Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?

Abstract Expression of the platelet-activating factor receptor is upregulated in the respiratory epithelium of smokers and chronic obstructive pulmonary disease patients. We have recently determined that increased expression of PAFr correlates with higher levels of adhesion to human bronchial epithe...
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Gespeichert in:

Autor*in:	Ronan F. O’Toole [verfasserIn] Shakti D. Shukla [verfasserIn] Eugene H. Walters [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Airway epithelium Platelet-activating factor receptor Non-typeable Haemophilus influenzae Streptococcus pneumoniae

Übergeordnetes Werk:	In: Journal of Translational Medicine - BMC, 2003, 14(2016), 1, Seite 4
Übergeordnetes Werk:	volume:14 ; year:2016 ; number:1 ; pages:4

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12967-016-1063-x

Katalog-ID:	DOAJ005504503

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520			\|a Abstract Expression of the platelet-activating factor receptor is upregulated in the respiratory epithelium of smokers and chronic obstructive pulmonary disease patients. We have recently determined that increased expression of PAFr correlates with higher levels of adhesion to human bronchial epithelial cells by non-typable Haemophilus influenzae and Streptococcus pneumoniae which are major bacterial pathogens in acute exacerbations of COPD. In addition, we found that a PAFr antagonist decreased the adhesion of both respiratory bacterial pathogens to non-cigarette exposure control levels. This highlights the possibility that epithelial receptors, that are upregulated in response to cigarette smoke, could be targeted to specifically block chronic bacterial infections of the lower respiratory tract. In this commentary, we explore the question of whether adhesion to a temporally-upregulated host receptor is a common event in chronic bacterial disease, and as such, could represent a putative therapeutic target for blocking infection by respiratory and other pathogens.
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author	Ronan F. O’Toole
spellingShingle	Ronan F. O’Toole misc Airway epithelium misc Platelet-activating factor receptor misc Non-typeable Haemophilus influenzae misc Streptococcus pneumoniae misc Medicine misc R Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?
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topic_title	Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease? Airway epithelium Platelet-activating factor receptor Non-typeable Haemophilus influenzae Streptococcus pneumoniae
topic	misc Airway epithelium misc Platelet-activating factor receptor misc Non-typeable Haemophilus influenzae misc Streptococcus pneumoniae misc Medicine misc R
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title	Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?
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title_sort	does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?
title_auth	Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?
abstract	Abstract Expression of the platelet-activating factor receptor is upregulated in the respiratory epithelium of smokers and chronic obstructive pulmonary disease patients. We have recently determined that increased expression of PAFr correlates with higher levels of adhesion to human bronchial epithelial cells by non-typable Haemophilus influenzae and Streptococcus pneumoniae which are major bacterial pathogens in acute exacerbations of COPD. In addition, we found that a PAFr antagonist decreased the adhesion of both respiratory bacterial pathogens to non-cigarette exposure control levels. This highlights the possibility that epithelial receptors, that are upregulated in response to cigarette smoke, could be targeted to specifically block chronic bacterial infections of the lower respiratory tract. In this commentary, we explore the question of whether adhesion to a temporally-upregulated host receptor is a common event in chronic bacterial disease, and as such, could represent a putative therapeutic target for blocking infection by respiratory and other pathogens.
abstractGer	Abstract Expression of the platelet-activating factor receptor is upregulated in the respiratory epithelium of smokers and chronic obstructive pulmonary disease patients. We have recently determined that increased expression of PAFr correlates with higher levels of adhesion to human bronchial epithelial cells by non-typable Haemophilus influenzae and Streptococcus pneumoniae which are major bacterial pathogens in acute exacerbations of COPD. In addition, we found that a PAFr antagonist decreased the adhesion of both respiratory bacterial pathogens to non-cigarette exposure control levels. This highlights the possibility that epithelial receptors, that are upregulated in response to cigarette smoke, could be targeted to specifically block chronic bacterial infections of the lower respiratory tract. In this commentary, we explore the question of whether adhesion to a temporally-upregulated host receptor is a common event in chronic bacterial disease, and as such, could represent a putative therapeutic target for blocking infection by respiratory and other pathogens.
abstract_unstemmed	Abstract Expression of the platelet-activating factor receptor is upregulated in the respiratory epithelium of smokers and chronic obstructive pulmonary disease patients. We have recently determined that increased expression of PAFr correlates with higher levels of adhesion to human bronchial epithelial cells by non-typable Haemophilus influenzae and Streptococcus pneumoniae which are major bacterial pathogens in acute exacerbations of COPD. In addition, we found that a PAFr antagonist decreased the adhesion of both respiratory bacterial pathogens to non-cigarette exposure control levels. This highlights the possibility that epithelial receptors, that are upregulated in response to cigarette smoke, could be targeted to specifically block chronic bacterial infections of the lower respiratory tract. In this commentary, we explore the question of whether adhesion to a temporally-upregulated host receptor is a common event in chronic bacterial disease, and as such, could represent a putative therapeutic target for blocking infection by respiratory and other pathogens.
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title_short	Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?
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