/ABS1402601L kostenfrei https://doaj.org/article/57f7431837d446759b966fd892f3f21c kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402601L.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei https://doaj.org/toc/1821-4339 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 66 2014 2 601-608
allfieldsSound	10.2298/ABS1402601L doi (DE-627)DOAJ005422124 (DE-599)DOAJ57f7431837d446759b966fd892f3f21c DE-627 ger DE-627 rakwb eng QH301-705.5 Lazarević Ivana verfasserin aut Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] Hepatitis B virus (HBV) lamivudine resistance mutations Biology (General) Ćupić Maja verfasserin aut Banko Ana verfasserin aut Karalić Danijela verfasserin aut Delić D. verfasserin aut Švirtlih Neda verfasserin aut Simonović Jasmina verfasserin aut Jovanović Tanja verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 66(2014), 2, Seite 601-608 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:66 year:2014 number:2 pages:601-608 https://doi.org/10.2298/ABS1402601L kostenfrei https://doaj.org/article/57f7431837d446759b966fd892f3f21c kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402601L.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei https://doaj.org/toc/1821-4339 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 66 2014 2 601-608
language	English
source	In Archives of Biological Sciences 66(2014), 2, Seite 601-608 volume:66 year:2014 number:2 pages:601-608
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topic_facet	Hepatitis B virus (HBV) lamivudine resistance mutations Biology (General)
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authorswithroles_txt_mv	Lazarević Ivana @@aut@@ Ćupić Maja @@aut@@ Banko Ana @@aut@@ Karalić Danijela @@aut@@ Delić D. @@aut@@ Švirtlih Neda @@aut@@ Simonović Jasmina @@aut@@ Jovanović Tanja @@aut@@
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callnumber-first	Q - Science
author	Lazarević Ivana
spellingShingle	Lazarević Ivana misc QH301-705.5 misc Hepatitis B virus (HBV) misc lamivudine misc resistance misc mutations misc Biology (General) Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients
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topic_title	QH301-705.5 Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients Hepatitis B virus (HBV) lamivudine resistance mutations
topic	misc QH301-705.5 misc Hepatitis B virus (HBV) misc lamivudine misc resistance misc mutations misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc Hepatitis B virus (HBV) misc lamivudine misc resistance misc mutations misc Biology (General)
topic_browse	misc QH301-705.5 misc Hepatitis B virus (HBV) misc lamivudine misc resistance misc mutations misc Biology (General)
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title	Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients
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title_full	Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients
author_sort	Lazarević Ivana
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author_browse	Lazarević Ivana Ćupić Maja Banko Ana Karalić Danijela Delić D. Švirtlih Neda Simonović Jasmina Jovanović Tanja
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title_sort	prevalence and mutational patterns of lamivudine-resistant hbv strains in chronically infected serbian patients
callnumber	QH301-705.5
title_auth	Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients
abstract	This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073]
abstractGer	This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073]
abstract_unstemmed	This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073]
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	2
title_short	Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients
url	https://doi.org/10.2298/ABS1402601L https://doaj.org/article/57f7431837d446759b966fd892f3f21c http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402601L.pdf https://doaj.org/toc/0354-4664 https://doaj.org/toc/1821-4339
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author2	Ćupić Maja Banko Ana Karalić Danijela Delić D. Švirtlih Neda Simonović Jasmina Jovanović Tanja
author2Str	Ćupić Maja Banko Ana Karalić Danijela Delić D. Švirtlih Neda Simonović Jasmina Jovanović Tanja
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doi_str	10.2298/ABS1402601L
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up_date	2024-07-03T14:55:06.832Z
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Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients

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