<i<Pediococcus pentosaceus</i<-Fermented <i<Cordyceps militaris</i< Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis

<i<Cordyceps militaris</i< is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of <i<C. militaris</i< grown on germinated <i<Rhynchosia nulubilis</i< (GRC) fermented with <i<...
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Autor*in:	Ha-Kyoung Kwon [verfasserIn] Min-Jung Song [verfasserIn] Hye-Ji Lee [verfasserIn] Tae-Sik Park [verfasserIn] Moon Il Kim [verfasserIn] Hye-Jin Park [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	GRC-ON89A macrophage anti-inflammatory DNFB-induced ACD mice NF-κB

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 19(2018), 11, p 3504
Übergeordnetes Werk:	volume:19 ; year:2018 ; number:11, p 3504

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms19113504

Katalog-ID:	DOAJ005509475

Internformat


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Indexfelder

author_variant	h k k hkk m j s mjs h j l hjl t s p tsp m i k mik h j p hjp
matchkey_str	article:14220067:2018----::pdoocsetscuiemneiodcpmltrsihbtifamtrratosn
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allfields	10.3390/ijms19113504 doi (DE-627)DOAJ005509475 (DE-599)DOAJe41423507d954d58875fe81512ddf67a DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Ha-Kyoung Kwon verfasserin aut <i<Pediococcus pentosaceus</i<-Fermented <i<Cordyceps militaris</i< Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Cordyceps militaris</i< is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of <i<C. militaris</i< grown on germinated <i<Rhynchosia nulubilis</i< (GRC) fermented with <i<Pediococcus pentosaceus</i< ON89A isolated from onion (GRC-ON89A) in vivo as well as in vitro. The anti-inflammatory effect of GRC-ON89A was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The total polyphenol content (TPC) and total flavonoid content (TFC) in the GRC-ON89A ethanol extract were significantly increased compared to that in GRC. GRC-ON89A hexane fraction (GRC-ON89A-Hex) inhibited the release of nitric oxide (NO) compared to that of the LPS-treated control without cytotoxicity in LPS-stimulated RAW 264.7 macrophages. GRC-ON89A-Hex decreased the inducible NO synthase (iNOS), cyclooxygenase 2 (COX2), and tumor necrosis factor (TNF)-α mRNA expression in LPS-stimulated RAW 264.7 macrophages. In addition, pre-treatment with GRC-ON89A-Hex significantly inhibited LPS-stimulated phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB. To induce allergic contact dermatitis (ACD), 1-fluoro-2, 4-dinitrofluorobenzene (DNFB) was applied to the surface of the right ears of C57BL/6N mice. GRC-ON89A reduced the ear swelling and thickness in DNFB-induced ACD mice. This study demonstrates the potential usefulness of GRC-ON89A as an anti-inflammatory dietary supplement or drug. GRC-ON89A macrophage anti-inflammatory DNFB-induced ACD mice NF-κB Biology (General) Chemistry Min-Jung Song verfasserin aut Hye-Ji Lee verfasserin aut Tae-Sik Park verfasserin aut Moon Il Kim verfasserin aut Hye-Jin Park verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 19(2018), 11, p 3504 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:19 year:2018 number:11, p 3504 https://doi.org/10.3390/ijms19113504 kostenfrei https://doaj.org/article/e41423507d954d58875fe81512ddf67a kostenfrei https://www.mdpi.com/1422-0067/19/11/3504 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2018 11, p 3504
spelling	10.3390/ijms19113504 doi (DE-627)DOAJ005509475 (DE-599)DOAJe41423507d954d58875fe81512ddf67a DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Ha-Kyoung Kwon verfasserin aut <i<Pediococcus pentosaceus</i<-Fermented <i<Cordyceps militaris</i< Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Cordyceps militaris</i< is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of <i<C. militaris</i< grown on germinated <i<Rhynchosia nulubilis</i< (GRC) fermented with <i<Pediococcus pentosaceus</i< ON89A isolated from onion (GRC-ON89A) in vivo as well as in vitro. The anti-inflammatory effect of GRC-ON89A was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The total polyphenol content (TPC) and total flavonoid content (TFC) in the GRC-ON89A ethanol extract were significantly increased compared to that in GRC. GRC-ON89A hexane fraction (GRC-ON89A-Hex) inhibited the release of nitric oxide (NO) compared to that of the LPS-treated control without cytotoxicity in LPS-stimulated RAW 264.7 macrophages. GRC-ON89A-Hex decreased the inducible NO synthase (iNOS), cyclooxygenase 2 (COX2), and tumor necrosis factor (TNF)-α mRNA expression in LPS-stimulated RAW 264.7 macrophages. In addition, pre-treatment with GRC-ON89A-Hex significantly inhibited LPS-stimulated phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB. To induce allergic contact dermatitis (ACD), 1-fluoro-2, 4-dinitrofluorobenzene (DNFB) was applied to the surface of the right ears of C57BL/6N mice. GRC-ON89A reduced the ear swelling and thickness in DNFB-induced ACD mice. This study demonstrates the potential usefulness of GRC-ON89A as an anti-inflammatory dietary supplement or drug. GRC-ON89A macrophage anti-inflammatory DNFB-induced ACD mice NF-κB Biology (General) Chemistry Min-Jung Song verfasserin aut Hye-Ji Lee verfasserin aut Tae-Sik Park verfasserin aut Moon Il Kim verfasserin aut Hye-Jin Park verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 19(2018), 11, p 3504 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:19 year:2018 number:11, p 3504 https://doi.org/10.3390/ijms19113504 kostenfrei https://doaj.org/article/e41423507d954d58875fe81512ddf67a kostenfrei https://www.mdpi.com/1422-0067/19/11/3504 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2018 11, p 3504
allfields_unstemmed	10.3390/ijms19113504 doi (DE-627)DOAJ005509475 (DE-599)DOAJe41423507d954d58875fe81512ddf67a DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Ha-Kyoung Kwon verfasserin aut <i<Pediococcus pentosaceus</i<-Fermented <i<Cordyceps militaris</i< Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Cordyceps militaris</i< is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of <i<C. militaris</i< grown on germinated <i<Rhynchosia nulubilis</i< (GRC) fermented with <i<Pediococcus pentosaceus</i< ON89A isolated from onion (GRC-ON89A) in vivo as well as in vitro. The anti-inflammatory effect of GRC-ON89A was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The total polyphenol content (TPC) and total flavonoid content (TFC) in the GRC-ON89A ethanol extract were significantly increased compared to that in GRC. GRC-ON89A hexane fraction (GRC-ON89A-Hex) inhibited the release of nitric oxide (NO) compared to that of the LPS-treated control without cytotoxicity in LPS-stimulated RAW 264.7 macrophages. GRC-ON89A-Hex decreased the inducible NO synthase (iNOS), cyclooxygenase 2 (COX2), and tumor necrosis factor (TNF)-α mRNA expression in LPS-stimulated RAW 264.7 macrophages. In addition, pre-treatment with GRC-ON89A-Hex significantly inhibited LPS-stimulated phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB. To induce allergic contact dermatitis (ACD), 1-fluoro-2, 4-dinitrofluorobenzene (DNFB) was applied to the surface of the right ears of C57BL/6N mice. GRC-ON89A reduced the ear swelling and thickness in DNFB-induced ACD mice. This study demonstrates the potential usefulness of GRC-ON89A as an anti-inflammatory dietary supplement or drug. GRC-ON89A macrophage anti-inflammatory DNFB-induced ACD mice NF-κB Biology (General) Chemistry Min-Jung Song verfasserin aut Hye-Ji Lee verfasserin aut Tae-Sik Park verfasserin aut Moon Il Kim verfasserin aut Hye-Jin Park verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 19(2018), 11, p 3504 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:19 year:2018 number:11, p 3504 https://doi.org/10.3390/ijms19113504 kostenfrei https://doaj.org/article/e41423507d954d58875fe81512ddf67a kostenfrei https://www.mdpi.com/1422-0067/19/11/3504 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2018 11, p 3504
allfieldsGer	10.3390/ijms19113504 doi (DE-627)DOAJ005509475 (DE-599)DOAJe41423507d954d58875fe81512ddf67a DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Ha-Kyoung Kwon verfasserin aut <i<Pediococcus pentosaceus</i<-Fermented <i<Cordyceps militaris</i< Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Cordyceps militaris</i< is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of <i<C. militaris</i< grown on germinated <i<Rhynchosia nulubilis</i< (GRC) fermented with <i<Pediococcus pentosaceus</i< ON89A isolated from onion (GRC-ON89A) in vivo as well as in vitro. The anti-inflammatory effect of GRC-ON89A was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The total polyphenol content (TPC) and total flavonoid content (TFC) in the GRC-ON89A ethanol extract were significantly increased compared to that in GRC. GRC-ON89A hexane fraction (GRC-ON89A-Hex) inhibited the release of nitric oxide (NO) compared to that of the LPS-treated control without cytotoxicity in LPS-stimulated RAW 264.7 macrophages. GRC-ON89A-Hex decreased the inducible NO synthase (iNOS), cyclooxygenase 2 (COX2), and tumor necrosis factor (TNF)-α mRNA expression in LPS-stimulated RAW 264.7 macrophages. In addition, pre-treatment with GRC-ON89A-Hex significantly inhibited LPS-stimulated phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB. To induce allergic contact dermatitis (ACD), 1-fluoro-2, 4-dinitrofluorobenzene (DNFB) was applied to the surface of the right ears of C57BL/6N mice. GRC-ON89A reduced the ear swelling and thickness in DNFB-induced ACD mice. This study demonstrates the potential usefulness of GRC-ON89A as an anti-inflammatory dietary supplement or drug. GRC-ON89A macrophage anti-inflammatory DNFB-induced ACD mice NF-κB Biology (General) Chemistry Min-Jung Song verfasserin aut Hye-Ji Lee verfasserin aut Tae-Sik Park verfasserin aut Moon Il Kim verfasserin aut Hye-Jin Park verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 19(2018), 11, p 3504 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:19 year:2018 number:11, p 3504 https://doi.org/10.3390/ijms19113504 kostenfrei https://doaj.org/article/e41423507d954d58875fe81512ddf67a kostenfrei https://www.mdpi.com/1422-0067/19/11/3504 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2018 11, p 3504
allfieldsSound	10.3390/ijms19113504 doi (DE-627)DOAJ005509475 (DE-599)DOAJe41423507d954d58875fe81512ddf67a DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Ha-Kyoung Kwon verfasserin aut <i<Pediococcus pentosaceus</i<-Fermented <i<Cordyceps militaris</i< Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Cordyceps militaris</i< is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of <i<C. militaris</i< grown on germinated <i<Rhynchosia nulubilis</i< (GRC) fermented with <i<Pediococcus pentosaceus</i< ON89A isolated from onion (GRC-ON89A) in vivo as well as in vitro. The anti-inflammatory effect of GRC-ON89A was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The total polyphenol content (TPC) and total flavonoid content (TFC) in the GRC-ON89A ethanol extract were significantly increased compared to that in GRC. GRC-ON89A hexane fraction (GRC-ON89A-Hex) inhibited the release of nitric oxide (NO) compared to that of the LPS-treated control without cytotoxicity in LPS-stimulated RAW 264.7 macrophages. GRC-ON89A-Hex decreased the inducible NO synthase (iNOS), cyclooxygenase 2 (COX2), and tumor necrosis factor (TNF)-α mRNA expression in LPS-stimulated RAW 264.7 macrophages. In addition, pre-treatment with GRC-ON89A-Hex significantly inhibited LPS-stimulated phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB. To induce allergic contact dermatitis (ACD), 1-fluoro-2, 4-dinitrofluorobenzene (DNFB) was applied to the surface of the right ears of C57BL/6N mice. GRC-ON89A reduced the ear swelling and thickness in DNFB-induced ACD mice. This study demonstrates the potential usefulness of GRC-ON89A as an anti-inflammatory dietary supplement or drug. GRC-ON89A macrophage anti-inflammatory DNFB-induced ACD mice NF-κB Biology (General) Chemistry Min-Jung Song verfasserin aut Hye-Ji Lee verfasserin aut Tae-Sik Park verfasserin aut Moon Il Kim verfasserin aut Hye-Jin Park verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 19(2018), 11, p 3504 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:19 year:2018 number:11, p 3504 https://doi.org/10.3390/ijms19113504 kostenfrei https://doaj.org/article/e41423507d954d58875fe81512ddf67a kostenfrei https://www.mdpi.com/1422-0067/19/11/3504 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2018 11, p 3504
language	English
source	In International Journal of Molecular Sciences 19(2018), 11, p 3504 volume:19 year:2018 number:11, p 3504
sourceStr	In International Journal of Molecular Sciences 19(2018), 11, p 3504 volume:19 year:2018 number:11, p 3504
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	GRC-ON89A macrophage anti-inflammatory DNFB-induced ACD mice NF-κB Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Ha-Kyoung Kwon @@aut@@ Min-Jung Song @@aut@@ Hye-Ji Lee @@aut@@ Tae-Sik Park @@aut@@ Moon Il Kim @@aut@@ Hye-Jin Park @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
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callnumber-first	Q - Science
author	Ha-Kyoung Kwon
spellingShingle	Ha-Kyoung Kwon misc QH301-705.5 misc QD1-999 misc GRC-ON89A misc macrophage misc anti-inflammatory misc DNFB-induced ACD mice misc NF-κB misc Biology (General) misc Chemistry <i<Pediococcus pentosaceus</i<-Fermented <i<Cordyceps militaris</i< Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis
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topic_title	QH301-705.5 QD1-999 <i<Pediococcus pentosaceus</i<-Fermented <i<Cordyceps militaris</i< Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis GRC-ON89A macrophage anti-inflammatory DNFB-induced ACD mice NF-κB
topic	misc QH301-705.5 misc QD1-999 misc GRC-ON89A misc macrophage misc anti-inflammatory misc DNFB-induced ACD mice misc NF-κB misc Biology (General) misc Chemistry
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title	<i<Pediococcus pentosaceus</i<-Fermented <i<Cordyceps militaris</i< Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis
ctrlnum	(DE-627)DOAJ005509475 (DE-599)DOAJe41423507d954d58875fe81512ddf67a
title_full	<i<Pediococcus pentosaceus</i<-Fermented <i<Cordyceps militaris</i< Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis
author_sort	Ha-Kyoung Kwon
journal	International Journal of Molecular Sciences
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author_browse	Ha-Kyoung Kwon Min-Jung Song Hye-Ji Lee Tae-Sik Park Moon Il Kim Hye-Jin Park
container_volume	19
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author-letter	Ha-Kyoung Kwon
doi_str_mv	10.3390/ijms19113504
author2-role	verfasserin
title_sort	<i<pediococcus pentosaceus</i<-fermented <i<cordyceps militaris</i< inhibits inflammatory reactions and alleviates contact dermatitis
callnumber	QH301-705.5
title_auth	<i<Pediococcus pentosaceus</i<-Fermented <i<Cordyceps militaris</i< Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis
abstract	<i<Cordyceps militaris</i< is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of <i<C. militaris</i< grown on germinated <i<Rhynchosia nulubilis</i< (GRC) fermented with <i<Pediococcus pentosaceus</i< ON89A isolated from onion (GRC-ON89A) in vivo as well as in vitro. The anti-inflammatory effect of GRC-ON89A was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The total polyphenol content (TPC) and total flavonoid content (TFC) in the GRC-ON89A ethanol extract were significantly increased compared to that in GRC. GRC-ON89A hexane fraction (GRC-ON89A-Hex) inhibited the release of nitric oxide (NO) compared to that of the LPS-treated control without cytotoxicity in LPS-stimulated RAW 264.7 macrophages. GRC-ON89A-Hex decreased the inducible NO synthase (iNOS), cyclooxygenase 2 (COX2), and tumor necrosis factor (TNF)-α mRNA expression in LPS-stimulated RAW 264.7 macrophages. In addition, pre-treatment with GRC-ON89A-Hex significantly inhibited LPS-stimulated phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB. To induce allergic contact dermatitis (ACD), 1-fluoro-2, 4-dinitrofluorobenzene (DNFB) was applied to the surface of the right ears of C57BL/6N mice. GRC-ON89A reduced the ear swelling and thickness in DNFB-induced ACD mice. This study demonstrates the potential usefulness of GRC-ON89A as an anti-inflammatory dietary supplement or drug.
abstractGer	<i<Cordyceps militaris</i< is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of <i<C. militaris</i< grown on germinated <i<Rhynchosia nulubilis</i< (GRC) fermented with <i<Pediococcus pentosaceus</i< ON89A isolated from onion (GRC-ON89A) in vivo as well as in vitro. The anti-inflammatory effect of GRC-ON89A was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The total polyphenol content (TPC) and total flavonoid content (TFC) in the GRC-ON89A ethanol extract were significantly increased compared to that in GRC. GRC-ON89A hexane fraction (GRC-ON89A-Hex) inhibited the release of nitric oxide (NO) compared to that of the LPS-treated control without cytotoxicity in LPS-stimulated RAW 264.7 macrophages. GRC-ON89A-Hex decreased the inducible NO synthase (iNOS), cyclooxygenase 2 (COX2), and tumor necrosis factor (TNF)-α mRNA expression in LPS-stimulated RAW 264.7 macrophages. In addition, pre-treatment with GRC-ON89A-Hex significantly inhibited LPS-stimulated phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB. To induce allergic contact dermatitis (ACD), 1-fluoro-2, 4-dinitrofluorobenzene (DNFB) was applied to the surface of the right ears of C57BL/6N mice. GRC-ON89A reduced the ear swelling and thickness in DNFB-induced ACD mice. This study demonstrates the potential usefulness of GRC-ON89A as an anti-inflammatory dietary supplement or drug.
abstract_unstemmed	<i<Cordyceps militaris</i< is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of <i<C. militaris</i< grown on germinated <i<Rhynchosia nulubilis</i< (GRC) fermented with <i<Pediococcus pentosaceus</i< ON89A isolated from onion (GRC-ON89A) in vivo as well as in vitro. The anti-inflammatory effect of GRC-ON89A was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The total polyphenol content (TPC) and total flavonoid content (TFC) in the GRC-ON89A ethanol extract were significantly increased compared to that in GRC. GRC-ON89A hexane fraction (GRC-ON89A-Hex) inhibited the release of nitric oxide (NO) compared to that of the LPS-treated control without cytotoxicity in LPS-stimulated RAW 264.7 macrophages. GRC-ON89A-Hex decreased the inducible NO synthase (iNOS), cyclooxygenase 2 (COX2), and tumor necrosis factor (TNF)-α mRNA expression in LPS-stimulated RAW 264.7 macrophages. In addition, pre-treatment with GRC-ON89A-Hex significantly inhibited LPS-stimulated phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB. To induce allergic contact dermatitis (ACD), 1-fluoro-2, 4-dinitrofluorobenzene (DNFB) was applied to the surface of the right ears of C57BL/6N mice. GRC-ON89A reduced the ear swelling and thickness in DNFB-induced ACD mice. This study demonstrates the potential usefulness of GRC-ON89A as an anti-inflammatory dietary supplement or drug.
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container_issue	11, p 3504
title_short	<i<Pediococcus pentosaceus</i<-Fermented <i<Cordyceps militaris</i< Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis
url	https://doi.org/10.3390/ijms19113504 https://doaj.org/article/e41423507d954d58875fe81512ddf67a https://www.mdpi.com/1422-0067/19/11/3504 https://doaj.org/toc/1422-0067
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up_date	2024-07-03T15:27:23.397Z
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