Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells

Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal express...
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Autor*in:	Luana Abballe [verfasserIn] Angela Mastronuzzi [verfasserIn] Evelina Miele [verfasserIn] Andrea Carai [verfasserIn] Zein Mersini Besharat [verfasserIn] Marta Moretti [verfasserIn] Enrico De Smaele [verfasserIn] Felice Giangaspero [verfasserIn] Franco Locatelli [verfasserIn] Elisabetta Ferretti [verfasserIn] Agnese Po [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	medulloblastoma numb NUMB isoforms cancer stem cells neural stem cells sonic hedgehog signaling

Übergeordnetes Werk:	In: Frontiers in Pediatrics - Frontiers Media S.A., 2013, 6(2018)
Übergeordnetes Werk:	volume:6 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fped.2018.00315

Katalog-ID:	DOAJ005446295

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allfields	10.3389/fped.2018.00315 doi (DE-627)DOAJ005446295 (DE-599)DOAJ7b751c360de14a23911c397eeb4ea3ee DE-627 ger DE-627 rakwb eng RJ1-570 Luana Abballe verfasserin aut Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal expression has been described in several types of cancer. Involvement of deregulated Numb expression has been described in the malignant childhood brain tumor medulloblastoma, while Numb isoforms in these tumors and in cancer stem-like cells derived from them, have not been studied to date. Here we show that medulloblastoma stem-like cells and cerebellar neuronal stem cells (NSCs) express Numb p66 where its expression tampers stemness features. Furthermore, medulloblastoma samples evaluated in this study express decreased levels of Numb p66 while overexpressed Numb p72 compared with normal tissues. Our results uncover different roles for the two major Numb isoforms examined in medulloblastoma and a critical role for Numb p66 in regulating stem-like cells and NSCs maintenance. medulloblastoma numb NUMB isoforms cancer stem cells neural stem cells sonic hedgehog signaling Pediatrics Angela Mastronuzzi verfasserin aut Evelina Miele verfasserin aut Andrea Carai verfasserin aut Zein Mersini Besharat verfasserin aut Marta Moretti verfasserin aut Enrico De Smaele verfasserin aut Felice Giangaspero verfasserin aut Felice Giangaspero verfasserin aut Franco Locatelli verfasserin aut Franco Locatelli verfasserin aut Elisabetta Ferretti verfasserin aut Elisabetta Ferretti verfasserin aut Agnese Po verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 6(2018) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:6 year:2018 https://doi.org/10.3389/fped.2018.00315 kostenfrei https://doaj.org/article/7b751c360de14a23911c397eeb4ea3ee kostenfrei https://www.frontiersin.org/article/10.3389/fped.2018.00315/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2018
spelling	10.3389/fped.2018.00315 doi (DE-627)DOAJ005446295 (DE-599)DOAJ7b751c360de14a23911c397eeb4ea3ee DE-627 ger DE-627 rakwb eng RJ1-570 Luana Abballe verfasserin aut Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal expression has been described in several types of cancer. Involvement of deregulated Numb expression has been described in the malignant childhood brain tumor medulloblastoma, while Numb isoforms in these tumors and in cancer stem-like cells derived from them, have not been studied to date. Here we show that medulloblastoma stem-like cells and cerebellar neuronal stem cells (NSCs) express Numb p66 where its expression tampers stemness features. Furthermore, medulloblastoma samples evaluated in this study express decreased levels of Numb p66 while overexpressed Numb p72 compared with normal tissues. Our results uncover different roles for the two major Numb isoforms examined in medulloblastoma and a critical role for Numb p66 in regulating stem-like cells and NSCs maintenance. medulloblastoma numb NUMB isoforms cancer stem cells neural stem cells sonic hedgehog signaling Pediatrics Angela Mastronuzzi verfasserin aut Evelina Miele verfasserin aut Andrea Carai verfasserin aut Zein Mersini Besharat verfasserin aut Marta Moretti verfasserin aut Enrico De Smaele verfasserin aut Felice Giangaspero verfasserin aut Felice Giangaspero verfasserin aut Franco Locatelli verfasserin aut Franco Locatelli verfasserin aut Elisabetta Ferretti verfasserin aut Elisabetta Ferretti verfasserin aut Agnese Po verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 6(2018) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:6 year:2018 https://doi.org/10.3389/fped.2018.00315 kostenfrei https://doaj.org/article/7b751c360de14a23911c397eeb4ea3ee kostenfrei https://www.frontiersin.org/article/10.3389/fped.2018.00315/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2018
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allfieldsSound	10.3389/fped.2018.00315 doi (DE-627)DOAJ005446295 (DE-599)DOAJ7b751c360de14a23911c397eeb4ea3ee DE-627 ger DE-627 rakwb eng RJ1-570 Luana Abballe verfasserin aut Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal expression has been described in several types of cancer. Involvement of deregulated Numb expression has been described in the malignant childhood brain tumor medulloblastoma, while Numb isoforms in these tumors and in cancer stem-like cells derived from them, have not been studied to date. Here we show that medulloblastoma stem-like cells and cerebellar neuronal stem cells (NSCs) express Numb p66 where its expression tampers stemness features. Furthermore, medulloblastoma samples evaluated in this study express decreased levels of Numb p66 while overexpressed Numb p72 compared with normal tissues. Our results uncover different roles for the two major Numb isoforms examined in medulloblastoma and a critical role for Numb p66 in regulating stem-like cells and NSCs maintenance. medulloblastoma numb NUMB isoforms cancer stem cells neural stem cells sonic hedgehog signaling Pediatrics Angela Mastronuzzi verfasserin aut Evelina Miele verfasserin aut Andrea Carai verfasserin aut Zein Mersini Besharat verfasserin aut Marta Moretti verfasserin aut Enrico De Smaele verfasserin aut Felice Giangaspero verfasserin aut Felice Giangaspero verfasserin aut Franco Locatelli verfasserin aut Franco Locatelli verfasserin aut Elisabetta Ferretti verfasserin aut Elisabetta Ferretti verfasserin aut Agnese Po verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 6(2018) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:6 year:2018 https://doi.org/10.3389/fped.2018.00315 kostenfrei https://doaj.org/article/7b751c360de14a23911c397eeb4ea3ee kostenfrei https://www.frontiersin.org/article/10.3389/fped.2018.00315/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2018
language	English
source	In Frontiers in Pediatrics 6(2018) volume:6 year:2018
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topic_facet	medulloblastoma numb NUMB isoforms cancer stem cells neural stem cells sonic hedgehog signaling Pediatrics
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container_title	Frontiers in Pediatrics
authorswithroles_txt_mv	Luana Abballe @@aut@@ Angela Mastronuzzi @@aut@@ Evelina Miele @@aut@@ Andrea Carai @@aut@@ Zein Mersini Besharat @@aut@@ Marta Moretti @@aut@@ Enrico De Smaele @@aut@@ Felice Giangaspero @@aut@@ Franco Locatelli @@aut@@ Elisabetta Ferretti @@aut@@ Agnese Po @@aut@@
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callnumber-first	R - Medicine
author	Luana Abballe
spellingShingle	Luana Abballe misc RJ1-570 misc medulloblastoma misc numb misc NUMB isoforms misc cancer stem cells misc neural stem cells misc sonic hedgehog signaling misc Pediatrics Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells
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topic_title	RJ1-570 Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells medulloblastoma numb NUMB isoforms cancer stem cells neural stem cells sonic hedgehog signaling
topic	misc RJ1-570 misc medulloblastoma misc numb misc NUMB isoforms misc cancer stem cells misc neural stem cells misc sonic hedgehog signaling misc Pediatrics
topic_unstemmed	misc RJ1-570 misc medulloblastoma misc numb misc NUMB isoforms misc cancer stem cells misc neural stem cells misc sonic hedgehog signaling misc Pediatrics
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title	Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells
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title_full	Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells
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author_browse	Luana Abballe Angela Mastronuzzi Evelina Miele Andrea Carai Zein Mersini Besharat Marta Moretti Enrico De Smaele Felice Giangaspero Franco Locatelli Elisabetta Ferretti Agnese Po
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title_sort	numb isoforms deregulation in medulloblastoma and role of p66 isoform in cancer and neural stem cells
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title_auth	Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells
abstract	Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal expression has been described in several types of cancer. Involvement of deregulated Numb expression has been described in the malignant childhood brain tumor medulloblastoma, while Numb isoforms in these tumors and in cancer stem-like cells derived from them, have not been studied to date. Here we show that medulloblastoma stem-like cells and cerebellar neuronal stem cells (NSCs) express Numb p66 where its expression tampers stemness features. Furthermore, medulloblastoma samples evaluated in this study express decreased levels of Numb p66 while overexpressed Numb p72 compared with normal tissues. Our results uncover different roles for the two major Numb isoforms examined in medulloblastoma and a critical role for Numb p66 in regulating stem-like cells and NSCs maintenance.
abstractGer	Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal expression has been described in several types of cancer. Involvement of deregulated Numb expression has been described in the malignant childhood brain tumor medulloblastoma, while Numb isoforms in these tumors and in cancer stem-like cells derived from them, have not been studied to date. Here we show that medulloblastoma stem-like cells and cerebellar neuronal stem cells (NSCs) express Numb p66 where its expression tampers stemness features. Furthermore, medulloblastoma samples evaluated in this study express decreased levels of Numb p66 while overexpressed Numb p72 compared with normal tissues. Our results uncover different roles for the two major Numb isoforms examined in medulloblastoma and a critical role for Numb p66 in regulating stem-like cells and NSCs maintenance.
abstract_unstemmed	Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal expression has been described in several types of cancer. Involvement of deregulated Numb expression has been described in the malignant childhood brain tumor medulloblastoma, while Numb isoforms in these tumors and in cancer stem-like cells derived from them, have not been studied to date. Here we show that medulloblastoma stem-like cells and cerebellar neuronal stem cells (NSCs) express Numb p66 where its expression tampers stemness features. Furthermore, medulloblastoma samples evaluated in this study express decreased levels of Numb p66 while overexpressed Numb p72 compared with normal tissues. Our results uncover different roles for the two major Numb isoforms examined in medulloblastoma and a critical role for Numb p66 in regulating stem-like cells and NSCs maintenance.
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title_short	Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells
url	https://doi.org/10.3389/fped.2018.00315 https://doaj.org/article/7b751c360de14a23911c397eeb4ea3ee https://www.frontiersin.org/article/10.3389/fped.2018.00315/full https://doaj.org/toc/2296-2360
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author2	Angela Mastronuzzi Evelina Miele Andrea Carai Zein Mersini Besharat Marta Moretti Enrico De Smaele Felice Giangaspero Franco Locatelli Elisabetta Ferretti Agnese Po
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up_date	2024-07-03T15:03:20.954Z
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Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells

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