Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients
This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequen...
Ausführliche Beschreibung
Autor*in: |
Lazarević Ivana [verfasserIn] Ćupić Maja [verfasserIn] Banko Ana [verfasserIn] Karalić Danijela [verfasserIn] Delić D. [verfasserIn] Švirtlih Neda [verfasserIn] Simonović Jasmina [verfasserIn] Jovanović Tanja [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2014 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Archives of Biological Sciences - University of Belgrade, University of Novi Sad, 2010, 66(2014), 2, Seite 601-608 |
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Übergeordnetes Werk: |
volume:66 ; year:2014 ; number:2 ; pages:601-608 |
Links: |
Link aufrufen |
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DOI / URN: |
10.2298/ABS1402601L |
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Katalog-ID: |
DOAJ005422124 |
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10.2298/ABS1402601L doi (DE-627)DOAJ005422124 (DE-599)DOAJ57f7431837d446759b966fd892f3f21c DE-627 ger DE-627 rakwb eng QH301-705.5 Lazarević Ivana verfasserin aut Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] Hepatitis B virus (HBV) lamivudine resistance mutations Biology (General) Ćupić Maja verfasserin aut Banko Ana verfasserin aut Karalić Danijela verfasserin aut Delić D. verfasserin aut Švirtlih Neda verfasserin aut Simonović Jasmina verfasserin aut Jovanović Tanja verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 66(2014), 2, Seite 601-608 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:66 year:2014 number:2 pages:601-608 https://doi.org/10.2298/ABS1402601L kostenfrei https://doaj.org/article/57f7431837d446759b966fd892f3f21c kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402601L.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei https://doaj.org/toc/1821-4339 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 66 2014 2 601-608 |
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10.2298/ABS1402601L doi (DE-627)DOAJ005422124 (DE-599)DOAJ57f7431837d446759b966fd892f3f21c DE-627 ger DE-627 rakwb eng QH301-705.5 Lazarević Ivana verfasserin aut Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] Hepatitis B virus (HBV) lamivudine resistance mutations Biology (General) Ćupić Maja verfasserin aut Banko Ana verfasserin aut Karalić Danijela verfasserin aut Delić D. verfasserin aut Švirtlih Neda verfasserin aut Simonović Jasmina verfasserin aut Jovanović Tanja verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 66(2014), 2, Seite 601-608 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:66 year:2014 number:2 pages:601-608 https://doi.org/10.2298/ABS1402601L kostenfrei https://doaj.org/article/57f7431837d446759b966fd892f3f21c kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402601L.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei https://doaj.org/toc/1821-4339 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 66 2014 2 601-608 |
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10.2298/ABS1402601L doi (DE-627)DOAJ005422124 (DE-599)DOAJ57f7431837d446759b966fd892f3f21c DE-627 ger DE-627 rakwb eng QH301-705.5 Lazarević Ivana verfasserin aut Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] Hepatitis B virus (HBV) lamivudine resistance mutations Biology (General) Ćupić Maja verfasserin aut Banko Ana verfasserin aut Karalić Danijela verfasserin aut Delić D. verfasserin aut Švirtlih Neda verfasserin aut Simonović Jasmina verfasserin aut Jovanović Tanja verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 66(2014), 2, Seite 601-608 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:66 year:2014 number:2 pages:601-608 https://doi.org/10.2298/ABS1402601L kostenfrei https://doaj.org/article/57f7431837d446759b966fd892f3f21c kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402601L.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei https://doaj.org/toc/1821-4339 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 66 2014 2 601-608 |
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10.2298/ABS1402601L doi (DE-627)DOAJ005422124 (DE-599)DOAJ57f7431837d446759b966fd892f3f21c DE-627 ger DE-627 rakwb eng QH301-705.5 Lazarević Ivana verfasserin aut Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] Hepatitis B virus (HBV) lamivudine resistance mutations Biology (General) Ćupić Maja verfasserin aut Banko Ana verfasserin aut Karalić Danijela verfasserin aut Delić D. verfasserin aut Švirtlih Neda verfasserin aut Simonović Jasmina verfasserin aut Jovanović Tanja verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 66(2014), 2, Seite 601-608 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:66 year:2014 number:2 pages:601-608 https://doi.org/10.2298/ABS1402601L kostenfrei https://doaj.org/article/57f7431837d446759b966fd892f3f21c kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402601L.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei https://doaj.org/toc/1821-4339 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 66 2014 2 601-608 |
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10.2298/ABS1402601L doi (DE-627)DOAJ005422124 (DE-599)DOAJ57f7431837d446759b966fd892f3f21c DE-627 ger DE-627 rakwb eng QH301-705.5 Lazarević Ivana verfasserin aut Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] Hepatitis B virus (HBV) lamivudine resistance mutations Biology (General) Ćupić Maja verfasserin aut Banko Ana verfasserin aut Karalić Danijela verfasserin aut Delić D. verfasserin aut Švirtlih Neda verfasserin aut Simonović Jasmina verfasserin aut Jovanović Tanja verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 66(2014), 2, Seite 601-608 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:66 year:2014 number:2 pages:601-608 https://doi.org/10.2298/ABS1402601L kostenfrei https://doaj.org/article/57f7431837d446759b966fd892f3f21c kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402601L.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei https://doaj.org/toc/1821-4339 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 66 2014 2 601-608 |
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Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients |
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This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] |
abstractGer |
This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] |
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This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. [Projekat Ministarstva nauke Republike Srbije, br. 175073] |
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The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs. 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